Abstract:
:Prostaglandins exhibit antiviral activity against a wide variety of RNA and DNA viruses. In the present report, we describe the effect of cyclopentenone prostaglandin A(1) (PGA(1)) on Mayaro virus replication in Vero cells. Virus yield was significantly reduced at nontoxic concentrations which did not suppress DNA, RNA or protein synthesis in uninfected or infected cells. Antiviral action decreased if PGA(1) was added at later times after infection. In Mayaro virus-infected cells, PGA(1) inhibited the synthesis of virus proteins. This effect is accompanied by the induction of heat shock proteins (HSPs). Actinomycin D treatment not only inhibited the induction of HSPs but also partially prevented PGA(1) antiviral activity.
journal_name
Intervirologyjournal_title
Intervirologyauthors
Burlandy FM,Rebello MAdoi
10.1159/000050069keywords:
subject
Has Abstractpub_date
2001-01-01 00:00:00pages
344-9issue
6eissn
0300-5526issn
1423-0100pii
int44344journal_volume
44pub_type
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