听力与言语-语言病理学

行为科学

医学伦理学

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  • Havachoobe (Onosma dichroanthum Boiss) Root Extract Decreases the Hepatitis B Virus Surface Antigen Secretion in the PLC/PRF/5 Cell Line.

    abstract:BACKGROUND:Many efforts are currently focused on functional treatment of the hepatitis B virus (HBV). This can be done by suppressing the secretion of HBV surface antigen (HBsAg). Scientific communities are very interested in natural products in that respect. OBJECTIVE:Use of root extract of Havachoobe (Onosma dichroa...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000512140

    authors: Mohebbi A,Azadi F,Hashemi MM,Askari FS,Razzaghi N

    更新日期:2020-12-15 00:00:00

  • Historical Discoveries on Viruses in the Environment and Their Impact on Public Health.

    abstract:BACKGROUND:Transmission of many viruses occurs by direct transmission during a close contact between two hosts, or by an indirect transmission through the environment. Several and often interconnected factors, both abiotic and biotic, determine the persistence of these viruses released in the environment, which can las...

    journal_title:Intervirology

    pub_type: 历史文章,杂志文章,评审

    doi:10.1159/000511575

    authors: Labadie T,Batéjat C,Leclercq I,Manuguerra JC

    更新日期:2020-01-01 00:00:00

  • Clinical, Virological, and Immunological Profiles of DENV, ZIKV, and/or CHIKV-Infected Brazilian Patients.

    abstract:BACKGROUND:Arboviruses co-circulating within a population that are transmitted by the same vector have the potential to cause coinfections. Coinfections with dengue virus (DENV), Zika virus (ZIKV), and chikungunya virus (CHIKV) have been occurring in Brazil, but it is not well-understood how human responses vary during...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000510223

    authors: Sánchez-Arcila JC,Badolato-Correa J,de Souza TMA,Paiva IA,Barbosa LS,Nunes PCG,Lima MDRQ,Dos Santos FB,Damasco PV,da Cunha RV,Azeredo EL,de Oliveira-Pinto LM

    更新日期:2020-01-01 00:00:00

  • Variation in Hepatitis C Virus Subtype Distribution during 20 Years in Venezuela.

    abstract:OBJECTIVE:Hepatitis C virus (HCV) infection is a public health problem and a major cause of chronic hepatitis. This virus exhibits a great genetic variability, with 8 genotypes and numerous subtypes. The aim of this study was to evaluate the fluctuations of HCV subtypes during 2 decades in Venezuela. METHODS:HCV genot...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000505065

    authors: Loureiro CL,Jaspe RC,Pujol FH

    更新日期:2019-01-01 00:00:00

  • Use of Multiplex Polymerase Chain Reaction for Detection of High-Risk Human Papillomavirus Genotypes in Women Attending Routine Cervical Cancer Screening in Harare.

    abstract:BACKGROUND/AIMS:In Zimbabwe, cervical cancer is screened through cytology and visual inspection with acetic acid and cervicography (VIAC). The effectiveness of these methods can be increased if complemented by a human papillomavirus DNA detection tool since most cervical cancer cases are caused by persistent infection ...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000502206

    authors: Marembo T,Dube Mandishora R,Borok M

    更新日期:2019-01-01 00:00:00

  • Epstein-Barr Virus Seroprevalence and Primary Infection at the University Hospital Luigi Vanvitelli of Naples from 2007 to 2017.

    abstract::Epstein-Barr virus (EBV) is a common herpesvirus that may cause asymptomatic infection or various diseases, such as mononucleosis, lymphoproliferative disorders and several cancers. Our objective was to estimate the prevalence of EBV among patients hospitalized in "Luigi Vanvitelli" University Hospital in the last 10 ...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000496828

    authors: Franci G,Crudele V,Della Rocca MT,Melardo C,Chianese A,Finamore E,Bencivenga F,Astorri R,Vitiello M,Galdiero E,Galdiero M

    更新日期:2019-01-01 00:00:00

  • Viral Metagenomics Revealed a Novel Cardiovirus in Feces of Wild Rats.

