Abstract:
:Early hepatocellular carcinoma (HCC) as defined by the Liver Cancer Study Group of Japan would correspond to high-grade dysplastic nodules with small foci of HCC in the majority of cases, using the classification system proposed by the International Working Party. A large number of early HCCs were revealed to be hypo- or isovascular in the arterial phase of dynamic CT. Only 5% of the lesions evaluated were hypervascular, which contrasted with advanced small HCCs, of which 94% were hypervascular. CT arterial portography (CTAP) showed hypoattenuation in 66% of early HCCs and isoattenuation in 34%. CT hepatic arteriography (CTHA) demonstrated hypoattenuation in 55% of early HCC, isoattenuation in 30% and hyperattenuation in 15%. These findings suggest that most early HCCs receive equal or reduced blood supply from both portal and arterial flow compared with surrounding noncancerous parenchyma. In contrast, 97% of small HCCs are hypoattenuated on CTAP, and 93% are hyperattenuated on CTHA. For nodule-in-nodule type HCC (advanced HCC within early HCC), the CT attenuation of the central and peripheral portions revealed areas of isolated advanced HCC and isolated early HCC, respectively. Adenomatous hyperplasia (low-grade dysplastic nodules) was not readily differentiated using the various imaging modalities, mainly due to the smaller size of these lesions compared to early HCC and/or a portal and arterial blood supply very similar to that of the surrounding parenchyma. Hemodynamic changes in cirrhotic liver were similarly evaluated using CTAP and CTHA, and the treatment of early HCC is briefly discussed herein.
journal_name
Intervirologyjournal_title
Intervirologyauthors
Takayasu K,Muramatsu Y,Mizuguchi Y,Moriyama N,Ojima Hdoi
10.1159/000078473keywords:
subject
Has Abstractpub_date
2004-01-01 00:00:00pages
199-208issue
3-5eissn
0300-5526issn
1423-0100pii
78473journal_volume
47pub_type
杂志文章,评审相关文献
INTERVIROLOGY文献大全abstract::Human cytomegalovirus (CMV) has devised numerous means of escaping immune surveillance. The CMV genome encodes at least 4 genes involved in downregulating surface expression of HLA class I molecules. In addition, it sequesters CC chemokines, induces Fc receptors, interferes with induction of HLA class II antigens, and...
journal_title:Intervirology
pub_type: 杂志文章,评审
doi:10.1159/000053964
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVES:Chikungunya virus (CHIKV) is an alphavirus belonging to the Togaviridae family. Alphaviruses cause a chronic non-cytopathic infection in mosquito cells, while they develop a highly cytopathic infection in cells originating from various vertebrates. In this study, we compared the cytopathic effect (CPE) induc...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000339985
更新日期:2013-01-01 00:00:00
abstract::In this study, 574 stool samples from children with gastroenteritis were obtained from different hospitals in Costa Rica, Honduras, Nicaragua and the Dominican Republic during 2005-2006. Diarrhea stool samples were analyzed for rotavirus by ELISA and typed by the RT-PCR-based method. Unusual strains were detected: G1P...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000317288
更新日期:2010-01-01 00:00:00
abstract::Antibodies of individuals infected with the human immunodeficiency virus type 1 (HIV-1) were used to probe the antigenicity of the HIV-1 transmembrane protein of 41 kD (gp41) by antibody-reactive peptide scanning (Pepscan). Eleven distinct sequential antibody-binding sites were defined by testing reactivity to 339 ove...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000150169
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:Herpesviridae encode a family of protein homologues that function as the 'port of entry' for insertion of the viral DNA into preformed capsids during encapsidation. METHODS:Transmission electron microscopy (TEM) of recombinant varicella-zoster virus pORF54 was performed. RESULTS:Results suggest that pORF54...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000360225
更新日期:2014-01-01 00:00:00
abstract::Intrauterine viral infections show a wide range of fetal involvement with variable fetal outcome. The histopathologic changes of the placenta during viral infection show a wide spectrum. The most active processes are proliferative with a variety of cells involved. Vascular changes, including inflammatory and obliterat...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000024940
更新日期:1998-01-01 00:00:00
abstract::Solubilized envelope antigens (glycoproteins) of Sendai virus were purified in a DEAE-Bio-Gel A column. Monospecific antisera were prepared against the antigens, designated HN and F glycoproteins. These glycoproteins are antigenically distinct. Immunodiffusion analyses of the envelope antigens of three representative ...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000149462
更新日期:1975-01-01 00:00:00
abstract::Infection with hepatitis B virus (HBV) continues to be a major problem in the human population. There remains a specific requirement for HBV vaccines capable of circumventing the non-responder/inadequate responder status of some vaccinees. Hepacare has been primarily developed to (1) improve anti-SHBs antibody titres ...
