Human skin fibroblasts are nonpermissive to coxsackie B4 infection: an age-dependent phenomenon.

Abstract:

:Human skin fibroblasts were previously shown to be resistant to coxsackie B4 virus infection. We have cultured fibroblasts from skin and lung tissues of donors of various ages. By a novel method for direct assay of virus absorption and penetration, we have shown that skin fibroblasts from young fetuses are susceptible to coxsackie B4 infection, whereas those from older fetuses, children and adults are not and that this refractoriness is caused by a tissue-specific block to virus penetration.

journal_name

Intervirology

journal_title

Intervirology

authors

Hornberger E,Plotkin SA

doi

10.1159/000149360

subject

Has Abstract

pub_date

1983-01-01 00:00:00

pages

195-200

issue

4

eissn

0300-5526

issn

1423-0100

journal_volume

19

pub_type

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