听力与言语-语言病理学

行为科学

医学伦理学

你正在浏览MOLECULAR CARCINOGENESIS期刊下所有文献
  • Silencing of UAP1L1 inhibits proliferation and induces apoptosis in esophageal squamous cell carcinoma.

    abstract::Esophageal squamous cell carcinoma (ESCC) is recognized as one of the malignant tumors with poor prognosis. UAP1L1 (UDP-N-acetylglucosamine-1-like-1) affects numerous biological processes, which is a key regulator of the development of malignant tumors. The biological function and molecular mechanism of UAP1L1 in ESCC...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章

    doi:10.1002/mc.23278

    authors: Xiao X,Jiang L,Hu H,Huang Y,Yang L,Jiao Y,Wei G

    更新日期:2021-01-12 00:00:00

  • RNA-seq reveals novel cancer-selective and disease subtype-independent mechanistic targets of withaferin A in human breast cancer cells.

    abstract::Withaferin A (WA) exhibits cancer chemopreventive efficacy in preclinical models representative of two different subtypes of breast cancer. However, the mechanism(s) underlying breast cancer chemoprevention by WA is not fully elucidated. We performed RNA-seq analyses using a non-tumorigenic mammary epithelial cell lin...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章

    doi:10.1002/mc.23266

    authors: Hahm ER,Kim SH,Singh KB,Singh SV

    更新日期:2021-01-01 00:00:00

  • Longitudinal change of metabolite profile and its relation to multiple risk factors for the risk of developing hepatitis B-related hepatocellular carcinoma.

    abstract::Despite considerable knowledge of viral pathogenesis, the pathophysiological changes related to the multifactorial, multistep process of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) development remains unclear. Longitudinal metabolomics study can reveal biological process for disease progression. We ...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章

    doi:10.1002/mc.23255

    authors: Huang BY,Tsai MR,Hsu JK,Lin CY,Lin CL,Hu JT,Huang YW,Liu CJ,Wu WJ,Wu CF,Sung FY,Chen PJ,Liang HJ,Lin SM,Yu MW

    更新日期:2020-11-01 00:00:00

  • SOX6 represses tumor growth of clear cell renal cell carcinoma by HMG domain-dependent regulation of Wnt/β-catenin signaling.

    abstract::Sex-determining region Y box (SOXs) are expressed in various cells and control cell fate and differentiation in a multitude of physiologic processes. SOX6, a main representative of SOXs, is involved in the regulation of carcinogenesis in various human malignancies. However, the role of SOX6 in clear cell renal cell ca...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章

    doi:10.1002/mc.23246

    authors: Chen L,Xie Y,Ma X,Zhang Y,Li X,Zhang F,Gao Y,Fan Y,Gu L,Wang L,Zhang X,Fu B

    更新日期:2020-10-01 00:00:00

  • Nicotinamide N-methyltransferase decreases 5-fluorouracil sensitivity in human esophageal squamous cell carcinoma through metabolic reprogramming and promoting the Warburg effect.

    abstract::Esophageal squamous cell carcinoma (ESCC) is a common malignant tumor with poor prognosis. And different individuals respond to the same drug differently. Increasing evidence has confirmed that metabolism reprogramming was involved in the drug sensitivity of tumor cells. However, the potential molecular mechanism of 5...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章

    doi:10.1002/mc.23209

    authors: Cui Y,Yang D,Wang W,Zhang L,Liu H,Ma S,Guo W,Yao M,Zhang K,Li W,Zhang Y,Guan F

    更新日期:2020-08-01 00:00:00

  • Immunogenic cell death in colon cancer prevention and therapy.

    abstract::Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide. The colonic mucosa constitutes a critical barrier and a major site of immune regulation. The immune system plays important roles in cancer development and treatment, and immune activation caused by chronic infection or inflammation is well-k...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章,评审

    doi:10.1002/mc.23183

    authors: Ruan H,Leibowitz BJ,Zhang L,Yu J

    更新日期:2020-07-01 00:00:00

  • The role of transforming growth factor-beta in immune suppression and chronic inflammation of squamous cell carcinomas.

    abstract::Despite a decline in the incidence of squamous cell carcinomas (SCCs) over the past 20 years, their survival rate has remained nearly the same, indicating that treatment options have not improved relative to other cancer types. Immunotherapies have a high potential for a sustained effect in SCC patients, but their res...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章,评审

    doi:10.1002/mc.23196

    authors: Strait AA,Wang XJ

    更新日期:2020-07-01 00:00:00

  • PCAT6 mediates cellular biological functions in gastrointestinal stromal tumor via upregulation of PRDX5 and activation of Wnt pathway.