journal_title:Intervirology
pub_type: 临床试验,杂志文章
doi:10.1159/000050036
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVE:In this study we established a mouse brain injection system to detect infectious dengue-2 virus produced from the full-length RNA transcripts. METHODS:In vitro transcription was used to synthesize full-length dengue-2 virus RNA from the plasmid pRS424FLDEN2NGC, which was intracerebrally injected into the 6-d...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000081744
更新日期:2005-01-01 00:00:00
abstract::Examination of thin sections from the cerebral cortex of scrapie-infected hamster brains revealed characteristic circular 26-30 nm diameter tubulofilamentous particles, identical to those previously described in both experimentally induced scrapie in mice, hamsters and natural scrapie of sheep, bovine spongiform encep...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000150269
更新日期:1992-01-01 00:00:00
abstract::3 mM n-butyrate, which effectively induces synthesis of Epstein-Barr virus (EBV) antigens in the producer P3HR-1 cell line, inhibited the transformation of umbilical cord blood lymphocytes by EBV. The drug inhibited both EBNA synthesis and stimulation of host cell DNA synthesis by strain B95-8. This effect was less pr...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000149566
更新日期:1985-01-01 00:00:00
abstract::Hepatitis E virus (HEV), the main etiologic agent of enterically transmitted acute hepatitis in developing countries, is now recognized as an emerging agent of autochthonous disease and chronic hepatitis E in immunocompromised patients in Europe where HEV infection is probably zoonotically acquired. We describe the fi...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000335664
更新日期:2012-01-01 00:00:00
abstract::Previous reports documented the recovery of a DNA virus from a patient with posttransfusion non-A-G hepatitis and named TT virus (TTV). Although the virus was initially detected as a causative agent of hepatitis, there is doubt about its pathogenicity. The aim of this study was to clarify the relationship between TTV ...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000050060
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVES:To express E1 glycoprotein of rubella virus (RuV) strain JR23 in yeast and develop a diagnostic assay using expressed E1 protein as coating antigen in comparison with other diagnostic assays. METHODS:cDNA of E1 open reading frame of RuV was PCR amplified using plasmid pMD18-T-E1 as template and cloned into ...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000085101
更新日期:2005-01-01 00:00:00
abstract::Analysis of translation products synthesized in vitro in the presence of a mixture of brome mosaic virus (BMV) RNAs 1, 2, 3, and 4 usually shows a predominance of coat protein, coded by RNA4. The proportion of products directed by RNAs 1 and 2 decreased at saturating concentrations of BMV RNA and in the presence of 7-...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000149008
更新日期:1979-01-01 00:00:00
abstract:OBJECTIVES:Theiler's murine encephalomyelitis virus (TMEV) infection of mice is a widely used animal model for demyelinating disorders, such as multiple sclerosis (MS). The aim of the present study was to identify topographical differences of TMEV spread and demyelination in the brain of experimentally infected suscept...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000336563
更新日期:2012-01-01 00:00:00
abstract::Human skin fibroblasts were previously shown to be resistant to coxsackie B4 virus infection. We have cultured fibroblasts from skin and lung tissues of donors of various ages. By a novel method for direct assay of virus absorption and penetration, we have shown that skin fibroblasts from young fetuses are susceptible...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000149360
更新日期:1983-01-01 00:00:00
abstract::The effect of caffeine on cytomegalovirus (CMV) replication in human embryo lung (HEL) and human embryo kidney (HEK) cells was studied. In HEL cultures, nonirradiated CMV yielded up to 6.7 times more plaques in caffeine-treated cultures than in control cultures. Virus growth curves exhibited different profiles, depend...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000148987
更新日期:1978-01-01 00:00:00
abstract:OBJECTIVE:Cervical cancer is the third most common malignancy in females. Since the human papillomavirus (HPV) genotype can vary geographically, it is essential to define its genotypic distribution before establishing health care policies and vaccination programs in any given area. The aim of this study was to determin...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000477848
