abstract：BACKGROUND:Delayed intubation is associated with high mortality. There is a lack of objective criteria to decide the time of intubation. We assessed a recently described combined oxygenation index (ROX index) to predict intubation in immunocompromised patients. The study is a secondary analysis of randomized trials in ...

journal_title：Annals of intensive care

authors： Lemiale V,Dumas G,Demoule A,Pène F,Kouatchet A,Bisbal M,Nseir S,Argaud L,Kontar L,Klouche K,Barbier F,Seguin A,Louis G,Constantin JM,Mayaux J,Wallet F,Peigne V,Girault C,Oziel J,Nyunga M,Terzi N,Bouadma L,Laut

更新日期：2021-01-27 00:00:00

abstract：BACKGROUND:SARS coronavirus 2 (SARS-CoV-2) is responsible for high morbidity and mortality worldwide, mostly due to the exacerbated inflammatory response observed in critically ill patients. However, little is known about the kinetics of the systemic immune response and its association with survival in SARS-CoV-2+ pati...

journal_title：Annals of intensive care

authors： Lavillegrand JR,Garnier M,Spaeth A,Mario N,Hariri G,Pilon A,Berti E,Fieux F,Thietart S,Urbina T,Turpin M,Darrivière L,Fartoukh M,Verdonk F,Dumas G,Tedgui A,Guidet B,Maury E,Chantran Y,Voiriot G,Ait-Oufella H

更新日期：2021-01-13 00:00:00

abstract：BACKGROUND:The data on incidence, clinical presentation, and outcomes of ventilator-associated pneumonia (VAP) in patients with severe coronavirus disease 2019 (COVID-19) pneumonia requiring mechanical ventilation (MV) are limited. We performed this retrospective cohort study to assess frequency, clinical characteristi...

journal_title：Annals of intensive care

authors： Luyt CE,Sahnoun T,Gautier M,Vidal P,Burrel S,Pineton de Chambrun M,Chommeloux J,Desnos C,Arzoine J,Nieszkowska A,Bréchot N,Schmidt M,Hekimian G,Boutolleau D,Robert J,Combes A,Chastre J

更新日期：2020-11-23 00:00:00

abstract：BACKGROUND:Empirical antimicrobial therapy (EAT) is a challenge for community-acquired, hospital-acquired and ventilator-associated pneumonia, particularly in the context of the increasing occurrence of third-generation cephalosporin-resistant Enterobacterales (3GCR-E), including extended-spectrum beta-lactamase Entero...

journal_title：Annals of intensive care

authors： Elsa M,Matthieu LD,De Ponfilly Gauthier P,Hanaa B,Rishma A,Emmanuelle C,Benjamin S,Glenn CB,Hervé J

更新日期：2020-10-29 00:00:00

abstract：BACKGROUND:The impact of neutropenia in critically ill immunocompromised patients admitted in a context of acute respiratory failure (ARF) remains uncertain. The primary objective was to assess the prognostic impact of neutropenia on outcomes of these patients. Secondary objective was to assess etiology of ARF accordin...

journal_title：Annals of intensive care

authors： Mokart D,Darmon M,Schellongowski P,Pickkers P,Soares M,Rello J,Bauer PR,van de Louw A,Lemiale V,Taccone FS,Martin-Loeches I,Salluh J,Rusinova K,Mehta S,Antonelli M,Kouatchet A,Barratt-Due A,Valkonen M,Landburg PP,Bu

更新日期：2020-10-22 00:00:00

abstract：BACKGROUND:Despite advances in the management of bloodstream infections (BSI) caused by Candida spp., the mortality still remains high in critically ill patients. The worldwide epidemiology of yeast-related BSI is subject to changing species distribution and resistance patterns, challenging antifungal treatment strateg...

journal_title：Annals of intensive care

authors： Schroeder M,Weber T,Denker T,Winterland S,Wichmann D,Rohde H,Ozga AK,Fischer M,Kluge S

更新日期：2020-10-16 00:00:00

abstract：BACKGROUND AND AIMS:Data on outcome of critically ill children with cirrhosis are scarce. We aimed to evaluate the prognostic accuracy of sequential organs scoring systems in children with cirrhosis admitted to Paediatric Intensive Care Units (PICU). METHODS:We performed a multicentre retrospective analysis of childre...

journal_title：Annals of intensive care

authors： Claude C,Deep A,Kneyber M,Siddiqui S,Renolleau S,Morin L,Jacquemin E,Teglas JP,Gajdos V,Tissières P,Durand P,ESPNIC liver failure, support working group.

