当前位置： SCI文献检索 > INTERNATIONAL IMMUNOPHARMACOLOGY期刊下所有文献 > Exosomes from high glucose-treated macrophages activate macrophages andinduce inflammatory responses via NF-κB signaling pathway in vitro and in vivo.

Exosomes from high glucose-treated macrophages activate macrophages andinduce inflammatory responses via NF-κB signaling pathway in vitro and in vivo.

Abstract：

:There is increasing evidence that macrophages play an important role in the development and pathogenesis of diabetic nephropathy (DN) by secreting inflammatory cytokines. Exosomes are a family of extracellular vesicles that are secreted from almost all types of cells and associated with cell-to-cell communications. In this article, we try to investigate whether high glucose (HG)-treated macrophages-derived exosomes could activate macrophages and induce inflammatory responses in vivo and in vitro. We incubated the exosomes from high glucose-treated Raw264.7 cells (HG-Exo) and Raw264.7 cells for 24 h. The expression levels of related inflammatory molecules and NF-κB p65 signaling pathway were identified, as well as the intracellular localization of NF-κB p65 was detected. In vivo, HG-Exo was injected into mice via tail vein and the related parameters of kidneys were detected. Compared with the exosomes from normal glucose-treated Raw264.7 cells (NG-Exo), HG-Exo contained higher concentrations of IL-1β and iNOS. HG-Exo-treated Raw264.7 cells secreted higher level of related inflammatory molecules and promoted NF-κB p65 signaling pathway expression. HG-Exo induced the production of intracellular iNOS and α-SMA. In the HG-Exo group, NF-κB p65 positive signals were mainly distributed in the nucleus area. HG-Exo treated mice kidneys displayed a significantly mesangial expansion and proliferation. NF-κB p65 protein expression levels in mice renal tissue treated with HG-Exo was significantly up-regulated. These findings suggest that high glucose treated macrophages-derived exosomes may activate macrophages and accelerate kidney injury via NF-κB p65 signaling pathway.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Zhu M,Sun X,Qi X,Xia L,Wu Y

doi

10.1016/j.intimp.2020.106551

subject

Has Abstract

pub_date

2020-07-01 00:00:00

pages

106551

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(20)30117-X

journal_volume

84

pub_type

杂志文章

相关文献

INTERNATIONAL IMMUNOPHARMACOLOGY文献大全
  • Key regulators in bee venom-induced apoptosis are Bcl-2 and caspase-3 in human leukemic U937 cells through downregulation of ERK and Akt.

    abstract：:Bee venom (BV) has been known to inhibit proliferation and induce apoptosis in cancer cells. However, the molecular mechanisms involved in BV-induced apoptosis are still uncharacterized in human leukemic cells. In the present study, we report that BV induces apoptosis in leukemic U937 cells through downregulation of E...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2006.07.027

    authors： Moon DO,Park SY,Heo MS,Kim KC,Park C,Ko WS,Choi YH,Kim GY

    更新日期：2006-12-05 00:00:00

  • Neuroinflammation in hemorrhagic transformation after tissue plasminogen activator thrombolysis: Potential mechanisms, targets, therapeutic drugs and biomarkers.

    abstract：:Hemorrhagic transformation (HT) is a common and serious complication following ischemic stroke, especially after tissue plasminogen activator (t-PA) thrombolysis, which is associated with increased mortality and disability. Due to the unknown mechanisms and targets of HT, there are no effective therapeutic drugs to de...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.intimp.2020.107216

    authors： Ma G,Pan Z,Kong L,Du G

    更新日期：2021-01-01 00:00:00

  • Stimulatory effect of antidepressants on the production of IL-6.

    abstract：:A body of evidence indicates that the therapeutic activity of antidepressants is connected with their modulatory effect on the inflammatory response system and cell-mediated immunity. The present study was carried out to examine the effects of antidepressant agents, such as imipramne, venlafaxine, l-5-hydroxytryptopha...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2003.11.006

    authors： Kubera M,Kenis G,Bosmans E,Kajta M,Basta-Kaim A,Scharpe S,Budziszewska B,Maes M

    更新日期：2004-02-01 00:00:00

  • Selective impairment of CD4+CD25+Foxp3+ regulatory T cells by paclitaxel is explained by Bcl-2/Bax mediated apoptosis.

