Clinical, Virological, and Immunological Profiles of DENV, ZIKV, and/or CHIKV-Infected Brazilian Patients.

Abstract:

BACKGROUND:Arboviruses co-circulating within a population that are transmitted by the same vector have the potential to cause coinfections. Coinfections with dengue virus (DENV), Zika virus (ZIKV), and chikungunya virus (CHIKV) have been occurring in Brazil, but it is not well-understood how human responses vary during mono- or coinfections and whether they play different roles in pathogenesis. METHODS:We investigated the clinical, virological, and immunological status during patients' acute infections, focusing on the CCL/CXC chemokines, proinflammatory, as well as anti-inflammatory cytokines levels quantified by ELISAs. Viral load was determined by qRT-PCR in serum samples from 116 acute DENV, ZIKV, CHIKV, DENV/ZIKV, and CHIKV/ZIKV-infected adult patients from Brazil. RESULTS:Most of the acute patients displayed fever, headache, prostration, and myalgia, regardless of the type of arbovirus infection. Zika viral load was higher in CHIKV/ZIKV coinfected patients compared with ZIKV or DENV/ZIKV infections. All infected individuals presented increased concentrations of C-X-C motif chemokine ligand 10/interferon protein-10 (CXCL10/IP-10), C-C motif chemokine ligand 2/monocyte chemoattractant protein-1 (CCL2/MCP-1), and tumor necrosis factor alpha (TNF-α) compared to healthy donors. Interestingly, the ZIKV group separated from CHIKV/ZIKV due to higher levels of interleukin-10 (IL-10) and lower levels of TNF-α. While DENV/ZIKV differentiated from CHIKV due to their higher levels of CCL2/MCP-1, in CHIKV- and CHIKV/ZIKV-infected patients, levels of CXC10/IP-10, CCL2/MCP-1, and migration inhibitory factor (MIF) were associated with CHIKV viral load. By contrast, in DENV/ZIKV- and CHIKV/ZIKV-infected patients, levels of CXCL10/IP-10, CCL2/MCP-1, and TNF-α showed a significant inverse correlation with ZIKV viral load. CONCLUSIONS:From all the circulating mediators measured, we detected differences of IL-10, TNF-α, and CCL2/MCP-1 between arbovirus groups. We hypothesize that CXC10/IP-10, CCL2/MCP-1, and MIF in the CHIKV-infected group could regulate the CHIKV viral load, while CXC10/IP-10, CCL2/MCP-1, and TNF-α in DENV/ZIKV, and CHIKV/ZIKV groups, could regulate ZIKV viral load.

journal_name

Intervirology

journal_title

Intervirology

authors

Sánchez-Arcila JC,Badolato-Correa J,de Souza TMA,Paiva IA,Barbosa LS,Nunes PCG,Lima MDRQ,Dos Santos FB,Damasco PV,da Cunha RV,Azeredo EL,de Oliveira-Pinto LM

doi

10.1159/000510223

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

33-45

issue

1-6

eissn

0300-5526

issn

1423-0100

pii

000510223

journal_volume

63

pub_type

杂志文章
  • Natural antibodies to EBV-VCA antigens in common marmosets (Callithrix jacchus) and response after EBV inoculation.

    abstract::Healthy common marmosets from two separate colonies, one in England and one in France, were found to have antibodies cross-reacting with Epstein-Barr virus structural antigens (EBV-VCA). All seropositive animals were at least 2 years old. Experimental EBV infection of marmosets of different ages led to seroconversion ...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000149198

    authors: de-Thé G,Dubouch P,Fontaine C,Wedderburn N,Carter RL,Edwards MB,Cohen B

    更新日期:1980-01-01 00:00:00

  • Biology of rat cytomegalovirus infection.

    abstract::Cytomegalovirus infection of Brown Norway rats was studied after intraperitoneal or subcutaneous inoculation of virus. No clinical illness was apparent during the 1st month postinfection (p.i.). Low titers of virus were detected in many organs at day 4 p.i. for the intraperitoneally inoculated animals and at day 11 p....

