Phylogenetic Analysis of Torque Teno Virus in Thalassemic Children in Egypt.

Abstract:

OBJECTIVE:Torque teno virus (TTV) is a ubiquitous virus that is commonly associated with blood transfusion. The main aims of this study were to evaluate the incidence of TTV in polytransfused children with thalassemia and to determine for the first time the prevalent TTV genotypes in Egypt. METHODS:TTV was detected in 2 groups by nested PCR: the first group comprised 200 children with thalassemia, and the second included age- and sex-matched healthy children with no history of blood transfusion. RESULTS:TTV was detected in 60 and 57%, respectively, of the children with thalassemia and the healthy children. Among the TTV-positive children with thalassemia, 71.6% were HCV positive. No hepatitis B surface antigen was detected in the thalassemic children. Significant elevations of alanine transaminase and aspartate transaminase were found in TTV-positive patients with thalassemia compared to TTV-negative patients. Phylogenetic analysis of sequenced TTV isolates showed close relationships to genotypes 1 and 2. CONCLUSION:TTV is highly prevalent among children with thalassemia in Egypt, with a relatively high infection rate also detected among healthy children.

journal_name

Intervirology

journal_title

Intervirology

authors

Hassuna NA,Naguib E,Abdel-Fatah M,Mousa SMO

doi

10.1159/000480507

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

102-108

issue

3

eissn

0300-5526

issn

1423-0100

pii

000480507

journal_volume

60

pub_type

杂志文章
  • A study of measles virus antigens in acutely and persistently infected cells using monoclonal antibodies: differences in the accumulation of certain viral proteins.

    abstract::Monoclonal antibodies were used to study measles virus (Hallé strain) infections. The distribution of virus antigens in acutely and persistently infected cells was examined by immunofluorescence, and the synthesis of the virus polypeptides in acutely infected cells was measured after immunoprecipitation and analysis i...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000149509

    authors: Giraudon P,Gerald C,Wild TF

    更新日期:1984-01-01 00:00:00

  • Mutations in the core promoter/enhancer II regions of naturally occurring hepatitis B virus variants and analysis of the effects on transcription activities.

    abstract::The regulatory regions for transcription and replication of several hepatitis B virus (HBV) genomes from 19 patients having various forms of HBV infection were sequenced. Predominant mutations were found to occur naturally in nucleotide positions 1762 (A to T) and 1764 (G to A) in chronic hepatitis patients and in asy...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000150453

    authors: Nishizono A,Hiraga M,Kohno K,Sonoda YT,Terao H,Fujioka T,Nasu M,Mifune K

    更新日期:1995-01-01 00:00:00

  • Use of simian immunodeficiency viruses for AIDS research.

    abstract::Despite frequent statements to the contrary, there are good animal models for AIDS. In this review, we summarize the properties of one of the most useful animal models: infection of rhesus monkeys with simian immunodeficiency virus (SIV). The SIVs are an extensive group of HIV-related lentiviruses of nonhuman primates...

    journal_title:Intervirology

    pub_type: 杂志文章,评审

    doi:10.1159/000150108

    authors: Desrosiers RC,Ringler DJ

    更新日期:1989-01-01 00:00:00

  • How ancient are the tobamoviruses?

    abstract::The amino acid sequences of the virion proteins of 7 definitive tobamoviruses have been compared. The results show that the proteins may be arranged unequivocally in a single dendrogram which, by analogy with similar comparisons of other sets of homologous proteins, probably reflects their phylogeny. The magnitude of ...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000149169

    authors: Gibbs A

    更新日期:1980-01-01 00:00:00

  • Impairment of the M-protein and unmasking of a superficial type-specific antigen by proteolytic treatment of influenza A virions with preservation of host-specific antigenicity.

    abstract::Influenza PR8 particles resulting from strong treatment with caseinase C are spikeless, devoid of neuraminidase and hemagglutinin 1 and 2 glycopeptides, and contain a Schiff-negative polypeptide of about 13,000 molecular weight which exists as traces in intact virions. Their M-protein polypeptide content is reduced to...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000149478

    authors: Reginster M,Rentier B,Dierickx L

    更新日期:1975-01-01 00:00:00

  • A new family of vertebrate viruses: Toroviridae.

    abstract::The proposed family Toroviridae is characterized by eveloped, peplomer-bearing particles containing an elongated tubular nucleocapsid with helical symmetry. The capsid may bend into an open torus, conferring a biconcave disk or kidney-shaped morphology to the virion (largest diameter 120-140 nm) or the capsid may be s...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000149710

    authors: Horzinek MC,Flewett TH,Saif LJ,Spaan WJ,Weiss M,Woode GN

    更新日期:1987-01-01 00:00:00

  • Rotavirus genotypes in Costa Rica, Nicaragua, Honduras and the Dominican Republic.