    abstract:BACKGROUND/AIMS:Cardiovirus is a genus of viruses belonging to the family Picornaviridae. Here, we used viral metagenomic techniques to detect the viral nucleic acid in the fecal samples from wild rats in Zhenjiang city in China. METHOD:Fecal samples were collected from 20 wild rats and pooled into four sample pools a...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000500555

    authors: Mahmood A,Shama S,Ni H,Wang H,Ling Y,Xu H,Yang S,Naseer QA,Zhang W

    更新日期:2019-01-01 00:00:00

  • Sequence Similarities between Viroids and Human MicroRNAs.

    abstract::Viroids are minute unencapsidated non-coding circular RNAs known to be present and to cause diseases only in plants. Infections were associated with the occurrence of specific single-stranded RNAs similar in size to miRNAs and endogenous small interfering RNAs, and viroid pathogenicity is suspected to occur through RN...

    journal_title:Intervirology

    pub_type: 新闻

    doi:10.1159/000509212

    authors: Bengone-Abogourin JG,Chelkha N,Verdin E,Colson P

    更新日期:2019-01-01 00:00:00

  • The Use of Immunochromatographic Technique for Rotavirus Detection: Experience from a Tertiary Care Hospital in Central Greece.

    abstract::Despite the significant medical advances which have taken place in the last decades, acute diarrhoea cases remain a public health issue of major significance, with gastroenteritis agents being associated with severe symptoms in adults and high morbidity in infants and children. Regarding rotaviruses, while children ar...

    journal_title:Intervirology

    pub_type: 新闻

    doi:10.1159/000502007

    authors: Vontas A,Hadjicristodoulou C,Krikelis V,Petinaki E

    更新日期:2019-01-01 00:00:00

  • Prevalence and Clinical Profile of Human Salivirus in Children with Acute Gastroenteritis in Northern Italy, 2014-2015.

    abstract:OBJECTIVE:Human Salivirus (SalV) has been associated with gastroenteritis on all continents. METHODS:This paper presents the real-time RT-PCR assay for the detection of SalV in clinical fecal samples collected from 192 hospitalized children with acute gastroenteritis in Piedmont, Italy. RESULTS:The most commonly dete...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000490568

    authors: Bergallo M,Daprà V,Rassu M,Bonamin S,Cuccu R,Calvi C,Montanari P,Galliano I

    更新日期:2018-01-01 00:00:00

  • Three Main Inducers of Alphacoronavirus Infection of Enterocytes: Sialic Acid, Proteases, and Low pH.

    abstract::Transmissible gastroenteritis virus (TGEV) and porcine epidemic diarrhea virus (PEDV) are similar coronaviruses, causing diseases characterized by vomiting, diarrhea, and death from severe dehydration in piglets. Thus, they have caused huge losses to the swine-breeding industry worldwide. Nowadays, they are easily tra...

    journal_title:Intervirology

    pub_type: 杂志文章,评审

    doi:10.1159/000492424

    authors: Yuan P,Yang Z,Song H,Wang K,Yang Y,Xie L,Huang S,Liu J,Ran L,Song Z

    更新日期:2018-01-01 00:00:00

  • Distribution of Hepatitis C Virus Genotypes and Subtypes in the Metropolitan Area of Naples, Italy, in the Era of Interferon-Free Regimens.

    abstract:AIMS:The objective of this work was to study the distribution of hepatitis C virus (HCV) genotypes and subtypes from 2010 to 2015 in 1,221 anti-HCV/HCV-RNA-positive specimens from patients living in the metropolitan area of Naples, since HCV genotypes and subtypes remain cornerstones in the management of chronic HCV in...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000481821

    authors: Grimaldi E,Della Pepa ME,Martora F,Magliocca P,Iovene MR,Coppola N,Donnarumma G,Galdiero M

    更新日期:2017-01-01 00:00:00

  • Concurrent Infection with Plasmodium vivax and the Dengue and Chikungunya Viruses in a Paediatric Patient from New Delhi, India in 2016.

    abstract::Dengue and chikungunya fevers are transmitted by the common mosquito vector Aedes and malaria by Anopheles. Concurrent infections are reported due to co-circulation of these pathogens, especially in endemic regions. We report a rare case of triple infection with 3 arthropod-borne pathogens (Plasmodium vivax and the de...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000479430

    authors: Tazeen A,Abdullah M,Hisamuddin M,Ali S,Naqvi IH,Verma HN,Ahmed A,Parveen S

