Determination of drug resistance and virus typology in HIV-1-positive pediatric patients in Istanbul, Turkey.

Abstract:

:The aim of the study was to determine the prevalence of drug resistance of HIV-1 in pediatric patients from Istanbul, Turkey. Genotypic drug resistance testing revealed transmission of drug resistance from mother to child in 20%. Due to rising numbers of children with HIV-1, baseline resistance testing is recommended for Turkey.

journal_name

Intervirology

journal_title

Intervirology

authors

Yoldaş O,Ağaçfidan A,Lübke N,Somer A,Hançerli S,Verheyen J,Kaiser R,Akgül B

doi

10.1159/000362335

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

297-9

issue

5

eissn

0300-5526

issn

1423-0100

pii

000362335

journal_volume

57

pub_type

杂志文章
  • Nonstructural Protein 1 of Tick-Borne Encephalitis Virus Induces Oxidative Stress and Activates Antioxidant Defense by the Nrf2/ARE Pathway.

    abstract:BACKGROUND:Infection with tick-borne encephalitis virus (TBEV) causes pathological changes in the central nervous system. However, the possible redox alterations in the infected cells that can contribute to the virus pathogenicity remain unknown. OBJECTIVE:In the current study we explored the ability of TBEV nonstruct...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000452160

    authors: Kuzmenko YV,Smirnova OA,Ivanov AV,Starodubova ES,Karpov VL

    更新日期:2016-01-01 00:00:00

  • HIV-1 Subtype Diversity and Prevalence of Primary Drug Resistance in a Single-Center Pediatric Cohort in Germany.

    abstract:OBJECTIVES:Data on drug-resistant mutations (DRMs) in HIV-1-infected therapy-naïve children are scarce. The aim of this study was to determine the HIV-1 subtype distribution and the prevalence of DRMs in therapy-naïve HIV-1-infected children who received routine care at the University Hospital Düsseldorf, Düsseldorf, G...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000477811

    authors: Neubert J,Michalsky N,Laws HJ,Borkhardt A,Jensen B,Lübke N

    更新日期:2016-01-01 00:00:00

  • c-Jun, c-Fos and their family members activate the transcription mediated by three 21-bp repetitive sequences in the HTLV-I long terminal repeat.

    abstract::Transcription of human T-cell leukemia virus type I is regulated by a viral transactivatior Tax, through the 21-bp sequence in the long terminal repeat (LTR). We found that cellular transcription factor AP-1 (c-Jun/c-Fos heterocomplex) bound to the 21-bp sequence. The binding affinity of the complex increased in propo...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000150436

    authors: Fujii M,Tsuchiya H,Meng XB,Seiki M

    更新日期:1995-01-01 00:00:00

  • Molecular virology of hepatitis B virus and targets for antiviral intervention.

    abstract::The members of the viral family Hepadnaviridae comprise one of the smallest enveloped DNA viruses and cause acute and chronic infections in mammals and birds, leading to large virus and antigen loads in the blood. They have a restricted host range and depend on differentiated hepatocytes for replication. Hepatitis B v...

    journal_title:Intervirology

    pub_type: 杂志文章,评审

    doi:10.1159/000360946

    authors: Glebe D,König A

    更新日期:2014-01-01 00:00:00

  • Genetic barrier to the development of resistance to integrase inhibitors in HIV-1 subtypes CRF01_AE and B.

    abstract:OBJECTIVE:The genetic barrier for the evolution of integrase inhibitors (INIs) including raltegravir (RAL), elvitegravir (EVG), and dolutegravir (DTG) resistance was compared between HIV-1 subtypes CRF01_AE and B. METHODS:Analysis of 66 substitutions associated with INI resistance at 41 amino acid positions in 144 nuc...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000336658

    authors: Nguyen HL,Ruxrungtham K,Delaugerre C

    更新日期:2012-01-01 00:00:00

  • Identification of the coat protein gene of bean golden mosaic geminivirus.

    abstract::An open-reading frame designated 1R1, on DNA component 1 of bean golden mosaic geminivirus (BGMV), has been identified as the coat protein gene. A DraI restriction fragment of BGMV DNA1 that includes 1R1 was inserted into the SmaI pKK223-3 expression vector. The 32 kD protein expressed in Escherichia coli cells reacte...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000150208

    authors: Murayama A,Yamaya Y,Ikegami M

    更新日期:1991-01-01 00:00:00

  • Microscopic examination of the intracellular fate of infectious herpes simplex virus DNA.

