Abstract:
:Rauscher murine leukemia virus (RLV) infection of adult mice results in splenomegaly that is proportional to the virus titer. We have used this model to study the therapy of chronic viremia as well as chemoprophylaxis after viral exposure, both with single agents and with combination therapy. We showed that prompt initiation of effective antiviral therapy after viral exposure can prevent de novo infection. We have also developed a murine neurotropic retrovirus model which allows analysis of candidate antiviral agents for activity across the blood-brain barrier. This model can also be used to study therapeutic approaches to retroviral infections acquired at midgestation or during the neonatal period.
journal_name
Intervirologyjournal_title
Intervirologyauthors
Ruprecht RMdoi
10.1159/000150118subject
Has Abstractpub_date
1989-01-01 00:00:00pages
2-11eissn
0300-5526issn
1423-0100journal_volume
30 Suppl 1pub_type
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