    更新日期:2017-01-01 00:00:00

  • Distribution of Human Papillomavirus Genotypes among Women in Mashhad, Iran.

    abstract:OBJECTIVE:Cervical cancer is the third most common malignancy in females. Since the human papillomavirus (HPV) genotype can vary geographically, it is essential to define its genotypic distribution before establishing health care policies and vaccination programs in any given area. The aim of this study was to determin...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000477848

    authors: Taghizadeh E,Taheri F,Abdolkarimi H,Ghorbani Renani P,Gheibi Hayat SM

    更新日期:2017-01-01 00:00:00

  • Phylogenetic Analysis of Torque Teno Virus in Thalassemic Children in Egypt.

    abstract:OBJECTIVE:Torque teno virus (TTV) is a ubiquitous virus that is commonly associated with blood transfusion. The main aims of this study were to evaluate the incidence of TTV in polytransfused children with thalassemia and to determine for the first time the prevalent TTV genotypes in Egypt. METHODS:TTV was detected in...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000480507

    authors: Hassuna NA,Naguib E,Abdel-Fatah M,Mousa SMO

    更新日期:2017-01-01 00:00:00

  • Syncytia Induction by Clinical Isolates of Human Respiratory Syncytial Virus A.

    abstract:OBJECTIVE:Syncytia formation is the hallmark of the cytopathic effect caused by human respiratory syncytial virus (HRSV), which is the most important viral respiratory pathogen in children. This article reports methodological improvements in primary HRSV isolation and the importance of syncytia formation and mRNA level...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000480014

    authors: Gagliardi TB,Criado MF,Proença-Módena JL,Saranzo AM,Iwamoto MA,de Paula FE,Cardoso RS,Delcaro LS,Silva ML,Câmara AA,Arruda E

    更新日期:2017-01-01 00:00:00

  • Membrane-Associated Kaposi Sarcoma-Associated Herpesvirus Glycoprotein B Promotes Cell Adhesion and Inhibits Migration of Cells via Upregulating IL-1β and TNF-α.

    abstract:OBJECTIVES:Kaposi sarcoma-associated herpesvirus (KSHV) glycoprotein B (gB) is expressed on the viral envelope as well as on the cytoplasmic membrane of infected cells. In the current study, we aimed to decipher the impact of membrane-associated gB on adhesion and migration of cells via modulating the expression of cyt...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000487596

    authors: Hussein HAM,Abdel-Raouf UM,Akula SM

    更新日期:2017-01-01 00:00:00

  • Preliminary Characterization of El Tor Vibriophage M4.

    abstract:AIMS:The aim of the present study is the preliminary characterization of an El Tor vibriophage M4 (ATCC 51352-B4). METHODS:We studied the growth characteristics and sustainability of this phage under various stresses like temperature, pH, and UV. The phage morphology and phage genome were also examined using electron ...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000485835

    authors: Das S,Ghosh AN

    更新日期:2017-01-01 00:00:00

  • Exposure of Piglets to Enteroviruses Investigated by an Immunoassay Based on the EV-G1 VP4 Peptide.

    abstract:OBJECTIVE:The aim of this study was to investigate the exposure of piglets to enteroviruses-G (EV-G) through the presence of antibodies in their serum. METHODS:Serum samples were obtained from the vena cava of 10 piglets at 9 weeks of age and again 39 days later (day 39). They were tested using an immunoassay based on...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000449058

    authors: Benkahla MA,Sane F,Desailloud R,Hober D

    更新日期:2016-01-01 00:00:00

  • The Genotyping Resistance Profile of the Pol Gene Detected in Blood of Newly Diagnosed HIV-Positive Men Is Durably Archived in the Gut Whatever the Time of Initiation of cART.

    abstract:OBJECTIVE:To evaluate the mutational patterns on the pol gene of the main HIV-1 strain archived in cell genome of 10 chronically infected men according to their clinical and therapeutic history. The genotyping resistance profiles were compared between the first blood plasma available at the time of HIV diagnosis and re...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000472716

    authors: Depincé AE,Dussert E,Vergnon-Miszczycha D,Keita A,Pillet S,Botelho-Nevers E,Frésard A,Gagneux-Brunon A,Lucht FR,Roblin X,Pozzetto B,Paul S,Bourlet T

