Abstract:
:Interferon induction in BSC-1 cells by measles virus isolates previously found to be interferon inducing (IF+) or interferon noninducing (IF-) was studied in different cell types. Lack of induction by the IF- viruses was not due to an inhibitory factor since BSC-1 cells coinfected with IF+ and IF- stocks produced interferon levels similar to those infected with IF+ stocks alone. Various tests indicated that the phenotypic expression of interferon induction by these isolates was dependent on an infectious virus genome, the cell type tested, and the passage history of the virus. In contrast to the in vitro results, the IF- phenotype was stable in vivo, whereas passage of the IF+ virus resulted in selection against the IF+ phenotype. The phenotypic expression of interferon induction by measles virus was, therefore, controlled by complex interactions between virus and host cell factors exerted both in vivo and in vitro.
journal_name
Intervirologyjournal_title
Intervirologyauthors
McKimm-Breschkin JL,Rapp Fdoi
10.1159/000149274subject
Has Abstractpub_date
1981-01-01 00:00:00pages
250-9issue
4eissn
0300-5526issn
1423-0100journal_volume
16pub_type
杂志文章相关文献
INTERVIROLOGY文献大全abstract::Despite the significant medical advances which have taken place in the last decades, acute diarrhoea cases remain a public health issue of major significance, with gastroenteritis agents being associated with severe symptoms in adults and high morbidity in infants and children. Regarding rotaviruses, while children ar...
journal_title:Intervirology
pub_type: 新闻
doi:10.1159/000502007
更新日期:2019-01-01 00:00:00
abstract::Serological and physical properties of isolated particles as well as reactions of barley cultivars after virus inoculation showed that the yellow disease of barley is caused by different viruses. Results summarized in this paper suggest that the European isolates BaYMV-So and BaYMV-NM are closely related to, or identi...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000150132
更新日期:1990-01-01 00:00:00
abstract::Two DNA-negative temperature-sensitive mutants of human cytomegalovirus strain AD169 were shown to be deficient in induction of several prominent viral polypeptides when grown in human foreskin fibroblasts under nonpermissive conditions. The use of a monospecific polyclonal antiserum allowed recognition of a further d...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000150034
更新日期:1988-01-01 00:00:00
abstract::The early gene products of simian virus 40 (SV40) transform human fibroblasts, whereas those of the human papovavirus BK (BKV) do not. The early gene products of both SV40 and BKV transform baby rat kidney cells. SV40-BKV chimerics were constructed which were able to transform baby rat kidney cells. Using the SV40-BKV...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000150019
更新日期:1987-01-01 00:00:00
abstract::Human immunodeficiency virus type 1 (HIV-1) genetic diversity is one of the most important features of HIV-1 infections and the result of error accumulation during reverse transcription and of high viral turnover. HIV-1 reverse transcription is influenced by factors such as the level of nucleotides and/or the cellular...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000362415
更新日期:2014-01-01 00:00:00
abstract::In Spodoptera frugiperda (SF IPLB-21) cells productively infected with S. frugiperda multicapsid nuclear polyhedrosis virus (SfMNPV), we observed the synthesis of infected-cell-specific polypeptides (ICSPs) using the protein synthesis inhibitor cycloheximide (CX) and the DAN synthesis inhibitor cytosine arabinoside (A...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000150520
更新日期:1997-01-01 00:00:00
abstract:OBJECTIVE:Pandemic viral infections as emerging infectious diseases are of a great global concern. However, for some viruses, particular strains are endemic to specific areas and can be genetically distinguished from strains in other regions. In contrast, for some other viruses, genetically similar strains can spread a...
journal_title:Intervirology
pub_type: 杂志文章,meta分析
doi:10.1159/000320967
更新日期:2011-01-01 00:00:00
abstract::Early hepatocellular carcinoma (HCC) as defined by the Liver Cancer Study Group of Japan would correspond to high-grade dysplastic nodules with small foci of HCC in the majority of cases, using the classification system proposed by the International Working Party. A large number of early HCCs were revealed to be hypo-...