    abstract::Gastrointestinal stromal tumor (GIST) is a common mesenchymal tumor in the gastrointestinal tract. Prostate cancer associated transcript 6 (PCAT6) is a long noncoding RNA (lncRNA) and plays a pivotal role in tumor formation. Present study was designed to explore the function of PCAT6 in GIST. Ki67 staining, colony for...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章

    doi:10.1002/mc.23199

    authors: Bai F,Zhang N,Fang W,He X,Zheng Y,Gu D

    更新日期:2020-06-01 00:00:00

  • New genetic variations discovered in KRAS wild-type cetuximab resistant chinese colorectal cancer patients.

    abstract::To perform a comprehensive genomic analysis of colorectal cancer (CRC) tumor to detect genetic variants and identify novel resistant mutations associated with cetuximab-resistance in CRC patients. A retrospective study was performed using whole exome sequencing (WES) to identify common genetic factors from 22 cetuxima...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章

    doi:10.1002/mc.23172

    authors: Jing C,Wang T,Ma R,Cao H,Wang Z,Liu S,Chen D,Zhang J,Wu Y,Zhang Y,Wu J,Feng J

    更新日期:2020-05-01 00:00:00

  • SOX2 upregulates side population cells and enhances their chemoresistant ability by transactivating ABCC1 expression contributing to intrinsic resistance to paclitaxel in melanoma.

    abstract::Paclitaxel is the last choice for the treatment of advanced melanoma as a second-line chemotherapeutic agent, but there are still many cases of intrinsic resistance to paclitaxel in melanoma and the reasons that cause paclitaxel resistance remain unclear. Here, we identified that high expression of SRY-box transcripti...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章

    doi:10.1002/mc.23148

    authors: Si X,Gao Z,Xu F,Zheng Y

    更新日期:2020-03-01 00:00:00

  • Attenuation of immune-mediated bone marrow damage in conventionally housed mice.

    abstract::In humans, bone marrow (BM) failure syndromes, both constitutional and acquired, predispose to myeloid malignancies. We have modeled acquired immune aplastic anemia, the paradigmatic disease of these syndromes, in the mouse by infusing lymph node cells from specific pathogen-free (SPF) CD45.1 congenic C57BL/6 (B6) don...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章

    doi:10.1002/mc.23151

    authors: Li J,Dubois W,Thovarai V,Wu Z,Feng X,Peat T,Zhang S,Sen SK,Trinchieri G,Chen J,Mock BA,Young NS

    更新日期:2020-02-01 00:00:00

  • circMTDH.4/miR-630/AEG-1 axis participates in the regulation of proliferation, migration, invasion, chemoresistance, and radioresistance of NSCLC.

    abstract::Astrocyte elevated gene-1 (AEG-1) plays a critical role in the development, progression, and metastasis of a variety of cancers, including non-small-cell lung cancer (NSCLC). The objective of the current study is to unravel the upstream signaling of AEG-1. A cohort of 28 NSCLC tissues and 30 normal tissues were collec...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章

    doi:10.1002/mc.23135

    authors: Li YH,Xu CL,He CJ,Pu HH,Liu JL,Wang Y

    更新日期:2020-02-01 00:00:00

  • LncRNA DANCR promotes tumor growth and angiogenesis in ovarian cancer through direct targeting of miR-145.

    abstract::Differentiation antagonizing non-protein coding RNA (DANCR) is a newly identified oncogenic long noncoding RNA found in various cancers. However, the functional role of DANCR in tumor angiogenesis and the underlying mechanisms are still unclear. The expression of DANCR was determined in ovarian malignant tissues and c...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章

    doi:10.1002/mc.23117

    authors: Lin X,Yang F,Qi X,Li Q,Wang D,Yi T,Yin R,Zhao X,Zhong X,Bian C

    更新日期:2019-12-01 00:00:00

  • IRX5 promotes colorectal cancer metastasis by negatively regulating the core components of the RHOA pathway.

