abstract：OBJECTIVE:T cell activation triggers metabolic reprogramming to meet increased demands for energy and metabolites required for cellular proliferation. Ethanolamine phospholipid synthesis has emerged as a regulator of metabolic shifts in stem cells and cancer cells, which led us to investigate its potential role during ...

journal_title：Molecular metabolism

authors： Ma C,Hoffmann FW,Marciel MP,Page KE,Williams-Aduja MA,Akana ENL,Gojanovich GS,Gerschenson M,Urschitz J,Moisyadi S,Khadka VS,Rozovsky S,Deng Y,Horgen FD,Hoffmann PR

更新日期：2021-01-20 00:00:00

abstract：BACKGROUND:The abundance of energy metabolites is intimately interconnected with the activity of chromatin-modifying enzymes in order to guarantee the finely tuned modulation of gene expression in response to cellular energetic status. Metabolism-induced epigenetic gene regulation is a key molecular axis for the mainte...

journal_title：Molecular metabolism

authors： Roberti A,Fernández AF,Fraga MF

更新日期：2021-01-14 00:00:00

abstract：OBJECTIVE:Heart disease risk can be programmed by intrauterine exposure to obesity. Dysregulating key transcription factors in cardiac progenitors can cause subsequent adult-onset heart disease. In this study, we investigated the transcriptional pathways that are altered in the embryonic heart and linked to heart disea...

journal_title：Molecular metabolism

authors： Ahmed A,Liang M,Chi L,Zhou YQ,Sled JG,Wilson MD,Delgado-Olguín P

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVE:Increasing muscle mass and activating beige fat both have great potential for ameliorating obesity and its comorbidities. Myostatin null mice have increased skeletal muscle mass and are protected from obesity and its sequelae. Deletion of myostatin has also been suggested to result in the activation of beige ...

journal_title：Molecular metabolism

authors： Marchildon F,Chi J,O'Connor S,Bediako H,Cohen P

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVES:Preferential damage to fast, glycolytic myofibers is common in many muscle-wasting diseases, including Duchenne muscular dystrophy (DMD). Promoting an oxidative phenotype could protect muscles from damage and ameliorate the dystrophic pathology with therapeutic relevance, but developing efficacious strategie...

journal_title：Molecular metabolism

authors： Hardee JP,Martins KJB,Miotto PM,Ryall JG,Gehrig SM,Reljic B,Naim T,Chung JD,Trieu J,Swiderski K,Philp AM,Philp A,Watt MJ,Stroud DA,Koopman R,Steinberg GR,Lynch GS

更新日期：2020-12-24 00:00:00

abstract：BACKGROUND:Non-alcoholic steatohepatitis (NASH) is a spectrum of histological liver pathologies ranging from hepatocyte fat accumulation, hepatocellular ballooning, lobular inflammation, and pericellular fibrosis. Based on early investigations, it was discovered that visceral fat accumulation, hepatic insulin resistanc...

journal_title：Molecular metabolism

authors： Finan B,Parlee SD,Yang B

更新日期：2020-12-23 00:00:00

abstract：OBJECTIVE:Aging and weight gain lead to a decline in brown and beige adipocyte functionality that exacerbates obesity and insulin resistance. We sought to determine whether sphingolipids, such as ceramides, a class of lipid metabolites that accumulate in aging and overnutrition, are sufficient or necessary for the meta...

journal_title：Molecular metabolism

authors： Chaurasia B,Ying L,Talbot CL,Maschek JA,Cox J,Schuchman EH,Hirabayashi Y,Holland WL,Summers SA

更新日期：2020-12-19 00:00:00

abstract：OBJECTIVES:The skin is the largest sensory organ of the human body and plays a fundamental role in regulating body temperature. However, adaptive alterations in skin functions and morphology have only vaguely been associated with physiological responses to cold stress or sensation of ambient temperatures. We previously...

journal_title：Molecular metabolism

authors： Neess D,Kruse V,Marcher AB,Wæde MR,Vistisen J,Møller PM,Petersen R,Brewer JR,Ma T,Colleluori G,Severi I,Cinti S,Gerhart-Hines Z,Mandrup S,Færgeman NJ

