当前位置： SCI文献检索 > Molecular Metabolism期刊下所有文献 > Maternal obesity persistently alters cardiac progenitor gene expression and programs adult-onset heart disease susceptibility.

Maternal obesity persistently alters cardiac progenitor gene expression and programs adult-onset heart disease susceptibility.

Abstract：

OBJECTIVE:Heart disease risk can be programmed by intrauterine exposure to obesity. Dysregulating key transcription factors in cardiac progenitors can cause subsequent adult-onset heart disease. In this study, we investigated the transcriptional pathways that are altered in the embryonic heart and linked to heart disease risk in offspring exposed to obesity during pregnancy. METHODS:Female mice were fed an obesogenic diet and mated with males fed a control diet. Heart function and genome-wide gene expression were analyzed in adult offspring born to obese and lean mice at baseline and in response to stress. Cross-referencing with genes dysregulated genome-wide in cardiac progenitors from embryos of obese mice and human fetal hearts revealed the transcriptional events associated with adult-onset heart disease susceptibility. RESULTS:We found that adult mice born to obese mothers develop mild heart dysfunction consistent with early stages of disease. Accordingly, hearts of these mice dysregulated genes controlling extracellular matrix remodeling, metabolism, and TGF-β signaling, known to control heart disease progression. These pathways were already dysregulated in cardiac progenitors in embryos of obese mice. Moreover, in response to cardiovascular stress, the heart of adults born to obese dams developed exacerbated myocardial remodeling and excessively activated regulators of cell-extracellular matrix interactions but failed to activate metabolic regulators. Expression of developmentally regulated genes was altered in cardiac progenitors of embryos of obese mice and human hearts of fetuses of obese donors. Accordingly, the levels of Nkx2-5, a key regulator of heart development, inversely correlated with maternal body weight in mice. Furthermore, Nkx2-5 target genes were dysregulated in cardiac progenitors and persistently in adult hearts born to obese mice and human hearts from pregnancies affected by obesity. CONCLUSIONS:Obesity during pregnancy alters Nkx2-5-controlled transcription in differentiating cardiac progenitors and persistently in the adult heart, making the adult heart vulnerable to dysregulated stress responses.

journal_name

Mol Metab

journal_title

Molecular metabolism

authors

Ahmed A,Liang M,Chi L,Zhou YQ,Sled JG,Wilson MD,Delgado-Olguín P

doi

10.1016/j.molmet.2020.101116

subject

Has Abstract

pub_date

2021-01-01 00:00:00

pages

101116

issn

2212-8778

pii

S2212-8778(20)30190-3

journal_volume

43

pub_type

杂志文章

相关文献

Molecular Metabolism文献大全
  • Nicotinamide N-methyltransferase: At the crossroads between cellular metabolism and epigenetic regulation.

    abstract：BACKGROUND:The abundance of energy metabolites is intimately interconnected with the activity of chromatin-modifying enzymes in order to guarantee the finely tuned modulation of gene expression in response to cellular energetic status. Metabolism-induced epigenetic gene regulation is a key molecular axis for the mainte...

    journal_title：Molecular metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/j.molmet.2021.101165

    authors： Roberti A,Fernández AF,Fraga MF

    更新日期：2021-01-14 00:00:00

  • The disassembly of the neuromuscular synapse in high-fat diet-induced obese male mice.

    abstract：OBJECTIVE:A sustained high fat diet in mice mimics many features of human obesity. We used male and female Non-Swiss albino mice to investigate the impact of short and long-term high-fat diet-(HFD)-induced obesity on the peripheral neuromuscular junction (NMJ) and whether obesity-related synaptic structural alterations...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2020.100979

    authors： Martinez-Pena Y Valenzuela I,Akaaboune M

    更新日期：2020-06-01 00:00:00

  • An unbiased silencing screen in muscle cells identifies miR-320a, miR-150, miR-196b, and miR-34c as regulators of skeletal muscle mitochondrial metabolism.