    abstract::Colorectal cancer (CRC) is one of the most common malignant tumors worldwide. As tumor metastasis is the leading cause of death in patients with CRC, it is important to elucidate the molecular mechanisms that drive CRC metastasis. Studies have shown a close relationship between Iroquois homeobox (IRX) family genes and...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章

    doi:10.1002/mc.23098

    authors: Zhu Q,Wu Y,Yang M,Wang Z,Zhang H,Jiang X,Chen M,Jin T,Wang T

    更新日期:2019-11-01 00:00:00

  • AEBP1, a prognostic indicator, promotes colon adenocarcinoma cell growth and metastasis through the NF-κB pathway.

    abstract::The abnormal expression of adipocyte enhancer binding protein 1 (AEBP1) has been implicated in the carcinogenesis and progression of various types of human tumors. However, the role of AEBP1 in colon adenocarcinoma (COAD) remains largely unelucidated. In this study, we explored the clinical significance and biological...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章

    doi:10.1002/mc.23066

    authors: Xing Y,Zhang Z,Chi F,Zhou Y,Ren S,Zhao Z,Zhu Y,Piao D

    更新日期:2019-10-01 00:00:00

  • Targeting ERK beyond the boundaries of the kinase active site in melanoma.

    abstract::Extracellular signal-regulated kinase 1/2 (ERK1/2) constitute a point of convergence for complex signaling events that regulate essential cellular processes, including proliferation and survival. As such, dysregulation of the ERK signaling pathway is prevalent in many cancers. In the case of BRAF-V600E mutant melanoma...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章,评审

    doi:10.1002/mc.23047

    authors: Sammons RM,Ghose R,Tsai KY,Dalby KN

    更新日期:2019-09-01 00:00:00

  • Molecular and immune targets for Merkel cell carcinoma therapy and prevention.

    abstract::Merkel cell carcinoma (MCC) is a rare neuroendocrine carcinoma of the skin, for which the exact mechanisms of carcinogenesis remain unknown. Therapeutic options for this highly aggressive malignancy have historically been limited in both their initial response and response durability. Recent improvements in our unders...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章,评审

    doi:10.1002/mc.23042

    authors: Cohen L,Tsai KY

    更新日期:2019-09-01 00:00:00

  • Cancer-bone microenvironmental interactions promotes STAT3 signaling.

    abstract::Prostate cancer (PCa) patients' mortality is mainly attributed to complications caused by metastasis of the tumor cells to organs critical for survival, such as bone. We hypothesized that PCa cell-bone interactions would promote paracrine signaling. A panel of PCa cell lines were cocultured with hydroxyapatite ([HA]; ...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章

    doi:10.1002/mc.23019

    authors: Henderson VM,Hawsawi O,Burton LJ,Campbell T,Trice K,Dougan J,Howard SM,Odero-Marah VA

    更新日期:2019-08-01 00:00:00

  • Effects of supplemental calcium and vitamin D on tight-junction proteins and mucin-12 expression in the normal rectal mucosa of colorectal adenoma patients.

    abstract::The physical gut barrier, comprised of a thick mucus layer and the epithelium, plays an important role in defense against microbes and foreign antigens. Calcium and vitamin D may be involved in maintaining the integrity of the intestinal mucosal barrier, the dysfunction of which may lead to endotoxemia and inflammatio...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1002/mc.23010

    authors: Mandle HB,Jahan FA,Bostick RM,Baron JA,Barry EL,Yacoub R,Merrill J,Rutherford RE,Seabrook ME,Fedirko V

    更新日期:2019-07-01 00:00:00

  • Association of expression quantitative trait loci for long noncoding RNAs with lung cancer risk in Asians.

    abstract::Identification of long noncoding RNA (lncRNA) expression quantitative trait loci (lncR-eQTL) that associated with lung cancer can provide insights into regulatory mechanisms of lncRNA, and help reveal the role of lncRNA in lung cancer. A two-stage case-control design was implemented in this study. We first selected th...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章

    doi:10.1002/mc.23013

    authors: Sun Q,Wang Y,Fan J,Li Z,Zhang J,Wang L,Fan X,Ji M,Zhu M,Dai J,Ma H,Jin G,Hu Z,Shen H

    更新日期:2019-07-01 00:00:00

  • Molecular evidence supporting the precursor nature of atypical adenomatous hyperplasia of the prostate.