更新日期：2020-12-18 00:00:00

abstract：OBJECTIVE:Increasing adaptive thermogenesis by stimulating browning in white adipose tissue is a promising method of improving metabolic health. However, the molecular mechanisms underlying this transition remain elusive. Our study examined the molecular determinants driving the differentiation of precursor cells into ...

journal_title：Molecular metabolism

authors： Rabiee A,Plucińska K,Isidor MS,Brown EL,Tozzi M,Sidoli S,Petersen PSS,Agueda-Oyarzabal M,Torsetnes SB,Chehabi GN,Lundh M,Altıntaş A,Barrès R,Jensen ON,Gerhart-Hines Z,Emanuelli B

更新日期：2020-12-05 00:00:00

abstract：OBJECTIVE:Dedifferentiation of pancreatic β-cells may reduce islet function in type 2 diabetes (T2D). However, the prevalence, plasticity and functional consequences of this cellular state remain unknown. METHODS:We employed single-cell RNAseq to detail the maturation program of α- and β-cells during human ontogeny. W...

journal_title：Molecular metabolism

authors： Avrahami D,Wang YJ,Schug J,Feleke E,Gao L,Liu C,HPAP Consortium.,Naji A,Glaser B,Kaestner KH

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVE:The mechanisms behind the efficacy of bariatric surgery (BS) for treating obesity and type 2 diabetes, particularly with respect to the influence of the small bowel, remain poorly understood. In vitro and animal models are suboptimal with respect to their ability to replicate the human intestinal epithelium u...

journal_title：Molecular metabolism

authors： Hasan NM,Johnson KF,Yin J,Baetz NW,Fayad L,Sherman V,Blutt SE,Estes MK,Kumbhari V,Zachos NC,Kovbasnjuk O

更新日期：2020-11-25 00:00:00

abstract：BACKGROUND:Diabetes is one of the greatest public health challenges worldwide, and we still lack complementary approaches to significantly enhance the efficacy of preventive and therapeutic approaches. Genetic and environmental factors are the culprits involved in diabetes risk. Evidence from the last decade has highli...

journal_title：Molecular metabolism

authors： Diedisheim M,Carcarino E,Vandiedonck C,Roussel R,Gautier JF,Venteclef N

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVE:Adaptive thermogenesis, which is partly mediated by sympathetic input on brown adipose tissue (BAT), is a mechanism of heat production that confers protection against prolonged cold exposure. Various endogenous stimuli, for example, norepinephrine and FGF-21, can also promote the conversion of inguinal white ...

journal_title：Molecular metabolism

authors： Diallo K,Dussault S,Noll C,Lopez AF,Rivard A,Carpentier AC,Lim GE

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Poly-ADP-ribose polymerases (PARPs) are key mediators of cellular stress response. They are intimately linked to cellular metabolism through the consumption of NAD+. PARP1/ARTD1 in the nucleus is the major NAD+ consuming activity and plays a key role in maintaining genomic integrity. SCOPE OF REVIEW:In this...

journal_title：Molecular metabolism

authors： Hurtado-Bagès S,Knobloch G,Ladurner AG,Buschbeck M

更新日期：2020-08-01 00:00:00

abstract：OBJECTIVE:A sustained high fat diet in mice mimics many features of human obesity. We used male and female Non-Swiss albino mice to investigate the impact of short and long-term high-fat diet-(HFD)-induced obesity on the peripheral neuromuscular junction (NMJ) and whether obesity-related synaptic structural alterations...

journal_title：Molecular metabolism

authors： Martinez-Pena Y Valenzuela I,Akaaboune M

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Polycystic ovary syndrome (PCOS) is the most common endocrinopathy among reproductive age women. Although its cardinal manifestations include hyperandrogenism, oligo/anovulation, and/or polycystic ovarian morphology, PCOS women often display also notable metabolic comorbidities. An array of pathogenic mechan...