    abstract：OBJECTIVE:Strategies improving skeletal muscle mitochondrial capacity are commonly paralleled by improvements in (metabolic) health. We and others previously identified microRNAs regulating mitochondrial oxidative capacity, but data in skeletal muscle are limited. Therefore, the present study aimed to identify novel mi...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2017.08.007

    authors： Dahlmans D,Houzelle A,Andreux P,Jörgensen JA,Wang X,de Windt LJ,Schrauwen P,Auwerx J,Hoeks J

    更新日期：2017-11-01 00:00:00

  • Mapping the molecular signatures of diet-induced NASH and its regulation by the hepatokine Tsukushi.

    abstract：OBJECTIVE:Nonalcoholic steatohepatitis (NASH) is closely associated with metabolic syndrome and increases the risk for end-stage liver disease, such as cirrhosis and hepatocellular carcinoma. Despite this, the molecular events that influence NASH pathogenesis remain poorly understood. The objectives of the current stud...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2018.12.004

    authors： Xiong X,Wang Q,Wang S,Zhang J,Liu T,Guo L,Yu Y,Lin JD

    更新日期：2019-02-01 00:00:00

  • N-terminal transactivation function, AF-1, of estrogen receptor alpha controls obesity through enhancement of energy expenditure.

    abstract：OBJECTIVE:Studies using the estrogen receptor alpha (ERα) knock-out (αERKO) mice have demonstrated that ERα plays a crucial role in various estrogen-mediated metabolic regulations. ERα is a ligand dependent transcription regulator and its activity is regulated by estrogenic compounds. ERα consists of two transcriptiona...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2018.09.006

    authors： Arao Y,Hamilton KJ,Lierz SL,Korach KS

    更新日期：2018-12-01 00:00:00

  • Distinct adipocyte progenitor cells are associated with regional phenotypes of perivascular aortic fat in mice.

    abstract：OBJECTIVE:Perivascular adipose tissue depots around the aorta are regionally distinct and have specific functional properties. Thoracic aorta perivascular adipose tissue (tPVAT) expresses higher levels of thermogenic genes and lower levels of inflammatory genes than abdominal aorta perivascular adipose tissue (aPVAT). ...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2017.12.014

    authors： Tran KV,Fitzgibbons T,Min SY,DeSouza T,Corvera S

    更新日期：2018-03-01 00:00:00

  • Beige fat is dispensable for the metabolic benefits associated with myostatin deletion.

    abstract：OBJECTIVE:Increasing muscle mass and activating beige fat both have great potential for ameliorating obesity and its comorbidities. Myostatin null mice have increased skeletal muscle mass and are protected from obesity and its sequelae. Deletion of myostatin has also been suggested to result in the activation of beige ...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2020.101120

    authors： Marchildon F,Chi J,O'Connor S,Bediako H,Cohen P

    更新日期：2021-01-01 00:00:00

  • Nuclear hormone and peptide hormone therapeutics for NAFLD and NASH.

    abstract：BACKGROUND:Non-alcoholic steatohepatitis (NASH) is a spectrum of histological liver pathologies ranging from hepatocyte fat accumulation, hepatocellular ballooning, lobular inflammation, and pericellular fibrosis. Based on early investigations, it was discovered that visceral fat accumulation, hepatic insulin resistanc...

    journal_title：Molecular metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/j.molmet.2020.101153

    authors： Finan B,Parlee SD,Yang B

    更新日期：2020-12-23 00:00:00

  • Peroxisome proliferator-activated receptor gamma (PPARG) modulates free fatty acid receptor 1 (FFAR1) dependent insulin secretion in humans.

    abstract：:Genetic variation in FFAR1 modulates insulin secretion dependent on non-esterified fatty acid (NEFA) concentrations. We previously demonstrated lower insulin secretion in minor allele carriers of PPARG Pro12Ala in high-NEFA environment, but the mode of action could not been revealed. We tested if this effect is mediat...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2014.07.001

    authors： Wagner R,Hieronimus A,Lamprinou A,Heni M,Hatziagelaki E,Ullrich S,Stefan N,Staiger H,Häring HU,Fritsche A

    更新日期：2014-07-07 00:00:00

  • "Omics" and "epi-omics" underlying the β-cell adaptation to insulin resistance.