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000149612

    authors: Bruggeman CA,Meijer H,Bosman F,van Boven CP

    更新日期:1985-01-01 00:00:00

  • Taxonomy of potyviruses: current problems and some solutions.

    abstract::There are two major requirements for potyvirus taxonomy; group-specific criteria and criteria which discriminate between distinct viruses and strains. This review discusses the relative merits in potyvirus taxonomy of molecular parameters, such as gene sequence data, nucleic acid hybridization, coat protein sequence d...

    journal_title:Intervirology

    pub_type: 杂志文章,评审

    doi:10.1159/000150211

    authors: Ward CW,Shukla DD

    更新日期:1991-01-01 00:00:00

  • Monkeys and Rats Are Not Susceptible to Ferret Hepatitis E Virus Infection.

    abstract::Ferret hepatitis E virus (HEV), a novel hepatitis E-like virus, has been identified in ferrets in the Netherlands, Japan, and the US. To determine whether ferret HEV transmits to other animals, we inoculated laboratory rats (Wistar), nude rats (Long-Evans-rnu/rnu), and cynomolgus monkeys with ferret HEV (F4351) by int...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000373891

    authors: Li TC,Yoshizaki S,Ami Y,Suzaki Y,Yang T,Takeda N,Takaji W

    更新日期:2015-01-01 00:00:00

  • Human cytomegalovirus escape from immune detection.

    abstract::Human cytomegalovirus (CMV) has devised numerous means of escaping immune surveillance. The CMV genome encodes at least 4 genes involved in downregulating surface expression of HLA class I molecules. In addition, it sequesters CC chemokines, induces Fc receptors, interferes with induction of HLA class II antigens, and...

    journal_title:Intervirology

    pub_type: 杂志文章,评审

    doi:10.1159/000053964

    authors: Michelson S

    更新日期:1999-01-01 00:00:00

  • Low to medium WU-virus titers in young children with lower respiratory tract infections.

    abstract::The WU-virus (WUV), a novel polyomavirus, has recently been recovered from respiratory tract samples. Within a study collective of children with severe lower respiratory tract disease, 3% of the patients tested WUV positive. Viral loads ranged from 5 x 10(2) copies/ml to 1 x 10(4) copies/ml. The WUV genome-positive pa...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000209673

    authors: Kleines M,Scheithauer S,Hengst M,Honnef D,Ritter K,Mühler E,Häusler M,Rostamzadeh A

    更新日期:2008-01-01 00:00:00

  • Genomic heterogeneities in bovine herpesvirus type 1 viral isolates: a major variant selected from a field isolate.

    abstract::We have analyzed viral DNA patterns, obtained following digestion of six different infectious bovine rhinotracheitis isolates, using a panel of restriction enzymes. Several differences in profiles were observed, particularly for a Canadian viral strain which presumably contained a genome that was larger than the other...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000150192

    authors: Simard C,LaBoissière S,Séguin C,Trudel M

    更新日期:1991-01-01 00:00:00

  • Early Evolution of Human Respiratory Syncytial Virus ON1 Strains: Analysis of the Diversity in the C-Terminal Hypervariable Region of Glycoprotein Gene within the First 3.5 Years since Their Detection.

    abstract:OBJECTIVE:Characterization of the phylogeny and diversity of human respiratory syncytial virus (HRSV) genotype ON1 that occurred during its early evolution (within the first 3.5 years since the detection of the first ON1 strains). ON1 strains have a 72-nucleotide-long in-frame duplication within the second hypervariabl...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000382018

    authors: Ivancic-Jelecki J,Forcic D,Mlinaric-Galinovic G,Tesovic G,Nikic Hecer A

    更新日期:2015-01-01 00:00:00

  • Pathogenic significance and organic virus levels in patients infected with TT virus.

    abstract::Previous reports documented the recovery of a DNA virus from a patient with posttransfusion non-A-G hepatitis and named TT virus (TTV). Although the virus was initially detected as a causative agent of hepatitis, there is doubt about its pathogenicity. The aim of this study was to clarify the relationship between TTV ...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000050060

    authors: Suzuki F,Chayama K,Tsubota A,Akuta N,Someya T,Kobayashi M,Suzuki Y,Saitoh S,Arase Y,Ikeda K,Kumada H

