Two domains within the early coding region of SV40 involved in the transformation of human fibroblasts.

Abstract:

:The early gene products of simian virus 40 (SV40) transform human fibroblasts, whereas those of the human papovavirus BK (BKV) do not. The early gene products of both SV40 and BKV transform baby rat kidney cells. SV40-BKV chimerics were constructed which were able to transform baby rat kidney cells. Using the SV40-BKV chimerics, two domains within the SV40 large T protein were identified which are involved in the transformation of human fibroblasts.

journal_name

Intervirology

journal_title

Intervirology

authors

de Ronde A,Sol CJ,MacDonald ME,Koot M,ter Schegget J,van Strien A,Wouters E,van der Noordaa J

doi

10.1159/000150019

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

221-31

issue

4

eissn

0300-5526

issn

1423-0100

journal_volume

28

pub_type

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