abstract：:Charcot spine arthropathy (CSA), a result of reduced afferent innervation, is an occurrence of Charcot joint, a progressive, degenerative disorder in vertebral joints, related mostly to spinal cord injury. The repeated microtrauma is a result of a lack of muscle protection and destroys cartilage, ligaments, and disc s...

journal_title：Therapeutic advances in musculoskeletal disease

authors： Urits I,Amgalan A,Israel J,Dugay C,Zhao A,Berger AA,Kassem H,Paladini A,Varrassi G,Kaye AD,Miriyala S,Viswanath O

更新日期：2020-12-17 00:00:00

abstract：:Osteoarthritis is a painful, disabling condition which is increasing in prevalence as a result of an ageing population. With no recognized disease-limiting therapeutics, arthroplasty of the hip and knee is the most common and effective treatment for lower limb osteoarthritis, however lower limb arthroplasty has a fini...

journal_title：Therapeutic advances in musculoskeletal disease

authors： Sorial AK,Anjum SA,Cook MJ,Board TN,O'Neill TW

更新日期：2020-12-16 00:00:00

abstract：:Osteoporosis in children differs from adults in terms of definition, diagnosis, monitoring and treatment options. Primary osteoporosis comprises primarily of osteogenesis imperfecta (OI), but there are significant other causes of bone fragility in children that require treatment. Secondary osteoporosis can be a result...

journal_title：Therapeutic advances in musculoskeletal disease

authors： Sakka SD,Cheung MS

更新日期：2020-11-02 00:00:00

abstract：:Patients with autoimmune rheumatic diseases (ARD) have an increased risk for tuberculosis (TB). The use of tumor necrosis factor inhibitors (TNFi) and glucocorticoids in these patients has been associated with an increased prevalence of latent TB reactivation. Over the last few years, several biologic disease-modifyin...

journal_title：Therapeutic advances in musculoskeletal disease

authors： Evangelatos G,Koulouri V,Iliopoulos A,Fragoulis GE

更新日期：2020-06-22 00:00:00

abstract：:We aimed to perform a structured literature review of spinal radiographic progression, as assessed by the modified Stoke Ankylosing Spondylitis Spine Score (mSASSS), in patients with ankylosing spondylitis (AS) or nonradiographic axial spondyloarthritis (nr-axSpA) treated with biologic therapy. Searches were limited t...

journal_title：Therapeutic advances in musculoskeletal disease

authors： Baraliakos X,Gensler LS,D'Angelo S,Iannone F,Favalli EG,de Peyrecave N,Auteri SE,Caporali R

更新日期：2020-03-04 00:00:00

abstract：:Rheumatoid arthritis (RA) is an autoimmune disorder with multifactorial etiology; both genetic and environmental factors are known to be involved in pathogenesis. Treatment with disease-modifying antirheumatic drugs (DMARDs) plays an essential role in controlling disease progression and symptoms. DMARDs have immunomod...

journal_title：Therapeutic advances in musculoskeletal disease

authors： Bodkhe R,Balakrishnan B,Taneja V

更新日期：2019-07-30 00:00:00

abstract：Background:'Unsafe' movement strategies used to perform everyday activities were quantified using scores for tasks included in the Short Form Safe Functional Motion test series (SSFM). Baseline scores were independently associated with incident fractures after adjusting for factors known to effect fracture risk. The pu...

journal_title：Therapeutic advances in musculoskeletal disease

authors： Recknor CP,Van Dussen D,MacIntyre N,Recknor J

更新日期：2019-06-24 00:00:00

abstract：Background:We aimed to systematically review the effectiveness of healthcare behavioral and education interventions for gout patients on clinical outcomes. Methods:We searched multiple databases to identify trials or observational studies of educational or behavioral interventions in gout. Risk of bias was assessed wi...

journal_title：Therapeutic advances in musculoskeletal disease

authors： Ramsubeik K,Ramrattan LA,Kaeley GS,Singh JA

更新日期：2018-11-19 00:00:00

abstract：:[This corrects the article DOI: 10.1177/1759720X18776224.]. ...

journal_title：Therapeutic advances in musculoskeletal disease

authors：

更新日期：2018-10-08 00:00:00

abstract：:Osteoporosis is the most commonly encountered metabolic bone disease, and metabolic bone-disease clinics have been established to assist in the diagnosis and treatment of uncommon causes of low bone-mineral density. Hypophosphatemia leading to metabolic bone disease may be encountered, and an understanding of phosphat...

