Abstract:
:Analysis of translation products synthesized in vitro in the presence of a mixture of brome mosaic virus (BMV) RNAs 1, 2, 3, and 4 usually shows a predominance of coat protein, coded by RNA4. The proportion of products directed by RNAs 1 and 2 decreased at saturating concentrations of BMV RNA and in the presence of 7-methylguanosine 5'-phosphate (m7G5'p) at nonsaturating concentrations of RNA. No differences in the relative proportions of the various proteins produced were detected in the presence of T-2 toxin, which interferes with the formation of the first peptidyl bond rather than competing for initiation factor, as has been suggested for m7G5'p. These data show that the ability of BMV RNA4 to outcompete BMV RNAs 1, 2, and 3 results, at least in part, from its ability to bind more efficiently to ribosomes.
journal_name
Intervirologyjournal_title
Intervirologyauthors
Pyne JW,Hall TCdoi
10.1159/000149008subject
Has Abstractpub_date
1979-01-01 00:00:00pages
23-9issue
1eissn
0300-5526issn
1423-0100journal_volume
11pub_type
杂志文章相关文献
INTERVIROLOGY文献大全abstract::We examined the effect of infection by other herpesviruses on the induction of Epstein-Barr virus (EBV) antigens. Raji cells were infected with a variety of viruses before superinfection with P3HR-1 virus 6 h later. Much earlier and greater synthesis of EBV antigens was observed in herpesvirus (herpes simplex virus ty...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000150057
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND:Infection with tick-borne encephalitis virus (TBEV) causes pathological changes in the central nervous system. However, the possible redox alterations in the infected cells that can contribute to the virus pathogenicity remain unknown. OBJECTIVE:In the current study we explored the ability of TBEV nonstruct...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000452160
更新日期:2016-01-01 00:00:00
abstract::When Vero cells infected with Junín virus are cultured in the presence of 16 mM glucosamine, no infectious virus is produced and no surface antigens or virions are detected. Cytoplasmic viral antigen, however, is synthesized normally. ...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000149032
更新日期:1979-01-01 00:00:00
abstract::Two closely related viruses were isolated from the blood of bovines near Darwin, Northern Territory, Australia. When studies of virus morphology indicated that these were rhabdoviruses, serologic studies were done. These isolates are closely related or identical and are related to, but distinct from, the rabies-relate...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000150274
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVES:Fluctuation profile has been observed in chronic hepatitis B patients who are untreated or interrupt therapy. A mathematical model and its parameters could be used to diagnose the assumption of superinfection of hepatocytes and to understand the causes for the spontaneous fluctuation pattern of HBV DNA loads...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000321454
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVES:Chikungunya virus (CHIKV) is an alphavirus belonging to the Togaviridae family. Alphaviruses cause a chronic non-cytopathic infection in mosquito cells, while they develop a highly cytopathic infection in cells originating from various vertebrates. In this study, we compared the cytopathic effect (CPE) induc...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000339985
更新日期:2013-01-01 00:00:00
abstract::Adult Hartley guinea pigs infected with guinea pig cytomegalovirus (CMV) develop a mononucleosis syndrome with a brief viremia, splenomegaly, lymphadenopathy, and peripheral lymphocytosis with circulating atypical lymphocytes. The present study used this experimental model to evaluate in vivo the therapeutic efficacy ...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000149512
更新日期:1984-01-01 00:00:00
abstract::Five distinct antigenic sites recognized by cytotoxic T lymphocytes in H-2b mice have been identified on simian virus 40 (SV40) T antigen. Cocultivation of SV40-transformed cells with cytotoxic T lymphocyte (CTL) clones specific for epitopes I-IV results in the selection of variants which show a loss of either epitope...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000150154
更新日期:1990-01-01 00:00:00
abstract:OBJECTIVE:Cervical cancer is the third most common malignancy in females. Since the human papillomavirus (HPV) genotype can vary geographically, it is essential to define its genotypic distribution before establishing health care policies and vaccination programs in any given area. The aim of this study was to determin...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000477848
更新日期:2017-01-01 00:00:00
abstract::HIV-2 is responsible for a limited epidemic in West Africa. Around 20% of all infected patients will progress to AIDS, and will need antiretroviral therapy. Unfortunately, antiretrovirals were developed to suppress HIV-1 replication; not all of them are active against HIV-2, e.g. all nonnucleoside reverse transcriptas...
