Construction of rat cell lines that contain potential morphologically transforming regions of the herpes simplex virus type 2 genome.

abstract：:Three independently isolated herpes simplex virus type 1 recombinant viruses containing a deletion of approximately 14 kilobase pairs, representing greater than 95% of the internal repeat DNA sequences, were analyzed for their pathogenicity in mice. The recombinant viruses were found to be avirulent, exhibiting drasti...

journal_title：Intervirology

authors： Jenkins FJ,Martin JR

更新日期：1990-01-01 00:00:00

abstract：:Cytomegalovirus-infected human fibroblasts developed large numbers of fine microvilli within 90 min after addition of virus. The structure of these microvilli gradually changed as the infection proceeded, although the infected cells were easily detected by their large number of processes. These processes may be involv...

journal_title：Intervirology

authors： Garnett HM

更新日期：1979-01-01 00:00:00

abstract：OBJECTIVE:Sandfly fever phleboviruses are endemic in Mediterranean countries. We report a febrile phlebovirus case in a Greek patient who presented signs of neuroinvasive infection. METHODS:In summer 2010, a 20-year-old male was admitted to hospital with fever and lethargy; he was a resident of central Macedonia, nort...

journal_title：Intervirology

authors： Papa A,Mallias J,Tsergouli K,Markou F,Poulou A,Milidis T

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:Genome-wide sequences of hepatitis B virus strain associated with type B fulminant hepatitis have not been compared with those of acute self-limited hepatitis. We carried out full-length sequencing analysis of viral strains derived from patients with type B acute liver injury. METHODS:Nine acute self-limited...

journal_title：Intervirology

authors： Kanada A,Takehara T,Ohkawa K,Tatsumi T,Sakamori R,Yamaguchi S,Uemura A,Kohga K,Sasakawa A,Hikita H,Hijioka T,Katayama K,Deguchi M,Kagita M,Kanto T,Hiramatsu N,Hayashi N

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVES:Single-nucleotide polymorphisms (SNPs) near the interleukin (IL) 28B gene encoding a type III interferon (IFN-λ) are the most important genetic predictors of treatment response to hepatitis C virus (HCV). This retrospective study was undertaken to determine any association between IL28B SNPs and the developm...

journal_title：Intervirology

authors： Akay E,Patel M,Conibear T,Chaggar T,Haque T

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVES:To investigate the prevalence of hepatitis E virus (HEV) among patients with chronic hepatitis B and chronic hepatitis C, serum samples were collected between January and December 2004 from patients with chronic hepatitis B and chronic hepatitis C. METHODS:There were 190 adult patients with chronic hepatiti...

journal_title：Intervirology

authors： Bayram A,Eksi F,Mehli M,Sözen E

更新日期：2007-01-01 00:00:00

abstract：:Serial passage of undiluted herpes simplex virus types 1 and 2 resulted in cyclic production of infectious and defective virions. Defective virus production was characterized by the appearance of a new species of viral DNA with a higher bouyant density in CsCl than standard viral DNA. Measurement of the infectivity ti...

journal_title：Intervirology

authors： Murray BK,Biswal N,Bookout JB,Lanford RE,Courtney RJ,Melnick JL

更新日期：1975-01-01 00:00:00

abstract：:The WU-virus (WUV), a novel polyomavirus, has recently been recovered from respiratory tract samples. Within a study collective of children with severe lower respiratory tract disease, 3% of the patients tested WUV positive. Viral loads ranged from 5 x 10(2) copies/ml to 1 x 10(4) copies/ml. The WUV genome-positive pa...

journal_title：Intervirology

authors： Kleines M,Scheithauer S,Hengst M,Honnef D,Ritter K,Mühler E,Häusler M,Rostamzadeh A

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND/AIMS:In Zimbabwe, cervical cancer is screened through cytology and visual inspection with acetic acid and cervicography (VIAC). The effectiveness of these methods can be increased if complemented by a human papillomavirus DNA detection tool since most cervical cancer cases are caused by persistent infection ...

journal_title：Intervirology

authors： Marembo T,Dube Mandishora R,Borok M

更新日期：2019-01-01 00:00:00

abstract：:Cancer of the cervix is the most common malignant tumor among women in Africa and, in particular, Senegal. Studies of the prevalence of human papilloma virus (HPV) infection in Africa have mainly focused on carcinomas. Data on the presence of the virus in women with normal cervical cytology are scarce. In this study, ...

