abstract：:The study focused on formulation of carmellose sodium hydrogels and nonionic microemulsions with 5% and 10% of levetiracetam and investigation of drug concentration influence on their physicochemical characteristics and in-use stability as well as influence of drug concentration and carrier type on in vitro drug relea...

journal_title：Drug delivery and translational research

authors： Djekic L,Marković B,Micov A,Tomić M,Pecikoza U,Stepanović-Petrović R

更新日期：2021-02-01 00:00:00

abstract：:The present work investigates the targeting efficacy of a novel thiolated polymer-based nanocomposite reinforced with glycyrrhetinic acid (GA) and loaded with 5-fluorouracil in hepatocellular carcinoma (HCC). The thiolated polymers were synthesized by EDAC-mediated conjugation reactions and lyophilization. The nanopar...

journal_title：Drug delivery and translational research

authors： Bhat SS,Mukherjee D,Sukharamwala P,Dehuri R,Murali A,Teja BV

更新日期：2021-01-11 00:00:00

abstract：:Oil in water nano-emulsions are drug delivery systems constituted by liquid lipophilic nano-droplets dispersed through the external aqueous phase, often reaching the kinetic stability with surfactant as stabilizers. Essential oils can be the oily phase or the source of bioactive compounds. In this study, the essential...

journal_title：Drug delivery and translational research

authors： de Oliveira Ferraz T,Ferreira DQ,Mourão RHV,Formiga FR,Carvalho JCT,Fernandes CP

更新日期：2020-12-01 00:00:00

abstract：:Intranasal administration of mucus-penetrating nanoparticles is an emerging trend to increase drug delivery to the brain. In order to overcome rapid nasal mucociliary clearance, low epithelial permeation, and local enzymatic degradation, we investigated the influence of PEGylation on nose-to-brain delivery of polycapr...

journal_title：Drug delivery and translational research

authors： de Oliveira Junior ER,Santos LCR,Salomão MA,Nascimento TL,de Almeida Ribeiro Oliveira G,Lião LM,Lima EM

更新日期：2020-12-01 00:00:00

abstract：:The cutaneous penetration of acyclovir from the conventional topical formulations such as cream and ointments is poor due to low water solubility and low octanol buffer partition coefficient of the drug. The present investigation was aimed to prepare acyclovir-loaded microsponge-based emulgel to improve its topical de...

journal_title：Drug delivery and translational research

authors： Gusai T,Dhavalkumar M,Soniwala M,Dudhat K,Vasoya J,Chavda J

更新日期：2020-11-06 00:00:00

abstract：:In the present investigation, temozolomide (TMZ) loaded chondroitin sulfate conjugated albumin nanoparticles (CS-TNPs) were fabricated by desolvation method were chondroitin sulfate (CS) was used as the surface exposed ligand to achieve CD44 receptor mediated targeting of brain tumor. The developed CS-TNPs were charac...

journal_title：Drug delivery and translational research

authors： Kudarha RR,Sawant KK

更新日期：2020-10-07 00:00:00

abstract：:Over the past two decades, polymersomes have been widely investigated for the delivery of diagnostic and therapeutic agents in cancer therapy. Polymersomes are stable polymeric vesicles, which are prepared using amphiphilic block polymers of different molecular weights. The use of high molecular weight amphiphilic cop...

journal_title：Drug delivery and translational research

authors： Sharma AK,Prasher P,Aljabali AA,Mishra V,Gandhi H,Kumar S,Mutalik S,Chellappan DK,Tambuwala MM,Dua K,Kapoor DN

更新日期：2020-10-01 00:00:00

abstract：:In bovine estrus synchronization, intravaginal devices made of silicone are used to administer exogenous progesterone with the aim of maintain plasmatic levels above 2 ng ml-1 during the treatment. After their use, devices must be discarded. There is an important concern on the environmental impact of the disposal of ...