    abstract：:Paclitaxel has become one of the most effective and widely used chemotherapeutic agents over the past decades. Although it has shown promise to selectively deplete regulatory T (Treg) cells in our previous study, the underlying molecular mechanism remains to be further elucidated. The present study focused on the effe...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2010.11.021

    authors： Liu N,Zheng Y,Zhu Y,Xiong S,Chu Y

    更新日期：2011-02-01 00:00:00

  • Efficacy of steroid and immunosuppressant combined therapy in Chinese patients with Henoch-Schönlein purpura nephritis: A retrospective study.

    abstract：:Suitable and efficient treatments for Henoch-Schönlein purpura nephritis (HSPN) with proteinuria remains unclear. Whether steroids combined with immunosuppressive agents improves prognosis compared to steroid therapy alone also remains controversial. This study explored whether combined therapy reduces proteinuria in ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106229

    authors： Yu Y,Chen J,Yin H,Deng Z,Xie Y,Yuan Q,Xu H,Liu S,Tao L,Peng Z

    更新日期：2020-04-01 00:00:00

  • Low dose cepharanthine ameliorates immune thrombocytopenic purpura associated with multiple myeloma.

    abstract：:Immune thrombocytopenic purpura associated with multiple myeloma is extremely rare. Here, we present the successful management of an elderly Japanese patient with multiple myeloma complicated by immune thrombocytopenia with low dose cepharanthine - a plant derived alkaloid. A 78-year-old male patient with IgGκ multipl...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.intimp.2012.04.015

    authors： Tabata R,Tabata C,Tazoh A,Nagai T

    更新日期：2012-07-01 00:00:00

  • Activation of NRF2 pathway in spleen, thymus as well as peripheral blood mononuclear cells by acute arsenic exposure in mice.

    abstract：:Arsenic has already been demonstrated to activate the nuclear factor erythroid 2-related factor 2 (NRF2) in many different organs and cell lines. The present study tried to explore the expression of NRF2 pathway by acute arsenic exposure in immune system in vivo. Our results showed that treatment with arsenic (sodium ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2015.08.025

    authors： Duan X,Li J,Zhang Y,Li W,Zhao L,Nie H,Sun G,Li B

    更新日期：2015-10-01 00:00:00

  • The role of kinins in the proliferation of fibroblast primed with TNF in scratch wound assay: Kinins and cell proliferation.

    abstract：:The aim of this study was to evaluate the involvement of both B1 and B2 kinins receptors (B1R and B2R) in the fibroblast proliferation induced by the cytokine tumour necrosis factor (TNF) attempting to establish an in vitro model of wound healing. Murine fibroblasts L-929 were cultivated in 24 wells plaque until total...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2018.09.036

    authors： França AJVBDV,De Faveri R,Nunes R,Steimbach VMB,Santin JR,Quintão NLM

    更新日期：2018-12-01 00:00:00

  • Naringenin ameliorates daunorubicin induced nephrotoxicity by mitigating AT1R, ERK1/2-NFκB p65 mediated inflammation.

    abstract：:Inflammation and oxidative stress play important roles in the progression of renal damage. The natural polyphenol naringenin is known to exert potent antioxidant and anti-inflammatory effects. In this study, we have investigated the effect of naringenin on kidney dysfunction, fibrosis, endoplasmic reticulum (ER) stres...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2015.05.050

    authors： Karuppagounder V,Arumugam S,Thandavarayan RA,Pitchaimani V,Sreedhar R,Afrin R,Harima M,Suzuki H,Suzuki K,Nakamura M,Ueno K,Watanabe K

    更新日期：2015-09-01 00:00:00

  • Lectin from Abelmoschus esculentus reduces zymosan-induced temporomandibular joint inflammatory hypernociception in rats via heme oxygenase-1 pathway integrity and tnf-α and il-1β suppression.

    abstract：:Temporomandibular joint (TMJ) disorders show inflammatory components, heavily impacting on quality of life. Abelmoschus esculentus is largely cultivated in Northeastern Brazil for medicinal purposes, having it shown anti-inflammatory activity. We evaluated A. esculentus lectin (AEL) efficacy in reducing zymosan-induce...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2016.06.012

    authors： Freitas RS,do Val DR,Fernandes ME,Gomes FI,de Lacerda JT,SantiGadelha T,de Almeida Gadelha CA,de Paulo Teixeira Pinto V,Cristino-Filho G,Pereira KM,de Castro Brito GA,Bezerra MM,Chaves HV