journal_title:Intervirology
pub_type: 杂志文章,评审
doi:10.1159/000332025
更新日期:2012-01-01 00:00:00
abstract::Serological and physical properties of isolated particles as well as reactions of barley cultivars after virus inoculation showed that the yellow disease of barley is caused by different viruses. Results summarized in this paper suggest that the European isolates BaYMV-So and BaYMV-NM are closely related to, or identi...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000150132
更新日期:1990-01-01 00:00:00
abstract:OBJECTIVES:In the present study, we aimed to determine whether signal-to-cutoff (S/Co) ratios of reactive anti-HCV samples could be used as a basis for avoiding the need for supplemental testing in our study population. METHODS:We analyzed 901 anti-HCV-positive sera from 8 institutions in China. The Ortho VITROS anti-...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000441474
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVES:Kaposi sarcoma-associated herpesvirus (KSHV) glycoprotein B (gB) is expressed on the viral envelope as well as on the cytoplasmic membrane of infected cells. In the current study, we aimed to decipher the impact of membrane-associated gB on adhesion and migration of cells via modulating the expression of cyt...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000487596
更新日期:2017-01-01 00:00:00
abstract::Rotavirus is the most common cause of severe diarrhoea worldwide, affecting over 125 million young children every year in developing countries. The present study is a part of ongoing childhood diarrhoeal surveillance to determine the strain diversity of rotaviruses prevalent in Andaman and Nicobar Islands. From Octobe...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000342219
更新日期:2013-01-01 00:00:00
abstract::Serial passage of undiluted herpes simplex virus types 1 and 2 resulted in cyclic production of infectious and defective virions. Defective virus production was characterized by the appearance of a new species of viral DNA with a higher bouyant density in CsCl than standard viral DNA. Measurement of the infectivity ti...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000149894
更新日期:1975-01-01 00:00:00
abstract:OBJECTIVE:The open reading frame 8 (ORF8) within the short unique (U(s)) region of the bovine herpesvirus 1 (BHV-1) genome was predicted to encode a protein with homology to U(s)9 protein of other alpha herpesviruses. The aim of this study is to identify the protein encoded by the U(s) ORF8 and to examine the effect of...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000063236
更新日期:2002-01-01 00:00:00
abstract::An amyloid-like isoform of a 33- to 34-kD glycoprotein, termed as the scrapie prion protein (PrPsc), plays a critical role in transmissible spongiform encephalopathies of animals and humans. It has even been suggested to present the responsible infectious agent. This protein is a posttranslationally modified form of t...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000150457
更新日期:1995-01-01 00:00:00
abstract::Scrapie brain homogenate was mixed with mouse peritoneal macrophages in vitro. After 2 h of incubation at 37 degrees, a portion of the scrapie infectivity was associated with macrophages. In contrast, very little infectivity was associated with kidney cells that had been exposed to scrapie brain homogenate. After incu...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000149241
更新日期:1981-01-01 00:00:00
abstract::Plants mixedly infected with the U2 strain of tobacco mosaic virus (T2MV) and sunnhemp mosaic virus (SHMV) and grown at 35 degrees, yield particles of the same modal lengths (300 and 40 nm) as those found in plants singly infected with SHMV, but not in plants infected with T2MV, which yield only the long particles. At...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000149973
更新日期:1976-01-01 00:00:00
abstract::Marek's disease herpesvirus (MDHV) isolated from chickens free of naturally occurring avian leukosis virus (ALV) infection produced characteristic foci in both chicken embryo fibroblast (CEF) and chicken kidney cell (CKC) cultures. MDHV-A, which was extracted from the feather follicle epithelium of chickens naturally ...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000148963