journal_title：Drug delivery and translational research

authors： Helbling IM,Karp F,Cappadoro A,Luna JA

更新日期：2020-10-01 00:00:00

abstract：:Osteoporosis, due to its prevalence worldwide, is a serious health problem. Topical administration of quercetin, a phytoestrogen, in the form of deformable transfersomes, could be used to treat osteoporosis to overcome its low oral solubility and bioavailability. Formulation process of transfersomes was screened by fr...

journal_title：Drug delivery and translational research

authors： Pandit AP,Omase SB,Mute VM

更新日期：2020-10-01 00:00:00

abstract：:Curcumin, resveratrol, and thymoquinone are the potential natural bio-actives reported with good anti-psoriatic activity. However, poor aqueous solubility and limited skin permeation of these natural bio-actives hinder their effective delivery and potential therapeutic outcome. In this regard, current research work fo...

journal_title：Drug delivery and translational research

authors： Khatoon K,Ali A,Ahmad FJ,Hafeez Z,Rizvi MMA,Akhter S,Beg S

更新日期：2020-09-23 00:00:00

abstract：:Simvastatin (SIM) is a commonly used cholesterol-lowering drug that can reduce the risk of major cardiovascular events. However, due to its poor intrinsic water solubility, the drug is poorly absorbed from the gastrointestinal tract and exhibits a low oral bioavailability of approximately 5%. The aim of this study was...

journal_title：Drug delivery and translational research

authors： Meola TR,Abuhelwa AY,Joyce P,Clifton P,Prestidge CA

更新日期：2020-09-11 00:00:00

abstract：:The involvement of recent technologies, such as nanotechnology and three-dimensional printing (3DP), in drug delivery has become the utmost importance for effective and safe delivery of potent therapeutics, and thus, recent advancement for oral drug delivery through 3DP technology has been expanded. The use of compute...

journal_title：Drug delivery and translational research

authors： Pandey M,Choudhury H,Fern JLC,Kee ATK,Kou J,Jing JLJ,Her HC,Yong HS,Ming HC,Bhattamisra SK,Gorain B

更新日期：2020-08-01 00:00:00

abstract：:Access to medicines, including their availability and affordability, is a major public health challenge worldwide. This research aimed to characterise rectal formulations containing amoxicillin for the treatment of pneumonia in children under five, as an accessible alternative to existing formulations. Lipophilic Supp...

journal_title：Drug delivery and translational research

authors： Hanning SM,Matiz S,Krasser K,Orlu M,Dodoo C,Gaisford S,Tuleu C

更新日期：2020-06-25 00:00:00

abstract：:Combination therapy that uses multiple drugs against different molecular targets should be considered as interesting alternatives for treating complex diseases such as glioblastoma (GBM). Drugs like alpha-cyano-4-hydroxycinnamic acid (CHC) and the monoclonal antibody cetuximab (CTX) are already explored for their capa...

journal_title：Drug delivery and translational research

authors： Ferreira NN,Granja S,Boni FI,Ferreira LMB,Reis RM,Baltazar F,Gremião MPD

更新日期：2020-06-01 00:00:00

abstract：:Hydrogel-forming microneedle array patches (MAPs) have been proposed as viable clinical tools for patient monitoring purposes, providing an alternative to traditional methods of sample acquisition, such as venepuncture and intradermal sampling. They are also undergoing investigation in the management of non-melanoma s...

journal_title：Drug delivery and translational research

authors： Al-Kasasbeh R,Brady AJ,Courtenay AJ,Larrañeta E,McCrudden MTC,O'Kane D,Liggett S,Donnelly RF

更新日期：2020-06-01 00:00:00

abstract：:The present research work summarises the development of an in situ gelling ophthalmic nanoemulsion of brinzolamide providing sustained release and prolonged therapeutic effect for the treatment of glaucoma. Nanoemulsions were prepared using castor oil, polyoxyl 35 castor oil and polysorbate 80 and with gellan gum as t...