journal_title：Molecular metabolism

authors： Sanchez-Garrido MA,Tena-Sempere M

更新日期：2020-05-01 00:00:00

abstract：OBJECTIVE:Estrogen receptor-α (ERα) is a nuclear receptor family member thought to substantially contribute to the metabolic regulation of skeletal muscle. However, previous mouse models utilized to assess the necessity of ERα signaling in skeletal muscle were confounded by altered developmental programming and/or infl...

journal_title：Molecular metabolism

authors： Iñigo MR,Amorese AJ,Tarpey MD,Balestrieri NP,Jones KG,Patteson DJ,Jackson KC,Torres MJ,Lin CT,Smith CD,Heden TD,McMillin SL,Weyrauch LA,Stanley EC,Schmidt CA,Kilburg-Basnyat BB,Reece SW,Psaltis CE,Leinwand LA,Funai

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVES:Nutrient sensing by hypothalamic neurons is critical for the regulation of food intake and energy expenditure. We aimed to identify long- and medium-chain fatty acid species transported into the brain, their effects on energy balance, and the mechanisms by which they regulate activity of hypothalamic neurons...

journal_title：Molecular metabolism

authors： Haynes VR,Michael NJ,van den Top M,Zhao FY,Brown RD,De Souza D,Dodd GT,Spanswick D,Watt MJ

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:The TP53 gene is one of the most commonly inactivated tumor suppressors in human cancers. p53 functions during cancer progression have been linked to a variety of transcriptional and non-transcriptional activities that lead to the tight control of cell proliferation, senescence, DNA repair, and cell death. H...

journal_title：Molecular metabolism

authors： Lacroix M,Riscal R,Arena G,Linares LK,Le Cam L

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Modern lifestyles, especially high-caloric intake and physical inactivity, contribute to the increased prevalence of non-alcoholic fatty liver disease (NAFLD), which becomes a significant health problem worldwide. Lifestyle changes, however, affect not only parental generation, but also their offspring, rein...

journal_title：Molecular metabolism

authors： Stevanović J,Beleza J,Coxito P,Ascensão A,Magalhães J

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVE:The glycoprotein hormone erythropoietin (EPO) is required for erythropoiesis, and the kidney is the primary site of adult EPO synthesis. Limited evidence has suggested that EPO could be detectable in the brain under certain conditions, but it remains unknown if the brain might have its own EPO system for biol...

journal_title：Molecular metabolism

authors： Wang Z,Khor S,Cai D

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVE:Fasting results in major metabolic changes including a switch from glycogenolysis to gluconeogenesis to maintain glucose homeostasis. However, the relationship between the length of fasting and the relative contribution of gluconeogenic substrates remains unclear. We investigated the relative contribution of ...

journal_title：Molecular metabolism

authors： Wang Y,Kwon H,Su X,Wondisford FE

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVES:Hepatokines are proteins secreted by the liver that impact the functions of the liver and various tissues through autocrine, paracrine, and endocrine signaling. Recently, Tsukushi (TSK) was identified as a new hepatokine that is induced by obesity and cold exposure. It was proposed that TSK controls sympathe...

journal_title：Molecular metabolism

authors： Mouchiroud M,Camiré É,Aldow M,Caron A,Jubinville É,Turcotte L,Kaci I,Beaulieu MJ,Roy C,Labbé SM,Varin TV,Gélinas Y,Lamothe J,Trottier J,Mitchell PL,Guénard F,Festuccia WT,Joubert P,Rose CF,Karvellas CJ,Barbier O,

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVE:Despite the large body of work describing the tumor suppressor functions of Phosphatase and tensin homologue deleted on chromosome ten (PTEN), its roles in adipose homeostasis of adult animals are not yet fully understood. Here, we sought to determine the role of PTEN in whole-body adipose homeostasis. METHO...

journal_title：Molecular metabolism

authors： Huang W,Queen NJ,McMurphy TB,Ali S,Cao L

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVE:Enteroendocrine cells (EECs) of the gastro-intestinal tract sense gut luminal factors and release peptide hormones or serotonin (5-HT) to coordinate energy uptake and storage. Our goal is to decipher the gene regulatory networks controlling EECs specification from enteroendocrine progenitors. In this context,...

