A short hairpin loop-structured oligodeoxynucleotide targeting the virion-associated RNase H of HIV inhibits HIV production in cell culture and in huPBL-SCID mice.

abstract：:The proposed family Toroviridae is characterized by eveloped, peplomer-bearing particles containing an elongated tubular nucleocapsid with helical symmetry. The capsid may bend into an open torus, conferring a biconcave disk or kidney-shaped morphology to the virion (largest diameter 120-140 nm) or the capsid may be s...

journal_title：Intervirology

authors： Horzinek MC,Flewett TH,Saif LJ,Spaan WJ,Weiss M,Woode GN

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVE:To study the anti-herpes simplex virus (HSV) activity of a (1→6)-(1→3)-β-D-glucan isolated from Agaricus brasiliensis fruiting bodies (FR) as well as its chemically sulfated derivative (FR-S). METHODS:The antiherpetic activity and mechanism of action was studied by viral plaque assay applying different metho...

journal_title：Intervirology

authors： Cardozo FT,Camelini CM,Leal PC,Kratz JM,Nunes RJ,Mendonça MM,Simões CM

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:To screen and identify cellular proteins binding to the core region of hepatitis C virus (HCV) RNA genome. METHODS:The plasmid pHCV core was constructed to generate in vitro transcripts of the core region of HCV RNA genome. Ultraviolet (UV) cross-linking experiment and competition analysis were performed to ...

journal_title：Intervirology

authors： Su HX,Xu DZ,Zhang YH,Men K,Zhao XN,Li D,Zhang L,Zhang JX,Yan YP

更新日期：2007-01-01 00:00:00

abstract：:Cultures of human cells transformed by SV40 were found to release infectious virus, even after several passages in vitro. Virus shedding by these cultures did not depend on propagation of virus from cell to cell, as it was not affected by anti-SV40 antiserum that could effectively block virus propagation in acutely in...

journal_title：Intervirology

authors： Lomax CA,Thirion JP,Bourgaux-Ramoisy D

更新日期：1978-01-01 00:00:00

abstract：:Herpes simplex virus type 1 (HSV-1) latency was established in human embryo lung (HEL) cells by treatment with (E)-5-(2'-bromovinyl)-2'-deoxyuridine and human leukocyte interferon and subsequent temperature increase (from 37 degrees to 40.5 degrees). This in vitro system was used to study reactivation after temperatur...

journal_title：Intervirology

authors： Vonka V,Shiraki K,Wrzos J,Rapp F

更新日期：1986-01-01 00:00:00

abstract：:Human skin fibroblasts were previously shown to be resistant to coxsackie B4 virus infection. We have cultured fibroblasts from skin and lung tissues of donors of various ages. By a novel method for direct assay of virus absorption and penetration, we have shown that skin fibroblasts from young fetuses are susceptible...

journal_title：Intervirology

authors： Hornberger E,Plotkin SA

更新日期：1983-01-01 00:00:00

abstract：:In Spodoptera frugiperda (SF IPLB-21) cells productively infected with S. frugiperda multicapsid nuclear polyhedrosis virus (SfMNPV), we observed the synthesis of infected-cell-specific polypeptides (ICSPs) using the protein synthesis inhibitor cycloheximide (CX) and the DAN synthesis inhibitor cytosine arabinoside (A...

journal_title：Intervirology

authors： Liu HS,Bilimoria SL

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVE:Human Salivirus (SalV) has been associated with gastroenteritis on all continents. METHODS:This paper presents the real-time RT-PCR assay for the detection of SalV in clinical fecal samples collected from 192 hospitalized children with acute gastroenteritis in Piedmont, Italy. RESULTS:The most commonly dete...

journal_title：Intervirology

authors： Bergallo M,Daprà V,Rassu M,Bonamin S,Cuccu R,Calvi C,Montanari P,Galliano I

更新日期：2018-01-01 00:00:00

abstract：:Human cytomegalovirus (CMV) has devised numerous means of escaping immune surveillance. The CMV genome encodes at least 4 genes involved in downregulating surface expression of HLA class I molecules. In addition, it sequesters CC chemokines, induces Fc receptors, interferes with induction of HLA class II antigens, and...

journal_title：Intervirology

authors： Michelson S

更新日期：1999-01-01 00:00:00

abstract：OBJECTIVES:The potential risk of accidental infection by hantaviruses in a clinical or research laboratory necessitates special precautionary measures. A biosafety program must address handling and disposal of infectious materials as well as appropriate virus inactivation or depletion procedures to permit necessary fur...