journal_title：Drug delivery and translational research

authors： Bhalerao H,Koteshwara KB,Chandran S

更新日期：2020-04-01 00:00:00

abstract：:Psoriasis and atopic dermatitis are widespread pathologies with a need to improve their treatment. Topical administration of cyclosporine A (CyA) could be used if targeted to the skin, thus avoiding systemic levels. Unfortunately, CyA molecular weight and lipophilicity prevent its diffusion through human skin. Four no...

journal_title：Drug delivery and translational research

authors： Carreras JJ,Tapia-Ramirez WE,Sala A,Guillot AJ,Garrigues TM,Melero A

更新日期：2020-04-01 00:00:00

abstract：:Supersaturated drug delivery systems are commonly used to address the problems of poor aqueous solubility posed by most of the active pharmaceutical ingredients (APIs). However, the supersaturated systems are highly unstable due to their high free energy levels and demonstrate a tendency to precipitate. Understanding ...

journal_title：Drug delivery and translational research

authors： Rathi S,Chavan RB,Shastri NR

更新日期：2020-02-01 00:00:00

abstract：:Wound healing is a physiological event that generates reconstitution and restoration of granulation tissue that ends with scar formation. As omega fatty acids are part of membrane phospholipids and participate in the inflammatory response, we investigated the effects of omega-3, omega-6, and omega-9 fatty acids in the...

journal_title：Drug delivery and translational research

authors： Ishak WMW,Katas H,Yuen NP,Abdullah MA,Zulfakar MH

更新日期：2019-04-01 00:00:00

abstract：:The objectives of this study were to develop biodegradable poly-lactic-co-glycolic acid (PLGA) based injectable phase inversion in situ forming system for sustained delivery of triamcinolone acetonide (TA) and to conduct physicochemical characterisation including in vitro drug release of the prepared formulations. TA ...

journal_title：Drug delivery and translational research

authors： Sheshala R,Hong GC,Yee WP,Meka VS,Thakur RRS

更新日期：2019-04-01 00:00:00

abstract：:Atopic dermatitis (AD) is a chronically relapsing eczematous skin disease characterised by frequent episodes of rashes, severe flares, and inflammation. Till date, there is no absolute therapy for the treatment of AD; however, topical corticosteroids (TCs) are the majorly prescribed class of drugs for the management o...

journal_title：Drug delivery and translational research

authors： Pandey M,Choudhury H,Gunasegaran TAP,Nathan SS,Md S,Gorain B,Tripathy M,Hussain Z

更新日期：2019-04-01 00:00:00

abstract：:In this study, we developed, characterized, and tested in vivo polymeric nanoparticle of ethambutol labeled with 99mTc as nanoradiopharmaceutical for early diagnosis of tuberculosis by single-photon emission computed tomography, also as a therapeutic choice. Nanoparticles were developed by double emulsification. All c...

journal_title：Drug delivery and translational research

authors： Helal-Neto E,Rocha Pinto S,Portilho FL,da Costa MD,Pereira JX,Nigro F,Ricci-Junior E,Candéa ALP,das Graças Muller de Oliveira Henriques M,Santos-Oliveira R

更新日期：2019-02-01 00:00:00

abstract：:High-energy methods for the manufacturing of nanomedicines are widely used; however, interest in low-energy methods is increasing due to their simplicity, better control over the process, and energy-saving characteristics during upscaling. Here, we developed a novel lipid-core micelle (LCM) as a nanocarrier to encapsu...

journal_title：Drug delivery and translational research

authors： Fritz HF,Ortiz AC,Velaga SP,Morales JO

更新日期：2018-12-01 00:00:00

abstract：:The purpose of this study was to explore poly(vinylpyrrolidone-co-vinyl acetate) (PVP VA64) as a novel release-modifier to tailor the drug release from ethylcellulose (EC)-based mini-matrices prepared via hot melt extrusion (HME). Quetiapine fumarate (QF) was selected as model drug. QF/EC/PVP VA64 mini-matrices were e...

