Abstract:
:Despite frequent statements to the contrary, there are good animal models for AIDS. In this review, we summarize the properties of one of the most useful animal models: infection of rhesus monkeys with simian immunodeficiency virus (SIV). The SIVs are an extensive group of HIV-related lentiviruses of nonhuman primates. They closely resemble the human AIDS viruses, HIV-1 and HIV-2, in both genetic sequence and biological properties. Some SIV isolates, most notably those derived from macaques and mangabeys, induce AIDS in rhesus monkeys in a time frame suitable for laboratory investigation. Rhesus monkeys are not endangered in the wild, they breed well in captivity, and they are available in reasonably large numbers. Study of SIV has already resulted in seminal contributions regarding the origins of the HIVs, AIDS pathogenesis, and vaccine and therapy research. Continued use of SIV systems will be an important weapon in our arsenal against AIDS.
journal_name
Intervirologyjournal_title
Intervirologyauthors
Desrosiers RC,Ringler DJdoi
10.1159/000150108subject
Has Abstractpub_date
1989-01-01 00:00:00pages
301-12issue
6eissn
0300-5526issn
1423-0100journal_volume
30pub_type
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