    abstract：BACKGROUND:Pancreatic β-cells adapt to high metabolic demand by expanding their β-cell mass and/or enhancing insulin secretion to maintain glucose homeostasis. Type 2 diabetes (T2D) is typically characterized by β-cell decompensation. SCOPE OF THE REVIEW:The current review focuses on summarizing the "omics" and "epi-o...

    journal_title：Molecular metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/j.molmet.2019.06.003

    authors： De Jesus DF,Kulkarni RN

    更新日期：2019-09-01 00:00:00

  • The insulin like growth factor and binding protein family: Novel therapeutic targets in obesity & diabetes.

    abstract：BACKGROUND:Recent changes in nutrition and lifestyle have provoked an unprecedented increase in the prevalence of obesity and metabolic disorders. Recognition of the adverse effects on health has prompted intense efforts to understand the molecular determinants of insulin sensitivity and dysglycemia. In many respects, ...

    journal_title：Molecular metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/j.molmet.2018.10.008

    authors： Haywood NJ,Slater TA,Matthews CJ,Wheatcroft SB

    更新日期：2019-01-01 00:00:00

  • Nrg4 promotes fuel oxidation and a healthy adipokine profile to ameliorate diet-induced metabolic disorders.

    abstract：OBJECTIVE:Brown and white adipose tissue exerts pleiotropic effects on systemic energy metabolism in part by releasing endocrine factors. Neuregulin 4 (Nrg4) was recently identified as a brown fat-enriched secreted factor that ameliorates diet-induced metabolic disorders, including insulin resistance and hepatic steato...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2017.03.016

    authors： Chen Z,Wang GX,Ma SL,Jung DY,Ha H,Altamimi T,Zhao XY,Guo L,Zhang P,Hu CR,Cheng JX,Lopaschuk GD,Kim JK,Lin JD

    更新日期：2017-06-21 00:00:00

  • Preadipocytes of obese humans display gender-specific bioenergetic responses to glucose and insulin.

    abstract：BACKGROUND/OBJECTIVES:Although the prevalence of obesity and its associated metabolic disorders is increasing in both sexes, the clinical phenotype differs between men and women, highlighting the need for individual treatment options. Mitochondrial dysfunction in various tissues, including white adipose tissue (WAT), h...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2018.11.006

    authors： Keuper M,Berti L,Raedle B,Sachs S,Böhm A,Fritsche L,Fritsche A,Häring HU,Hrabě de Angelis M,Jastroch M,Hofmann SM,Staiger H

    更新日期：2019-02-01 00:00:00

  • SIRT1 metabolic actions: Integrating recent advances from mouse models.

    abstract：:SIRT1 has attracted a lot of interest since it was discovered as a mammalian homolog of Sir2, a protein that influences longevity in yeast. Intensive early research suggested a key role of SIRT1 in mammalian development, metabolic flexibility and oxidative metabolism. However, it is the growing body of transgenic mode...

    journal_title：Molecular metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/j.molmet.2013.10.006

    authors： Boutant M,Cantó C

    更新日期：2013-10-23 00:00:00

  • Cadm2 regulates body weight and energy homeostasis in mice.

    abstract：OBJECTIVE:Obesity is strongly linked to genes regulating neuronal signaling and function, implicating the central nervous system in the maintenance of body weight and energy metabolism. Genome-wide association studies identified significant associations between body mass index (BMI) and multiple loci near Cell adhesion...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2017.11.010

    authors： Yan X,Wang Z,Schmidt V,Gauert A,Willnow TE,Heinig M,Poy MN

    更新日期：2018-02-01 00:00:00

  • Epigenetic control of variation and stochasticity in metabolic disease.

    abstract：BACKGROUND:The alarming rise of obesity and its associated comorbidities represents a medical burden and a major global health and economic issue. Understanding etiological mechanisms underpinning susceptibility and therapeutic response is of primary importance. Obesity, diabetes, and metabolic diseases are complex tra...

    journal_title：Molecular metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/j.molmet.2018.05.010

    authors： Panzeri I,Pospisilik JA

    更新日期：2018-08-01 00:00:00

  • Evidence for a novel functional role of astrocytes in the acute homeostatic response to high-fat diet intake in mice.