    更新日期：2016-09-01 00:00:00

  • Interleukin-10 delivered by mesenchymal stem cells attenuates experimental autoimmune myocarditis.

    abstract：BACKGROUNDS:Autoimmune myocarditis is characterized by over-activated immune system attacking the cardiomyocytes, resulting in heart function decline. In the current study, we investigated the therapeutic advantages of delivering Interleukin-10 (IL-10) by mesenchymal stem cells (MSCs), both of which had immune suppress...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106212

    authors： Shao M,Wang D,Zhou Y,Du K,Liu W

    更新日期：2020-04-01 00:00:00

  • A prenylated flavonoid, 10-oxomornigrol F, exhibits anti-inflammatory effects by activating the Nrf2/heme oxygenase-1 pathway in macrophage cells.

    abstract：:Prenylated flavonoids are a unique class of naturally occurring flavonoids that have various pharmacological activities. In the present study, we investigated the anti-inflammatory effect in murine macrophages of a prenylated flavonoid, 10-oxomornigrol F (OMF), which was isolated from the twigs of Morus alba (Moraceae...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2017.12.015

    authors： Tran PL,Tran PT,Tran HNK,Lee S,Kim O,Min BS,Lee JH

    更新日期：2018-02-01 00:00:00

  • Astilbin promotes the induction of regulatory NK1.1- CD4+ NKG2D+ T cells through the PI3K, STAT3, and MAPK signaling pathways.

    abstract：:Astilbin is a potential agent for autoimmune and inflammatory diseases and has a protective effect in mice with DSS-induced colitis. NK1.1- CD4+ NKG2D+ T cells are a subpopulation of regulatory T cells that produce TGF-β1 and IL-10. Whether astilbin directly promotes the induction of NK1.1- CD4+ NKG2D+ T cells and whe...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.106143

    authors： Han S,Lin Z,Wen J,Wu K,Xu Y,Zhang Y,Lu G,Xiao W,Ding Y,Jia X,Deng B,Gong W

    更新日期：2020-04-01 00:00:00

  • (E)-1-(4-ethoxyphenyl)-3-(4-nitrophenyl)-prop-2-en-1-one suppresses LPS-induced inflammatory response through inhibition of NF-κB signaling pathway.

    abstract：:Flavonoids are a class of compounds that exist in nature with the structure of 2-phenyl-chromone. In Chinese traditional medicine, herbal drugs containing flavonoids are widely used for the treatment of inflammation, cardiovascular disease, tumor and so on. In this study, we investigated the anti-inflammatory effect a...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2013.02.024

    authors： Xu J,Jia YY,Chen SR,Ye JT,Bu XZ,Hu Y,Ma YZ,Guo JL,Liu PQ

    更新日期：2013-04-01 00:00:00

  • Anti-allergic potential of oligomannose-coated liposome-entrapped Cry j 1 as immunotherapy for Japanese cedar pollinosis in mice.

    abstract：:Administration of oligomannose-coated liposomes (OMLs) in mice can induce Th1 immune responses against antigens entrapped in the OMLs. In the present study, we investigated the anti-allergic effect of treatment with oligomannose-coated liposomes (OMLs) with entrapped Cry j 1, a major allergen of Japanese cedar pollen ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2010.06.003

    authors： Ishii M,Koyama A,Iseki H,Narumi H,Yokoyama N,Kojima N

    更新日期：2010-09-01 00:00:00

  • Acute morphine treatment alters cellular immune function in the lungs of healthy rats.

    abstract：:Previous work has shown that morphine suppresses the pulmonary immune response to infection and reduces pulmonary inflammation. No published studies have addressed the impact of morphine on lymphocyte function in the lungs without infection. This study addressed this question by assessing the impact of acute morphine ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/s1567-5769(01)00072-8

    authors： Coussons-Read ME,Giese S

    更新日期：2001-08-01 00:00:00

  • γδ T cells in infection and autoimmunity.

