Effect of n-butyrate on transformation of human lymphocytes by Epstein-Barr virus.

Abstract:

:3 mM n-butyrate, which effectively induces synthesis of Epstein-Barr virus (EBV) antigens in the producer P3HR-1 cell line, inhibited the transformation of umbilical cord blood lymphocytes by EBV. The drug inhibited both EBNA synthesis and stimulation of host cell DNA synthesis by strain B95-8. This effect was less pronounced at lower concentrations, but even at 0.1 mM (which did not affect DNA synthesis in EBNA and stimulation of host cell DNA synthesis in EBV-infected lymphocytes were delayed.

journal_name

Intervirology

journal_title

Intervirology

authors

Roubalová K,Roubal J

doi

10.1159/000149566

subject

Has Abstract

pub_date

1985-01-01 00:00:00

pages

51-4

issue

1

eissn

0300-5526

issn

1423-0100

journal_volume

23

pub_type

杂志文章
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