    更新日期:2001-01-01 00:00:00

  • Prediction of efficacy of interferon treatment of chronic hepatitis C and occurrence of HCC after interferon treatment by a new classification.

    abstract::One hundred and twenty-one chronic hepatitis C patients were administered interferon (IFN) and divided into two groups: 31 complete responders (CR) with prolonged HCV-RNA negative 1 year after treatment and 90 non-complete responders (non-CR), including partial responders (PR) with transiently negative HCV-RNA and non...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000082095

    authors: Kim KI,Sasase N,Taniguchi M,Mita K,Kim SR,Tanaka K,Hayashi Y

    更新日期:2005-01-01 00:00:00

  • Nucleotide sequence of rice dwarf phytoreovirus genome segment 2: completion of sequence analyses of rice dwarf virus.

    abstract::The complete nucleotide sequence of rice dwarf phytoreovirus genome segment 2 (S2) was determined to be 3,512 nucleotides long with one open reading frame initiating at nucleotide 15 and terminating at nucleotide 3363. The encoded polypeptide was predicted to have 1,116 residues with a relative molecular weight of 123...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000150348

    authors: Uyeda I,Suda N,Yamada N,Kudo H,Murao K,Suga H,Kimura I,Shikata E,Kitagawa Y,Kusano T

    更新日期:1994-01-01 00:00:00

  • Assessing the risk of transmission of viral diseases in flooded areas: viral load of the River Elbe in Dresden during the flood of August 2002.

    abstract::In order to assess the risk of transmission of viral diseases during floods, the viral burden in flooded areas of the city of Dresden (Germany) in August 2002 was investigated. Water samples were collected from 9 sampling sites and tested for the presence of 11 enteric viral pathogens. As a control, water samples from...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000095157

    authors: Rohayem J,Dumke R,Jaeger K,Schröter-Bobsin U,Mogel M,Kruse A,Jacobs E,Rethwilm A

    更新日期:2006-01-01 00:00:00

  • Nondetection of infectious hepatitis B virus in a human hepatoma cell line producing hepatitis B surface antigen.

    abstract::The PLC/PRF/5 human hepatoma cell line producing hepatitis B surface antigen (HBsAg) was studied to determine whether infectious hepatitis B virus (HBV) was also being produced. 2 chimpanzees with no previous exposure to HBV and no serologic markers of past or active HBV infection were inoculated intravenously with 50...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000149217

    authors: Tabor E,Copeland JA,Mann GF,Howard CR,Skelly J,Snoy P,Zuckerman AJ,Gerety RJ

    更新日期:1981-01-01 00:00:00

  • Importance of virus passage history on the growth of Coxsackie B4 in human skin fibroblasts.

    abstract::Human skin fibroblasts have previously been reported to display an age-dependent resistance to infection with coxsackie B4 virus. We have shown that the virus will replicate and produce CPE in human skin fibroblasts regardless of the age of the donor of the cells. The passage history of the virus was found to influenc...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000150029

    authors: Miller M,Harnett GB,Bucens MR

    更新日期:1988-01-01 00:00:00

  • Rotavirus genotypes in Costa Rica, Nicaragua, Honduras and the Dominican Republic.

    abstract::In this study, 574 stool samples from children with gastroenteritis were obtained from different hospitals in Costa Rica, Honduras, Nicaragua and the Dominican Republic during 2005-2006. Diarrhea stool samples were analyzed for rotavirus by ELISA and typed by the RT-PCR-based method. Unusual strains were detected: G1P...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000317288

    authors: Bourdett-Stanziola L,Ortega-Barria E,Espinoza F,Bucardo F,Jimenez C,Ferrera A

    更新日期:2010-01-01 00:00:00

  • Diagnostic value of nucleic-acid-sequence- based amplification for the detection of cytomegalovirus infection in renal and liver transplant recipients.