    abstract：:Standing at the interface of innate and adaptive immune, γδ T cells play important pathophysiologic roles in infection, autoimmunity, and tumorigenesis. Recent studies indicate that γδ T cells could be categorized into IFN-γ(+) and IL-17(+) subsets, both of which possess select TCR usages, bear unique surface markers ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.intimp.2015.03.038

    authors： Hou L,Wang T,Sun J

    更新日期：2015-10-01 00:00:00

  • Effects of ghrelin on pulmonary NOD2 mRNA expression and NF-κB activation when protects against acute lung injury in rats challenged with cecal ligation and puncture.

    abstract：BACKGROUND:Many studies have shown that ghrelin can down-regulate inflammatory cytokine expression via the inhibition of NF-κB activity and therefore, its administration to septic patients is considered beneficial. However, our knowledge of ghrelin's effects on the upstream activators of the NF-κB pathway, such as NOD2...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2012.04.006

    authors： Peng Z,Zhu Y,Zhang Y,Wilhelmsen K,Jia C,Jin J,Xue Q,Feng X,Zhang F,Yu B

    更新日期：2012-08-01 00:00:00

  • Tumor associated macrophages in the molecular pathogenesis of ovarian cancer.

    abstract：:The tumor microenvironment is a critical factor that enhances cancer progression, drug resistance, and failure of therapeutic approaches. Several cellular and non-cellular factors are involved in cancer promotion. Among the several cell populations in the tumor microenvironment, macrophages, as one of the most abundan...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.intimp.2020.106471

    authors： Yousefzadeh Y,Hallaj S,Baghi Moornani M,Asghary A,Azizi G,Hojjat-Farsangi M,Ghalamfarsa G,Jadidi-Niaragh F

    更新日期：2020-07-01 00:00:00

  • Comparative effect of berberine and its derivative 8-cetylberberine on attenuating atherosclerosis in ApoE-/- mice.

    abstract：:Berberine (BBR), one of the main bioactive compounds in Rhizoma coptidis, has multiple pharmacological activities. It has been reported that 8-cetylberberine (8-BBR-C16) has increased anti-microbial property in vivo and a higher bioavailability in hamsters. Therefore, in the present study, we used apolipoprotein E-def...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2016.12.001

    authors： Feng M,Zou Z,Zhou X,Hu Y,Ma H,Xiao Y,Li X,Ye X

    更新日期：2017-02-01 00:00:00

  • Thalidomide induce response in patients with corticosteroid-resistant or relapsed ITP by upregulating Neuropilin-1 expression.

    abstract：BACKGROUND:Immune thrombocytopenia (ITP) is an immune-mediated acquired autoimmune hemorrhagic disease. About one-third of patients are unresponsive to first-line therapies. Thalidomide (THD) as an immunomodulatory agent is now used to treat several autoimmune disorders. Therefore, we assessed the safety and efficacy o...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.04.041

    authors： Yang ZG,Wen RT,Zhang YM,Wu GC,Chen WJ,Wang YF,Weng ZY,Wen SS,Zhang XJ,Guan MH

    更新日期：2019-07-01 00:00:00

  • Increased circulating CD4+CXCR5+FoxP3+ follicular regulatory T cells correlated with severity of systemic lupus erythematosus patients.

    abstract：:As one specialized subset of regulatory T cells (Tregs), follicular regulatory T cells (TFR) could suppress follicular helper T cells (TFH) and B cells in germinal centers to maintain immune homeostasis. The unbalance of TFR and TFH cells could result in abnormal germinal center responses and contribute to pathogenesi...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2018.01.038

    authors： Liu C,Wang D,Song Y,Lu S,Zhao J,Wang H

    更新日期：2018-03-01 00:00:00

  • The role of the Annexin-A1/FPR2 system in the regulation of mast cell degranulation provoked by compound 48/80 and in the inhibitory action of nedocromil.

    abstract：:1.We investigated the role of Annexin (ANX)-A1 and its receptor, ALX/FPR2, in the regulation of mast cell degranulation produced by compound 48/80. 2.Both human cord-blood derived mast cells (CBDMCs) and murine bone marrow derived mast cells (BMDMCs) release phosphorylated ANX-A1 during treatment with glucocorticoids ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2016.01.003

    authors： Sinniah A,Yazid S,Perretti M,Solito E,Flower RJ

    更新日期：2016-03-01 00:00:00

  • The impact of a new immunomodulator oxo-quinoline-3-carboxamide on the progression of experimental lupus.

