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Resveratrol inhibits nitric oxide and TNF-alpha production by lipopolysaccharide-activated microglia.

Abstract：

:Upon activation, brain macrophages, the microglia, release proinflammatory mediators that play important roles in eliciting neuroinflammatory responses associated with neurodegenerative diseases. As resveratrol, an antioxidant component of grape, has been reported to exert anti-inflammatory activities on macrophages, we investigated its effects on the production of TNF-alpha (TNF-alpha) and nitric oxide (NO) by lipopolysaccharide (LPS)-activated microglia. Exposure of cultured rat cortical microglia and a mouse microglial cell line N9 to LPS increased their release of TNF-alpha and NO, which was significantly inhibited by resveratrol. Further studies revealed that resveratrol suppressed LPS-induced degradation of IkappaBalpha, expression of iNOS and phosphorylation of p38 mitogen-activated protein kinases (MAPKs) in N9 microglial cells. These results demonstrate a potent suppressive effect of resveratrol on proinflammatory responses of microglia, suggesting a therapeutic potential for this compound in neurodegenerative diseases accompanied by microglial activation.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Bi XL,Yang JY,Dong YX,Wang JM,Cui YH,Ikeshima T,Zhao YQ,Wu CF

doi

10.1016/j.intimp.2004.08.008

keywords:

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

185-93

issue

1

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(04)00276-0

journal_volume

5

pub_type

杂志文章

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