journal_title：Drug delivery and translational research

authors： Li Y,Lu M,Wu C

更新日期：2018-12-01 00:00:00

abstract：:Chemical injury by alkali burn is a major cause of corneal blindness in the clinical setting. Current management advocates multiple therapies aimed to prevent inflammation, initiate quick re-epithelialization, arrest the fibrosis, and avoid dry eye and pain by using bandage contact lenses. We hypothesized sustained de...

journal_title：Drug delivery and translational research

authors： Dixon P,Ghosh T,Mondal K,Konar A,Chauhan A,Hazra S

更新日期：2018-10-01 00:00:00

abstract：:Curcumin (CUR), a natural polyphenolic compound, is considered as one of the most potential candidates against Alzheimer disease (AD) by targeting multiple pathologies such as amyloid-beta, tau phosphorylation, and oxidative stress. Poor physicochemical profile and oral bioavailability (BA) are the major contributors ...

journal_title：Drug delivery and translational research

authors： Parikh A,Kathawala K,Li J,Chen C,Shan Z,Cao X,Zhou XF,Garg S

更新日期：2018-10-01 00:00:00

abstract：:This study evaluated effects of differing gel volumes on pharmacokinetics (PK). IQB4012, a gel containing the non-nucleoside reverse transcriptase inhibitor IQP-0528 and tenofovir (TFV), was applied to the pigtailed macaque vagina and rectum. Vaginal gel volumes (1% loading of both drugs) were 0.5 or 1.5 ml; following...

journal_title：Drug delivery and translational research

authors： Pereira LE,Singletary T,Martin A,Dinh CT,Deyounks F,Holder A,McNicholl J,Buckheit KW,Buckheit RW Jr,Ham A,Katz DF,Smith JM

更新日期：2018-10-01 00:00:00

abstract：:Inhalation therapy of lipid-based carriers has great potential in direct target towards the root of respiratory diseases, which make them superior over other drug deliveries. With the successful entry of lipid carriers into the target cells, drugs can be absorbed in a sustained release manner and yield extended medici...

journal_title：Drug delivery and translational research

authors： Ngan CL,Asmawi AA

更新日期：2018-10-01 00:00:00

abstract：:Polyelectrolyte nanoparticle constructs (NPs) comprising salmon calcitonin (sCT), chitosan (CS), and hyaluronic acid (HA) were previously established as having anti-inflammatory potential when injected via the intra-articular (i.a.) route to a mouse model. We attempted to translate the formulation to a large animal mo...

journal_title：Drug delivery and translational research

authors： Sladek S,Kearney C,Crean D,Brama PAJ,Tajber L,Fawcett K,Labberte MC,Leggett B,Brayden DJ

更新日期：2018-10-01 00:00:00

abstract：:Pulsed electric fields (PEFs) are applied as physical stimuli for DNA/drug delivery, cancer therapy, gene transformation, and microorganism eradication. Meanwhile, calcium electrotransfer offers an interesting approach to treat cancer, as it induces cell death easier in malignant cells than in normal cells. Here, we s...

journal_title：Drug delivery and translational research

authors： Guionet A,Moosavi Nejad S,Teissié J,Sakugawa T,Katsuki S,Akiyama H,Hosseini H

更新日期：2018-10-01 00:00:00

abstract：:Curcumin (CUR) is considered as one of the most bioactive molecules ever discovered from nature due to its proven anti-inflammatory and antioxidant in both preclinical and clinical studies. Despite its proven safety and efficacy, the clinical translation of CUR into a useful therapeutic agent is still limited due to i...

journal_title：Drug delivery and translational research

authors： Parikh A,Kathawala K,Song Y,Zhou XF,Garg S

更新日期：2018-10-01 00:00:00

abstract：:The work describes systematic development of nanomicellar cationic supersaturable self-nanoemulsifying drug delivery systems (CS-SNEDDS) for augmenting oral biopharmaceutical performance of raloxifene hydrochloride. Plain SNEDDS formulation containing Capryol 90, Cremophor RH 40, and Transcutol HP was optimized using ...