    abstract：:Autoimmune, lupus-prone MRL lpr/lpr mice were treated orally with oxo-quinoline-3-carboxamide (ABR-25757), a newly developed immunomodulator. Treatment was initiated in one set of experiment at the age of 10 weeks, before the onset of clinically apparent disease, and in another set at 15 weeks, after the development o...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2004.07.009

    authors： Carlsten H,Jonsson C,Bokarewa M,Svensson L,Tarkowski A

    更新日期：2004-11-01 00:00:00

  • Impaired function of hepatic natural killer cells from murine chronic HBsAg carriers.

    abstract：:In the present study, we demonstrated hepatic NK cells in murine chronic HBsAg carriers for the first time. It was found that the number of hepatic NK cells was decreased; natural activation of hepatic NK cells was declined; and cytotoxicity of hepatic NK cells was attenuated, which might relate to the down-regulated ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2005.06.004

    authors： Chen Y,Wei H,Sun R,Tian Z

    更新日期：2005-12-01 00:00:00

  • Immunomodulatory pretreatment with Kalanchoe pinnata extract and its quercitrin flavonoid effectively protects mice against fatal anaphylactic shock.

    abstract：:Previously, we reported the immunosuppressive action of the aqueous extract of Kalanchoe pinnata (Kp) in mice. In the present study, we report on the protective effect of Kp in fatal anaphylactic shock, likewise a Th2-driven immunopathology, and the identification of its active component. Mice daily treated with oral ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2008.07.006

    authors： Cruz EA,Da-Silva SA,Muzitano MF,Silva PM,Costa SS,Rossi-Bergmann B

    更新日期：2008-12-10 00:00:00

  • Sirt1 activation negatively regulates overt apoptosis in Mtb-infected macrophage through Bax.

    abstract：:Apoptotic pathways play an important role in Mycobacterium tuberculosis-infected macrophages. Sirt1 is a member of the deacetylase family that is known to promote apoptosis resistance in many mammalian cells. However, the apoptotic role of Sirt1 in the process of M. tuberculosis infection remains unclear. With the hel...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.107283

    authors： Yang H,Chen J,Chen Y,Jiang Y,Ge B,Hong L

    更新日期：2021-02-01 00:00:00

  • Antipsychotic treatment may alter T-helper (TH) 2 arm cytokines.

    abstract：:The alteration of T helper 1 (TH1) and TH2 responses and related cell-mediated immunity has been supposed to be associated with the immunological pathogenesis in the development of schizophrenia. Increasing evidence suggested the alteration of cytokines in accordance with the antipsychotic treatment as well, so that t...

    journal_title：International immunopharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.intimp.2005.10.004

    authors： Pae CU,Yoon CH,Kim TS,Kim JJ,Park SH,Lee CU,Lee SJ,Lee C,Paik IH

    更新日期：2006-04-01 00:00:00

  • Oridonin protects against the inflammatory response in diabetic nephropathy by inhibiting the TLR4/p38-MAPK and TLR4/NF-κB signaling pathways.

    abstract：:Inflammation plays a pivotal role in the development and progression of diabetic nephropathy (DN). Oridonin (Ori), a component isolated from Rabdosia rubescens, possesses remarkable anti-inflammatory, immunoregulatory and antitumor properties. However, the renoprotective effects of Ori and the underlying molecular mec...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2017.11.040

    authors： Li J,Bao L,Zha D,Zhang L,Gao P,Zhang J,Wu X

    更新日期：2018-02-01 00:00:00

  • Dendritic cells with an increased PD-L1 by TGF-β induce T cell anergy for the cytotoxicity of hepatocellular carcinoma cells.

    abstract：:The effects of TGF-β on dendritic cells (DCs) in the tumor microenvironment are not well-understood. In this study, we investigated the effect of TGF-β on the induction of programmed death ligand-1 (PD-L1) expression in DCs and the underlying mechanism, and we further investigated the influence of the DCs with PD-L1 e...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2014.02.027

    authors： Song S,Yuan P,Wu H,Chen J,Fu J,Li P,Lu J,Wei W

    更新日期：2014-05-01 00:00:00