Abstract:
OBJECTIVE:To understand the autoimmunity associated with chronic hepatitis C (CHC), we investigated autoantibodies (autoAbs) to CD69. METHODS:With this aim, we tested the reactivity of serum samples from patients with CHC and asymptomatic carriers of hepatitis C virus (HCV), as well as from patients with chronic hepatitis B (CHB) and autoimmune hepatitis (AIH), to recombinant CD69 molecules. RESULTS:Frequencies of anti-CD69 autoAbs were 38.7% in CHC, 15.8% in AIH and 12.3% in CHB. None of the tested asymptomatic HCV carriers had autoAbs to CD69. It is important clinically that the presence of anti-CD69 autoAbs was found to be associated with a poor response to interferon-alpha (IFN-alpha) therapy. In the epitope analysis, multiple epitopes were mapped on CD69, indicating antigen-driven production of the autoAbs. CONCLUSION:We evidenced existence of anti-CD69 autoAbs in patients with CHC, and found that the anti-CD69 autoAb may have potential for predicting responses to IFN-alpha therapy.
journal_name
Intervirologyjournal_title
Intervirologyauthors
Okamoto N,Yotsuyanagi H,Ooka S,Matsui T,Suzuki Kurokawa M,Suzuki M,Iino S,Nishioka K,Kato Tdoi
10.1159/000068126keywords:
subject
Has Abstractpub_date
2003-01-01 00:00:00pages
56-65issue
1eissn
0300-5526issn
1423-0100pii
68126journal_volume
46pub_type
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