    abstract::In this study, 574 stool samples from children with gastroenteritis were obtained from different hospitals in Costa Rica, Honduras, Nicaragua and the Dominican Republic during 2005-2006. Diarrhea stool samples were analyzed for rotavirus by ELISA and typed by the RT-PCR-based method. Unusual strains were detected: G1P...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000317288

    authors: Bourdett-Stanziola L,Ortega-Barria E,Espinoza F,Bucardo F,Jimenez C,Ferrera A

    更新日期:2010-01-01 00:00:00

  • Koolpinyah: a virus related to kotonkan from cattle in northern Australia.

    abstract::Two closely related viruses were isolated from the blood of bovines near Darwin, Northern Territory, Australia. When studies of virus morphology indicated that these were rhabdoviruses, serologic studies were done. These isolates are closely related or identical and are related to, but distinct from, the rabies-relate...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000150274

    authors: Gard GP,Melville LF,Calisher CH,Karabatsos N

    更新日期:1992-01-01 00:00:00

  • A novel real-time multiplex reverse transcriptase-polymerase chain reaction for the detection of HIV-1 RNA by using dual-specific armored RNA as internal control.

    abstract:OBJECTIVE:Transmission of HIV-1 and diagnosis of infection in hospitals and public health settings remains a worldwide concern. HIV-1 detection is sometimes not possible using current commercial assays, probably due to mismatches between the selected primers and probes. METHODS:By screening primers and probes, we deve...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000119119

    authors: Huang J,Yang CM,Wang LN,Meng S,Deng W,Li JM

    更新日期:2008-01-01 00:00:00

  • Regulation of infected-cell-specific protein synthesis in SF IPLB-21 cells productively infected with Spodoptera frugiperda multicapsid nuclear polyhedrosis virus.

    abstract::In Spodoptera frugiperda (SF IPLB-21) cells productively infected with S. frugiperda multicapsid nuclear polyhedrosis virus (SfMNPV), we observed the synthesis of infected-cell-specific polypeptides (ICSPs) using the protein synthesis inhibitor cycloheximide (CX) and the DAN synthesis inhibitor cytosine arabinoside (A...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000150520

    authors: Liu HS,Bilimoria SL

    更新日期:1997-01-01 00:00:00

  • c-Jun, c-Fos and their family members activate the transcription mediated by three 21-bp repetitive sequences in the HTLV-I long terminal repeat.

    abstract::Transcription of human T-cell leukemia virus type I is regulated by a viral transactivatior Tax, through the 21-bp sequence in the long terminal repeat (LTR). We found that cellular transcription factor AP-1 (c-Jun/c-Fos heterocomplex) bound to the 21-bp sequence. The binding affinity of the complex increased in propo...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000150436

    authors: Fujii M,Tsuchiya H,Meng XB,Seiki M

    更新日期:1995-01-01 00:00:00

  • Double-filtration plasmapheresis plus IFN for HCV-1b patients with non-sustained virological response to previous combination therapy: early viral dynamics.

    abstract::Double-filtration plasmapheresis (DFPP) was approved in Japan in April 2008 for the retreatment of chronic hepatitis C patients with genotype 1b and high viral loads, whose hepatitis C virus was not eradicated by earlier IFN therapy or by pegylated IFN plus ribavirin (PEG-IFN/RBV) combination therapy. In this study, w...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000252783

    authors: Kim SR,Imoto S,Kudo M,Mita K,Taniguchi M,Kim KI,Sasase N,Shoji I,Nagano-Fujii M,El-Shamy A,Hotta H,Nagai T,Nagata Y,Hayashi Y

    更新日期:2010-01-01 00:00:00

  • Serologic comparison of hepatitis A antigen to echovirus 25 isolate CR69(076) recovered from a patient with viral hepatitis.

    abstract::A serologic comparison was performed by immune electron microscopy between hepatitis A antigen (related to the MS-1 strain of hepatitis A virus) and a viral isolate, CR69(076), from the stool of a patient in Costa Rica with viral hepatitis. CR69(076) was not antigenically related to hepatitis A antigen but was related...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000149486

    authors: Dienstag JL,Pelon W,Tyeryar F,Purcell RH

    更新日期:1975-01-01 00:00:00

  • Low HBeAg serum levels correlate with the presence of the double A1762T/G1764A core promoter mutation and a positive response to interferon in patients with chronic hepatitis B virus infection.