journal_title：Molecular metabolism

authors： Piccand J,Vagne C,Blot F,Meunier A,Beucher A,Strasser P,Lund ML,Ghimire S,Nivlet L,Lapp C,Petersen N,Engelstoft MS,Thibault-Carpentier C,Keime C,Correa SJ,Schreiber V,Molina N,Schwartz TW,De Arcangelis A,Gradwohl G

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVE:Glucose-dependent insulinotropic polypeptide (GIP) is secreted from the gut in response to nutrient ingestion and promotes meal-dependent insulin secretion and lipid metabolism. Loss or attenuation of GIP receptor (GIPR) action leads to resistance to diet-induced obesity through incompletely understood mechan...

journal_title：Molecular metabolism

authors： Beaudry JL,Kaur KD,Varin EM,Baggio LL,Cao X,Mulvihill EE,Bates HE,Campbell JE,Drucker DJ

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVE:The sympathetic nervous system (SNS) is a key regulator of the metabolic and endocrine functions of adipose tissue. Increased SNS outflow promotes fat mobilization, stimulates non-shivering thermogenesis, promotes browning, and inhibits leptin production. Most of these effects are attributed to norepinephrine...

journal_title：Molecular metabolism

authors： Caron A,Reynolds RP,Castorena CM,Michael NJ,Lee CE,Lee S,Berdeaux R,Scherer PE,Elmquist JK

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:The availability of human pancreatic islets with characteristics closely resembling those present in vivo is instrumental for ex vivo studies in diabetes research. SCOPE OF REVIEW:In this review we propose metabolically phenotyped surgical patients as a novel source of pancreatic tissue for islet research. ...

journal_title：Molecular metabolism

authors： Barovic M,Distler M,Schöniger E,Radisch N,Aust D,Weitz J,Ibberson M,Schulte AM,Solimena M

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Pancreatic β-cells adapt to high metabolic demand by expanding their β-cell mass and/or enhancing insulin secretion to maintain glucose homeostasis. Type 2 diabetes (T2D) is typically characterized by β-cell decompensation. SCOPE OF THE REVIEW:The current review focuses on summarizing the "omics" and "epi-o...

journal_title：Molecular metabolism

authors： De Jesus DF,Kulkarni RN

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVE:Pancreatic β cell failure plays a central role in the development of type 2 diabetes (T2D). While the transcription factors shaping the β cell gene expression program have received much attention, the post-transcriptional controls that are activated in β cells during stress are largely unknown. We recently id...

journal_title：Molecular metabolism

authors： Good AL,Haemmerle MW,Oguh AU,Doliba NM,Stoffers DA

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVE:Leptin (Lep) plays a crucial role in controlling food intake and energy expenditure. Defective Lep/LepRb-signaling leads to fat accumulation, massive obesity, and the development of diabetes. We serendipitously noticed spontaneous development of obesity similar to LepR-deficient (db/db) mice in offspring from...

journal_title：Molecular metabolism

authors： Piattini F,Le Foll C,Kisielow J,Rosenwald E,Nielsen P,Lutz T,Schneider C,Kopf M

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVE:Understanding the mechanisms underlying the remarkable beneficial effects of gastric bypass surgery is important for the development of non-surgical therapies or less invasive surgeries in the fight against obesity and metabolic disease. Although the intestinal L-cell hormones glucagon-like peptide-1 (GLP-1) ...

journal_title：Molecular metabolism

authors： Boland BB,Mumphrey MB,Hao Z,Townsend RL,Gill B,Oldham S,Will S,Morrison CD,Yu S,Münzberg H,Rhodes CJ,Trevaskis JL,Berthoud HR

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND/OBJECTIVES:Although the prevalence of obesity and its associated metabolic disorders is increasing in both sexes, the clinical phenotype differs between men and women, highlighting the need for individual treatment options. Mitochondrial dysfunction in various tissues, including white adipose tissue (WAT), h...