    abstract::Atypical adenomatous hyperplasia (AAH) of the prostate is characterized by lobular proliferation of closely packed small acini. It is hypothesized that AAH is a precursor lesion for low-grade prostate cancer arising from the transition zone. Telomere dysfunction is common during malignant transformation of epithelia. ...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章

    doi:10.1002/mc.23009

    authors: Cheng L,Montironi R,Davidson DD,Wang M,Lopez-Beltran A,Zhang S

    更新日期:2019-07-01 00:00:00

  • ETS1 is coexpressed with ZEB2 and mediates ZEB2-induced epithelial-mesenchymal transition in human tumors.

    abstract::Epithelial-mesenchymal transition (EMT) is an embryonic program that is reactivated in cancer and regulates the invasion and metastasis of tumor cells. Zinc finger E-box binding homeobox 2 (ZEB2) induces EMT by upregulating matrix metalloproteinases (MMP), yet MMP genes lack ZEB2 binding motif in their promoters. Rece...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章

    doi:10.1002/mc.22994

    authors: Yalim-Camci I,Balcik-Ercin P,Cetin M,Odabas G,Tokay N,Sayan AE,Yagci T

    更新日期:2019-06-01 00:00:00

  • Aurora B kinase as a novel molecular target for inhibition the growth of osteosarcoma.

    abstract::Osteosarcoma is the primary human malignant tumor affecting bone. This cancer most frequently arises in children and adolescents, with a second peak in those over the age of 50. Currently, surgery followed by radiotherapy and chemotherapy are the main treatments, but long-term positive effects are very poor. Aurora B ...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章

    doi:10.1002/mc.22993

    authors: Zhao Z,Jin G,Yao K,Liu K,Liu F,Chen H,Wang K,Gorja DR,Reddy K,Bode AM,Guo Z,Dong Z

    更新日期:2019-06-01 00:00:00

  • Epigenetic regulation of the human ATP2A3 gene promoter in gastric and colon cancer cell lines.

    abstract::The knowledge about the role of calcium-regulated pathways in cancer cell growth and differentiation could be useful for the development of new therapeutic approaches to diminish its mortality. The ATP2A genes encode for SERCA pumps, which modulate cytosolic Ca2+ concentration, regulating various cellular processes in...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章

    doi:10.1002/mc.22978

    authors: Meneses-Morales I,Izquierdo-Torres E,Flores-Peredo L,Rodríguez G,Hernández-Oliveras A,Zarain-Herzberg Á

    更新日期:2019-06-01 00:00:00

  • Antitumor effects of circ-EPHB4 in hepatocellular carcinoma via inhibition of HIF-1α.

    abstract::The protein EPHB4 plays a vital role in various tumor types. However, few studies into the function of circ-EPHB4 (hsa_circ_0001730) in tumors have been conducted. This study aimed to investigate the functions of circ-EPHB4 and the underlying mechanism of circ-EPHB4 in regulating hepatocellular carcinoma (HCC). The ex...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章

    doi:10.1002/mc.22976

    authors: Tan Y,Du B,Zhan Y,Wang K,Wang X,Chen B,Wei X,Xiao J

    更新日期:2019-06-01 00:00:00

  • Antitumor Effect of Periplocin in TRAIL-Resistant gastric cancer cells via upregulation of death receptor through activating ERK1/2-EGR1 pathway.

    abstract::Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), a member of the tumor necrosis factor family, induces apoptosis in a variety of cancer cells. However, gastric cancer (GC) cells are insensitive to TRAIL usually. In the previous study, we showed that Periplocin could induce apoptosis in GC cells via the...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章

    doi:10.1002/mc.22991

    authors: Zhao LM,Li L,Huang Y,Han LJ,Li D,Huo BJ,Dai SL,Xu LY,Zhan Q,Shan BE

    更新日期:2019-06-01 00:00:00

  • No difference in 4-nitroquinoline induced tumorigenesis between germ-free and colonized mice.

    abstract::Variations in oral bacterial communities have been linked to oral cancer suggesting that the oral microbiome is an etiological factor that can influence oral cancer development. The 4-nitroquinoline 1-oxide (4-NQO)-induced murine oral and esophageal cancer model is frequently used to assess the effects of preventive a...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章

    doi:10.1002/mc.22972

    authors: Zhou YX,Fuentes-Creollo G,Ponce F,Langley SA,Jen KY,Celniker SE,Mao JH,Snijders AM

    更新日期:2019-05-01 00:00:00

  • Uridine-cytidine kinase 2 upregulation predicts poor prognosis of hepatocellular carcinoma and is associated with cancer aggressiveness.

