A score method for comparison of partial genomic regions in their representatives of full-length genome of hepatitis E virus for genotyping.

Abstract:

:In this article, a statistical score method for comparison of partial genomic regions in their representatives of full-length genome of hepatitis E virus (HEV) for genotyping was developed. The critical values of the statistics for hypothesis testing were generated through Monte Carlo simulations. It was found that fragment III might be a statistically representative region for the whole genome of HEV for genotyping. Based on both the full-length sequence and fragment III, the same four genotypes were identified by the subsequent phylogenetic analysis, and similar ranges of mean nucleotide difference were also observed to differentiate HEV sequences at the three levels genotype, subtype and isolate, which further verified the statistical results. It may be concluded from this study that the score method is effective for comparing partial genomic regions with full-length genome of HEV strains for genotyping.

journal_name

Intervirology

journal_title

Intervirology

authors

Xun P,Chen F,Dong C,Qian G,Lai D,Meng J

doi

10.1159/000106805

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

328-35

issue

5

eissn

0300-5526

issn

1423-0100

pii

000106805

journal_volume

50

pub_type

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