    abstract：OBJECTIVE:Introduction of a high-fat diet to mice results in a period of voracious feeding, known as hyperphagia, before homeostatic mechanisms prevail to restore energy intake to an isocaloric level. Acute high-fat diet hyperphagia induces astrocyte activation in the rodent hypothalamus, suggesting a potential role of...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2014.10.001

    authors： Buckman LB,Thompson MM,Lippert RN,Blackwell TS,Yull FE,Ellacott KL

    更新日期：2014-10-16 00:00:00

  • The role of GluN2A and GluN2B NMDA receptor subunits in AgRP and POMC neurons on body weight and glucose homeostasis.

    abstract：OBJECTIVE:Hypothalamic agouti-related peptide (AgRP) and pro-opiomelanocortin (POMC) expressing neurons play critical roles in control of energy balance. Glutamatergic input via n-methyl-d-aspartate receptors (NMDARs) is pivotal for regulation of neuronal activity and is required in AgRP neurons for normal body weight ...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2015.06.010

    authors： Üner A,Gonçalves GH,Li W,Porceban M,Caron N,Schönke M,Delpire E,Sakimura K,Bjørbæk C

    更新日期：2015-07-06 00:00:00

  • Granulocyte colony-stimulating factor (G-CSF): A saturated fatty acid-induced myokine with insulin-desensitizing properties in humans.

    abstract：OBJECTIVE:Circulating long-chain free fatty acids (FFAs) are important metabolic signals that acutely enhance fatty acid oxidation, thermogenesis, energy expenditure, and insulin secretion. However, if chronically elevated, they provoke inflammation, insulin resistance, and β-cell failure. Moreover, FFAs act via multip...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2016.02.001

    authors： Ordelheide AM,Gommer N,Böhm A,Hermann C,Thielker I,Machicao F,Fritsche A,Stefan N,Häring HU,Staiger H

    更新日期：2016-02-13 00:00:00

  • A novel crosstalk between Alk7 and cGMP signaling differentially regulates brown adipocyte function.

    abstract：OBJECTIVE:Obesity is an enormous burden for patients and health systems world-wide. Brown adipose tissue dissipates energy in response to cold and has been shown to be metabolically active in human adults. The type I transforming growth factor β (TGFβ) receptor Activin receptor-like kinase 7 (Alk7) is highly expressed ...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2015.06.003

    authors： Balkow A,Jagow J,Haas B,Siegel F,Kilić A,Pfeifer A

    更新日期：2015-06-14 00:00:00

  • Ceramides are necessary and sufficient for diet-induced impairment of thermogenic adipocytes.

    abstract：OBJECTIVE:Aging and weight gain lead to a decline in brown and beige adipocyte functionality that exacerbates obesity and insulin resistance. We sought to determine whether sphingolipids, such as ceramides, a class of lipid metabolites that accumulate in aging and overnutrition, are sufficient or necessary for the meta...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2020.101145

    authors： Chaurasia B,Ying L,Talbot CL,Maschek JA,Cox J,Schuchman EH,Hirabayashi Y,Holland WL,Summers SA

    更新日期：2020-12-19 00:00:00

  • Peroxisome proliferator-activated receptor alpha plays a crucial role in behavioral repetition and cognitive flexibility in mice.

    abstract：BACKGROUND/OBJECTIVES:Nuclear peroxisome proliferator activated receptor-α (PPAR-α) plays a fundamental role in the regulation of lipid homeostasis and is the target of medications used to treat dyslipidemia. However, little is known about the role of PPAR-α in mouse behavior. METHODS:To investigate the function of Pp...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2015.04.005

    authors： D'Agostino G,Cristiano C,Lyons DJ,Citraro R,Russo E,Avagliano C,Russo R,Raso GM,Meli R,De Sarro G,Heisler LK,Calignano A

    更新日期：2015-05-02 00:00:00

  • High-fidelity Glucagon-CreER mouse line generated by CRISPR-Cas9 assisted gene targeting.

