Chikungunya Virus Infection Alters Expression of MicroRNAs Involved in Cellular Proliferation, Immune Response and Apoptosis.

abstract：BACKGROUND:We have recently demonstrated that an oligodeoxynucleotide (ODN) can enter HIV particles and form a local hybrid at the highly conserved polypurine tract (PPT), the target site of the ODN. This hybrid is recognized by the retrovirus-specific RNase H, which is a virion-associated enzyme. It cleaves the RNA at...

journal_title：Intervirology

authors： Heinrich J,Schols D,Moelling K

更新日期：2012-01-01 00:00:00

abstract：:Transcription of human T-cell leukemia virus type I is regulated by a viral transactivatior Tax, through the 21-bp sequence in the long terminal repeat (LTR). We found that cellular transcription factor AP-1 (c-Jun/c-Fos heterocomplex) bound to the 21-bp sequence. The binding affinity of the complex increased in propo...

journal_title：Intervirology

authors： Fujii M,Tsuchiya H,Meng XB,Seiki M

更新日期：1995-01-01 00:00:00

abstract：:The transcriptases of several influenza viruses were tested for pH and temperature dependence and for thermal stability. Marked differences in pH dependence and thermostability were determined. ...

journal_title：Intervirology

authors： Broucek J,Závadová H,Vonka V

更新日期：1979-01-01 00:00:00

abstract：OBJECTIVE:To investigate the effect of HIV Tat protein on Bcl-2 expression in human monocytes, and observe apoptosis of Tat-stimulated monocytes induced by TNF-alpha-related apoptosis-induced ligand (TRAIL). METHODS:Western blot was used to detect Bcl-2 expression in monocytes stimulated by HIV Tat protein, and Annexi...

journal_title：Intervirology

authors： Zheng L,Yang Y,Guocai L,Pauza CD,Salvato MS

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVE:Characterization of the phylogeny and diversity of human respiratory syncytial virus (HRSV) genotype ON1 that occurred during its early evolution (within the first 3.5 years since the detection of the first ON1 strains). ON1 strains have a 72-nucleotide-long in-frame duplication within the second hypervariabl...

journal_title：Intervirology

authors： Ivancic-Jelecki J,Forcic D,Mlinaric-Galinovic G,Tesovic G,Nikic Hecer A

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:Giant viruses of the Megavirales order have been neglected in the literature because they are removed from samples during viral purification for viral metagenomic studies. Isolation via amoeba coculture has low efficiency and is extremely time-consuming. Thus, our objective was to improve Megavirales detectio...

journal_title：Intervirology

authors： Slimani M,Pagnier I,Boughalmi M,Raoult D,La Scola B

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:We studied the ability of human cytomegalovirus (HCMV) to infect peripheral blood mononuclear cells (PBMC) pretreated with or without Th2-cytokine interleukin-4 (IL-4) in vitro. METHODS:Adherent cells and nonadherent cells were obtained from PBMC. We inoculated these cells with HCMV at concentrations ranging...

journal_title：Intervirology

authors： Kitajima H,Okubo Y,Honda J,Yonemitsu J,Yoshida N,Fumimori T,Oizumi K

更新日期：2001-01-01 00:00:00

abstract：:Adult Hartley guinea pigs infected with guinea pig cytomegalovirus (CMV) develop a mononucleosis syndrome with a brief viremia, splenomegaly, lymphadenopathy, and peripheral lymphocytosis with circulating atypical lymphocytes. The present study used this experimental model to evaluate in vivo the therapeutic efficacy ...

journal_title：Intervirology

authors： Lucia HL,Griffith BP,Hsiung GD

更新日期：1984-01-01 00:00:00

abstract：:A reverse transcriptase, polymerase chain reaction (RT-PCR) procedure was used to amplify a segment of the genome of turkey coronavirus (TCV) spanning portions of the matrix and nucleocapsid (MN) protein genes (approximately 1.1 kb). The MN gene region of three epidemiologically distinct TCV strains (Minnesota, NC95, ...

journal_title：Intervirology

authors： Breslin JJ,Smith LG,Fuller FJ,Guy JS

更新日期：1999-01-01 00:00:00

abstract：:Hepatitis B virus (HBV) is one of the major causative agents of hepatocellular carcinoma (HCC) in Southeast Asia where HBV genotype B (HBV/B) and genotype C (HBV/C) are prevalent. Clinical and virological differences were evaluated between HCC patients in Japan and Taiwan, all of whom were infected with HBV/B and HBV/...