    abstract:OBJECTIVE:To investigate the correlation of serum hepatitis B e antigen (HBeAg) levels with the presence of core promoter (CP) mutations, hepatitis B virus (HBV) viremia and the response to interferon (IFN) in patients with chronic hepatitis B. METHODS:Fourteen HBeAg-positive patients received alpha-2a IFN. Diluted se...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000072431

    authors: Marrone A,Zampino R,Luongo G,Utili R,Karayiannis P,Ruggiero G

    更新日期:2003-01-01 00:00:00

  • Emergence of an unusual genotype of rotavirus in andaman and nicobar islands, India.

    abstract::Rotavirus is the most common cause of severe diarrhoea worldwide, affecting over 125 million young children every year in developing countries. The present study is a part of ongoing childhood diarrhoeal surveillance to determine the strain diversity of rotaviruses prevalent in Andaman and Nicobar Islands. From Octobe...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000342219

    authors: Reesu R,Bhattacharya D,Chaaithanya IK,Muruganandam N,Bharadwaj AP,Singhania M,Sugunan AP,Vijayachari P

    更新日期:2013-01-01 00:00:00

  • Evidence of vertical transmission of dengue virus in two endemic localities in the state of Oaxaca, Mexico.

    abstract:BACKGROUND:Dengue virus is spread in tropical areas of the world and is the causative agent of dengue fever and dengue hemorrhagic fever. It is horizontally transmitted to humans by infected Aedes mosquitoes, but it is also able to be vertically or transovarially transmitted to insect progeny. OBJECTIVE:In this work, ...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000107272

    authors: Günther J,Martínez-Muñoz JP,Pérez-Ishiwara DG,Salas-Benito J

    更新日期:2007-01-01 00:00:00

  • Sequence Similarities between Viroids and Human MicroRNAs.

    abstract::Viroids are minute unencapsidated non-coding circular RNAs known to be present and to cause diseases only in plants. Infections were associated with the occurrence of specific single-stranded RNAs similar in size to miRNAs and endogenous small interfering RNAs, and viroid pathogenicity is suspected to occur through RN...

    journal_title:Intervirology

    pub_type: 新闻

    doi:10.1159/000509212

    authors: Bengone-Abogourin JG,Chelkha N,Verdin E,Colson P

    更新日期:2019-01-01 00:00:00

  • Dengue in travellers is still underestimated.

    abstract:BACKGROUND:Dengue fever (DF), one of the main emerging virus diseases, also increases in German travellers, due to the increasing number of travellers to tropical regions. METHODS:We determined antibodies against DF virus in a group (n = 149) of long-distance travellers in order to evaluate the risk of acquiring DF. S...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000131667

    authors: Allwinn R,Hofknecht N,Doerr HW

    更新日期:2008-01-01 00:00:00

  • Viruses that cross borders: factors responsible for global dissemination of viral infections.

    abstract:OBJECTIVE:Pandemic viral infections as emerging infectious diseases are of a great global concern. However, for some viruses, particular strains are endemic to specific areas and can be genetically distinguished from strains in other regions. In contrast, for some other viruses, genetically similar strains can spread a...

    journal_title:Intervirology

    pub_type: 杂志文章,meta分析

    doi:10.1159/000320967

    authors: Furuse Y,Suzuki A,Kamigaki T,Mpolya EA,Khandaker I,Oshitani H

    更新日期:2011-01-01 00:00:00

  • Hepatitis A: hepatotropism and influence on myelopoiesis.

    abstract::Immunopathologic mechanisms leading to liver tissue injury in hepatitis caused by hepatitis A virus (HAV) were studied in an autologous in vitro model. Data show virus-specific killing by liver-infiltrating T lymphocytes in man and support the hypothesis that hepatocellular damage as well as efficient elimination of v...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000150304

    authors: Vallbracht A,Fleischer B,Busch FW

    更新日期:1993-01-01 00:00:00

  • Sequence analysis of the matrix/nucleocapsid gene region of turkey coronavirus.

    abstract::A reverse transcriptase, polymerase chain reaction (RT-PCR) procedure was used to amplify a segment of the genome of turkey coronavirus (TCV) spanning portions of the matrix and nucleocapsid (MN) protein genes (approximately 1.1 kb). The MN gene region of three epidemiologically distinct TCV strains (Minnesota, NC95, ...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000024956

    authors: Breslin JJ,Smith LG,Fuller FJ,Guy JS

    更新日期:1999-01-01 00:00:00

  • A novel, recombinant triple antigen hepatitis B vaccine (Hepacare).

    abstract::Infection with hepatitis B virus (HBV) continues to be a major problem in the human population. There remains a specific requirement for HBV vaccines capable of circumventing the non-responder/inadequate responder status of some vaccinees. Hepacare has been primarily developed to (1) improve anti-SHBs antibody titres ...

    journal_title:Intervirology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000050036

    authors: Page M,Jones CD,Bailey C

    更新日期:2001-01-01 00:00:00

  • The genome organization of pea stem necrosis virus and its assignment to the genus Carmovirus.