journal_title：Molecular metabolism

authors： Keuper M,Berti L,Raedle B,Sachs S,Böhm A,Fritsche L,Fritsche A,Häring HU,Hrabě de Angelis M,Jastroch M,Hofmann SM,Staiger H

更新日期：2019-02-01 00:00:00

abstract：OBJECTIVE:Hypothalamic glucose sensing (HGS) initiates insulin secretion (IS) via a vagal control, participating in energy homeostasis. This requires mitochondrial reactive oxygen species (mROS) signaling, dependent on mitochondrial fission, as shown by invalidation of the hypothalamic DRP1 protein. Here, our objective...

journal_title：Molecular metabolism

authors： Desmoulins L,Chrétien C,Paccoud R,Collins S,Cruciani-Guglielmacci C,Galinier A,Liénard F,Quinault A,Grall S,Allard C,Fenech C,Carneiro L,Mouillot T,Fournel A,Knauf C,Magnan C,Fioramonti X,Pénicaud L,Leloup C

更新日期：2019-02-01 00:00:00

abstract：OBJECTIVE:Nonalcoholic steatohepatitis (NASH) is closely associated with metabolic syndrome and increases the risk for end-stage liver disease, such as cirrhosis and hepatocellular carcinoma. Despite this, the molecular events that influence NASH pathogenesis remain poorly understood. The objectives of the current stud...

journal_title：Molecular metabolism

authors： Xiong X,Wang Q,Wang S,Zhang J,Liu T,Guo L,Yu Y,Lin JD

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Recent changes in nutrition and lifestyle have provoked an unprecedented increase in the prevalence of obesity and metabolic disorders. Recognition of the adverse effects on health has prompted intense efforts to understand the molecular determinants of insulin sensitivity and dysglycemia. In many respects, ...

journal_title：Molecular metabolism

authors： Haywood NJ,Slater TA,Matthews CJ,Wheatcroft SB

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:Studies using the estrogen receptor alpha (ERα) knock-out (αERKO) mice have demonstrated that ERα plays a crucial role in various estrogen-mediated metabolic regulations. ERα is a ligand dependent transcription regulator and its activity is regulated by estrogenic compounds. ERα consists of two transcriptiona...

journal_title：Molecular metabolism

authors： Arao Y,Hamilton KJ,Lierz SL,Korach KS

更新日期：2018-12-01 00:00:00

abstract：OBJECTIVE:The liver performs a central role in regulating energy homeostasis by increasing glucose output during fasting. Recent studies on Argonaute2 (Ago2), a key RNA-binding protein mediating the microRNA pathway, have illustrated its role in adaptive mechanisms according to changes in metabolic demand. Here we soug...

journal_title：Molecular metabolism

authors： Yan X,Wang Z,Bishop CA,Weitkunat K,Feng X,Tarbier M,Luo J,Friedländer MR,Burkhardt R,Klaus S,Willnow TE,Poy MN

更新日期：2018-12-01 00:00:00

abstract：OBJECTIVE:Mice with congenital loss of the glucagon receptor gene (Gcgr-/- mice) remain normoglycemic in insulinopenic conditions, suggesting that unopposed glucagon action is the driving force for hyperglycemia in Type-1 Diabetes Mellitus (T1DM). However, chronic loss of GCGR results in a neomorphic phenotype that inc...

journal_title：Molecular metabolism

authors： Rivero-Gutierrez B,Haller A,Holland J,Yates E,Khrisna R,Habegger K,Dimarchi R,D'Alessio D,Perez-Tilve D

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVES:Hepatic insulin resistance is a hallmark of type 2 diabetes and obesity. Insulin receptor signaling through AKT and FOXO has important metabolic effects that have traditionally been ascribed to regulation of gene expression. However, whether all the metabolic effects of FOXO arise from its regulation of prot...

journal_title：Molecular metabolism

authors： Langlet F,Tarbier M,Haeusler RA,Camastra S,Ferrannini E,Friedländer MR,Accili D

更新日期：2018-11-01 00:00:00