    更新日期:2016-01-01 00:00:00

  • Nonstructural Protein 1 of Tick-Borne Encephalitis Virus Induces Oxidative Stress and Activates Antioxidant Defense by the Nrf2/ARE Pathway.

    abstract:BACKGROUND:Infection with tick-borne encephalitis virus (TBEV) causes pathological changes in the central nervous system. However, the possible redox alterations in the infected cells that can contribute to the virus pathogenicity remain unknown. OBJECTIVE:In the current study we explored the ability of TBEV nonstruct...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000452160

    authors: Kuzmenko YV,Smirnova OA,Ivanov AV,Starodubova ES,Karpov VL

    更新日期:2016-01-01 00:00:00

  • HIV-1 Subtype Diversity and Prevalence of Primary Drug Resistance in a Single-Center Pediatric Cohort in Germany.

    abstract:OBJECTIVES:Data on drug-resistant mutations (DRMs) in HIV-1-infected therapy-naïve children are scarce. The aim of this study was to determine the HIV-1 subtype distribution and the prevalence of DRMs in therapy-naïve HIV-1-infected children who received routine care at the University Hospital Düsseldorf, Düsseldorf, G...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000477811

    authors: Neubert J,Michalsky N,Laws HJ,Borkhardt A,Jensen B,Lübke N

    更新日期:2016-01-01 00:00:00

  • Is Anti-Hepatitis C Virus Antibody Level an Appropriate Marker to Preclude the Need for Supplemental Testing.

    abstract:OBJECTIVES:In the present study, we aimed to determine whether signal-to-cutoff (S/Co) ratios of reactive anti-HCV samples could be used as a basis for avoiding the need for supplemental testing in our study population. METHODS:We analyzed 901 anti-HCV-positive sera from 8 institutions in China. The Ortho VITROS anti-...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000441474

    authors: Zhang K,Wang L,Lin G,Li J

    更新日期:2015-01-01 00:00:00

  • HLA-B alleles B*15:01 and B*15:02: opposite association with hepatitis C virus infection in Chinese voluntary blood donors.

    abstract:BACKGROUND:Although human leukocyte antigens (HLA) have been shown in association with the outcomes of hepatitis C virus (HCV) infection among different ethnic groups, such studies remain absent in China, where the HCV prevalence is higher than the global average. METHODS:In this study, 426 HCV-infected and 709 uninfe...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000369209

    authors: Xiong H,Huang J,Rong X,Zhang M,Huang K,Xu R,Wang M,Li C,Liao Q,Xia W,Luo G,Ye X,Lu L,Fu Y,Guo T,Nelson K

    更新日期:2015-01-01 00:00:00

  • One of the Mechanisms to Increase HSV-1 Uptake in HSV-1-Infected, Activated T Lymphocytes Is the Formation of Filopodia.

    abstract:OBJECTIVES:To explore the host transcription factor E2F-1 and/or any mechanisms that may support viral entry and its effect on the HSV-1 production in anti-CD3-activated Jurkat cells. METHODS:The expressions of ICP4, HVEM and E2F-1 were studied using reverse transcription-PCR and Western blot. HSV-1 production was det...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000437264

    authors: Bhattarakosol P,Donchai P

    更新日期:2015-01-01 00:00:00

  • Monkeys and Rats Are Not Susceptible to Ferret Hepatitis E Virus Infection.

    abstract::Ferret hepatitis E virus (HEV), a novel hepatitis E-like virus, has been identified in ferrets in the Netherlands, Japan, and the US. To determine whether ferret HEV transmits to other animals, we inoculated laboratory rats (Wistar), nude rats (Long-Evans-rnu/rnu), and cynomolgus monkeys with ferret HEV (F4351) by int...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000373891

    authors: Li TC,Yoshizaki S,Ami Y,Suzaki Y,Yang T,Takeda N,Takaji W

    更新日期:2015-01-01 00:00:00

  • Early Evolution of Human Respiratory Syncytial Virus ON1 Strains: Analysis of the Diversity in the C-Terminal Hypervariable Region of Glycoprotein Gene within the First 3.5 Years since Their Detection.