journal_title：Therapeutic advances in musculoskeletal disease

authors： Day AL,Morgan SL,Saag KG

更新日期：2018-07-01 00:00:00

abstract：:Anti-interleukin (IL) therapies have emerged as a major treatment for patients with moderate-to-severe psoriasis. This article reviews the up-to-date results of pivotal clinical trials targeting the interleukins used for the treatment of psoriasis, including IL-1, IL-2, IL-6, IL-8, IL-10, IL-12, IL-17, IL-20, IL-22, I...

journal_title：Therapeutic advances in musculoskeletal disease

authors： Tsai YC,Tsai TF

更新日期：2017-11-01 00:00:00

abstract：:Annual administration of 5 mg intravenous zoledronate is moderately effective in reducing fracture risk in older adults, decreasing the relative risk of clinical fracture by 33%. However, almost 10 years after its approval for use in clinical practice there remain very substantial uncertainties about the optimal treat...

journal_title：Therapeutic advances in musculoskeletal disease

authors： Grey A

更新日期：2016-08-01 00:00:00

abstract：:Denosumab is a human monoclonal antibody which specifically blocks receptor activator of nuclear factor κB ligand and is a very potent antiresorptive drug. Its efficacy in reducing the risk of vertebral, hip and nonskeletal fracture has been proven in a large prospective, randomized multicenter study of 7808 postmenop...

journal_title：Therapeutic advances in musculoskeletal disease

authors： Törring O

更新日期：2015-06-01 00:00:00

abstract：:Inflammatory eye reactions (IERs) are rare but have been associated with medications to treat osteoporosis. The aim of this review is to summarize the current literature on the association between IERs and specific medications to treat osteoporosis (bisphosphonates, selective estrogen receptor modulators, strontium, d...

journal_title：Therapeutic advances in musculoskeletal disease

authors： Clark EM,Durup D

更新日期：2015-02-01 00:00:00

abstract：:Biological therapies and new imaging techniques have changed the therapeutic and diagnostic approach to spondyloarthritis. In patients with axial spondyloarthritis, tumor necrosis factor α (TNFα) inhibitor treatment is currently the only effective therapy in patients for whom conventional therapy with nonsteroidal ant...

journal_title：Therapeutic advances in musculoskeletal disease

authors： Bruner V,Atteno M,Spanò A,Scarpa R,Peluso R

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Sarcoidosis is known as a T helper 1 lymphocyte (Th1-Ly) mediated disease which can imitate or sometimes accompany many primary rheumatic diseases. The purpose of this study is to share the clinical, demographic and laboratory data of patients presenting with rheumatologic manifestations and diagnosed with s...

journal_title：Therapeutic advances in musculoskeletal disease

authors： Kobak S,Sever F,Sivrikoz ON,Orman M

更新日期：2014-02-01 00:00:00

abstract：:Fibrates are used as lipid-lowering drugs to prevent cardiovascular pathology. Fibrates are ligands of peroxisome proliferator-activated receptor α (PPARα). Besides altering lipid metabolism, PPARα ligands exert anti-inflammatory effects on various cell types. In this study, we hypothesized that PPARα agonists exert b...

journal_title：Therapeutic advances in musculoskeletal disease

authors： van Eekeren IC,Clockaerts S,Bastiaansen-Jenniskens YM,Lubberts E,Verhaar JA,van Osch GJ,Bierma-Zeinstra SM

更新日期：2013-02-01 00:00:00

abstract：:Macrophages, T and B cells, and neutrophils concentrate mainly into the synovial tissue of rheumatoid arthritis (RA) patients and produce several inflammatory mediators including cytokines. More recently, small molecule inhibitors of signalling mediators which have intracellular targets (mainly in T and B cells) such ...

journal_title：Therapeutic advances in musculoskeletal disease

authors： Cutolo M

更新日期：2013-02-01 00:00:00

abstract：:Chronic pain conditions affect at least 116 million US adults and more than one-third of adults worldwide. Nonsteroidal anti-inflammatory drugs (NSAIDs) are used extensively for the treatment of chronic pain due to their efficacy as anti-inflammatory and analgesic agents. Gastrointestinal toxicity is the most well kno...

journal_title：Therapeutic advances in musculoskeletal disease

authors： Bello AE

更新日期：2012-10-01 00:00:00

abstract：OBJECTIVES:All biologic agents approved for the treatment of rheumatoid arthritis (RA) have been tested versus methotrexate (MTX) for efficacy on damage progression in several randomized clinical trials (RCTs), but direct head-to-head comparisons have never been conducted. The purpose of this investigation is to analys...

