Epigenetic regulation of the human ATP2A3 gene promoter in gastric and colon cancer cell lines.

abstract：:We examined whether betulin, a naturally abundant compound, has anticancer functions in human cancer cells. The results showed that betulin significantly inhibited cell viability in cervix carcinoma HeLa cells, hepatoma HepG2 cells, lung adenocarcinoma A549 cells, and breast cancer MCF-7 cells with IC(50) values rangi...

journal_title：Molecular carcinogenesis

authors： Li Y,He K,Huang Y,Zheng D,Gao C,Cui L,Jin YH

更新日期：2010-07-01 00:00:00

abstract：:As the prognostic significance of the three most frequently amplified oncogenes in breast cancer (c-myc, int-2/FGF3, and c-erbB-2/neu) is still unclear, and as the amplification of these genes appears to be mutually exclusive, we investigated the prognostic significance of oncogene amplification per se by multivariate...

journal_title：Molecular carcinogenesis

authors： Champème MH,Bièche I,Hacène K,Lidereau R

更新日期：1994-12-01 00:00:00

abstract：:Benzo[alpha]pyrene-7,8-diol-9,10-epoxide (B[a]PDE), the major metabolite of benzo[a]pyrene (B[a]P), shows an ultimate complete carcinogen in various animals and is a causative agent for human cancers. However, its effects on the activation of signal pathways and the expression of genes involved in its carcinogenic eff...

journal_title：Molecular carcinogenesis

authors： Ouyang W,Ma Q,Li J,Zhang D,Ding J,Huang Y,Xing MM,Huang C

更新日期：2007-01-01 00:00:00

abstract：:Several studies have shown that E-cadherin expression is lost during malignant transformation. We hypothesized that CpG methylation in the promoter region may inactivate the expression of the E-cadherin gene in human bladder cancer. Normal and bladder cancer samples from 51 patients were compared in terms of E-cadheri...

journal_title：Molecular carcinogenesis

authors： Ribeiro-Filho LA,Franks J,Sasaki M,Shiina H,Li LC,Nojima D,Arap S,Carroll P,Enokida H,Nakagawa M,Yonezawa S,Dahiya R

更新日期：2002-08-01 00:00:00

abstract：:Heterocyclic amines present in cooked foods are known to produce colon tumors in F344 rats at a high incidence, indicating the possibility of involvement of ras gene activation in colon carcinogenesis in rats as in humans. We examined mutations at codons 12, 13, and 61 of the Ki-ras, Ha-ras, and N-ras genes by polymer...

journal_title：Molecular carcinogenesis

authors： Kakiuchi H,Ushijima T,Ochiai M,Imai K,Ito N,Yachi A,Sugimura T,Nagao M

更新日期：1993-01-01 00:00:00

abstract：:The Ron receptor tyrosine kinase is overexpressed in approximately half of all human colon cancers. Increased Ron expression positively correlates with tumor progression, and reduction of Ron levels in human colon adenocarcinoma cells reverses their tumorigenic properties. Nearly all colon tumors demonstrate loss of t...

journal_title：Molecular carcinogenesis

authors： Meyer SE,Waltz SE,Goss KH

更新日期：2009-11-01 00:00:00

abstract：:Chromosomal double-strand breaks (DSBs) occurring in mammalian cells can initiate genomic instability, and their misrepairs result in chromosomal deletion, amplification, and translocation, common findings in human tumors. The tumor-suppressor protein p53 is involved in maintaining genomic stability. In this study, we...

journal_title：Molecular carcinogenesis

authors： Honma M,Momose M,Tanabe H,Sakamoto H,Yu Y,Little JB,Sofuni T,Hayashi M

更新日期：2000-08-01 00:00:00

abstract：:The cellular senescence program is controlled by multiple genetic pathways, one of which involves the regulation of telomerase and telomere shortening. The introduction of a normal human chromosome 3 into the human renal cell carcinoma cell line RCC23 caused repression of telomerase activity, progressive shortening of...

journal_title：Molecular carcinogenesis

authors： Horikawa I,Oshimura M,Barrett JC

更新日期：1998-06-01 00:00:00

abstract：:Recent studies of the individual functionalities of long non-coding RNAs (lncRNAs) in the development and progression of cancer have suggested that HOX transcript antisense RNA (HOTAIR) is capable of reprogramming chromatin organization and promoting cancer cell metastasis. In order to ascertain the expression pattern...

journal_title：Molecular carcinogenesis

authors： Chen FJ,Sun M,Li SQ,Wu QQ,Ji L,Liu ZL,Zhou GZ,Cao G,Jin L,Xie HW,Wang CM,Lv J,De W,Wu M,Cao XF

更新日期：2013-11-01 00:00:00

abstract：:Composition of extracellular matrix (ECM) is crucial to the establishment and maintenance of epithelial apical-basolateral polarity. Increased ECM rigidity caused by deposition of fibrillar collagen, for example, collagen type I (Col-1), promotes loss of epithelial polarity and tumor progression. microRNAs are small n...

