Abstract:
:In this article, a statistical score method for comparison of partial genomic regions in their representatives of full-length genome of hepatitis E virus (HEV) for genotyping was developed. The critical values of the statistics for hypothesis testing were generated through Monte Carlo simulations. It was found that fragment III might be a statistically representative region for the whole genome of HEV for genotyping. Based on both the full-length sequence and fragment III, the same four genotypes were identified by the subsequent phylogenetic analysis, and similar ranges of mean nucleotide difference were also observed to differentiate HEV sequences at the three levels genotype, subtype and isolate, which further verified the statistical results. It may be concluded from this study that the score method is effective for comparing partial genomic regions with full-length genome of HEV strains for genotyping.
journal_name
Intervirologyjournal_title
Intervirologyauthors
Xun P,Chen F,Dong C,Qian G,Lai D,Meng Jdoi
10.1159/000106805subject
Has Abstractpub_date
2007-01-01 00:00:00pages
328-35issue
5eissn
0300-5526issn
1423-0100pii
000106805journal_volume
50pub_type
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