Abstract:
:Hepatitis B virus (HBV) core antigen (HBcAg) detected by the peroxidase-antiperoxidase technique was present in the nucleus and cytoplasm of some infected hepatocytes but only in the cytoplasm of other hepatocytes. When cells expressing HBcAg were examined by in situ hybridization for the presence of HBV DNA, the intracellular level of cytoplasmic HBV replicative intermediate DNA correlated with the level of cytoplasmic HBcAg, but not with the presence or absence of nuclear HBcAg. This suggests that nuclear HBcAg may not be directly involved in hepadnavirus replication.
journal_name
Intervirologyjournal_title
Intervirologyauthors
Gowans EJ,Burrell CJ,Jilbert AR,Marmion BPdoi
10.1159/000149646subject
Has Abstractpub_date
1985-01-01 00:00:00pages
220-5issue
4eissn
0300-5526issn
1423-0100journal_volume
24pub_type
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