journal_title：Molecular carcinogenesis

authors： Li C,Nguyen HT,Zhuang Y,Lin Y,Flemington EK,Guo W,Guenther J,Burow ME,Morris GF,Sullivan D,Shan B

更新日期：2011-07-01 00:00:00

abstract：:Adenocarcinoma accounts for ∼40% of lung cancer, equating to ∼88 500 new patients in 2015, most of who will succumb to this disease, thus, the public health burden is evident. Unfortunately, few early biomarkers as well as effective therapies exist, hence the need for novel targets in lung cancer treatment. We previou...

journal_title：Molecular carcinogenesis

authors： Bauer AK,Velmurugan K,Xiong KN,Alexander CM,Xiong J,Brooks R

更新日期：2017-01-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF alpha) can function as both an autocrine and a paracrine growth factor and may therefore play a role in ovarian tumor progression. TNF alpha initiates multiple cellular responses, many of which are mediated through the mitogen-activated protein kinase pathways, which transduce signals ...

journal_title：Molecular carcinogenesis

authors： Yazlovitskaya EM,Pelling JC,Persons DL

更新日期：1999-05-01 00:00:00

abstract：:BCL2L10 is an apoptosis-related member of the BCL-2 protein family. The role of BCL2L10 in the pathogenesis of hepatocellular carcinoma (HCC) is poorly understood. This study was aimed to investigate the function and underlying mechanisms of BCL2L10 in HCC. BCL2L10 expression in human HCC and corresponding adjacent no...

journal_title：Molecular carcinogenesis

authors： Bai Y,Wang J,Han J,Xie XL,Ji CG,Yin J,Chen L,Wang CK,Jiang XY,Qi W,Jiang HQ

更新日期：2017-03-01 00:00:00

abstract：:The extracellular signal-regulated kinase (ERK), mitogen-activated protein kinase (MAPK) pathway is an important cell proliferation pathway. We previously reported that the transport protein particle complex 4 (TRAPPC4), ERK2 interaction may activate ERK1/2, modulate pERK2 nuclear localization and regulate proliferati...

journal_title：Molecular carcinogenesis

authors： Weng YR,Kong X,Yu YN,Wang YC,Hong J,Zhao SL,Fang JY

更新日期：2014-02-01 00:00:00

abstract：:Reports on the association of TP53 polymorphisms with oral cancer are not only limited but also not specific to site and/or gender. Hence, we examined the effect of TP53 polymorphisms (EX4 215G>C, IVS3+40-41ins16 and IVS6+62G>A) on buccal mucosa cancer (BMC) and tongue cancer (TC) risk, survival of patients in relatio...

journal_title：Molecular carcinogenesis

authors： Nagam SL,Katta S,Prasad VV

更新日期：2017-03-01 00:00:00

abstract：:Because oxidative processes can participate in tumor promotion, it is likely that the cellular antioxidant defense also plays a role. We have compared the levels of the three major antioxidant enzymes, Cu,Zn-superoxide dismutase (SOD), catalase and glutathione peroxidase (GPx), in promotable mouse epidermal JB6 cells ...

journal_title：Molecular carcinogenesis

authors： Crawford DR,Amstad PA,Foo DD,Cerutti PA

更新日期：1989-01-01 00:00:00

abstract：:AMP-activated protein kinase (AMPK) is a cellular energy sensor that is conserved in eukaryotes. Although AMPK is traditionally thought to play a major role in the regulation of cellular lipid and protein metabolism, recent discoveries reveal that AMPK inhibits mammalian target of rapamycin (mTOR) signaling and connec...

journal_title：Molecular carcinogenesis

authors： Tong X,Smith KA,Pelling JC

更新日期：2012-03-01 00:00:00

abstract：:Chloride intracellular channel 4 (CLIC4) is a putative chloride channel for intracellular organelles. CLIC4 has biological activities in addition to or because of its channel activity. In keratinocytes, CLIC4 resides in the mitochondria and cytoplasm, and CLIC4 gene expression is regulated by p53, TNF-alpha, and c-Myc...

journal_title：Molecular carcinogenesis

authors： Suh KS,Malik M,Shukla A,Yuspa SH

更新日期：2007-08-01 00:00:00

abstract：:Ras-mediated transformation is associated with upregulation of cyclooxygenase-2 (COX-2), which in turn promotes prostaglandin E2 (PGE2) synthesis and secretion. Although recent studies have identified molecular mechanisms by which Ras mediates upregulation of COX-2, conflicting observations have been made. Furthermore...

journal_title：Molecular carcinogenesis

authors： Repasky GA,Zhou Y,Morita S,Der CJ

更新日期：2007-12-01 00:00:00

abstract：:Flavonoids are the most investigated phytochemicals due to their pharmacological and therapeutic activities. Their ability to chelate with metal ions has resulted in the emergence of a new category of molecules with a broader spectrum of pharmacological activities. In this study, the ruthenium quercetin complex has be...

