Abstract:
:Serial passage of undiluted herpes simplex virus types 1 and 2 resulted in cyclic production of infectious and defective virions. Defective virus production was characterized by the appearance of a new species of viral DNA with a higher bouyant density in CsCl than standard viral DNA. Measurement of the infectivity titer and DNA synthesis revealed that the defective particles interfered with the replication of standard virions and stimulated the overproduction of a large molecular weight (175,000 daltons) polypeptide.
journal_name
Intervirologyjournal_title
Intervirologyauthors
Murray BK,Biswal N,Bookout JB,Lanford RE,Courtney RJ,Melnick JLdoi
10.1159/000149894subject
Has Abstractpub_date
1975-01-01 00:00:00pages
173-84issue
3-4eissn
0300-5526issn
1423-0100journal_volume
5pub_type
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