Aerosol infection of rhesus macaques with Junin virus.

Abstract:

:The purpose of our work was to determine if aerosols of Junin virus can infect rhesus macaques and if the disease is the same as that produced by virus inoculated parenterally. The 6 macaques exposed to the virus by aerosol became acutely ill during the 3rd week after exposure, and all died. Three died by day 21, while the remainder died after 1 month. Junin virus was found primarily in visceral organs of those animals dying before 21 days after infection and in the central nervous system tissues from animals dying later. Histological changes were similar to those reported in rhesus monkeys after parenteral Junin viral infection. Gastrointestinal necrosis, however, was less severe in aerosol-infected animals and the associated septicemia was not seen. High levels of alpha interferon were detected by the 3rd day in all infected macaques. Experimental Argentine hemorrhagic fever induced by aerosol infection in rhesus macaques was similar to that seen after parenteral challenge and mimicked closely the clinical syndrome observed in humans.

journal_name

Intervirology

journal_title

Intervirology

authors

Kenyon RH,McKee KT Jr,Zack PM,Rippy MK,Vogel AP,York C,Meegan J,Crabbs C,Peters CJ

doi

10.1159/000150227

keywords:

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

23-31

issue

1

eissn

0300-5526

issn

1423-0100

journal_volume

33

pub_type

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