journal_title:Intervirology
pub_type: 杂志文章,评审
doi:10.1159/000078473
更新日期:2004-01-01 00:00:00
abstract::In this article, a statistical score method for comparison of partial genomic regions in their representatives of full-length genome of hepatitis E virus (HEV) for genotyping was developed. The critical values of the statistics for hypothesis testing were generated through Monte Carlo simulations. It was found that fr...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000106805
更新日期:2007-01-01 00:00:00
abstract:AIMS:The aim of the present study is the preliminary characterization of an El Tor vibriophage M4 (ATCC 51352-B4). METHODS:We studied the growth characteristics and sustainability of this phage under various stresses like temperature, pH, and UV. The phage morphology and phage genome were also examined using electron ...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000485835
更新日期:2017-01-01 00:00:00
abstract::XTrack, a rapid, cost-effective diagnostic HIV tropism system, yields predictive results and dissects virus mixtures. It is based on the duplexing of patient samples with selective DNA probes, combined with sequence-based analysis and replicative phenotyping for ambiguous samples. ...
journal_title:Intervirology
pub_type: 杂志文章,评审
doi:10.1159/000332003
更新日期:2012-01-01 00:00:00
abstract::Plants mixedly infected with the U2 strain of tobacco mosaic virus (T2MV) and sunnhemp mosaic virus (SHMV) and grown at 35 degrees, yield particles of the same modal lengths (300 and 40 nm) as those found in plants singly infected with SHMV, but not in plants infected with T2MV, which yield only the long particles. At...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000149973
更新日期:1976-01-01 00:00:00
abstract::Among patients undergoing maintenance hemodialysis, a high prevalence of hepatitis C virus (HCV) infection can be observed. In a prospective study, sera of 273 patients were examined for the presence of HCV infection by serological tests and by PCR. Thirty-five patients (12.8%) were HCV antibody positive, and in 31 of...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000150558
更新日期:1997-01-01 00:00:00
abstract::The Holland strain of anatid herpesvirus (AHV) was 2-to 10-fold more efficiently plaqued under liquid medium or semisolid medium containing methylcellulose than in media containing agar, agarose, or Nobel agar. Virus adsorption was complete in 45 min, with the maximum virus titers obtained under liquid medium at 48 h ...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000149193
更新日期:1980-01-01 00:00:00
abstract::The amino acid composition (AAC) of the coat proteins (CPs) of 126 plant viruses or strains were analyzed by stepwise discriminant analysis. The criteria chosen for discrimination were: the structure of virus particles (3 clusters); the mode of of transmission of the viruses (6 clusters); and the grouping of viruses a...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000149675
更新日期:1986-01-01 00:00:00
abstract::3 mM n-butyrate, which effectively induces synthesis of Epstein-Barr virus (EBV) antigens in the producer P3HR-1 cell line, inhibited the transformation of umbilical cord blood lymphocytes by EBV. The drug inhibited both EBNA synthesis and stimulation of host cell DNA synthesis by strain B95-8. This effect was less pr...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000149566
更新日期:1985-01-01 00:00:00
abstract::Infection with hepatitis B virus (HBV) continues to be a major problem in the human population. There remains a specific requirement for HBV vaccines capable of circumventing the non-responder/inadequate responder status of some vaccinees. Hepacare has been primarily developed to (1) improve anti-SHBs antibody titres ...