    abstract::To evaluate the diagnostic value of nucleic-acid-sequence-based amplification (NASBA) for the detection of cytomegalovirus (CMV) infection in transplant recipients, we compared immediate early 1 (IE1) and late pp67 mRNA detection by NASBA with the antigenemia assay, PCR and viral culture in 72 renal transplant (RTx) r...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000053974

    authors: Goossens VJ,Blok MJ,Christiaans MH,van Hooff JP,Sillekens P,Höckerstedt K,Lautenschlager I,Middeldorp JM,Bruggeman CA

    更新日期:1999-01-01 00:00:00

  • Periventricular demyelination and axonal pathology is associated with subependymal virus spread in a murine model for multiple sclerosis.

    abstract:OBJECTIVES:Theiler's murine encephalomyelitis virus (TMEV) infection of mice is a widely used animal model for demyelinating disorders, such as multiple sclerosis (MS). The aim of the present study was to identify topographical differences of TMEV spread and demyelination in the brain of experimentally infected suscept...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000336563

    authors: Kummerfeld M,Seehusen F,Klein S,Ulrich R,Kreutzer R,Gerhauser I,Herder V,Baumgärtner W,Beineke A

    更新日期:2012-01-01 00:00:00

  • One of the Mechanisms to Increase HSV-1 Uptake in HSV-1-Infected, Activated T Lymphocytes Is the Formation of Filopodia.

    abstract:OBJECTIVES:To explore the host transcription factor E2F-1 and/or any mechanisms that may support viral entry and its effect on the HSV-1 production in anti-CD3-activated Jurkat cells. METHODS:The expressions of ICP4, HVEM and E2F-1 were studied using reverse transcription-PCR and Western blot. HSV-1 production was det...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000437264

    authors: Bhattarakosol P,Donchai P

    更新日期:2015-01-01 00:00:00

  • A short hairpin loop-structured oligodeoxynucleotide targeting the virion-associated RNase H of HIV inhibits HIV production in cell culture and in huPBL-SCID mice.

    abstract:BACKGROUND:We have recently demonstrated that an oligodeoxynucleotide (ODN) can enter HIV particles and form a local hybrid at the highly conserved polypurine tract (PPT), the target site of the ODN. This hybrid is recognized by the retrovirus-specific RNase H, which is a virion-associated enzyme. It cleaves the RNA at...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000324544

    authors: Heinrich J,Schols D,Moelling K

    更新日期:2012-01-01 00:00:00

  • Measurement of human cytomegalovirus-associated DNA polymerase activity in patient urine as a potential diagnostic tool.

    abstract::Virus-associated DNA polymerase activity has recently been proposed for the detection of human cytomegalovirus (HCMV) in urine, a method that should allow rapid and quantitative determination of the viral load. In this report, the virus-associated DNA polymerase activity recovered from the urine of a group of patients...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000150530

    authors: Marcello A,Pisoni G,Pizzighella S,Palù G

    更新日期:1996-01-01 00:00:00

  • Treatment of cytomegalovirus diseases.

    abstract::This review summarizes current strategies for the treatment of human cytomegalovirus (CMV) infection/diseases in high-risk patients such as transplant recipients and AIDS patients. Since the major drugs ganciclovir (Cytovene), foscarnet (Foscavir) and cidofovir (Vistide) are frequently associated with severe side effe...

    journal_title:Intervirology

    pub_type: 杂志文章,评审

    doi:10.1159/000150568

    authors: Vogel JU,Scholz M,Cinatl J Jr

    更新日期:1997-01-01 00:00:00

  • Epitope mapping of antibodies recognising the N-terminal domain of simian virus large tumour antigen.

    abstract::The large tumour antigen (TAg) of simian virus 40 is the main regulatory protein in viral replication. We have investigated possible functional roles for the N-terminal domain of TAg while defining the epitopes of antibodies binding within that region. The epitopes recognised by eight monoclonal anti-TAg antibodies we...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000024910

    authors: Lindner K,Mole SE,Lane DP,Kenny MK

    更新日期:1998-01-01 00:00:00

  • Antigenic differences between HSV-1 and HSV-2 glycoproteins and their importance for type-specific serology.