journal_title：Intervirology

authors： Kraus AA,Priemer C,Heider H,Kruger DH,Ulrich R

更新日期：2005-01-01 00:00:00

abstract：:The actinomycin-D(AMD)-sensitive step of replication of three plant viruses - cowpea chlorotic mottle virus (CCMV), cowpea mosaic virus, and the cowpea strain of tobacco mosaic virus - in cowpea was specific for each virus. Different combinations of the viruses were examined in which leaves were inoculated with one vi...

journal_title：Intervirology

authors： Turner MS,Dawson WO

更新日期：1984-01-01 00:00:00

abstract：OBJECTIVE:The aim was to identify the codon usage bias between the newly identified duck plague virus (DPV) UL35 gene (GenBank accession No. EF643558) and the UL35-like genes of 27 other reference herpesviruses. METHODS:A comparative analysis of the codon usage bias of the 28 herpesviruses was performed by using the C...

journal_title：Intervirology

authors： Cai MS,Cheng AC,Wang MS,Zhao LC,Zhu DK,Luo QH,Liu F,Chen XY

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVES:Data on drug-resistant mutations (DRMs) in HIV-1-infected therapy-naïve children are scarce. The aim of this study was to determine the HIV-1 subtype distribution and the prevalence of DRMs in therapy-naïve HIV-1-infected children who received routine care at the University Hospital Düsseldorf, Düsseldorf, G...

journal_title：Intervirology

authors： Neubert J,Michalsky N,Laws HJ,Borkhardt A,Jensen B,Lübke N

更新日期：2016-01-01 00:00:00

abstract：:Examination of newborn mice, inoculated intraperitoneally with high doses of scrapie virus, revealed that the virus could not be reisolated from their tissues after about 1 week following inoculation, until almost 1 year later. The inoculum was rapidly removed and was not detectable, although the animals became latent...

journal_title：Intervirology

authors： Hotchin J,Sikora E,Baker F

更新日期：1983-01-01 00:00:00

abstract：OBJECTIVE:The open reading frame 8 (ORF8) within the short unique (U(s)) region of the bovine herpesvirus 1 (BHV-1) genome was predicted to encode a protein with homology to U(s)9 protein of other alpha herpesviruses. The aim of this study is to identify the protein encoded by the U(s) ORF8 and to examine the effect of...

journal_title：Intervirology

authors： Nakamichi K,Matsumoto Y,Tohya Y,Otsuka H

更新日期：2002-01-01 00:00:00

abstract：:Studies of human papillomavirus (HPV) infection are hampered by the lack of an adequate culture system. The athymic mouse xenograft system permits propagation of HPV, but only a few HPV types have been grown in this manner. To produce an oncogenic type for studies of HPV pathogenesis, a condylomata acuminata lesion fr...

journal_title：Intervirology

authors： Bryan JT,Tekchandani J,Schroeder JM,Brown DR

更新日期：2000-01-01 00:00:00

abstract：OBJECTIVE:The genetic barrier for the evolution of integrase inhibitors (INIs) including raltegravir (RAL), elvitegravir (EVG), and dolutegravir (DTG) resistance was compared between HIV-1 subtypes CRF01_AE and B. METHODS:Analysis of 66 substitutions associated with INI resistance at 41 amino acid positions in 144 nuc...

journal_title：Intervirology

authors： Nguyen HL,Ruxrungtham K,Delaugerre C

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Infection with tick-borne encephalitis virus (TBEV) causes pathological changes in the central nervous system. However, the possible redox alterations in the infected cells that can contribute to the virus pathogenicity remain unknown. OBJECTIVE:In the current study we explored the ability of TBEV nonstruct...

journal_title：Intervirology

authors： Kuzmenko YV,Smirnova OA,Ivanov AV,Starodubova ES,Karpov VL

更新日期：2016-01-01 00:00:00

abstract：:The genetic relationship between two enteroviruses causing the acute hemorrhagic conjunctivitis (AHC) syndrome was examined by the RNA-RNA hybridization technique. Nucleotide sequence homology between the J670/71 strain of enterovirus type 70 (EV70) and the EH 24/70 strain of Singapore epidemic conjunctivitis (SEC) vi...

journal_title：Intervirology

authors： Natori K,Yamazaki S,Miyamura K,Kono R

更新日期：1984-01-01 00:00:00

abstract：:In order to assess the risk of transmission of viral diseases during floods, the viral burden in flooded areas of the city of Dresden (Germany) in August 2002 was investigated. Water samples were collected from 9 sampling sites and tested for the presence of 11 enteric viral pathogens. As a control, water samples from...

journal_title：Intervirology

authors： Rohayem J,Dumke R,Jaeger K,Schröter-Bobsin U,Mogel M,Kruse A,Jacobs E,Rethwilm A

更新日期：2006-01-01 00:00:00

abstract：:Acute hemorrhagic conjunctivitis (AHC) virus strains isolated in eight different areas during epidemics of AHC were tested for the reproductive capacity at 33, 37 and 39 degrees. All of the 25 strains tested grew better at 33 degrees but restrictively at 39 degrees. The degree of temperature sensitivity varied slightl...