journal_title：Intervirology

authors： Astori G,Beltrame A,Pipan C,Raphenon G,Botta GA

更新日期：1999-01-01 00:00:00

abstract：:Viroids are minute unencapsidated non-coding circular RNAs known to be present and to cause diseases only in plants. Infections were associated with the occurrence of specific single-stranded RNAs similar in size to miRNAs and endogenous small interfering RNAs, and viroid pathogenicity is suspected to occur through RN...

journal_title：Intervirology

authors： Bengone-Abogourin JG,Chelkha N,Verdin E,Colson P

更新日期：2019-01-01 00:00:00

abstract：:Hepatitis B virus (HBV) core antigen (HBcAg) detected by the peroxidase-antiperoxidase technique was present in the nucleus and cytoplasm of some infected hepatocytes but only in the cytoplasm of other hepatocytes. When cells expressing HBcAg were examined by in situ hybridization for the presence of HBV DNA, the intr...

journal_title：Intervirology

authors： Gowans EJ,Burrell CJ,Jilbert AR,Marmion BP

更新日期：1985-01-01 00:00:00

abstract：:Bovine adenoviruses (BAVs) are important pathogens causing significant economic losses to the cattle industry. We have been interested in the differences among serotypes of these viruses, particularly in their pathogenicity and host range. As part of our efforts to better understand these viruses, we have determined t...

journal_title：Intervirology

authors： Yagubi A,Ojkic D,Bautista DS,Haj-Ahmad Y

更新日期：1998-01-01 00:00:00

abstract：:In this study, we analyzed the in vitro expression, potency and longevity of immune responses induced in a Balb/c mouse model by a synthetic HIV-1 GAG gene exhibiting a codon usage that was adapted to that of highly expressed mammalian genes (syngag). In contrast to a vector containing the wild-type (wt) GAG gene, the...

journal_title：Intervirology

authors： Bojak A,Wild J,Deml L,Wagner R

更新日期：2002-01-01 00:00:00

abstract：:CMV-transformed cell lines demonstrated a greater level of H-ras RNA (7.5- to 9.5-fold) relative to the level for H-ras in parental cells. Nuclear run off assays showed that the RNA levels for the H-ras gene were regulated at the level of transcriptional initiation. The increased RNA levels for H-ras correlated with t...

journal_title：Intervirology

authors： Boldogh I,Huang ES,Rady P,Arany I,Tyring S,Albrecht T

更新日期：1994-01-01 00:00:00

abstract：:Hepatitis C virus (HCV) induces chronic liver disease in hosts which can eventually progresses to liver cirrhosis and hepatocellular carcinoma. However, progression of liver disease is slower in patients with persistently normal levels of alanine aminotransferase (ALT) than in those with active hepatitis. Although dis...

journal_title：Intervirology

authors： Kanto T,Inoue M,Miyazaki M,Itose I,Miyatake H,Sakakibara M,Yakushijin T,Kaimori A,Oki C,Hiramatsu N,Kasahara A,Hayashi N

更新日期：2006-01-01 00:00:00

abstract：:In order to evaluate the usefulness of cytomegalovirus (CMV) antibody screening during pregnancy, women attending for antenatal care at the Antoine Béclère Hospital (Clamart, France) were prospectively studied during 22 months (1995-1996). Forty-five percent of these women were CMV-seropositive. Twenty suspected or co...

journal_title：Intervirology

authors： Grangeot-Keros L,Simon B,Audibert F,Vial M

更新日期：1998-01-01 00:00:00

abstract：:The results of this study show that the synthesis of the inner mitochondrial membrane phospholipid, cardiolipin, is markedly inhibited following infection of human embryonic lung or hamster embryo fibroblast cells with herpes simplex virus type 1 or 2. The synthesis of other phospholipids, i.e., phosphatidylcholine, p...

journal_title：Intervirology

authors： Tucker T,Steiner MR,Steiner S

更新日期：1974-01-01 00:00:00

abstract：:Studies of human papillomavirus (HPV) infection are hampered by the lack of an adequate culture system. The athymic mouse xenograft system permits propagation of HPV, but only a few HPV types have been grown in this manner. To produce an oncogenic type for studies of HPV pathogenesis, a condylomata acuminata lesion fr...

journal_title：Intervirology

authors： Bryan JT,Tekchandani J,Schroeder JM,Brown DR

更新日期：2000-01-01 00:00:00

abstract：:The large tumour antigen (TAg) of simian virus 40 is the main regulatory protein in viral replication. We have investigated possible functional roles for the N-terminal domain of TAg while defining the epitopes of antibodies binding within that region. The epitopes recognised by eight monoclonal anti-TAg antibodies we...