    abstract:OBJECTIVE:Characterization of the phylogeny and diversity of human respiratory syncytial virus (HRSV) genotype ON1 that occurred during its early evolution (within the first 3.5 years since the detection of the first ON1 strains). ON1 strains have a 72-nucleotide-long in-frame duplication within the second hypervariabl...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000382018

    authors: Ivancic-Jelecki J,Forcic D,Mlinaric-Galinovic G,Tesovic G,Nikic Hecer A

    更新日期:2015-01-01 00:00:00

  • Cytomegalovirus glycoprotein B genotypes in Mexican children and women.

    abstract:OBJECTIVE:Cytomegalovirus (CMV) is widely distributed and constitutes the main cause of congenital infections worldwide. CMV transmission during pregnancy represents one of the major impacts of this virus on public health. This study aimed at assessing glycoprotein B (gB) CMV genotypes in Mexican children and pregnant ...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000373922

    authors: Gonzalez-Sanchez HM,Alvarado-Hernandez DL,Guerra-Palomares S,Garcia-Sepulveda CA,Noyola DE

    更新日期:2015-01-01 00:00:00

  • Characterization of two temperate Lactobacillus paracasei bacteriophages: morphology, kinetics and adsorption.

    abstract:BACKGROUND/AIMS:Adsorption and kinetic parameters, latent period, burst size and burst time, are characteristics of phage/host systems and can be affected by several environmental factors. As only few studies have focused on temperate dairy phages, we characterized these parameters on temperate Lactobacillus paracasei ...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000369207

    authors: Mercanti DJ,Ackermann HW,Quiberoni A

    更新日期:2015-01-01 00:00:00

  • Chikungunya Virus Infection Alters Expression of MicroRNAs Involved in Cellular Proliferation, Immune Response and Apoptosis.

    abstract:OBJECTIVE(S):Chikungunya virus (CHIKV) is a reemerging virus of significant importance that has caused large-scale outbreaks in the countries with a temperate climate. CHIKV causes debilitating arthralgia which can persist for weeks and up to a year. Fibroblast cells are the main target of CHIKV infection. In this stud...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000441309

    authors: Sharma A,Balakathiresan NS,Maheshwari RK

    更新日期:2015-01-01 00:00:00

  • Neuroinvasive phlebovirus infection in Greece: a case report.

    abstract:OBJECTIVE:Sandfly fever phleboviruses are endemic in Mediterranean countries. We report a febrile phlebovirus case in a Greek patient who presented signs of neuroinvasive infection. METHODS:In summer 2010, a 20-year-old male was admitted to hospital with fever and lethargy; he was a resident of central Macedonia, nort...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000363505

    authors: Papa A,Mallias J,Tsergouli K,Markou F,Poulou A,Milidis T

    更新日期:2014-01-01 00:00:00

  • Characteristics and outcomes of HCV genotype-1-infected patients treated with peginterferon and ribavirin combination therapy with discordant HCV responses 4 and 12 weeks after starting therapy.

    abstract:OBJECTIVE:Some patients with chronic hepatitis C virus (HCV) infection fail to achieve complete early virologic response (EVR) despite a marked decrease in HCV RNA at 4 weeks. We investigated the characteristics and final treatment outcomes of this patient subpopulation. METHODS:A total of 516 patients with HCV genoty...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000362721

    authors: Toyoda H,Kumada T,Shimada N,Takaguchi K,Ide T,Sata M,Ginba H,Matsuyama K,Izumi N

    更新日期:2014-01-01 00:00:00

  • Determination of drug resistance and virus typology in HIV-1-positive pediatric patients in Istanbul, Turkey.

    abstract::The aim of the study was to determine the prevalence of drug resistance of HIV-1 in pediatric patients from Istanbul, Turkey. Genotypic drug resistance testing revealed transmission of drug resistance from mother to child in 20%. Due to rising numbers of children with HIV-1, baseline resistance testing is recommended ...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000362335

    authors: Yoldaş O,Ağaçfidan A,Lübke N,Somer A,Hançerli S,Verheyen J,Kaiser R,Akgül B