    abstract::The complete sequence of the single-stranded, positive-sense RNA genome of pea stem necrosis virus (PSNV) has been determined. The 4,048-nucleotide genome contains five open reading frames (ORFs). The 5'-proximal ORF encodes a 25-kD protein (p25). If the amber termination codon is read through, the ORF produces a read...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000065870

    authors: Suzuki S,Hase S,Takahashi H,Ikegami M

    更新日期:2002-01-01 00:00:00

  • Improvement in plaquing methods for the enumeration of anatid herpesvirus (duck plague virus).

    abstract::The Holland strain of anatid herpesvirus (AHV) was 2-to 10-fold more efficiently plaqued under liquid medium or semisolid medium containing methylcellulose than in media containing agar, agarose, or Nobel agar. Virus adsorption was complete in 45 min, with the maximum virus titers obtained under liquid medium at 48 h ...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000149193

    authors: Attanasio R,Olson R,Johnson JC

    更新日期:1980-01-01 00:00:00

  • Characterization and genome sequencing of a novel coliphage isolated from engineered Escherichia coli.

    abstract:OBJECTIVES:To characterize morphological, physicochemical and genomic features of a novel virulent coliphage which was isolated from an engineered Escherichia coli culture and termed engineered E. coli phage (EEP). METHODS AND RESULTS:Electron microscopy revealed that EEP has an icosahedral head (62 nm in diameter) an...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000299063

    authors: Li S,Liu L,Zhu J,Zou L,Li M,Cong Y,Rao X,Hu X,Zhou Y,Chen Z,Hu F

    更新日期:2010-01-01 00:00:00

  • Early Evolution of Human Respiratory Syncytial Virus ON1 Strains: Analysis of the Diversity in the C-Terminal Hypervariable Region of Glycoprotein Gene within the First 3.5 Years since Their Detection.

    abstract:OBJECTIVE:Characterization of the phylogeny and diversity of human respiratory syncytial virus (HRSV) genotype ON1 that occurred during its early evolution (within the first 3.5 years since the detection of the first ON1 strains). ON1 strains have a 72-nucleotide-long in-frame duplication within the second hypervariabl...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000382018

    authors: Ivancic-Jelecki J,Forcic D,Mlinaric-Galinovic G,Tesovic G,Nikic Hecer A

    更新日期:2015-01-01 00:00:00

  • Map of sequential B cell epitopes of the HIV-1 transmembrane protein using human antibodies as probe.

    abstract::Antibodies of individuals infected with the human immunodeficiency virus type 1 (HIV-1) were used to probe the antigenicity of the HIV-1 transmembrane protein of 41 kD (gp41) by antibody-reactive peptide scanning (Pepscan). Eleven distinct sequential antibody-binding sites were defined by testing reactivity to 339 ove...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000150169

    authors: Goudsmit J,Meloen RH,Brasseur R

    更新日期:1990-01-01 00:00:00

  • The two capsid proteins of maize rayado fino virus contain common peptide sequences.

    abstract::Virions of maize rayado fino virus (MRFV) were purified and two major capsid proteins (ca. Mr 29,000 and 22,000) were resolved by SDS-PAGE. When the two major capsid proteins were isolated from gels and compared by one-dimensional peptide mapping after digestion with Staphylococcus aureus V-8 protease, indistinguishab...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000149664

    authors: Falk BW,Tsai JH

    更新日期:1986-01-01 00:00:00

  • Expression of E1E2 on hepatitis C RNA-containing particles released from primary cultured human hepatocytes derived from infected cirrhotic livers.

    abstract:OBJECTIVE:To determine whether liver-derived hepatitis C RNA-containing particles express the E1E2 discontinuous antigenic determinant defined by unique monoclonal antibody (mAb) D32.10 which recognizes three highly conserved segments in E1 (aa297-306) and E2 (aa480-494 and aa613-621) envelope glycoproteins. METHODS:H...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000318886

    authors: Ndongo N,Selliah S,Berthillon P,Raymond VA,Trépo C,Bilodeau M,Petit MA

    更新日期:2011-01-01 00:00:00

  • Pathogenic significance and organic virus levels in patients infected with TT virus.

    abstract::Previous reports documented the recovery of a DNA virus from a patient with posttransfusion non-A-G hepatitis and named TT virus (TTV). Although the virus was initially detected as a causative agent of hepatitis, there is doubt about its pathogenicity. The aim of this study was to clarify the relationship between TTV ...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000050060

    authors: Suzuki F,Chayama K,Tsubota A,Akuta N,Someya T,Kobayashi M,Suzuki Y,Saitoh S,Arase Y,Ikeda K,Kumada H

    更新日期:2001-01-01 00:00:00