journal_title：Drug delivery and translational research

authors： Jain A,Kaur R,Beg S,Kushwah V,Jain S,Singh B

更新日期：2018-06-01 00:00:00

abstract：:Dry powder inhalers (DPIs) have been proposed as an alternative administration route for protein and peptide drugs. However, DPI particles are easy to aggregate due to the strong interactions between the particles, leading to poor aerosolization performance. In this study, fragmented particles containing octreotide ac...

journal_title：Drug delivery and translational research

authors： Hou A,Li L,Huang Y,Singh V,Zhu C,Pan X,Quan G,Wu C

更新日期：2018-06-01 00:00:00

abstract：:Bovine mastitis caused by bacterial infections of the mammary gland (udder) of dairy cows is a costly pathology for the dairy industry due to direct and indirect losses in production. Penethamate, a pro-drug of benzylpenicillin, is used by intramuscular injection (IM). The existing products are powders which must be r...

journal_title：Drug delivery and translational research

authors： Tucker IG,Jain R,Alawi F,Nanjan K,Bork O

更新日期：2018-04-01 00:00:00

abstract：:We previously showed that the combination of the non-nucleoside reverse transcriptase inhibitor (NNRTI) MIV-150 with zinc acetate (ZA) formulated in a carrageenan (CG; MZC) gel provided macaques significant protection against vaginal simian-human immunodeficiency virus-RT (SHIV-RT) challenge, better than either MIV-15...

journal_title：Drug delivery and translational research

authors： Mizenina O,Hsu M,Jean-Pierre N,Aravantinou M,Levendosky K,Paglini G,Zydowsky TM,Robbiani M,Fernández-Romero JA

更新日期：2017-12-01 00:00:00

abstract：:Oral pre-exposure prophylaxis for the prevention of HIV-1 transmission (HIV PrEP) has been widely successful as demonstrated by a number of clinical trials. However, studies have also demonstrated the need for patients to tightly adhere to oral dosing regimens in order to maintain protective plasma and tissue concentr...

journal_title：Drug delivery and translational research

authors： Lykins WR,Luecke E,Johengen D,van der Straten A,Desai TA

更新日期：2017-12-01 00:00:00

abstract：:The tissue distribution and percutaneous drug absorption of indomethacin (IND) patches were studied using commercial IND as a comparison. The concentration of IND in skin, plasma, and muscle in mice was measured by LC-MS/MS, and the IND concentration in the dermis of rats was also monitored by microdialysis. After per...

journal_title：Drug delivery and translational research

authors： Ma J,Gao Y,Sun Y,Ding D,Zhang Q,Sun B,Wang M,Sun J,He Z

更新日期：2017-10-01 00:00:00

abstract：:Lipid carrier-mediated transdermal drug delivery offers several advantages because it is non-irritating and non-toxic, provides effective control of drug release, and forms an adhesive film that hydrates the outer skin layers. However, to penetrate the deeper skin layers, these formulations need to overcome several ba...

journal_title：Drug delivery and translational research

authors： Nguyen CN,Nguyen TTT,Nguyen HT,Tran TH

更新日期：2017-10-01 00:00:00

abstract：:Most of non-steroidal anti-inflammatory drugs (NSAIDs) including ibuprofen at more than 1200 mg/day may generate gastrointestinal and cardiovascular side effects. Bilayer or multiparticulate devices have been developed for controlled release in order to prevent undesired side effects. A new "two release rate (2RR) mon...

journal_title：Drug delivery and translational research

authors： Le TC,Mateescu MA

更新日期：2017-08-01 00:00:00

abstract：:The objective of this research was to develop polymeric micellar formulations of inhibitors of signal transducer and activator of transcription 3 (STAT3) dimerization, i.e., S3I-1757 and S3I-201, and evaluate the activity of successful formulations in B16-F10 melanoma, a STAT3 hyperactive cancer model, in vitro and in...

journal_title：Drug delivery and translational research

authors： Soleimani AH,Garg SM,Paiva IM,Vakili MR,Alshareef A,Huang YH,Molavi O,Lai R,Lavasanifar A

更新日期：2017-08-01 00:00:00