Abstract:
:Early hepatocellular carcinoma (HCC) as defined by the Liver Cancer Study Group of Japan would correspond to high-grade dysplastic nodules with small foci of HCC in the majority of cases, using the classification system proposed by the International Working Party. A large number of early HCCs were revealed to be hypo- or isovascular in the arterial phase of dynamic CT. Only 5% of the lesions evaluated were hypervascular, which contrasted with advanced small HCCs, of which 94% were hypervascular. CT arterial portography (CTAP) showed hypoattenuation in 66% of early HCCs and isoattenuation in 34%. CT hepatic arteriography (CTHA) demonstrated hypoattenuation in 55% of early HCC, isoattenuation in 30% and hyperattenuation in 15%. These findings suggest that most early HCCs receive equal or reduced blood supply from both portal and arterial flow compared with surrounding noncancerous parenchyma. In contrast, 97% of small HCCs are hypoattenuated on CTAP, and 93% are hyperattenuated on CTHA. For nodule-in-nodule type HCC (advanced HCC within early HCC), the CT attenuation of the central and peripheral portions revealed areas of isolated advanced HCC and isolated early HCC, respectively. Adenomatous hyperplasia (low-grade dysplastic nodules) was not readily differentiated using the various imaging modalities, mainly due to the smaller size of these lesions compared to early HCC and/or a portal and arterial blood supply very similar to that of the surrounding parenchyma. Hemodynamic changes in cirrhotic liver were similarly evaluated using CTAP and CTHA, and the treatment of early HCC is briefly discussed herein.
journal_name
Intervirologyjournal_title
Intervirologyauthors
Takayasu K,Muramatsu Y,Mizuguchi Y,Moriyama N,Ojima Hdoi
10.1159/000078473keywords:
subject
Has Abstractpub_date
2004-01-01 00:00:00pages
199-208issue
3-5eissn
0300-5526issn
1423-0100pii
78473journal_volume
47pub_type
杂志文章,评审相关文献
INTERVIROLOGY文献大全abstract:OBJECTIVE:In this study we established a mouse brain injection system to detect infectious dengue-2 virus produced from the full-length RNA transcripts. METHODS:In vitro transcription was used to synthesize full-length dengue-2 virus RNA from the plasmid pRS424FLDEN2NGC, which was intracerebrally injected into the 6-d...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000081744
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:The hemagglutinin molecule of influenza virus is considered as an ideal model to study biological processes as well as the effect of glycosylation on the function of glycoproteins. OBJECTIVES:The large subunit of the influenza virus A/New Caledonia/20/99 (H1N1) hemagglutinin (HA1) was expressed in recombina...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000327784
更新日期:2012-01-01 00:00:00
abstract::XTrack, a rapid, cost-effective diagnostic HIV tropism system, yields predictive results and dissects virus mixtures. It is based on the duplexing of patient samples with selective DNA probes, combined with sequence-based analysis and replicative phenotyping for ambiguous samples. ...
journal_title:Intervirology
pub_type: 杂志文章,评审
doi:10.1159/000332003
更新日期:2012-01-01 00:00:00
abstract::The distribution of related sequences between the genomes of pseudorabies virus (PRV) and herpes simplex virus, types 1 (HSV-1) and 2 (HSV-2), was determined. Approximately 7% of the sequences in PRV are shared by HSV-1 and HSV-2 DNAs. By means of the Southern blot technique, it was found that the homologous sequences...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000149106
更新日期:1980-01-01 00:00:00
abstract::Biochemical studies on human coronavirus, strain 229E, indicate that the RNA is present in the virion in association with protein as a ribonucleoprotein (RNP) complex. Morphological studies have revealed that this nucleocapsid is probably a continuous helical RNP. ...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000149474
更新日期:1975-01-01 00:00:00
abstract:OBJECTIVE:We studied the ability of human cytomegalovirus (HCMV) to infect peripheral blood mononuclear cells (PBMC) pretreated with or without Th2-cytokine interleukin-4 (IL-4) in vitro. METHODS:Adherent cells and nonadherent cells were obtained from PBMC. We inoculated these cells with HCMV at concentrations ranging...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000050057
更新日期:2001-01-01 00:00:00
abstract::Replication-deficient alphavirus vectors have been developed for efficient high-level transgene expression. The broad host range of alphaviruses has allowed infection of a wide variety of mammalian cell lines and primary cultures. Particularly, G protein-coupled receptors have been expressed at high levels and subject...
