Abstract:
OBJECTIVE:The aim of this study was to investigate the distribution of hepatitis C virus (HCV) genotype and the possible association between genotype and HCV-associated liver disease in Indonesia. METHODS:32 anti-HCV-positive asymptomatic carriers (AC), 55 chronic hepatitis (CH), 41 liver cirrhosis (LC), and 35 hepatocellular carcinoma (HCC) patients were included in this study. HCV genotyping was performed by phylogenetic analysis of the NS5B and 5'-UTR regions. RESULTS:The HCV subtype 1b (36.5%), based on NS5B region, was the most prevalent, followed by subtypes 3k (15.4%), 2a (14.4%), 1a (12.5%) and 1c (12.5%), and 2e (4.8%). Subtypes 2f, 3a, 3b, and 4a were also found in some of the samples. HCV subtypes 3k (40.0%) and 1a (35.0%) were the two major subtypes in AC. HCV subtype 1b was not found in AC, but it was common in CH (31.3%), LC (50.0%), and HCC (57.1%). CONCLUSION:HCV subtype 1b was prevalent in samples of HCV-associated liver disease patients, including CH, LC and HCC. The percentage of subtype 1b was increased with the disease severity (AC < CH < LC < HCC).
journal_name
Intervirologyjournal_title
Intervirologyauthors
Utama A,Budiarto BR,Monasari D,Octavia TI,Chandra IS,Gani RA,Hasan I,Sanityoso A,Miskad UA,Yusuf I,Lesmana LA,Sulaiman A,Tai Sdoi
10.1159/000205515subject
Has Abstractpub_date
2008-01-01 00:00:00pages
410-6issue
6eissn
0300-5526issn
1423-0100pii
000205515journal_volume
51pub_type
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