    abstract::The intracellular fate of 3H-labeled exogenous herpes simplex virus type 2 DNA following the exposure of recipient cells to selected DNA facilitators and the ultrastructural changes which ensued in transfected cultures were examined. In most cases, electron microscopic radioautography demonstrated that exogenous DNA r...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000149253

    authors: Marciano-Cabral F,Cabral GA,Taylor MM,Patterson M,Farber FE

    更新日期:1981-01-01 00:00:00

  • How ancient are the tobamoviruses?

    abstract::The amino acid sequences of the virion proteins of 7 definitive tobamoviruses have been compared. The results show that the proteins may be arranged unequivocally in a single dendrogram which, by analogy with similar comparisons of other sets of homologous proteins, probably reflects their phylogeny. The magnitude of ...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000149169

    authors: Gibbs A

    更新日期:1980-01-01 00:00:00

  • Biochemically silent posttransfusion non-A, non-B hepatitis interferes with superinfection by hepatitis A virus.

    abstract::Superinfection of a silently non-A, non-B (NANB)-infected chimpanzee with hepatitis A virus (HAV) resulted in minimal liver enzyme elevations, lack of detectable HAV in stool, and questionable presence of HAV antigen in liver biopsy specimens obtained during the expected period of virus replication. Our findings indic...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000149724

    authors: Bradley DW,Krawczynski K,Humphrey CD,McCaustland KA

    更新日期:1987-01-01 00:00:00

  • Effect of 2-thiouracil on RNA and protein synthesis in synchronous and asynchronous infections of tobacco mosaic virus.

    abstract::Examination of the effect of 2-thiouracil on tobacco mosaic virus (TMV) RNA and protein synthesis in synchronous and asynchronous systems of replication in tobacco leaves demonstrated that 2-thiouracil does not prevent synthesis of TMV RNA, as suggested by previous studies, but inhibits some earlier function. When add...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000149351

    authors: Dawson WO,Grantham GL

    更新日期:1983-01-01 00:00:00

  • High rates of human immunodeficiency virus type 1 mutational profiles by single-genome amplification after 48-hour propagation in peripheral blood mononuclear cells at different levels of cell activation.

    abstract::Human immunodeficiency virus type 1 (HIV-1) genetic diversity is one of the most important features of HIV-1 infections and the result of error accumulation during reverse transcription and of high viral turnover. HIV-1 reverse transcription is influenced by factors such as the level of nucleotides and/or the cellular...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000362415

    authors: Russo CT,Alkmim W,Munerato P,Zukurov J,Maricato JT,Sucupira MC,Diaz RS,Janini LM

    更新日期:2014-01-01 00:00:00

  • Time-course of cowpea chlorotic mottle virus RNA replication.

    abstract::In a synchronous infection of cowpea chlorotic mottle virus in cowpea leaves, the three largest viral RNA components were synthesized throughout the infection at relatively constant ratios of two molecules of component 3 to one each of components 1 and 2. Component 4 (the coat protein message) was produced minimally d...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000148929

    authors: Dawson WO

    更新日期:1978-01-01 00:00:00

  • Characteristics and outcomes of HCV genotype-1-infected patients treated with peginterferon and ribavirin combination therapy with discordant HCV responses 4 and 12 weeks after starting therapy.

    abstract:OBJECTIVE:Some patients with chronic hepatitis C virus (HCV) infection fail to achieve complete early virologic response (EVR) despite a marked decrease in HCV RNA at 4 weeks. We investigated the characteristics and final treatment outcomes of this patient subpopulation. METHODS:A total of 516 patients with HCV genoty...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000362721

    authors: Toyoda H,Kumada T,Shimada N,Takaguchi K,Ide T,Sata M,Ginba H,Matsuyama K,Izumi N

    更新日期:2014-01-01 00:00:00

  • Human T cell lymphotropic retroviruses: association with diseases of the nervous system.

    abstract::In less than 1% of persistently infected individuals, human T cell lymphotropic virus type I (HTLV-I) causes a chronic inflammatory disease of the central nervous system (CNS), called HTLV-I-associated myelopathy/tropical spastic paraparesis. Important prerequisites for disease induction are oligoclonal expansion of H...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000150540

    authors: Kitze B,Brady JN

    更新日期:1997-01-01 00:00:00

  • Intracellular pools of thymidine reduce the antiviral action of acyclovir.