journal_title:Intervirology
pub_type: 杂志文章,评审
doi:10.1159/000053992
更新日期:2000-01-01 00:00:00
abstract::Four tetraploid cell lines were derived from the Epstein-Barr virus (EBV)-carrying, nonproducer Burkitt lymphoma line Raji after colcemide treatment. EBV early antigen (EA) was induced by P3HR-1 virus superinfection and by iododeoxyuridine treatment. Inducibility was reduced in all tetraploid lines compared to the nea...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000148973
更新日期:1978-01-01 00:00:00
abstract::Virions of maize rayado fino virus (MRFV) were purified and two major capsid proteins (ca. Mr 29,000 and 22,000) were resolved by SDS-PAGE. When the two major capsid proteins were isolated from gels and compared by one-dimensional peptide mapping after digestion with Staphylococcus aureus V-8 protease, indistinguishab...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000149664
更新日期:1986-01-01 00:00:00
abstract::Rauscher murine leukemia virus (RLV) infection of adult mice results in splenomegaly that is proportional to the virus titer. We have used this model to study the therapy of chronic viremia as well as chemoprophylaxis after viral exposure, both with single agents and with combination therapy. We showed that prompt ini...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000150118
更新日期:1989-01-01 00:00:00
abstract::Cytomegalovirus-infected human fibroblasts developed large numbers of fine microvilli within 90 min after addition of virus. The structure of these microvilli gradually changed as the infection proceeded, although the infected cells were easily detected by their large number of processes. These processes may be involv...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000149058
更新日期:1979-01-01 00:00:00
abstract:OBJECTIVE:The genetic barrier for the evolution of integrase inhibitors (INIs) including raltegravir (RAL), elvitegravir (EVG), and dolutegravir (DTG) resistance was compared between HIV-1 subtypes CRF01_AE and B. METHODS:Analysis of 66 substitutions associated with INI resistance at 41 amino acid positions in 144 nuc...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000336658
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVES:The potential risk of accidental infection by hantaviruses in a clinical or research laboratory necessitates special precautionary measures. A biosafety program must address handling and disposal of infectious materials as well as appropriate virus inactivation or depletion procedures to permit necessary fur...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000084603
更新日期:2005-01-01 00:00:00
abstract::Herpes simplex virus type 1 (HSV-1) latency was established in human embryo lung (HEL) cells by treatment with (E)-5-(2'-bromovinyl)-2'-deoxyuridine and human leukocyte interferon and subsequent temperature increase (from 37 degrees to 40.5 degrees). This in vitro system was used to study reactivation after temperatur...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000149668
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND:Human respiratory syncytial virus (RSV) infection in infancy and early childhood causes acute bronchiolitis and exacerbates bronchial asthma. Eosinophil infiltration may contribute to airway obstruction in RSV infection. OBJECTIVE:We hypothesized that RSV affects eosinophil function. METHODS:Eosinophil act...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000050086
更新日期:2002-01-01 00:00:00
abstract::Membrane particles possessing receptor activity for influenza virions have been reconstituted following solubilization of human erythrocyte membranes with octylglucoside (OG) and fractionation on a DEAE-cellulose column. Fractions that eluted with 1.5 M NaCl yielded, after removal of OG, reconstituted membrane particl...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000149334
更新日期:1983-01-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to investigate the distribution of hepatitis C virus (HCV) genotype and the possible association between genotype and HCV-associated liver disease in Indonesia. METHODS:32 anti-HCV-positive asymptomatic carriers (AC), 55 chronic hepatitis (CH), 41 liver cirrhosis (LC), and 35 hepato...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000205515
更新日期:2008-01-01 00:00:00
abstract::Proteins released from herpes simplex virus type 1 (HSV-1)-and type 2 (HSV-2)-infected HEp-2 cells have been characterized by the crossed immunoelectrophoretic technique. Both HSV type-common and type-specific antigens were found in the tissue culture medium 24 h after infection. Antigen Ag-6, an HSV-1-specific antige...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000149020
更新日期:1979-01-01 00:00:00
abstract::A whitefly-transmitted virus from Venezuela, potato yellow mosaic virus, has been propagated, isolated and characterized as a member of the Geminivirus group. The virus was transmitted to several species of Nicotiana and to Petunia hybrida by mechanical inoculation, and to potato and tomato plants by grafting. Purifie...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000150042
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVE:Cervical cancer is the third most common malignancy in females. Since the human papillomavirus (HPV) genotype can vary geographically, it is essential to define its genotypic distribution before establishing health care policies and vaccination programs in any given area. The aim of this study was to determin...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000477848
更新日期:2017-01-01 00:00:00
abstract::This review summarizes current strategies for the treatment of human cytomegalovirus (CMV) infection/diseases in high-risk patients such as transplant recipients and AIDS patients. Since the major drugs ganciclovir (Cytovene), foscarnet (Foscavir) and cidofovir (Vistide) are frequently associated with severe side effe...