journal_title：Molecular carcinogenesis

authors： Roy S,Das R,Ghosh B,Chakraborty T

更新日期：2018-06-01 00:00:00

abstract：:Prostate cancer (PCA) is the second most malignancy in American men. Advanced stage PCA cells possess unlimited replication potential as well as resistance to apoptosis. Therefore, targeting survival mechanisms and activating apoptotic machinery in PCA cells using nontoxic phytochemicals is suggested as an attractive ...

journal_title：Molecular carcinogenesis

authors： Deep G,Gangar SC,Oberlies NH,Kroll DJ,Agarwal R

更新日期：2010-10-01 00:00:00

abstract：:Liver tumor initiating cells (TICs), a small subset cells in tumor bulk, are responsible for liver tumor initiation, metastasis, and relapse. However, the regulatory mechanism of liver TICs remains largely unknown. Here we found a long noncoding RNA lncAPC, locating near from APC locus, was highly expressed in liver c...

journal_title：Molecular carcinogenesis

authors： Fu X,Lin J,Qin F,Yang Z,Ding Y,Zhang Y,Han L,Zhu X,Zhang Q

更新日期：2018-03-01 00:00:00

abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), a member of the tumor necrosis factor family, induces apoptosis in a variety of cancer cells. However, gastric cancer (GC) cells are insensitive to TRAIL usually. In the previous study, we showed that Periplocin could induce apoptosis in GC cells via the...

journal_title：Molecular carcinogenesis

authors： Zhao LM,Li L,Huang Y,Han LJ,Li D,Huo BJ,Dai SL,Xu LY,Zhan Q,Shan BE

更新日期：2019-06-01 00:00:00

abstract：:Angiogenesis is a prerequisite for progression of cancers. The number of genes linked to angiogenesis suggests the existence of complex gene-networks, which remain to be elucidated. To identify angiogenesis genes deregulated in carcinomas, we performed a meta-profiling analysis of published gene expression microarray ...

journal_title：Molecular carcinogenesis

authors： Anders M,Fehlker M,Wang Q,Wissmann C,Pilarsky C,Kemmner W,Höcker M

更新日期：2013-01-01 00:00:00

abstract：:Studies with murine models suggest that maternal exposure to aromatic hydrocarbon receptor (AhR) agonists may impair mammary gland differentiation and increase the susceptibility to mammary carcinogenesis in offspring. However, the molecular mechanisms responsible for these perturbations remain largely unknown. Previo...

journal_title：Molecular carcinogenesis

authors： Papoutsis AJ,Selmin OI,Borg JL,Romagnolo DF

更新日期：2015-04-01 00:00:00

abstract：:Sex-determining region Y box (SOXs) are expressed in various cells and control cell fate and differentiation in a multitude of physiologic processes. SOX6, a main representative of SOXs, is involved in the regulation of carcinogenesis in various human malignancies. However, the role of SOX6 in clear cell renal cell ca...

journal_title：Molecular carcinogenesis

authors： Chen L,Xie Y,Ma X,Zhang Y,Li X,Zhang F,Gao Y,Fan Y,Gu L,Wang L,Zhang X,Fu B

更新日期：2020-10-01 00:00:00

abstract：:Tumor-associated stromal cells are dynamic characters that endorse the carcinogenic process in a multitude of ways. The tumor microenvironment plays a crucial role throughout the tumor progression, which includes initiation, growth, invasion, and metastasis. The tumor microenvironment consists of cellular and non-cell...

journal_title：Molecular carcinogenesis

authors： Spaw M,Anant S,Thomas SM

更新日期：2017-04-01 00:00:00

abstract：:Mutational activation of RAS proteins occurs in nearly 30% of all human tumors. To date direct pharmacological inhibition of RAS oncoproteins has not been possible. As a consequence, current strategies are focusing on the development of inhibitors that target those kinases acting downstream of RAS proteins, including ...

journal_title：Molecular carcinogenesis

authors： Urosevic J,Sum EY,Moneo V,Drosten M,Dhawahir A,Becerra M,Carnero A,Barbacid M

更新日期：2009-11-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is frequently over-expressed in human cancers and is associated with tumorigenesis, and increased tumor proliferation and progression. Also found in breast tumors with high levels is B-Myb, a transcription factor whose expression is activated b...

journal_title：Molecular carcinogenesis

authors： Hanada N,Lo HW,Day CP,Pan Y,Nakajima Y,Hung MC

更新日期：2006-01-01 00:00:00

abstract：:Gap junctions are cellular structures which permit direct exchanges of small molecules from cytoplasm to cytoplasm in most of the cells of metazoan organisms. For four decades, it has been observed that the inhibition of this type of intercellular communication is often associated with tumorigenesis. The assumption th...

journal_title：Molecular carcinogenesis

authors： Mennecier G,Derangeon M,Coronas V,Hervé JC,Mesnil M

更新日期：2008-05-01 00:00:00