Abstract:
:Transcription of human T-cell leukemia virus type I is regulated by a viral transactivatior Tax, through the 21-bp sequence in the long terminal repeat (LTR). We found that cellular transcription factor AP-1 (c-Jun/c-Fos heterocomplex) bound to the 21-bp sequence. The binding affinity of the complex increased in proportion to the number of the 21-bp sequence, and the transcriptional activation by AP-1 became evident only when the reporters had more than three 21-bp sequences. Thus, AP-1 may play a role in the viral transcription from the LTR with three 21-bp sequences in the absence of Tax, such as in the early stage of the virus infection.
journal_name
Intervirologyjournal_title
Intervirologyauthors
Fujii M,Tsuchiya H,Meng XB,Seiki Mdoi
10.1159/000150436subject
Has Abstractpub_date
1995-01-01 00:00:00pages
221-8issue
3-4eissn
0300-5526issn
1423-0100journal_volume
38pub_type
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