journal_title:Intervirology
pub_type: 杂志文章,评审
doi:10.1159/000150568
更新日期:1997-01-01 00:00:00
abstract::One hundred and twenty-one chronic hepatitis C patients were administered interferon (IFN) and divided into two groups: 31 complete responders (CR) with prolonged HCV-RNA negative 1 year after treatment and 90 non-complete responders (non-CR), including partial responders (PR) with transiently negative HCV-RNA and non...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000082095
更新日期:2005-01-01 00:00:00
abstract::To identify specific environmental, viral, and genetic risk factors for hepatocellular carcinoma (HCC) and the interaction of such factors, we are conducting a prospective study in a high-incidence area of China. Questionnaires were completed and biosamples collected by 60,984 men ages 30-64 years, at study entry. Wit...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000150426
更新日期:1995-01-01 00:00:00
abstract::An RNA virus was isolated from Trichoplusia ni larvae infected with inoculum of the baculovirus of Autographa californica. Physicochemical characterization has revealed a 35-nm virus with a density in CsCl of 1.3 g/cm3 and a sedimentation coefficient of 200S. The virus consisted of 10--15% single-stranded RNA with an ...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000149040
更新日期:1979-01-01 00:00:00
abstract:BACKGROUND:Herpesviridae encode a family of protein homologues that function as the 'port of entry' for insertion of the viral DNA into preformed capsids during encapsidation. METHODS:Transmission electron microscopy (TEM) of recombinant varicella-zoster virus pORF54 was performed. RESULTS:Results suggest that pORF54...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000360225
更新日期:2014-01-01 00:00:00
abstract::The Holland strain of anatid herpesvirus (AHV) was 2-to 10-fold more efficiently plaqued under liquid medium or semisolid medium containing methylcellulose than in media containing agar, agarose, or Nobel agar. Virus adsorption was complete in 45 min, with the maximum virus titers obtained under liquid medium at 48 h ...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000149193
更新日期:1980-01-01 00:00:00
abstract::5 patients with primary genital herpes simplex virus (HSV) infection were studied prospectively for the production of serum antibody reactivity as measured by the virus micro-neutralization test (NT), micro-solid phase radioimmunometric assay (micro-SPRIA), and antibody-dependent cellular-cytotoxic (ADCC) test. ADCC a...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000149320
更新日期:1982-01-01 00:00:00
abstract::In this study, we analyzed the in vitro expression, potency and longevity of immune responses induced in a Balb/c mouse model by a synthetic HIV-1 GAG gene exhibiting a codon usage that was adapted to that of highly expressed mammalian genes (syngag). In contrast to a vector containing the wild-type (wt) GAG gene, the...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000067919
更新日期:2002-01-01 00:00:00
abstract::Coinfections with hepatitis B virus (HBV) and HIV are very frequent. Although HBV is a DNA virus, it replicates via reverse transcription like HIV. Structural similarities between the enzymatic pocket of the HBV DNA polymerase and HIV-1 reverse transcriptase are the basis that certain drugs inhibit both enzymes and th...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000360942
更新日期:2014-01-01 00:00:00
abstract::Diseases induced by animal retroviruses are not considered to be good models for the human acquired immunodeficiency syndrome (AIDS) at present. The lack of an animal model for the human immunodeficiency virus (HIV) infection presents a main problem in the complete understanding of the pathogenesis of HIV-mediated dis...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000150125
更新日期:1989-01-01 00:00:00