    abstract::Acyclovir inhibits herpes simplex virus (HSV) infections better in human fibroblasts than in green monkey kidney cells. Thymidine and acyclovir compete for the active site of HSV thymidine kinase. Large intracellular pools of thymidine found by high-performance liquid chromatography (HPLC) seemed to be responsible for...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000149373

    authors: Harmenberg J

    更新日期:1983-01-01 00:00:00

  • Nondetection of infectious hepatitis B virus in a human hepatoma cell line producing hepatitis B surface antigen.

    abstract::The PLC/PRF/5 human hepatoma cell line producing hepatitis B surface antigen (HBsAg) was studied to determine whether infectious hepatitis B virus (HBV) was also being produced. 2 chimpanzees with no previous exposure to HBV and no serologic markers of past or active HBV infection were inoculated intravenously with 50...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000149217

    authors: Tabor E,Copeland JA,Mann GF,Howard CR,Skelly J,Snoy P,Zuckerman AJ,Gerety RJ

    更新日期:1981-01-01 00:00:00

  • Numerical diagnoses of superinfection in chronic hepatitis B viral dynamics.

    abstract:OBJECTIVES:Fluctuation profile has been observed in chronic hepatitis B patients who are untreated or interrupt therapy. A mathematical model and its parameters could be used to diagnose the assumption of superinfection of hepatocytes and to understand the causes for the spontaneous fluctuation pattern of HBV DNA loads...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000321454

    authors: Wang K,Tan W,Tang Y,Deng G

    更新日期:2011-01-01 00:00:00

  • Monkeys and Rats Are Not Susceptible to Ferret Hepatitis E Virus Infection.

    abstract::Ferret hepatitis E virus (HEV), a novel hepatitis E-like virus, has been identified in ferrets in the Netherlands, Japan, and the US. To determine whether ferret HEV transmits to other animals, we inoculated laboratory rats (Wistar), nude rats (Long-Evans-rnu/rnu), and cynomolgus monkeys with ferret HEV (F4351) by int...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000373891

    authors: Li TC,Yoshizaki S,Ami Y,Suzaki Y,Yang T,Takeda N,Takaji W

    更新日期:2015-01-01 00:00:00

  • Effect of glucosamine on the replication of the arenavirus Junín in Vero cells.

    abstract::When Vero cells infected with Junín virus are cultured in the presence of 16 mM glucosamine, no infectious virus is produced and no surface antigens or virions are detected. Cytoplasmic viral antigen, however, is synthesized normally. ...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000149032

    authors: Martínez Peralta LA,León ME,Coto CE,Laguens RP

    更新日期:1979-01-01 00:00:00

  • Alternatives to the species concept for virus taxonomy.

    abstract::The species concept seems to be inescapably based on the occurrence, in a population, of regular genetic interchange which leads to the formation of common gene pools and on the presence of barriers to interchange which distinguish one gene pool from another. Present knowledge indicates that some types of viruses (e.g...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000149624

    authors: Milne RG

    更新日期:1985-01-01 00:00:00

  • Non-axial view of the varicella-zoster virus portal protein reveals conserved crown, wing and clip architecture.

    abstract:BACKGROUND:Herpesviridae encode a family of protein homologues that function as the 'port of entry' for insertion of the viral DNA into preformed capsids during encapsidation. METHODS:Transmission electron microscopy (TEM) of recombinant varicella-zoster virus pORF54 was performed. RESULTS:Results suggest that pORF54...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000360225

    authors: Visalli RJ,Howard AJ

    更新日期:2014-01-01 00:00:00

  • Evolutionary relationship of three southern African maize streak virus isolates.

    abstract::The aligned restriction endonuclease maps of three sequenced maize streak virus isolates, three restriction-mapped southern African maize streak virus isolates, and two other sequenced geminiviruses were used as a means of calculating the sequence divergence between these viruses. The degree of divergence was used to ...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000150080

    authors: Kirby R,Clarke BA,Rybicki EP

    更新日期:1989-01-01 00:00:00

  • Biological properties of Junin virus proteins. I. Identification of the immunogenic glycoprotein.

