Molecular virology of hepatitis B virus and targets for antiviral intervention.

abstract：:When Vero cells infected with Junín virus are cultured in the presence of 16 mM glucosamine, no infectious virus is produced and no surface antigens or virions are detected. Cytoplasmic viral antigen, however, is synthesized normally. ...

journal_title：Intervirology

authors： Martínez Peralta LA,León ME,Coto CE,Laguens RP

更新日期：1979-01-01 00:00:00

abstract：OBJECTIVE:Because the determination of the stage of fibrosis depends on rather subjective judgment, more objective parameters are needed. In this study, we followed the long-term outcome, with monitoring of platelet counts, in patients with chronic hepatitis C or liver cirrhosis (LC) who had undergone interferon (IFN) ...

journal_title：Intervirology

authors： Moriyama M,Matsumura H,Aoki H,Shimizu T,Nakai K,Saito T,Yamagami H,Shioda A,Kaneko M,Goto I,Tanaka N,Arakawa Y

更新日期：2003-01-01 00:00:00

abstract：:Studies of human papillomavirus (HPV) infection are hampered by the lack of an adequate culture system. The athymic mouse xenograft system permits propagation of HPV, but only a few HPV types have been grown in this manner. To produce an oncogenic type for studies of HPV pathogenesis, a condylomata acuminata lesion fr...

journal_title：Intervirology

authors： Bryan JT,Tekchandani J,Schroeder JM,Brown DR

更新日期：2000-01-01 00:00:00

abstract：OBJECTIVES:To express E1 glycoprotein of rubella virus (RuV) strain JR23 in yeast and develop a diagnostic assay using expressed E1 protein as coating antigen in comparison with other diagnostic assays. METHODS:cDNA of E1 open reading frame of RuV was PCR amplified using plasmid pMD18-T-E1 as template and cloned into ...

journal_title：Intervirology

authors： Wen H,Wang Z

更新日期：2005-01-01 00:00:00

abstract：:Epstein-Barr virus (EBV) is a common herpesvirus that may cause asymptomatic infection or various diseases, such as mononucleosis, lymphoproliferative disorders and several cancers. Our objective was to estimate the prevalence of EBV among patients hospitalized in "Luigi Vanvitelli" University Hospital in the last 10 ...

journal_title：Intervirology

authors： Franci G,Crudele V,Della Rocca MT,Melardo C,Chianese A,Finamore E,Bencivenga F,Astorri R,Vitiello M,Galdiero E,Galdiero M

更新日期：2019-01-01 00:00:00

abstract：:Human skin fibroblasts were previously shown to be resistant to coxsackie B4 virus infection. We have cultured fibroblasts from skin and lung tissues of donors of various ages. By a novel method for direct assay of virus absorption and penetration, we have shown that skin fibroblasts from young fetuses are susceptible...

journal_title：Intervirology

authors： Hornberger E,Plotkin SA

更新日期：1983-01-01 00:00:00

abstract：OBJECTIVE:Hepatitis C virus (HCV) infection is a public health problem and a major cause of chronic hepatitis. This virus exhibits a great genetic variability, with 8 genotypes and numerous subtypes. The aim of this study was to evaluate the fluctuations of HCV subtypes during 2 decades in Venezuela. METHODS:HCV genot...

journal_title：Intervirology

authors： Loureiro CL,Jaspe RC,Pujol FH

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to investigate the exposure of piglets to enteroviruses-G (EV-G) through the presence of antibodies in their serum. METHODS:Serum samples were obtained from the vena cava of 10 piglets at 9 weeks of age and again 39 days later (day 39). They were tested using an immunoassay based on...

journal_title：Intervirology

authors： Benkahla MA,Sane F,Desailloud R,Hober D

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:To determine whether liver-derived hepatitis C RNA-containing particles express the E1E2 discontinuous antigenic determinant defined by unique monoclonal antibody (mAb) D32.10 which recognizes three highly conserved segments in E1 (aa297-306) and E2 (aa480-494 and aa613-621) envelope glycoproteins. METHODS:H...

journal_title：Intervirology

authors： Ndongo N,Selliah S,Berthillon P,Raymond VA,Trépo C,Bilodeau M,Petit MA

更新日期：2011-01-01 00:00:00

abstract：:Three independently isolated herpes simplex virus type 1 recombinant viruses containing a deletion of approximately 14 kilobase pairs, representing greater than 95% of the internal repeat DNA sequences, were analyzed for their pathogenicity in mice. The recombinant viruses were found to be avirulent, exhibiting drasti...