journal_title：Intervirology

authors： Orito E,Mizokami M

更新日期：2003-01-01 00:00:00

abstract：:The complete nucleotide sequence of rice dwarf phytoreovirus genome segment 2 (S2) was determined to be 3,512 nucleotides long with one open reading frame initiating at nucleotide 15 and terminating at nucleotide 3363. The encoded polypeptide was predicted to have 1,116 residues with a relative molecular weight of 123...

journal_title：Intervirology

authors： Uyeda I,Suda N,Yamada N,Kudo H,Murao K,Suga H,Kimura I,Shikata E,Kitagawa Y,Kusano T

更新日期：1994-01-01 00:00:00

abstract：:Despite the significant medical advances which have taken place in the last decades, acute diarrhoea cases remain a public health issue of major significance, with gastroenteritis agents being associated with severe symptoms in adults and high morbidity in infants and children. Regarding rotaviruses, while children ar...

journal_title：Intervirology

authors： Vontas A,Hadjicristodoulou C,Krikelis V,Petinaki E

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:To study the anti-herpes simplex virus (HSV) activity of a (1→6)-(1→3)-β-D-glucan isolated from Agaricus brasiliensis fruiting bodies (FR) as well as its chemically sulfated derivative (FR-S). METHODS:The antiherpetic activity and mechanism of action was studied by viral plaque assay applying different metho...

journal_title：Intervirology

authors： Cardozo FT,Camelini CM,Leal PC,Kratz JM,Nunes RJ,Mendonça MM,Simões CM

更新日期：2014-01-01 00:00:00

abstract：:The complex etiology of mucosal disease of cattle has been unravelled by experimental reproduction of the fatal syndrome, thereby validating Koch's postulates. The causal virus, bovine virus diarrhea virus (BVDV), has two biotypes, noncytopathogenic and cytopathogenic; the former can infect the early bovine fetus, ind...

journal_title：Intervirology

authors： Brownlie J,Clarke MC

更新日期：1993-01-01 00:00:00

abstract：:In order to assess the risk of transmission of viral diseases during floods, the viral burden in flooded areas of the city of Dresden (Germany) in August 2002 was investigated. Water samples were collected from 9 sampling sites and tested for the presence of 11 enteric viral pathogens. As a control, water samples from...

journal_title：Intervirology

authors： Rohayem J,Dumke R,Jaeger K,Schröter-Bobsin U,Mogel M,Kruse A,Jacobs E,Rethwilm A

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Transmission of many viruses occurs by direct transmission during a close contact between two hosts, or by an indirect transmission through the environment. Several and often interconnected factors, both abiotic and biotic, determine the persistence of these viruses released in the environment, which can las...

journal_title：Intervirology

authors： Labadie T,Batéjat C,Leclercq I,Manuguerra JC

更新日期：2020-01-01 00:00:00

abstract：:Biochemical studies on human coronavirus, strain 229E, indicate that the RNA is present in the virion in association with protein as a ribonucleoprotein (RNP) complex. Morphological studies have revealed that this nucleocapsid is probably a continuous helical RNP. ...

journal_title：Intervirology

authors： Kennedy DA,Johnson-Lussenburg CM

更新日期：1975-01-01 00:00:00

abstract：:Marituba virus was purified by rate-zonal sedimentation and equilibrium density centrifugation in sucrose gradients. The buoyant density of virus particles was 1.19 g/ml. Purified virus was dissociated and its proteins were analyzed by SDS-PAGE. Four virus polypeptides were identified and designated L, G1, G2 and N. T...

journal_title：Intervirology

authors： Frugulhetti IC,Soares MC,Rebello MA

更新日期：1983-01-01 00:00:00

abstract：OBJECTIVE:Because the determination of the stage of fibrosis depends on rather subjective judgment, more objective parameters are needed. In this study, we followed the long-term outcome, with monitoring of platelet counts, in patients with chronic hepatitis C or liver cirrhosis (LC) who had undergone interferon (IFN) ...

journal_title：Intervirology

authors： Moriyama M,Matsumura H,Aoki H,Shimizu T,Nakai K,Saito T,Yamagami H,Shioda A,Kaneko M,Goto I,Tanaka N,Arakawa Y

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVE:Human Salivirus (SalV) has been associated with gastroenteritis on all continents. METHODS:This paper presents the real-time RT-PCR assay for the detection of SalV in clinical fecal samples collected from 192 hospitalized children with acute gastroenteritis in Piedmont, Italy. RESULTS:The most commonly dete...