    abstract::Purified Junin virus was disrupted by nonionic detergent treatment (Triton X-100), and subviral components were separated by ultracentrifugation. Only the soluble fraction, containing all of the major glycoprotein (mol.wt. 38,000), induced the formation of neutralizing antibodies in laboratory animals and protected th...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000149136

    authors: Cresta B,Padula P,de Martinez Segovia M

    更新日期:1980-01-01 00:00:00

  • Replication and serial passage of a singly enveloped baculovirus of Orgyia leucostigma in homologous cell lines.

    abstract::A singly enveloped nuclear polyhedrosis virus (SNPV) of the white-marked tussock moth, Orgyia leucostigma, was successfully grown in four continuous cell lines developed from minced neonate larvae of this insect. Level of infection in two cell lines, IPRI-OL-12 and IPRI-OL-13, was 65-90%, but in the other two, IPRI-OL...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000149502

    authors: Sohi SS,Percy J,Arif BM,Cunningham JC

    更新日期:1984-01-01 00:00:00

  • Effect of gamma-interferon or cycloheximide treatment on viral and c-myc transcripts in bovine-papillomavirus-type-1-transformed primary mouse fibroblasts.

    abstract::We have studied the effect of gamma-interferon (IFN-gamma) treatment on the transcription of viral and c-myc oncogenes in bovine papillomavirus type 1 (BPV-1)-transformed mouse fibroblast cell lines. Upon IFN-gamma treatment, viral transcripts always decreased in cell lines containing episomal BPV-1 DNA, while the eff...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000150320

    authors: Agrawal R,Pelkonen J,Mäntyjärvi RA

    更新日期:1993-01-01 00:00:00

  • Structural proteins of Marituba virus (Bunyaviridae).

    abstract::Marituba virus was purified by rate-zonal sedimentation and equilibrium density centrifugation in sucrose gradients. The buoyant density of virus particles was 1.19 g/ml. Purified virus was dissociated and its proteins were analyzed by SDS-PAGE. Four virus polypeptides were identified and designated L, G1, G2 and N. T...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000149383

    authors: Frugulhetti IC,Soares MC,Rebello MA

    更新日期:1983-01-01 00:00:00

  • Early Evolution of Human Respiratory Syncytial Virus ON1 Strains: Analysis of the Diversity in the C-Terminal Hypervariable Region of Glycoprotein Gene within the First 3.5 Years since Their Detection.

    abstract:OBJECTIVE:Characterization of the phylogeny and diversity of human respiratory syncytial virus (HRSV) genotype ON1 that occurred during its early evolution (within the first 3.5 years since the detection of the first ON1 strains). ON1 strains have a 72-nucleotide-long in-frame duplication within the second hypervariabl...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000382018

    authors: Ivancic-Jelecki J,Forcic D,Mlinaric-Galinovic G,Tesovic G,Nikic Hecer A

    更新日期:2015-01-01 00:00:00

  • Characterization of hepatitis B virus molecular genotypes in Chongqing and quantitative serological markers in patients during natural phases of chronic hepatitis B infection.

    abstract:BACKGROUND/AIMS:The present study was launched to systematically characterize the molecular genotypes and quantitative serological biomarkers during the natural course of chronic hepatitis B (CHB) infection in a patient population from Chongqing, China. METHODS:A total of 140 patients were enrolled and grouped accordi...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000323524

    authors: Xiang Y,Huang S,Xia J,Ye D,Chen P,Zhang L

    更新日期:2012-01-01 00:00:00

  • Kinetics of human antibody responses to primary genital herpes simplex virus infection.

    abstract::5 patients with primary genital herpes simplex virus (HSV) infection were studied prospectively for the production of serum antibody reactivity as measured by the virus micro-neutralization test (NT), micro-solid phase radioimmunometric assay (micro-SPRIA), and antibody-dependent cellular-cytotoxic (ADCC) test. ADCC a...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000149320

    authors: Kohl S,Adam E,Matson DO,Kaufman RH,Dreesman GR

    更新日期:1982-01-01 00:00:00

  • Emergence of an unusual genotype of rotavirus in andaman and nicobar islands, India.

    abstract::Rotavirus is the most common cause of severe diarrhoea worldwide, affecting over 125 million young children every year in developing countries. The present study is a part of ongoing childhood diarrhoeal surveillance to determine the strain diversity of rotaviruses prevalent in Andaman and Nicobar Islands. From Octobe...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000342219

    authors: Reesu R,Bhattacharya D,Chaaithanya IK,Muruganandam N,Bharadwaj AP,Singhania M,Sugunan AP,Vijayachari P

    更新日期:2013-01-01 00:00:00