Abstract:
:In less than 1% of persistently infected individuals, human T cell lymphotropic virus type I (HTLV-I) causes a chronic inflammatory disease of the central nervous system (CNS), called HTLV-I-associated myelopathy/tropical spastic paraparesis. Important prerequisites for disease induction are oligoclonal expansion of HTLV-I-infected CD4+ T lymphocytes, their trafficking across the blood-brain barrier, expression of viral proteins in the CNS, and an increased immune response within the CNS. The HTLV-I Tax1 protein has unique abilities to transactivate viral and cellular genes in T lymphocytes, but possibly also in cells of the CNS. Thus Tax1 supports the persistence of HTLV-I, the ongoing immune responses within the CNS and the destruction of myelin and axons, most pronounced in the thoracic spinal cord.
journal_name
Intervirologyjournal_title
Intervirologyauthors
Kitze B,Brady JNdoi
10.1159/000150540subject
Has Abstractpub_date
1997-01-01 00:00:00pages
132-42issue
2-3eissn
0300-5526issn
1423-0100journal_volume
40pub_type
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