    abstract::The ability to discriminate between herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) infections by serological means is of increasing importance for clinical virological diagnostics. HSV type-specific serology has a number of applications, e.g. to guide duration and dosage of antiviral therapy, to allow for string...

    journal_title:Intervirology

    pub_type: 杂志文章,评审

    doi:10.1159/000150493

    authors: Bergström T,Trybala E

    更新日期:1996-01-01 00:00:00

  • Molecular epidemiology of porcine H3N2 influenza A viruses isolated in Germany between 1982 and 2001.

    abstract::We examined influenza virus strains of the subtype H3N2 from outbreaks of respiratory diseases in swine herds in Germany. Four different clusters can be distinguished when comparing parts of the HA1 gene from porcine H3N2 isolates analyzed between 1982 and 2001. Comparison between these clusters reveals a bp homology ...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000077829

    authors: Schrader C,Süss J

    更新日期:2004-01-01 00:00:00

  • First human case of co-infection with two different subtypes of hepatitis E virus.

    abstract::Hepatitis E virus (HEV), the main etiologic agent of enterically transmitted acute hepatitis in developing countries, is now recognized as an emerging agent of autochthonous disease and chronic hepatitis E in immunocompromised patients in Europe where HEV infection is probably zoonotically acquired. We describe the fi...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000335664

    authors: Moal V,Gerolami R,Colson P

    更新日期:2012-01-01 00:00:00

  • Improvement in plaquing methods for the enumeration of anatid herpesvirus (duck plague virus).

    abstract::The Holland strain of anatid herpesvirus (AHV) was 2-to 10-fold more efficiently plaqued under liquid medium or semisolid medium containing methylcellulose than in media containing agar, agarose, or Nobel agar. Virus adsorption was complete in 45 min, with the maximum virus titers obtained under liquid medium at 48 h ...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000149193

    authors: Attanasio R,Olson R,Johnson JC

    更新日期:1980-01-01 00:00:00

  • Phylogenetic Analysis of Torque Teno Virus in Thalassemic Children in Egypt.

    abstract:OBJECTIVE:Torque teno virus (TTV) is a ubiquitous virus that is commonly associated with blood transfusion. The main aims of this study were to evaluate the incidence of TTV in polytransfused children with thalassemia and to determine for the first time the prevalent TTV genotypes in Egypt. METHODS:TTV was detected in...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000480507

    authors: Hassuna NA,Naguib E,Abdel-Fatah M,Mousa SMO

    更新日期:2017-01-01 00:00:00

  • Barley yellow mosaic virus (BaYMV) and BaYMV-M: two different viruses.

    abstract::Serological and physical properties of isolated particles as well as reactions of barley cultivars after virus inoculation showed that the yellow disease of barley is caused by different viruses. Results summarized in this paper suggest that the European isolates BaYMV-So and BaYMV-NM are closely related to, or identi...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000150132

    authors: Huth W,Adams MJ

    更新日期:1990-01-01 00:00:00

  • Two domains within the early coding region of SV40 involved in the transformation of human fibroblasts.

    abstract::The early gene products of simian virus 40 (SV40) transform human fibroblasts, whereas those of the human papovavirus BK (BKV) do not. The early gene products of both SV40 and BKV transform baby rat kidney cells. SV40-BKV chimerics were constructed which were able to transform baby rat kidney cells. Using the SV40-BKV...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000150019

    authors: de Ronde A,Sol CJ,MacDonald ME,Koot M,ter Schegget J,van Strien A,Wouters E,van der Noordaa J

    更新日期:1987-01-01 00:00:00

  • High percentage of seronegative HCV infections in hemodialysis patients: the need for PCR.

    abstract::Among patients undergoing maintenance hemodialysis, a high prevalence of hepatitis C virus (HCV) infection can be observed. In a prospective study, sera of 273 patients were examined for the presence of HCV infection by serological tests and by PCR. Thirty-five patients (12.8%) were HCV antibody positive, and in 31 of...

    journal_title:Intervirology

    pub_type: 杂志文章

    doi:10.1159/000150558

    authors: Schröter M,Feucht HH,Schäfer P,Zöllner B,Laufs R

    更新日期:1997-01-01 00:00:00