Polyploidization of Epstein-Barr virus (EBV)-carrying lymphoma lines decreases the inducibility of EBV-determined early antigen following P3HR-1 virus superinfection or iododeoxyuridine treatment.

Abstract:

:Four tetraploid cell lines were derived from the Epstein-Barr virus (EBV)-carrying, nonproducer Burkitt lymphoma line Raji after colcemide treatment. EBV early antigen (EA) was induced by P3HR-1 virus superinfection and by iododeoxyuridine treatment. Inducibility was reduced in all tetraploid lines compared to the near-diploid counterpart. The average number of EBV genome equivalents per tetraploid cell was 60-70, compared to 50 in diploid cells. This contrasts with the EBV genome amplification previously observed in somatic cell hybrids.

journal_name

Intervirology

journal_title

Intervirology

authors

Shapiro IM,Andersson-Anvret M,Klein G

doi

10.1159/000148973

subject

Has Abstract

pub_date

1978-01-01 00:00:00

pages

94-101

issue

2

eissn

0300-5526

issn

1423-0100

journal_volume

10

pub_type

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