更新日期:1978-01-01 00:00:00
abstract::Virions of maize rayado fino virus (MRFV) were purified and two major capsid proteins (ca. Mr 29,000 and 22,000) were resolved by SDS-PAGE. When the two major capsid proteins were isolated from gels and compared by one-dimensional peptide mapping after digestion with Staphylococcus aureus V-8 protease, indistinguishab...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000149664
更新日期:1986-01-01 00:00:00
abstract::Echinochloa ragged stunt virus (ERSV) and rice ragged stunt virus (RRSV; Reoviridae) were purified from their respective host plants and disrupted in SDS. Evidence for the double-strandedness of ERSV RNA was obtained. Electrophoresis in 10% polyacrylamide gels resolved the RNAs of each virus into 10 segments, ranging ...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000150103
更新日期:1989-01-01 00:00:00
abstract::The 20-nm noninfectious empty envelope particles carrying the hepatitis B surface antigen are secreted in large excess from hepatocytes during a hepatitis B infection. Similar particles produced in cell lines or yeast are an efficient vaccine against hepatitis B virus. We have analyzed the assembly of 20-nm particles ...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000150410
更新日期:1995-01-01 00:00:00
abstract::To identify specific environmental, viral, and genetic risk factors for hepatocellular carcinoma (HCC) and the interaction of such factors, we are conducting a prospective study in a high-incidence area of China. Questionnaires were completed and biosamples collected by 60,984 men ages 30-64 years, at study entry. Wit...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000150426
更新日期:1995-01-01 00:00:00
abstract::Four tetraploid cell lines were derived from the Epstein-Barr virus (EBV)-carrying, nonproducer Burkitt lymphoma line Raji after colcemide treatment. EBV early antigen (EA) was induced by P3HR-1 virus superinfection and by iododeoxyuridine treatment. Inducibility was reduced in all tetraploid lines compared to the nea...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000148973
更新日期:1978-01-01 00:00:00
abstract::5 patients with primary genital herpes simplex virus (HSV) infection were studied prospectively for the production of serum antibody reactivity as measured by the virus micro-neutralization test (NT), micro-solid phase radioimmunometric assay (micro-SPRIA), and antibody-dependent cellular-cytotoxic (ADCC) test. ADCC a...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000149320
更新日期:1982-01-01 00:00:00
abstract:OBJECTIVE:To investigate the correlation of serum hepatitis B e antigen (HBeAg) levels with the presence of core promoter (CP) mutations, hepatitis B virus (HBV) viremia and the response to interferon (IFN) in patients with chronic hepatitis B. METHODS:Fourteen HBeAg-positive patients received alpha-2a IFN. Diluted se...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000072431
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVE:Transmission of HIV-1 and diagnosis of infection in hospitals and public health settings remains a worldwide concern. HIV-1 detection is sometimes not possible using current commercial assays, probably due to mismatches between the selected primers and probes. METHODS:By screening primers and probes, we deve...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000119119
更新日期:2008-01-01 00:00:00
abstract::The results of this study show that the synthesis of the inner mitochondrial membrane phospholipid, cardiolipin, is markedly inhibited following infection of human embryonic lung or hamster embryo fibroblast cells with herpes simplex virus type 1 or 2. The synthesis of other phospholipids, i.e., phosphatidylcholine, p...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000149969
更新日期:1974-01-01 00:00:00
abstract::The distribution of related sequences between the genomes of pseudorabies virus (PRV) and herpes simplex virus, types 1 (HSV-1) and 2 (HSV-2), was determined. Approximately 7% of the sequences in PRV are shared by HSV-1 and HSV-2 DNAs. By means of the Southern blot technique, it was found that the homologous sequences...
journal_title:Intervirology
pub_type: 杂志文章
doi:10.1159/000149106
更新日期:1980-01-01 00:00:00