journal_title：Therapeutic advances in musculoskeletal disease

authors： Favalli EG,Pregnolato F,Biggioggero M,Meroni PL

更新日期：2012-08-01 00:00:00

abstract：:Pseudogout and the associated calcium pyrophosphate dihydrate (CPPD)- crystal-related arthropathies are common conditions that present particular management problems in clinical practice as they often affect older patients with multiple medical comorbidities. The epidemiology, metabolic and endocrine disease associati...

journal_title：Therapeutic advances in musculoskeletal disease

authors： Macmullan P,McCarthy G

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND/OBJECTIVES:This postmarketing surveillance study assessed the preference, satisfaction, usability, and tolerability of subcutaneous self-administration of a high-concentration (50 mg/ml) ready-to-use formulation of methotrexate (MTX) in patients with rheumatoid arthritis or psoriatic arthritis. METHODS:The ...

journal_title：Therapeutic advances in musculoskeletal disease

authors： Striesow F,Brandt A

更新日期：2012-02-01 00:00:00

abstract：OBJECTIVES:We tested the ability of the VASFIQ, a seven-item scale composed of Fibromyalgia Impact Questionnaire (FIQ) visual analog scales (VASs), to quantify fibromyalgia global disease severity and identify fibromyalgia patients with significant symptoms of fatigue, poor sleep, depression or anxiety. METHODS:Spearm...

journal_title：Therapeutic advances in musculoskeletal disease

authors： Boomershine CS,Emir B,Wang Y,Zlateva G

更新日期：2011-10-01 00:00:00

abstract：:Sternocostoclavicular hyperostosis (SCCH) is a chronic inflammatory disorder which presents with erythema, swelling, and pain of the sternoclavicular joint. Approximately one half of patients have acne or pustular lesions with the best described association being with palmoplantar pustulosis (PPP). Extrasternal articu...

journal_title：Therapeutic advances in musculoskeletal disease

authors： Carroll MB

更新日期：2011-04-01 00:00:00

abstract：:Osteoarthritis (OA) is the most common form of arthritis worldwide yet there is still a lack of effective treatments for this condition. Increasingly, attention has turned to the role of the synovium in OA as it is now recognized, in part from the use of modern imaging techniques, that synovitis is both common and ass...

journal_title：Therapeutic advances in musculoskeletal disease

authors： Wenham CY,Conaghan PG

更新日期：2010-12-01 00:00:00

abstract：:Out of 100 patients with osteoarthritis (OA), almost 40 have a concomitant diagnosis of hypertension. Nonsteroidal anti-inflammatory drugs (NSAIDs) and cyclooxygenase-2 (COX-2) inhibitors may trigger a rise in blood pressure (BP), which is more marked in patients with established hypertension. NSAIDs and COX-2 inhibit...

journal_title：Therapeutic advances in musculoskeletal disease

authors： Verdecchia P,Angeli F,Mazzotta G,Martire P,Garofoli M,Gentile G,Reboldi G

更新日期：2010-08-01 00:00:00

abstract：:Botulinum (BoNT) toxin has been used for its muscle-paralyzing action in conditions such as treatment of wrinkles, cervical dystonia and blephrospasm. There is preclinical and emerging clinical evidence of another mechanism of action of BoNT, namely, an antinociceptive action. In this review, we provide an evidence-ba...

journal_title：Therapeutic advances in musculoskeletal disease

authors： Singh JA

更新日期：2010-04-01 00:00:00

abstract：:Despite important progress in the treatment of rheumatoid arthritis in the last decade, even in the era of tumour necrosis factor (TNF) blockade there is a need for additional therapeutic options in many patients. In recent years three therapies with a distinct mode of action became available: rituximab, an anti-B cel...

journal_title：Therapeutic advances in musculoskeletal disease

authors： Westhovens R,Verschueren P

更新日期：2010-04-01 00:00:00

abstract：:Osteocytes were the forgotten bone cell until the bone community could become convinced that these cells do serve an important role in bone function and maintenance. In this review we trace the history of osteocyte characterization and present some of the major observations that are leading to the conclusion that thes...

journal_title：Therapeutic advances in musculoskeletal disease

authors： Guo D,Bonewald LF

更新日期：2009-04-01 00:00:00