更新日期：2020-10-14 00:00:00

abstract：BACKGROUND:Data on respiratory mechanics of COVID-19 ARDS patients are scarce. Respiratory mechanics and response to positive expiratory pressure (PEEP) may be different in obese and non-obese patients. METHODS:We investigated esophageal pressure allowing determination of transpulmonary pressures (PL ) and elastances ...

journal_title：Annals of intensive care

authors： Mezidi M,Daviet F,Chabert P,Hraiech S,Bitker L,Forel JM,Yonis H,Gragueb I,Dhelft F,Papazian L,Richard JC,Guervilly C

更新日期：2020-10-01 00:00:00

abstract：INTRODUCTION:About 30% of patients with Guillain-Barré syndrome become ventilator dependent, of whom roughly 75% develop pneumonia. This trial aimed at assessing the impact of early mechanical ventilation (EMV) on pneumonia occurrence in GBS patients. We hypothesize that EMV will reduce the incidence of pneumonia. MET...

journal_title：Annals of intensive care

authors： Melone MA,Heming N,Meng P,Mompoint D,Aboab J,Clair B,Salomon J,Sharshar T,Orlikowski D,Chevret S,Annane D

更新日期：2020-09-30 00:00:00

abstract：BACKGROUND:Preliminary reports have described significant procoagulant events in patients with coronavirus disease-2019 (COVID-19), including life-threatening pulmonary embolism (PE). MAIN TEXT:We review the current data on the epidemiology, the possible underlying pathophysiologic mechanisms, and the therapeutic impl...

journal_title：Annals of intensive care

authors： Sakr Y,Giovini M,Leone M,Pizzilli G,Kortgen A,Bauer M,Tonetti T,Duclos G,Zieleskiewicz L,Buschbeck S,Ranieri VM,Antonucci E

更新日期：2020-09-16 00:00:00

abstract：Introduction:Acute respiratory failure is the main reason for admission to the intensive care unit (ICU) in HIV-infected adults. There is little data about the epidemiology of respiratory viruses in this population. Methods:HIV-infected adults admitted to two intensive care units over a 6-year period for an acute resp...

journal_title：Annals of intensive care

authors： Elabbadi A,Pichon J,Visseaux B,Schnuriger A,Bouadma L,Philippot Q,Patrier J,Labbé V,Ruckly S,Fartoukh M,Timsit JF,Voiriot G

更新日期：2020-09-14 00:00:00

abstract：BACKGROUND:Critical illness has detrimental effects on the diaphragm, but the impact of critical illness on other major muscles of the respiratory pump has been largely neglected. This study aimed to determine the impact of critical illness on the most important muscles of the respiratory muscle pump, especially on the...

journal_title：Annals of intensive care

authors： IJland MM,Lemson J,van der Hoeven JG,Heunks LMA

更新日期：2020-08-27 00:00:00

abstract：BACKGROUND:The impact on infectious risk of ultrasound guidance at insertion remains controversial in short-term arterial catheters (ACs). The present study investigated the association between ultrasound guidance (US) during AC insertion and major catheter-related infections (MCRI), catheter-related bloodstream infect...

journal_title：Annals of intensive care

authors： Buetti N,Ruckly S,Lucet JC,Bouadma L,Schwebel C,Mimoz O,Timsit JF

更新日期：2020-07-08 00:00:00

abstract：BACKGROUND:Endotoxins can induce an excessive inflammatory response and result in microcirculatory dysfunction. Polymyxin-B hemoperfusion (PMX-HP) has been recognized to effectively remove endotoxins in patients with sepsis and septic shock, and a rat sepsis model revealed that PMX-HP treatment can maintain a better mi...

journal_title：Annals of intensive care

authors： Chen SH,Chan WS,Liu CM,Chiu CT,Chao A,Wu VC,Sheng WH,Lai CH,Wang MJ,Yeh YC

更新日期：2020-06-12 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via the original article. ...

journal_title：Annals of intensive care

authors： Blanchard F,Charbit J,Van der Meersch G,Popoff B,Picod A,Cohen R,Chemouni F,Gaudry S,Bihan H,Cohen Y

更新日期：2020-06-02 00:00:00

abstract：BACKGROUND:The echocardiography working group of the European Society of Intensive Care Medicine recognized the need to provide structured guidance for future CCE research methodology and reporting based on a systematic appraisal of the current literature. Here is reported this systematic appraisal. METHODS:We conduct...

