Interferon induction by measles virus.

Abstract:

:Interferon induction in BSC-1 cells by measles virus isolates previously found to be interferon inducing (IF+) or interferon noninducing (IF-) was studied in different cell types. Lack of induction by the IF- viruses was not due to an inhibitory factor since BSC-1 cells coinfected with IF+ and IF- stocks produced interferon levels similar to those infected with IF+ stocks alone. Various tests indicated that the phenotypic expression of interferon induction by these isolates was dependent on an infectious virus genome, the cell type tested, and the passage history of the virus. In contrast to the in vitro results, the IF- phenotype was stable in vivo, whereas passage of the IF+ virus resulted in selection against the IF+ phenotype. The phenotypic expression of interferon induction by measles virus was, therefore, controlled by complex interactions between virus and host cell factors exerted both in vivo and in vitro.

journal_name

Intervirology

journal_title

Intervirology

authors

McKimm-Breschkin JL,Rapp F

doi

10.1159/000149274

subject

Has Abstract

pub_date

1981-01-01 00:00:00

pages

250-9

issue

4

eissn

0300-5526

issn

1423-0100

journal_volume

16

pub_type

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