    更新日期:2014-01-01 00:00:00

  • High rates of human immunodeficiency virus type 1 mutational profiles by single-genome amplification after 48-hour propagation in peripheral blood mononuclear cells at different levels of cell activation.

    abstract::Human immunodeficiency virus type 1 (HIV-1) genetic diversity is one of the most important features of HIV-1 infections and the result of error accumulation during reverse transcription and of high viral turnover. HIV-1 reverse transcription is influenced by factors such as the level of nucleotides and/or the cellular...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000362415

    authors: Russo CT,Alkmim W,Munerato P,Zukurov J,Maricato JT,Sucupira MC,Diaz RS,Janini LM

    更新日期:2014-01-01 00:00:00

  • Characterization of human Influenza Viruses in Lebanon during 2010-2011 and 2011-2012 post-pandemic seasons.

    abstract:OBJECTIVE:To genetically characterize human influenza viruses and their susceptibilities to antivirals during two post-pandemic seasons in Lebanon. METHODS:Influenza virus was isolated from nasopharyngeal swabs that were obtained from patients with influenza-like illness during 2010-2012 and further analyzed both phen...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000365758

    authors: Zaraket H,Dapat C,Ghanem S,Ali Z,Lteif M,Kondo H,Dapat IC,Saito K,Kayali G,Suzuki H,Dbaibo G,Saito R

    更新日期:2014-01-01 00:00:00

  • Antiherpetic mechanism of a sulfated derivative of Agaricus brasiliensis fruiting bodies polysaccharide.

    abstract:OBJECTIVE:To study the anti-herpes simplex virus (HSV) activity of a (1→6)-(1→3)-β-D-glucan isolated from Agaricus brasiliensis fruiting bodies (FR) as well as its chemically sulfated derivative (FR-S). METHODS:The antiherpetic activity and mechanism of action was studied by viral plaque assay applying different metho...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000365194

    authors: Cardozo FT,Camelini CM,Leal PC,Kratz JM,Nunes RJ,Mendonça MM,Simões CM

    更新日期:2014-01-01 00:00:00

  • Non-axial view of the varicella-zoster virus portal protein reveals conserved crown, wing and clip architecture.

    abstract:BACKGROUND:Herpesviridae encode a family of protein homologues that function as the 'port of entry' for insertion of the viral DNA into preformed capsids during encapsidation. METHODS:Transmission electron microscopy (TEM) of recombinant varicella-zoster virus pORF54 was performed. RESULTS:Results suggest that pORF54...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000360225

    authors: Visalli RJ,Howard AJ

    更新日期:2014-01-01 00:00:00

  • Molecular virology of hepatitis B virus and targets for antiviral intervention.

    abstract::The members of the viral family Hepadnaviridae comprise one of the smallest enveloped DNA viruses and cause acute and chronic infections in mammals and birds, leading to large virus and antigen loads in the blood. They have a restricted host range and depend on differentiated hepatocytes for replication. Hepatitis B v...

    journal_title:Intervirology

    pub_type: 杂志文章,评审

    doi:10.1159/000360946

    authors: Glebe D,König A

    更新日期:2014-01-01 00:00:00

  • Effect of antiretroviral HIV therapy on hepatitis B virus replication and pathogenicity.

    abstract::Coinfections with hepatitis B virus (HBV) and HIV are very frequent. Although HBV is a DNA virus, it replicates via reverse transcription like HIV. Structural similarities between the enzymatic pocket of the HBV DNA polymerase and HIV-1 reverse transcriptase are the basis that certain drugs inhibit both enzymes and th...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000360942

    authors: Gürtler LG

    更新日期:2014-01-01 00:00:00

  • Interleukin 28B gene polymorphisms and Epstein-Barr virus-associated lymphoproliferative diseases.

    abstract:OBJECTIVES:Single-nucleotide polymorphisms (SNPs) near the interleukin (IL) 28B gene encoding a type III interferon (IFN-λ) are the most important genetic predictors of treatment response to hepatitis C virus (HCV). This retrospective study was undertaken to determine any association between IL28B SNPs and the developm...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000357326

    authors: Akay E,Patel M,Conibear T,Chaggar T,Haque T

    更新日期:2014-01-01 00:00:00

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