journal_title：Intervirology

authors： Bergallo M,Daprà V,Rassu M,Bonamin S,Cuccu R,Calvi C,Montanari P,Galliano I

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVE:Pandemic viral infections as emerging infectious diseases are of a great global concern. However, for some viruses, particular strains are endemic to specific areas and can be genetically distinguished from strains in other regions. In contrast, for some other viruses, genetically similar strains can spread a...

journal_title：Intervirology

authors： Furuse Y,Suzuki A,Kamigaki T,Mpolya EA,Khandaker I,Oshitani H

更新日期：2011-01-01 00:00:00

abstract：:Solubilized envelope antigens (glycoproteins) of Sendai virus were purified in a DEAE-Bio-Gel A column. Monospecific antisera were prepared against the antigens, designated HN and F glycoproteins. These glycoproteins are antigenically distinct. Immunodiffusion analyses of the envelope antigens of three representative ...

journal_title：Intervirology

authors： Urata DM,Seto JT

更新日期：1975-01-01 00:00:00

abstract：OBJECTIVE:The open reading frame 8 (ORF8) within the short unique (U(s)) region of the bovine herpesvirus 1 (BHV-1) genome was predicted to encode a protein with homology to U(s)9 protein of other alpha herpesviruses. The aim of this study is to identify the protein encoded by the U(s) ORF8 and to examine the effect of...

journal_title：Intervirology

authors： Nakamichi K,Matsumoto Y,Tohya Y,Otsuka H

更新日期：2002-01-01 00:00:00

abstract：:A seroepidemiological survey of the human syncytial (foamy) virus was done by means of an indirect immunofluorescence test on 1,717 sera from nine different Pacific island territories. The specificity of the reaction was verified by neutralization tests. The study indicated that the virus is ubiquitous in this part of...

journal_title：Intervirology

authors： Loh PC,Matsuura F,Mizumoto C

更新日期：1980-01-01 00:00:00

abstract：OBJECTIVE:This study sought to investigate the presence of dengue virus binding proteins expressed on the surface of HepG2 cells and to determine if there were serotype specific differences in binding. METHODS:HepG2 cell membrane proteins were extracted and separated by SDS-PAGE, transferred to nitrocellulose membrane...

journal_title：Intervirology

authors： Jindadamrongwech S,Smith DR

更新日期：2004-01-01 00:00:00

abstract：:HIV-2 is responsible for a limited epidemic in West Africa. Around 20% of all infected patients will progress to AIDS, and will need antiretroviral therapy. Unfortunately, antiretrovirals were developed to suppress HIV-1 replication; not all of them are active against HIV-2, e.g. all nonnucleoside reverse transcriptas...

journal_title：Intervirology

authors： Camacho RJ

更新日期：2012-01-01 00:00:00

abstract：:Ferret hepatitis E virus (HEV), a novel hepatitis E-like virus, has been identified in ferrets in the Netherlands, Japan, and the US. To determine whether ferret HEV transmits to other animals, we inoculated laboratory rats (Wistar), nude rats (Long-Evans-rnu/rnu), and cynomolgus monkeys with ferret HEV (F4351) by int...

journal_title：Intervirology

authors： Li TC,Yoshizaki S,Ami Y,Suzaki Y,Yang T,Takeda N,Takaji W

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:The genetic barrier for the evolution of integrase inhibitors (INIs) including raltegravir (RAL), elvitegravir (EVG), and dolutegravir (DTG) resistance was compared between HIV-1 subtypes CRF01_AE and B. METHODS:Analysis of 66 substitutions associated with INI resistance at 41 amino acid positions in 144 nuc...

journal_title：Intervirology

authors： Nguyen HL,Ruxrungtham K,Delaugerre C

更新日期：2012-01-01 00:00:00

abstract：:Human cytomegalovirus (HCMV), like all herpesviruses, persists in the host after primary infection, with reactivation often occurring as a result of immunosuppression. The lack of a model system has made analysis of HCMV latency and reactivation difficult. However, the ability to analyse which specific cell types in v...

journal_title：Intervirology

authors： Sinclair J,Sissons P

更新日期：1996-01-01 00:00:00

abstract：:The amino acid composition (AAC) of the coat proteins (CPs) of 126 plant viruses or strains were analyzed by stepwise discriminant analysis. The criteria chosen for discrimination were: the structure of virus particles (3 clusters); the mode of of transmission of the viruses (6 clusters); and the grouping of viruses a...

journal_title：Intervirology

authors： Fauquet C,Dejardin J,Thouvenel JC

更新日期：1986-01-01 00:00:00