更新日期:2017-01-01 00:00:00
abstract::Human immunodeficiency virus type 1 (HIV-1) genetic diversity is one of the most important features of HIV-1 infections and the result of error accumulation during reverse transcription and of high viral turnover. HIV-1 reverse transcription is influenced by factors such as the level of nucleotides and/or the cellular...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000362415
更新日期:2014-01-01 00:00:00
abstract::The actinomycin-D(AMD)-sensitive step of replication of three plant viruses - cowpea chlorotic mottle virus (CCMV), cowpea mosaic virus, and the cowpea strain of tobacco mosaic virus - in cowpea was specific for each virus. Different combinations of the viruses were examined in which leaves were inoculated with one vi...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000149524
更新日期:1984-01-01 00:00:00
abstract::Plants mixedly infected with the U2 strain of tobacco mosaic virus (T2MV) and sunnhemp mosaic virus (SHMV) and grown at 35 degrees, yield particles of the same modal lengths (300 and 40 nm) as those found in plants singly infected with SHMV, but not in plants infected with T2MV, which yield only the long particles. At...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000149973
更新日期:1976-01-01 00:00:00
abstract::Hepatitis B virus (HBV) is one of the major causative agents of hepatocellular carcinoma (HCC) in Southeast Asia where HBV genotype B (HBV/B) and genotype C (HBV/C) are prevalent. Clinical and virological differences were evaluated between HCC patients in Japan and Taiwan, all of whom were infected with HBV/B and HBV/...
journal_title:Intervirology
pub_type: 杂志文章,评审
doi:10.1159/000075000
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVE:Syncytia formation is the hallmark of the cytopathic effect caused by human respiratory syncytial virus (HRSV), which is the most important viral respiratory pathogen in children. This article reports methodological improvements in primary HRSV isolation and the importance of syncytia formation and mRNA level...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000480014
更新日期:2017-01-01 00:00:00
abstract::There are two major requirements for potyvirus taxonomy; group-specific criteria and criteria which discriminate between distinct viruses and strains. This review discusses the relative merits in potyvirus taxonomy of molecular parameters, such as gene sequence data, nucleic acid hybridization, coat protein sequence d...
journal_title:Intervirology
pub_type: 杂志文章,评审
doi:10.1159/000150211
更新日期:1991-01-01 00:00:00
abstract:OBJECTIVE:To determine whether liver-derived hepatitis C RNA-containing particles express the E1E2 discontinuous antigenic determinant defined by unique monoclonal antibody (mAb) D32.10 which recognizes three highly conserved segments in E1 (aa297-306) and E2 (aa480-494 and aa613-621) envelope glycoproteins. METHODS:H...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000318886
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:The open reading frame 8 (ORF8) within the short unique (U(s)) region of the bovine herpesvirus 1 (BHV-1) genome was predicted to encode a protein with homology to U(s)9 protein of other alpha herpesviruses. The aim of this study is to identify the protein encoded by the U(s) ORF8 and to examine the effect of...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000063236
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVE:Torque teno virus (TTV) is a ubiquitous virus that is commonly associated with blood transfusion. The main aims of this study were to evaluate the incidence of TTV in polytransfused children with thalassemia and to determine for the first time the prevalent TTV genotypes in Egypt. METHODS:TTV was detected in...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000480507
更新日期:2017-01-01 00:00:00
abstract::Genital infection with high-risk human papillomaviruses (HPV) has been etiologically linked with the development of cervical and other anogenital cancers. There is therefore a need for an effective HPV vaccine with the potential to significantly reduce the burden of more than half a million new cervical cancer cases i...
journal_title:Intervirology
pub_type: 杂志文章,评审
doi:10.1159/000150475
更新日期:1996-01-01 00:00:00
abstract::The species concept seems to be inescapably based on the occurrence, in a population, of regular genetic interchange which leads to the formation of common gene pools and on the presence of barriers to interchange which distinguish one gene pool from another. Present knowledge indicates that some types of viruses (e.g...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000149624
更新日期:1985-01-01 00:00:00