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The Hepatokine TSK does not affect brown fat thermogenic capacity, body weight gain, and glucose homeostasis.

Abstract：

OBJECTIVES:Hepatokines are proteins secreted by the liver that impact the functions of the liver and various tissues through autocrine, paracrine, and endocrine signaling. Recently, Tsukushi (TSK) was identified as a new hepatokine that is induced by obesity and cold exposure. It was proposed that TSK controls sympathetic innervation and thermogenesis in brown adipose tissue (BAT) and that loss of TSK protects against diet-induced obesity and improves glucose homeostasis. Here we report the impact of deleting and/or overexpressing TSK on BAT thermogenic capacity, body weight regulation, and glucose homeostasis. METHODS:We measured the expression of thermogenic genes and markers of BAT innervation and activation in TSK-null and TSK-overexpressing mice. Body weight, body temperature, and parameters of glucose homeostasis were also assessed in the context of TSK loss and overexpression. RESULTS:The loss of TSK did not affect the thermogenic activation of BAT. We found that TSK-null mice were not protected against the development of obesity and did not show improvement in glucose tolerance. The overexpression of TSK also failed to modulate thermogenesis, body weight gain, and glucose homeostasis in mice. CONCLUSIONS:TSK is not a significant regulator of BAT thermogenesis and is unlikely to represent an effective target to prevent obesity and improve glucose homeostasis.

journal_name

Mol Metab

journal_title

Molecular metabolism

authors

Mouchiroud M,Camiré É,Aldow M,Caron A,Jubinville É,Turcotte L,Kaci I,Beaulieu MJ,Roy C,Labbé SM,Varin TV,Gélinas Y,Lamothe J,Trottier J,Mitchell PL,Guénard F,Festuccia WT,Joubert P,Rose CF,Karvellas CJ,Barbier O,

doi

10.1016/j.molmet.2019.09.014

subject

Has Abstract

pub_date

2019-12-01 00:00:00

pages

184-191

issn

2212-8778

pii

S2212-8778(19)30917-2

journal_volume

30

pub_type

杂志文章

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