journal_title：Annals of intensive care

authors： Huang S,Sanfilippo F,Herpain A,Balik M,Chew M,Clau-Terré F,Corredor C,De Backer D,Fletcher N,Geri G,Mekontso-Dessap A,McLean A,Morelli A,Orde S,Petrinic T,Slama M,van der Horst ICC,Vignon P,Mayo P,Vieillard-Baron A

更新日期：2020-04-25 00:00:00

abstract：BACKGROUND:Infection and sepsis are a main cause of acute-on-chronic liver failure (ACLF). Adequate dosing of antimicrobial therapy is of central importance to improve outcome. Liver failure may alter antibiotic drug concentrations via changes of drug distribution and elimination. We studied the pharmacokinetics of mer...

journal_title：Annals of intensive care

authors： Grensemann J,Busse D,König C,Roedl K,Jäger W,Jarczak D,Iwersen-Bergmann S,Manthey C,Kluge S,Kloft C,Fuhrmann V

更新日期：2020-04-22 00:00:00

abstract：BACKGROUND:Despite improvements in intermittent hemodialysis management, intradialytic hemodynamic instability (IHI) remains a common issue that could account for increased mortality and delayed renal recovery. However, predictive factors of IHI remain poorly explored. The objective of this study was to evaluate the re...

journal_title：Annals of intensive care

authors： Bigé N,Lavillegrand JR,Dang J,Attias P,Deryckere S,Joffre J,Dubée V,Preda G,Dumas G,Hariri G,Pichereau C,Baudel JL,Guidet B,Maury E,Boelle PY,Ait-Oufella H

更新日期：2020-04-22 00:00:00

abstract：BACKGROUND:Pendelluft, the movement of gas within different lung regions, is present in animal models of assisted mechanical ventilation and associated with lung overstretching. Due to rebreathing of CO2 as compared to fresh gas, pendelluft might reduce ventilatory efficiency possibly exacerbating patient's respiratory...

journal_title：Annals of intensive care

authors： Coppadoro A,Grassi A,Giovannoni C,Rabboni F,Eronia N,Bronco A,Foti G,Fumagalli R,Bellani G

更新日期：2020-04-07 00:00:00

abstract：BACKGROUND:Lactate is a robust prognostic marker for the outcome of critically ill patients. Several small studies reported that metformin users have higher lactate levels at ICU admission without a concomitant increase in mortality. However, this has not been investigated in a larger cohort. We aimed to determine whet...

journal_title：Annals of intensive care

authors： Posma RA,Frøslev T,Jespersen B,van der Horst ICC,Touw DJ,Thomsen RW,Nijsten MW,Christiansen CF

更新日期：2020-03-26 00:00:00

abstract：BACKGROUND:Optimal anti-bacterial activity of meropenem requires maintenance of its plasma concentration (Cp) above the minimum inhibitory concentration (MIC) of the pathogen for at least 40% of the dosing interval (fT > MIC > 40). We aimed to determine whether a 3-h extended infusion (EI) of meropenem achieves fT > MI...

journal_title：Annals of intensive care

authors： Kothekar AT,Divatia JV,Myatra SN,Patil A,Nookala Krishnamurthy M,Maheshwarappa HM,Siddiqui SS,Gurjar M,Biswas S,Gota V

更新日期：2020-01-10 00:00:00

abstract：BACKGROUND:Many maneuvers assessing fluid responsiveness (minifluid challenge, lung recruitment maneuver, end-expiratory occlusion test, passive leg raising) are considered as positive when small variations in cardiac index, stroke volume index, stroke volume variation or pulse pressure variation occur. Pulse contour a...

journal_title：Annals of intensive care

authors： de Courson H,Ferrer L,Cane G,Verchère E,Sesay M,Nouette-Gaulain K,Biais M

更新日期：2019-10-11 00:00:00

abstract：BACKGROUND:Occlusion pressure at 100 ms (P0.1), defined as the negative pressure measured 100 ms after the initiation of an inspiratory effort performed against a closed respiratory circuit, has been shown to be well correlated with central respiratory drive and respiratory effort. Automated P0.1 measurement is availab...

journal_title：Annals of intensive care

authors： Beloncle F,Piquilloud L,Olivier PY,Vuillermoz A,Yvin E,Mercat A,Richard JC

更新日期：2019-09-13 00:00:00

abstract：:In the past, the only treatment of acute exacerbations of obstructive diseases with hypercapnic respiratory failure refractory to medical treatment was invasive mechanical ventilation (IMV). Considerable technical improvements transformed extracorporeal techniques for carbon dioxide removal in an attractive option to ...

