Abstract:
:Four tetraploid cell lines were derived from the Epstein-Barr virus (EBV)-carrying, nonproducer Burkitt lymphoma line Raji after colcemide treatment. EBV early antigen (EA) was induced by P3HR-1 virus superinfection and by iododeoxyuridine treatment. Inducibility was reduced in all tetraploid lines compared to the near-diploid counterpart. The average number of EBV genome equivalents per tetraploid cell was 60-70, compared to 50 in diploid cells. This contrasts with the EBV genome amplification previously observed in somatic cell hybrids.
journal_name
Intervirologyjournal_title
Intervirologyauthors
Shapiro IM,Andersson-Anvret M,Klein Gdoi
10.1159/000148973subject
Has Abstractpub_date
1978-01-01 00:00:00pages
94-101issue
2eissn
0300-5526issn
1423-0100journal_volume
10pub_type
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