Abstract:
BACKGROUND:Herpesviridae encode a family of protein homologues that function as the 'port of entry' for insertion of the viral DNA into preformed capsids during encapsidation. METHODS:Transmission electron microscopy (TEM) of recombinant varicella-zoster virus pORF54 was performed. RESULTS:Results suggest that pORF54 forms higher-order structures with itself. Enriched fractions analyzed by TEM revealed non-axial oriented portals with defined central channels and distinguishable crown, wing and clip regions. CONCLUSION:These morphological features are consistent with those previously reported for other herpesvirus and bacteriophage portal proteins.
journal_name
Intervirologyjournal_title
Intervirologyauthors
Visalli RJ,Howard AJdoi
10.1159/000360225subject
Has Abstractpub_date
2014-01-01 00:00:00pages
121-5issue
2eissn
0300-5526issn
1423-0100pii
000360225journal_volume
57pub_type
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