    abstract::Patients with advanced hepatocellular carcinoma (HCC) continue to have a dismal prognosis. Potential biomarkers to determine prognosis and select targeted therapies are urgently needed for patients with HCC. This study aimed to elucidate the role of UCK2 in HCC prognosis and tumor progression. We performed a screen of...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章

    doi:10.1002/mc.22954

    authors: Huang S,Li J,Tam NL,Sun C,Hou Y,Hughes B,Wang Z,Zhou Q,He X,Wu L

    更新日期:2019-04-01 00:00:00

  • The role of the hypoxia-Nrp-1 axis in the activation of M2-like tumor-associated macrophages in the tumor microenvironment of cervical cancer.

    abstract::To explore the mechanisms through which hypoxic tumor microenvironment (TME) modulates the transition of tumor-associated macrophages (TAMs). The migration ability of RAW264.7 macrophages was determined by transwell assay. Flow cytometric, western blot and immunofluorescence analyses of CD206 further validated the M2 ...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章

    doi:10.1002/mc.22936

    authors: Chen XJ,Wu S,Yan RM,Fan LS,Yu L,Zhang YM,Wei WF,Zhou CF,Wu XG,Zhong M,Yu YH,Liang L,Wang W

    更新日期:2019-03-01 00:00:00

  • Exportin-T promotes tumor proliferation and invasion in hepatocellular carcinoma.

    abstract::Exportin-T (XPOT) belongs to the RAN-GTPase exportin family that mediates export of tRNA from the nucleus to the cytoplasm. Up-regulation of XPOT indicates poor prognosis in breast cancer patients. However, the correlation between XPOT and hepatocellular carcinoma (HCC) remains unclear. Here, we found that high expres...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章

    doi:10.1002/mc.22928

    authors: Lin J,Hou Y,Huang S,Wang Z,Sun C,Wang Z,He X,Tam NL,Wu C,Wu L

    更新日期:2019-02-01 00:00:00

  • Magnolin targeting of ERK1/2 inhibits cell proliferation and colony growth by induction of cellular senescence in ovarian cancer cells.

    abstract::Ras/Raf/MEKs/ERKs and PI3 K/Akt/mTOR signaling pathways have key roles in cancer development and growth processes, as well as in cancer malignance and chemoresistance. In this study, we screened the therapeutic potential of magnolin using 15 human cancer cell lines and combined magnolin sensitivity with the CCLE mutao...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章

    doi:10.1002/mc.22909

    authors: Song JH,Lee CJ,An HJ,Yoo SM,Kang HC,Lee JY,Kim KD,Kim DJ,Lee HS,Cho YY

    更新日期:2019-01-01 00:00:00

  • Harnessing the gatekeepers of glucocorticoids for chemoprevention of non-melanoma skin cancer.

    abstract::Despite effective surgical methods for non-melanoma skin cancer (NMSC), patients suffer from tissue damage, scarring, or even disfigurement; thus, there is a need for chemopreventive approaches. Because of the complex interplay between glucocorticoids (GCs), inflammation, and cancer, we sought to determine the role of...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章

    doi:10.1002/mc.22912

    authors: Mancha-Ramirez AM,Yang X,Liang H,Junco J,Lee KP,Bovio SF,Espinoza M,Wool J,Slaga A,Glade DC,Hanes M,Malik G,Kim DJ,DiGiovanni J,Slaga TJ

    更新日期:2019-01-01 00:00:00

  • Dual use of hematopoietic and mesenchymal stem cells enhances engraftment and immune cell trafficking in an allogeneic humanized mouse model of head and neck cancer.

    abstract::In this report, we describe in detail the evolving procedures to optimize humanized mouse cohort generation, including optimal conditioning, choice of lineage for engraftment, threshold for successful engraftment, HNSCC tumor implantation, and immune and stroma cell analyses. We developed a dual infusion protocol of h...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章

    doi:10.1002/mc.22887

    authors: Morton JJ,Keysar SB,Perrenoud L,Chimed TS,Reisinger J,Jackson B,Le PN,Nieto C,Gomez K,Miller B,Gao D,Somerset H,Wang XJ,Jimeno A

    更新日期:2018-11-01 00:00:00

  • Protein interactions of FAM134B with EB1 and APC/beta-catenin in vitro in colon carcinoma.