journal_title：Intervirology

authors： Miyamura K,Sasagawa A,Tajiri E,Kono R

更新日期：1976-01-01 00:00:00

abstract：:We report a case in which sustained viral response was achieved after switching treatment from pegylated interferon (PEG-IFN) α-2b to α-2a and ribavirin (RBV) in patients with recurrence of hepatitis C virus (HCV) infection after living donor liver transplantation. The patient was a 62-year-old man with liver cirrhosi...

journal_title：Intervirology

authors： Kawaoka T,Hiraga N,Takahashi S,Takaki S,Tsuge M,Nagaoki Y,Hashimoto Y,Katamura Y,Miki D,Hiramatsu A,Waki K,Imamura M,Kawakami Y,Aikata H,Ochi H,Tashiro H,Ohdan H,Chayama K

更新日期：2012-01-01 00:00:00

abstract：:The Holland strain of anatid herpesvirus (AHV) was 2-to 10-fold more efficiently plaqued under liquid medium or semisolid medium containing methylcellulose than in media containing agar, agarose, or Nobel agar. Virus adsorption was complete in 45 min, with the maximum virus titers obtained under liquid medium at 48 h ...

journal_title：Intervirology

authors： Attanasio R,Olson R,Johnson JC

更新日期：1980-01-01 00:00:00

abstract：:Human papillomavirus (HPV) DNA was isolated from a clinically diagnosed flat wart and proved to be related to HPV2. The isolate showed 55% cross-hybridization with HPV2a. A physical map of restriction enzyme cleavage sites differed completely from those of HPV2a and HPV2b. The new HPV2 subtype, which will be classifie...

journal_title：Intervirology

authors： Fuchs PG,Pfister H

更新日期：1984-01-01 00:00:00

abstract：OBJECTIVE:In this study we established a mouse brain injection system to detect infectious dengue-2 virus produced from the full-length RNA transcripts. METHODS:In vitro transcription was used to synthesize full-length dengue-2 virus RNA from the plasmid pRS424FLDEN2NGC, which was intracerebrally injected into the 6-d...

journal_title：Intervirology

authors： Lee YR,Huang KJ,Lei HY,Chen SH,Lin YS,Yeh TM,Liu HS

更新日期：2005-01-01 00:00:00

abstract：:Double-filtration plasmapheresis (DFPP) was approved in Japan in April 2008 for the retreatment of chronic hepatitis C patients with genotype 1b and high viral loads, whose hepatitis C virus was not eradicated by earlier IFN therapy or by pegylated IFN plus ribavirin (PEG-IFN/RBV) combination therapy. In this study, w...

journal_title：Intervirology

authors： Kim SR,Imoto S,Kudo M,Mita K,Taniguchi M,Kim KI,Sasase N,Shoji I,Nagano-Fujii M,El-Shamy A,Hotta H,Nagai T,Nagata Y,Hayashi Y

更新日期：2010-01-01 00:00:00

abstract：:A seroepidemiological survey of the human syncytial (foamy) virus was done by means of an indirect immunofluorescence test on 1,717 sera from nine different Pacific island territories. The specificity of the reaction was verified by neutralization tests. The study indicated that the virus is ubiquitous in this part of...

journal_title：Intervirology

authors： Loh PC,Matsuura F,Mizumoto C

更新日期：1980-01-01 00:00:00

abstract：BACKGROUND/AIMS:The present study was launched to systematically characterize the molecular genotypes and quantitative serological biomarkers during the natural course of chronic hepatitis B (CHB) infection in a patient population from Chongqing, China. METHODS:A total of 140 patients were enrolled and grouped accordi...

journal_title：Intervirology

authors： Xiang Y,Huang S,Xia J,Ye D,Chen P,Zhang L

更新日期：2012-01-01 00:00:00

abstract：:By 48 h postinfection, 40--80% of SV40-infected CV-1 cells have undergone irreversible injury as indicated by trypan blue staining. Nevertheless, at this time the lysosomes of these cells appear as discrete structures after vital staining with either acridine orange or neutral red. Lysosomes, vitally stained with neut...

journal_title：Intervirology

authors： Einck KH,Norkin LC

更新日期：1979-01-01 00:00:00

abstract：:By a combination of PCR and direct-cycle sequencing using consensus primers, we analyzed approximately 400-bp fragments within the NS3 genes of twenty-one dengue virus type 3 strains isolated from five neighboring Southeast Asian countries at different time intervals from 1956 to 1992. The majority of base disparities...

journal_title：Intervirology

authors： Chow VT,Seah CL,Chan YC

更新日期：1994-01-01 00:00:00