journal_title：Intervirology

authors： Jenkins FJ,Martin JR

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVES:The aims of this study were to determine the hepatitis B virus (HBV) genotypes in hepatitis delta virus (HDV) RNA-positive patients and to characterize the HBV nucleotide sequences that may be found on a distant island of Japan. METHODS:This study included three patients with chronic hepatitis who were posi...

journal_title：Intervirology

authors： Moriyama M,Taira M,Matsumura H,Aoki H,Mikuni M,Kaneko M,Shioda A,Iwaguchi K,Arai S,Ichijima S,Iwasaki H,Tanaka N,Abe K,Arakawa Y

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND/AIMS:In Zimbabwe, cervical cancer is screened through cytology and visual inspection with acetic acid and cervicography (VIAC). The effectiveness of these methods can be increased if complemented by a human papillomavirus DNA detection tool since most cervical cancer cases are caused by persistent infection ...

journal_title：Intervirology

authors： Marembo T,Dube Mandishora R,Borok M

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVES:Chikungunya virus (CHIKV) is an alphavirus belonging to the Togaviridae family. Alphaviruses cause a chronic non-cytopathic infection in mosquito cells, while they develop a highly cytopathic infection in cells originating from various vertebrates. In this study, we compared the cytopathic effect (CPE) induc...

journal_title：Intervirology

authors： Li YG,Siripanyaphinyo U,Tumkosit U,Noranate N,A-nuegoonpipat A,Tao R,Kurosu T,Ikuta K,Takeda N,Anantapreecha S

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:To genetically characterize human influenza viruses and their susceptibilities to antivirals during two post-pandemic seasons in Lebanon. METHODS:Influenza virus was isolated from nasopharyngeal swabs that were obtained from patients with influenza-like illness during 2010-2012 and further analyzed both phen...

journal_title：Intervirology

authors： Zaraket H,Dapat C,Ghanem S,Ali Z,Lteif M,Kondo H,Dapat IC,Saito K,Kayali G,Suzuki H,Dbaibo G,Saito R

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:To investigate the relationship between enteroviral infection and myocardial tissue apoptosis during the development of viral myocarditis in a murine model. METHODS:C3H/HeJ mice were inoculated with two strains of coxsackievirus B3, specifically CVB3 (cardiovirulent Nancy strain) and CVB3/0 (noncardiovirulen...

journal_title：Intervirology

authors： Joo CH,Hong HN,Kim EO,Im JO,Yoon SY,Ye JS,Moon MS,Kim D,Lee H,Kim YK

更新日期：2003-01-01 00:00:00

abstract：:Solubilized envelope antigens (glycoproteins) of Sendai virus were purified in a DEAE-Bio-Gel A column. Monospecific antisera were prepared against the antigens, designated HN and F glycoproteins. These glycoproteins are antigenically distinct. Immunodiffusion analyses of the envelope antigens of three representative ...

journal_title：Intervirology

authors： Urata DM,Seto JT

更新日期：1975-01-01 00:00:00

abstract：:This review briefly summarises the recent knowledge about hantavirus infections and raises particular problems in hantavirus research that need further investigation. The following questions are addressed: (i) are hantaviruses distributed worldwide and what leads to new outbreaks, (ii) what is known about hantavirus e...

journal_title：Intervirology

authors： Ulrich R,Hjelle B,Pitra C,Krüger DH

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study is to investigate the molecular mechanism of hepatocellular carcinoma (HCC) development induced by hepatitis B virus X protein (HBx). METHODS:We previously established a H7402-X cell line that constitutively expresses HBx protein. In the present study, H7402-X gene expression profiles a...

journal_title：Intervirology

authors： Ye L,Dong N,Wang Q,Xu Z,Cai N,Wang H,Zhang X

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVES:Kaposi sarcoma-associated herpesvirus (KSHV) glycoprotein B (gB) is expressed on the viral envelope as well as on the cytoplasmic membrane of infected cells. In the current study, we aimed to decipher the impact of membrane-associated gB on adhesion and migration of cells via modulating the expression of cyt...

journal_title：Intervirology

authors： Hussein HAM,Abdel-Raouf UM,Akula SM

更新日期：2017-01-01 00:00:00

abstract：:Human cytomegalovirus (CMV) has devised numerous means of escaping immune surveillance. The CMV genome encodes at least 4 genes involved in downregulating surface expression of HLA class I molecules. In addition, it sequesters CC chemokines, induces Fc receptors, interferes with induction of HLA class II antigens, and...