journal_title:Intervirology
pub_type: 临床试验,杂志文章
doi:10.1159/000050036
更新日期:2001-01-01 00:00:00
abstract::Prostaglandins exhibit antiviral activity against a wide variety of RNA and DNA viruses. In the present report, we describe the effect of cyclopentenone prostaglandin A(1) (PGA(1)) on Mayaro virus replication in Vero cells. Virus yield was significantly reduced at nontoxic concentrations which did not suppress DNA, RN...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000050069
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVES:To express E1 glycoprotein of rubella virus (RuV) strain JR23 in yeast and develop a diagnostic assay using expressed E1 protein as coating antigen in comparison with other diagnostic assays. METHODS:cDNA of E1 open reading frame of RuV was PCR amplified using plasmid pMD18-T-E1 as template and cloned into ...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000085101
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVE:Genome-wide sequences of hepatitis B virus strain associated with type B fulminant hepatitis have not been compared with those of acute self-limited hepatitis. We carried out full-length sequencing analysis of viral strains derived from patients with type B acute liver injury. METHODS:Nine acute self-limited...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000110651
更新日期:2007-01-01 00:00:00
abstract::The results of this study show that the synthesis of the inner mitochondrial membrane phospholipid, cardiolipin, is markedly inhibited following infection of human embryonic lung or hamster embryo fibroblast cells with herpes simplex virus type 1 or 2. The synthesis of other phospholipids, i.e., phosphatidylcholine, p...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000149969
更新日期:1974-01-01 00:00:00
abstract::The phosphorylation state of H5R protein was investigated by two-dimensional gel electrophoresis of proteins of BSC-40 cells infected at 32 degrees or 39.5 degrees with vaccinia virus ts mutants of the viral B1R or F10L protein kinase genes. A temperature-dependent increase of underphosphorylated H5R protein (pI 6.8) ...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000025025
更新日期:2000-01-01 00:00:00
abstract::Human skin fibroblasts have previously been reported to display an age-dependent resistance to infection with coxsackie B4 virus. We have shown that the virus will replicate and produce CPE in human skin fibroblasts regardless of the age of the donor of the cells. The passage history of the virus was found to influenc...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000150029
更新日期:1988-01-01 00:00:00
abstract::The complete nucleotide sequence of rice dwarf phytoreovirus genome segment 2 (S2) was determined to be 3,512 nucleotides long with one open reading frame initiating at nucleotide 15 and terminating at nucleotide 3363. The encoded polypeptide was predicted to have 1,116 residues with a relative molecular weight of 123...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000150348
更新日期:1994-01-01 00:00:00
abstract::The use of bleach (hypochlorite) as a disinfectant for drug injection equipment in the intravenous-drug-using population was recommended early in the HIV-1/AIDS epidemic. Epidemiological studies have challenged the use of bleach as an effective measure to prevent HIV-1 transmission. However, in vitro HIV-1 coculture s...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000025015
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:Dengue fever (DF), one of the main emerging virus diseases, also increases in German travellers, due to the increasing number of travellers to tropical regions. METHODS:We determined antibodies against DF virus in a group (n = 149) of long-distance travellers in order to evaluate the risk of acquiring DF. S...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000131667
更新日期:2008-01-01 00:00:00
abstract::The large tumour antigen (TAg) of simian virus 40 is the main regulatory protein in viral replication. We have investigated possible functional roles for the N-terminal domain of TAg while defining the epitopes of antibodies binding within that region. The epitopes recognised by eight monoclonal anti-TAg antibodies we...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000024910
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVE:Torque teno virus (TTV) is a ubiquitous virus that is commonly associated with blood transfusion. The main aims of this study were to evaluate the incidence of TTV in polytransfused children with thalassemia and to determine for the first time the prevalent TTV genotypes in Egypt. METHODS:TTV was detected in...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000480507
更新日期:2017-01-01 00:00:00
abstract::The critical point dried (CPD) whole cell technique was applied to the study of the morphogenesis and morphology of rabies virus and vesicular stomatitis virus (VSV) in mouse neuroblastoma and baby hamster kidney (BHK) cells. With the stereoscopic technique, progeny viruses at the cell surface and within the cytoplasm...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000148939
更新日期:1978-01-01 00:00:00
abstract::The members of the viral family Hepadnaviridae comprise one of the smallest enveloped DNA viruses and cause acute and chronic infections in mammals and birds, leading to large virus and antigen loads in the blood. They have a restricted host range and depend on differentiated hepatocytes for replication. Hepatitis B v...
journal_title:Intervirology
pub_type: 杂志文章,评审
doi:10.1159/000360946
更新日期:2014-01-01 00:00:00