    abstract::FAM134B is an autophagy regulator of endoplasmic reticulum and acts as a cancer suppressor in colon cancer. However, the molecular signaling pathways by which FAM134B interacts within colon carcinogenesis is still unknown. Herein, this study aims to determine the interacting partners of FAM134B for the first time in c...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章

    doi:10.1002/mc.22871

    authors: Islam F,Chaousis S,Wahab R,Gopalan V,Lam AK

    更新日期:2018-11-01 00:00:00

  • Targeting HSP60 by subcutaneous injections of jetPEI/HSP60-shRNA destabilizes cytoplasmic survivin and inhibits hepatocellular carcinoma growth.

    abstract::Heat shock protein 60 (HSP60) overexpresses in various types of cancer, but its expression levels and functions in hepatocellular carcinoma (HCC) are still in dispute. We aim to clarify this issue and examine whether HSP60 could be a therapeutic target for HCC. We found drastically enhanced cell apoptosis and suppress...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章

    doi:10.1002/mc.22827

    authors: Huang YH,Lin KH,Yu JS,Wu TJ,Lee WC,Chao CC,Pan TL,Yeh CT

    更新日期:2018-09-01 00:00:00

  • Overexpression of SHCBP1 promotes migration and invasion in gliomas by activating the NF-κB signaling pathway.

    abstract::Gliomas are common, aggressive central nervous system tumors with poor overall survival rates. Despite improvements in neurosurgery, chemotherapy, and radiotherapy, the outcomes of patients with malignant gliomas remain poor. Therefore, increased knowledge of the molecular mechanisms that regulate glioma progression i...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章

    doi:10.1002/mc.22834

    authors: Zhou Y,Tan Z,Chen K,Wu W,Zhu J,Wu G,Cao L,Zhang X,Zeng X,Li J,Zhang W

    更新日期:2018-09-01 00:00:00

  • Identification of chromatin-accessible domains in non-alcoholic steatohepatitis-derived hepatocellular carcinoma.

    abstract::Non-alcoholic steatohepatitis (NASH) is becoming one of the major causes of hepatocellular carcinoma (HCC) in the United States and Western countries; however, the molecular mechanisms associated with NASH-related liver carcinogenesis are not well understood. In the present study, we investigated cancer-associated chr...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章

    doi:10.1002/mc.22818

    authors: Dechassa ML,Tryndyak V,de Conti A,Xiao W,Beland FA,Pogribny IP

    更新日期:2018-08-01 00:00:00

  • Phenylbutyl isoselenocyanate induces reactive oxygen species to inhibit androgen receptor and to initiate p53-mediated apoptosis in LNCaP prostate cancer cells.

    abstract::Previous studies have established the in vivo bioavailability and efficacious dosages of phenylbutyl isoselenocyanate (ISC-4), a selenium-substituted isothiocyanate, against mouse xenograft models of human melanoma and colorectal cancer. To explore its potential attributes against prostate cancer, we treated human LNC...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章

    doi:10.1002/mc.22825

    authors: Wu W,Karelia D,Pramanik K,Amin SG,Sharma AK,Jiang C,Lu J

    更新日期:2018-08-01 00:00:00

  • Deciphering the biochemical and molecular mechanism underlying the in vitro and in vivo chemotherapeutic efficacy of ruthenium quercetin complex in colon cancer.

    abstract::Flavonoids are the most investigated phytochemicals due to their pharmacological and therapeutic activities. Their ability to chelate with metal ions has resulted in the emergence of a new category of molecules with a broader spectrum of pharmacological activities. In this study, the ruthenium quercetin complex has be...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章

    doi:10.1002/mc.22792

    authors: Roy S,Das R,Ghosh B,Chakraborty T

    更新日期:2018-06-01 00:00:00

  • Triptolide sensitizes breast cancer cells to Doxorubicin through the DNA damage response inhibition.

    abstract::Triptolide is an active component from a Chinese herb, Tripterygium wilfordii which has been applied for treating immune-related diseases over centuries. Recently, it was reported that a variety of cancer cell lines could be sensitized to DNA-damage based chemotherapy drugs in combination with Triptolide treatment. In...

    journal_title:Molecular carcinogenesis

    pub_type: 杂志文章

    doi:10.1002/mc.22795

    authors: Deng Y,Li F,He P,Yang Y,Yang J,Zhang Y,Liu J,Tong Y,Li Q,Mei X,Shu Z,Zhao Q

    更新日期:2018-06-01 00:00:00

350 条记录 1/9 页 « 123456789 »