Abstract:
:Gliomas are common, aggressive central nervous system tumors with poor overall survival rates. Despite improvements in neurosurgery, chemotherapy, and radiotherapy, the outcomes of patients with malignant gliomas remain poor. Therefore, increased knowledge of the molecular mechanisms that regulate glioma progression is crucial to identify novel therapeutic targets. Here, we reported that SHCBP1, a member of Src homolog and collagen homolog (Shc) family, was significantly overexpressed in glioma tissues and glioma cell lines compared to the corresponding normal tissues and cells. Ectopic overexpression of SHCBP1 promoted glioma cell migration and invasion, whereas knockdown of endogenous SHCBP1 had the opposite effects. Importantly, we demonstrated that SHCBP1 promoted aggressiveness in gliomas by activating the NF-κB signaling pathway. Collectively, our study indicates that SHCBP1 plays a pivotal role to promote progression in gliomas and targeting the oncogenic effects of SHCBP1 may provide a clinical strategy to treat gliomas.
journal_name
Mol Carcinogjournal_title
Molecular carcinogenesisauthors
Zhou Y,Tan Z,Chen K,Wu W,Zhu J,Wu G,Cao L,Zhang X,Zeng X,Li J,Zhang Wdoi
10.1002/mc.22834subject
Has Abstractpub_date
2018-09-01 00:00:00pages
1181-1190issue
9eissn
0899-1987issn
1098-2744journal_volume
57pub_type
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