journal_title：Intervirology

authors： Lindner K,Mole SE,Lane DP,Kenny MK

更新日期：1998-01-01 00:00:00

abstract：OBJECTIVE:Some patients with chronic hepatitis C virus (HCV) infection fail to achieve complete early virologic response (EVR) despite a marked decrease in HCV RNA at 4 weeks. We investigated the characteristics and final treatment outcomes of this patient subpopulation. METHODS:A total of 516 patients with HCV genoty...

journal_title：Intervirology

authors： Toyoda H,Kumada T,Shimada N,Takaguchi K,Ide T,Sata M,Ginba H,Matsuyama K,Izumi N

更新日期：2014-01-01 00:00:00

abstract：:Immunopathologic mechanisms leading to liver tissue injury in hepatitis caused by hepatitis A virus (HAV) were studied in an autologous in vitro model. Data show virus-specific killing by liver-infiltrating T lymphocytes in man and support the hypothesis that hepatocellular damage as well as efficient elimination of v...

journal_title：Intervirology

authors： Vallbracht A,Fleischer B,Busch FW

更新日期：1993-01-01 00:00:00

abstract：:Two DNA-negative temperature-sensitive mutants of human cytomegalovirus strain AD169 were shown to be deficient in induction of several prominent viral polypeptides when grown in human foreskin fibroblasts under nonpermissive conditions. The use of a monospecific polyclonal antiserum allowed recognition of a further d...

journal_title：Intervirology

authors： Radsak K,Kaiser CJ,Haustein D,Rapp F

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVE:Cytomegalovirus (CMV) is widely distributed and constitutes the main cause of congenital infections worldwide. CMV transmission during pregnancy represents one of the major impacts of this virus on public health. This study aimed at assessing glycoprotein B (gB) CMV genotypes in Mexican children and pregnant ...

journal_title：Intervirology

authors： Gonzalez-Sanchez HM,Alvarado-Hernandez DL,Guerra-Palomares S,Garcia-Sepulveda CA,Noyola DE

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:Human Salivirus (SalV) has been associated with gastroenteritis on all continents. METHODS:This paper presents the real-time RT-PCR assay for the detection of SalV in clinical fecal samples collected from 192 hospitalized children with acute gastroenteritis in Piedmont, Italy. RESULTS:The most commonly dete...

journal_title：Intervirology

authors： Bergallo M,Daprà V,Rassu M,Bonamin S,Cuccu R,Calvi C,Montanari P,Galliano I

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVE:To investigate the effect of sequence variability between different genotypes of hepatitis C virus (HCV) on the antigenic properties of the NS3 proteins, and to evaluate the significance of the proteins in the serological diagnosis. METHODS:The recombinant expression plasmids of pET/NS3-1 and pET/NS3-6 were ...

journal_title：Intervirology

authors： Qiao W,Xie P,Cai B,Li L

更新日期：2011-02-01 00:00:00

abstract：OBJECTIVE:Cervical cancer is the third most common malignancy in females. Since the human papillomavirus (HPV) genotype can vary geographically, it is essential to define its genotypic distribution before establishing health care policies and vaccination programs in any given area. The aim of this study was to determin...

journal_title：Intervirology

authors： Taghizadeh E,Taheri F,Abdolkarimi H,Ghorbani Renani P,Gheibi Hayat SM

更新日期：2017-01-01 00:00:00

abstract：:The amino acid sequences of the virion proteins of 7 definitive tobamoviruses have been compared. The results show that the proteins may be arranged unequivocally in a single dendrogram which, by analogy with similar comparisons of other sets of homologous proteins, probably reflects their phylogeny. The magnitude of ...

journal_title：Intervirology

authors： Gibbs A

更新日期：1980-01-01 00:00:00

abstract：OBJECTIVES:Data on drug-resistant mutations (DRMs) in HIV-1-infected therapy-naïve children are scarce. The aim of this study was to determine the HIV-1 subtype distribution and the prevalence of DRMs in therapy-naïve HIV-1-infected children who received routine care at the University Hospital Düsseldorf, Düsseldorf, G...

journal_title：Intervirology

authors： Neubert J,Michalsky N,Laws HJ,Borkhardt A,Jensen B,Lübke N

更新日期：2016-01-01 00:00:00

abstract：:Transcription of human T-cell leukemia virus type I is regulated by a viral transactivatior Tax, through the 21-bp sequence in the long terminal repeat (LTR). We found that cellular transcription factor AP-1 (c-Jun/c-Fos heterocomplex) bound to the 21-bp sequence. The binding affinity of the complex increased in propo...

journal_title：Intervirology

authors： Fujii M,Tsuchiya H,Meng XB,Seiki M

更新日期：1995-01-01 00:00:00