journal_title：Annals of intensive care

authors： Morales-Quinteros L,Del Sorbo L,Artigas A

更新日期：2019-07-02 00:00:00

abstract：:Animal experiments are widely used in preclinical medical research with the goal of disease modeling and exploration of novel therapeutic approaches. In the context of sepsis and septic shock, the translation into clinical practice has been disappointing. Classical animal models of septic shock usually involve one-sex...

journal_title：Annals of intensive care

authors： Guillon A,Preau S,Aboab J,Azabou E,Jung B,Silva S,Textoris J,Uhel F,Vodovar D,Zafrani L,de Prost N,Radermacher P,Translational Research Committee of the French Intensive Care Society (Société de Réanimation de Langue Française).

更新日期：2019-06-10 00:00:00

abstract：:Although improving, the mortality from septic shock still remains high despite increased international awareness. As a consequence, much effort has focused on alternative treatment strategies in an effort to improve outcomes. The application of blood purification therapies to improve immune homeostasis has been sugges...

journal_title：Annals of intensive care

authors： Honore PM,Hoste E,Molnár Z,Jacobs R,Joannes-Boyau O,Malbrain MLNG,Forni LG

更新日期：2019-05-14 00:00:00

abstract：BACKGROUND:Mortality of critically ill hematology (HM) patients has improved over time. Thus, those patients require an extensive diagnostic workup and the optimal use of available treatments. There are no data regarding nutrition strategy for critically ill HM patients, while nutritional support is crucial for both HM...

journal_title：Annals of intensive care

authors： Ettori F,Henin A,Zemmour C,Chow-Chine L,Sannini A,Bisbal M,Gonzalez F,Servan L,de Guibert JM,Faucher M,Boher JM,Mokart D

更新日期：2019-05-07 00:00:00

abstract：:The 2018 Paris Intensive Care symposium entitled "Update in Neurocritical Care" was organized in Paris, June 21-22, 2018, under the auspices of the French Intensive Care Society. This 2-day post-graduate educational symposium comprised several chapters, aiming first to provide all-board intensivists with current stand...

journal_title：Annals of intensive care

authors： Oddo M,Bracard S,Cariou A,Chanques G,Citerio G,Clerckx B,Godeau B,Godier A,Horn J,Jaber S,Jung B,Kuteifan K,Leone M,Mailles A,Mazighi M,Mégarbane B,Outin H,Puybasset L,Sharshar T,Sandroni C,Sonneville R,Weiss N

更新日期：2019-04-16 00:00:00

abstract：BACKGROUND:Acute kidney injury (AKI) occurs in up to 50% of all critically ill patients and hemodynamic abnormalities are assumed to contribute, but their nature and share is still unclear. We explored the associations between hemodynamic variables, including cardiac index and right ventricular function, and the occurr...

journal_title：Annals of intensive care

authors： Wiersema R,Koeze J,Hiemstra B,Pettilä V,Perner A,Keus F,van der Horst ICC,SICS Study Group.

更新日期：2019-03-13 00:00:00

abstract：BACKGROUND:Intravenous crystalloid solutions are administered commonly for critically ill patients. We performed this meta-analysis of randomized trials with trial sequential analysis (TSA) to evaluate effects of chloride content of intravenous crystalloid solutions on clinical outcomes among critically ill adult patie...

journal_title：Annals of intensive care

authors： Xue M,Zhang X,Liu F,Chang W,Xie J,Xu J,Yang Y,Qiu H

更新日期：2019-02-13 00:00:00

abstract：BACKGROUND:We assessed the association of intravenous insulin and glucose infusion with intensive care unit (ICU) and hospital mortality. METHODS:For this retrospective association study, we used data from all patients admitted to a medical-surgical ICU between January 2012 and September 2017. We excluded patients adm...

journal_title：Annals of intensive care

authors： van Steen SC,Rijkenberg S,van der Voort PHJ,DeVries JH

更新日期：2019-02-11 00:00:00

abstract：:Although chest X-ray remains a fundamental lung imaging technique, through the years, CT scan has significantly improved our knowledge of the pathophysiological process and currently is the reference lung imaging tool for both a visual and quantitative computer-based analysis. The application of lung CT in the early p...