journal_title：Intervirology

authors： Michelson S

更新日期：1999-01-01 00:00:00

abstract：:SDS-polyacrylamide slab gel analysis of selected primate and nonprimate adenoviruses has shown these viruses to differ significantly at the polypeptide molecular level. It follows that data derived from study of a single adenovirus serotype are unique to that serotype and are not representative of the adenovirus group...

journal_title：Intervirology

authors： Marusyk RG,Cummings GT

更新日期：1978-01-01 00:00:00

abstract：:Two DNA-negative temperature-sensitive mutants of human cytomegalovirus strain AD169 were shown to be deficient in induction of several prominent viral polypeptides when grown in human foreskin fibroblasts under nonpermissive conditions. The use of a monospecific polyclonal antiserum allowed recognition of a further d...

journal_title：Intervirology

authors： Radsak K,Kaiser CJ,Haustein D,Rapp F

更新日期：1988-01-01 00:00:00

abstract：:Marituba virus was purified by rate-zonal sedimentation and equilibrium density centrifugation in sucrose gradients. The buoyant density of virus particles was 1.19 g/ml. Purified virus was dissociated and its proteins were analyzed by SDS-PAGE. Four virus polypeptides were identified and designated L, G1, G2 and N. T...

journal_title：Intervirology

authors： Frugulhetti IC,Soares MC,Rebello MA

更新日期：1983-01-01 00:00:00

abstract：:Examination of the effect of 2-thiouracil on tobacco mosaic virus (TMV) RNA and protein synthesis in synchronous and asynchronous systems of replication in tobacco leaves demonstrated that 2-thiouracil does not prevent synthesis of TMV RNA, as suggested by previous studies, but inhibits some earlier function. When add...

journal_title：Intervirology

authors： Dawson WO,Grantham GL

更新日期：1983-01-01 00:00:00

abstract：:In this study, we analyzed the in vitro expression, potency and longevity of immune responses induced in a Balb/c mouse model by a synthetic HIV-1 GAG gene exhibiting a codon usage that was adapted to that of highly expressed mammalian genes (syngag). In contrast to a vector containing the wild-type (wt) GAG gene, the...

journal_title：Intervirology

authors： Bojak A,Wild J,Deml L,Wagner R

更新日期：2002-01-01 00:00:00

abstract：:In order to assess the risk of transmission of viral diseases during floods, the viral burden in flooded areas of the city of Dresden (Germany) in August 2002 was investigated. Water samples were collected from 9 sampling sites and tested for the presence of 11 enteric viral pathogens. As a control, water samples from...

journal_title：Intervirology

authors： Rohayem J,Dumke R,Jaeger K,Schröter-Bobsin U,Mogel M,Kruse A,Jacobs E,Rethwilm A

更新日期：2006-01-01 00:00:00

abstract：:The amino acid sequences of the virion proteins of 7 definitive tobamoviruses have been compared. The results show that the proteins may be arranged unequivocally in a single dendrogram which, by analogy with similar comparisons of other sets of homologous proteins, probably reflects their phylogeny. The magnitude of ...

journal_title：Intervirology

authors： Gibbs A

更新日期：1980-01-01 00:00:00

abstract：OBJECTIVE:The aim was to identify the codon usage bias between the newly identified duck plague virus (DPV) UL35 gene (GenBank accession No. EF643558) and the UL35-like genes of 27 other reference herpesviruses. METHODS:A comparative analysis of the codon usage bias of the 28 herpesviruses was performed by using the C...

journal_title：Intervirology

authors： Cai MS,Cheng AC,Wang MS,Zhao LC,Zhu DK,Luo QH,Liu F,Chen XY

更新日期：2009-01-01 00:00:00

abstract：:The proposed family Toroviridae is characterized by eveloped, peplomer-bearing particles containing an elongated tubular nucleocapsid with helical symmetry. The capsid may bend into an open torus, conferring a biconcave disk or kidney-shaped morphology to the virion (largest diameter 120-140 nm) or the capsid may be s...

journal_title：Intervirology

authors： Horzinek MC,Flewett TH,Saif LJ,Spaan WJ,Weiss M,Woode GN

更新日期：1987-01-01 00:00:00

abstract：:Ferret hepatitis E virus (HEV), a novel hepatitis E-like virus, has been identified in ferrets in the Netherlands, Japan, and the US. To determine whether ferret HEV transmits to other animals, we inoculated laboratory rats (Wistar), nude rats (Long-Evans-rnu/rnu), and cynomolgus monkeys with ferret HEV (F4351) by int...

journal_title：Intervirology

authors： Li TC,Yoshizaki S,Ami Y,Suzaki Y,Yang T,Takeda N,Takaji W

更新日期：2015-01-01 00:00:00