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Tristetraprolin exerts tumor suppressive functions on the tumorigenesis of glioma by targeting IL-13.

Abstract：

:The RNA-binding protein tristetraprolin (TTP) is an adenine/uridine (AU)-rich elements (AREs)-binding protein that can induce the decay of AREs containing mRNAs. In this study, we demonstrated that TTP is significantly down-regulated in human glioma tissue samples and cell lines. It is also associated with diminished survival in glioma patients. Gain- and loss-of-function studies demonstrated that TTP inhibited the growth, migration and invasion of glioma cells through regulation of interleukin (IL)-13. Furthermore, mechanistic investigations showed that TTP attenuated activation of PI3K/Akt/mTOR pathway by IL-13, and the ectopic expression of IL-13 markedly abrogated the anti-invasive effect of TTP. Additionally, TTP were found inversely correlated with IL-13 in glioma specimens. In conclusion, our results suggested that the low expression of TTP is significantly associated with the growth and metastasis of human glioma cells by targeting IL-13, while TTP may be a potential therapeutic target for glioma treatment.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Zeng B,Zhu D,Su Z,Li Z,Yu Z

doi

10.1016/j.intimp.2016.07.001

subject

Has Abstract

pub_date

2016-10-01 00:00:00

pages

63-70

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(16)30270-3

journal_volume

39

pub_type

杂志文章

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