journal_title：Annals of intensive care

authors： Chiumello D,Formenti P,Coppola S

更新日期：2019-01-22 00:00:00

abstract：BACKGROUND:High-frequency oscillatory ventilation (HFOV) is a common but unproven management strategy in paediatric critical care. Oscillator settings have been traditionally guided by patient age and/or weight rather than by lung mechanics, thereby potentially negating any beneficial effects. We have adopted an open-l...

journal_title：Annals of intensive care

authors： de Jager P,Kamp T,Dijkstra SK,Burgerhof JGM,Markhorst DG,Curley MAQ,Cheifetz IM,Kneyber MCJ

更新日期：2019-01-18 00:00:00

abstract：BACKGROUND:During passive mechanical ventilation, the driving pressure of the respiratory system is an important mediator of ventilator-induced lung injury. Monitoring of driving pressure during assisted ventilation, similar to controlled ventilation, could be a tool to identify patients at risk of ventilator-induced l...

journal_title：Annals of intensive care

authors： Vaporidi K,Psarologakis C,Proklou A,Pediaditis E,Akoumianaki E,Koutsiana E,Chytas A,Chouvarda I,Kondili E,Georgopoulos D

更新日期：2019-01-03 00:00:00

abstract：BACKGROUND:The clinical interest of using bubble humidification of oxygen remains controversial. This study was designed to further explore whether delivering dry oxygen instead of bubble-moistened oxygen had an impact on discomfort of ICU patients. METHODS:This randomized multicenter non-inferiority open trial includ...

journal_title：Annals of intensive care

authors： Poiroux L,Piquilloud L,Seegers V,Le Roy C,Colonval K,Agasse C,Zinzoni V,Hodebert V,Cambonie A,Saletes J,Bourgeon I,Beloncle F,Mercat A,REVA Network.

更新日期：2018-12-17 00:00:00

abstract：BACKGROUND:Acute respiratory distress syndrome (ARDS) patients may present impaired in lung function and structure after hospital discharge that may be related to mechanical ventilation strategy. The aim of this study was to evaluate the association between functional and structural lung impairment, N-terminal-peptide ...

journal_title：Annals of intensive care

authors： Toufen Junior C,De Santis Santiago RR,Hirota AS,Carvalho ARS,Gomes S,Amato MBP,Carvalho CRR

更新日期：2018-12-07 00:00:00

abstract：BACKGROUND:The effects of perioperative statin therapy on clinical outcome after cardiac or non-cardiac surgery are controversial. We aimed to assess the association between perioperative statin therapy and postoperative outcome. METHODS:Electronic databases were searched up to May 1, 2018, for randomized controlled t...

journal_title：Annals of intensive care

authors： Putzu A,de Carvalho E Silva CMPD,de Almeida JP,Belletti A,Cassina T,Landoni G,Hajjar LA

更新日期：2018-09-27 00:00:00

abstract：BACKGROUND:Criteria for the Sepsis-3 definition of septic shock include vasopressor treatment to maintain a mean arterial pressure > 65 mmHg and a lactate concentration > 2 mmol/L. The impact of hyperoxia in patients with septic shock using these criteria is unknown. METHODS:A post hoc analysis was performed of the HY...

journal_title：Annals of intensive care

authors： Demiselle J,Wepler M,Hartmann C,Radermacher P,Schortgen F,Meziani F,Singer M,Seegers V,Asfar P,HYPER2S investigators.

更新日期：2018-09-17 00:00:00

abstract：BACKGROUND:Noninvasive ventilation (NIV) is the first-line treatment of adult patients with exacerbations of cystic fibrosis (CF). High-flow nasal oxygen therapy (HFNT) might benefit patients with hypoxemia and can reduce physiological dead space. We hypothesized that HFNT and NIV would similarly reduce work of breathi...

journal_title：Annals of intensive care

authors： Sklar MC,Dres M,Rittayamai N,West B,Grieco DL,Telias I,Junhasavasdikul D,Rauseo M,Pham T,Madotto F,Campbell C,Tullis E,Brochard L

更新日期：2018-09-05 00:00:00

abstract：BACKGROUND:The consequences of the ageing population concerning ICU hospitalisation need to be adequately described. We believe that this discussion should be disease specific. A focus on respiratory infections is of particular interest, because it is strongly associated with old age. Our objective was to assess trends...

journal_title：Annals of intensive care

authors： Laporte L,Hermetet C,Jouan Y,Gaborit C,Rouve E,Shea KM,Si-Tahar M,Dequin PF,Grammatico-Guillon L,Guillon A

更新日期：2018-08-15 00:00:00