    abstract：OBJECTIVE:α-cells are the second most prominent cell type in pancreatic islets and are responsible for producing glucagon to increase plasma glucose levels in times of fasting. α-cell dysfunction and inappropriate glucagon secretion occur in both type 1 and type 2 diabetes. Thus, there is growing interest in studying b...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2017.01.003

    authors： Ackermann AM,Zhang J,Heller A,Briker A,Kaestner KH

    更新日期：2017-01-12 00:00:00

  • Cannabinoid control of brain bioenergetics: Exploring the subcellular localization of the CB1 receptor.

    abstract：:Brain mitochondrial activity is centrally involved in the central control of energy balance. When studying mitochondrial functions in the brain, however, discrepant results might be obtained, depending on the experimental approaches. For instance, immunostaining experiments and biochemical isolation of organelles expo...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2014.03.007

    authors： Hebert-Chatelain E,Reguero L,Puente N,Lutz B,Chaouloff F,Rossignol R,Piazza PV,Benard G,Grandes P,Marsicano G

    更新日期：2014-04-02 00:00:00

  • (11)C-meta-hydroxyephedrine PET/CT imaging allows in vivo study of adaptive thermogenesis and white-to-brown fat conversion.

    abstract：:Several lines of evidence suggest that novel pharmacological approaches aimed at converting white adipose tissue (WAT) into brown adipose tissue (BAT) may represent an effective therapeutic strategy for obesity and related disorders. ((18))F-fluorodeoxyglucose ((18)F-FDG) is the only positron emission tomography (PET)...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2013.04.002

    authors： Quarta C,Lodi F,Mazza R,Giannone F,Boschi L,Nanni C,Nisoli E,Boschi S,Pasquali R,Fanti S,Iozzo P,Pagotto U

    更新日期：2013-04-21 00:00:00

  • Profiling plasma N-Acylethanolamine levels and their ratios as a biomarker of obesity and dysmetabolism.

    abstract：OBJECTIVE:N-acylethanolamines play different roles in energy balance; anandamide (AEA) stimulates energy intake and storage, N-palmitoylethanolamide (PEA) counters inflammation, and N-oleoylethanolamide (OEA) mediates anorectic signals and lipid oxidation. Inconsistencies in the association of plasma N-acylethanolamine...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2018.06.002

    authors： Fanelli F,Mezzullo M,Repaci A,Belluomo I,Ibarra Gasparini D,Di Dalmazi G,Mastroroberto M,Vicennati V,Gambineri A,Morselli-Labate AM,Pasquali R,Pagotto U

    更新日期：2018-08-01 00:00:00

  • CART neurons in the arcuate nucleus and lateral hypothalamic area exert differential controls on energy homeostasis.

    abstract：OBJECTIVE:The cocaine- and amphetamine-regulated transcript (CART) codes for a pivotal neuropeptide important in the control of appetite and energy homeostasis. However, limited understanding exists for the defined effector sites underlying CART function, as discrepant effects of central CART administration have been r...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2017.10.015

    authors： Lau J,Farzi A,Qi Y,Heilbronn R,Mietzsch M,Shi YC,Herzog H

    更新日期：2018-01-01 00:00:00

  • Integration of body temperature into the analysis of energy expenditure in the mouse.

    abstract：OBJECTIVES:We quantified the effect of environmental temperature on mouse energy homeostasis and body temperature. METHODS:The effect of environmental temperature (4-33 °C) on body temperature, energy expenditure, physical activity, and food intake in various mice (chow diet, high-fat diet, Brs3 (-/y) , lipodystrophic...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2015.03.001

    authors： Abreu-Vieira G,Xiao C,Gavrilova O,Reitman ML

    更新日期：2015-03-10 00:00:00

  • Epidermal Acyl-CoA-binding protein is indispensable for systemic energy homeostasis.

    abstract：OBJECTIVES:The skin is the largest sensory organ of the human body and plays a fundamental role in regulating body temperature. However, adaptive alterations in skin functions and morphology have only vaguely been associated with physiological responses to cold stress or sensation of ambient temperatures. We previously...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2020.101144

    authors： Neess D,Kruse V,Marcher AB,Wæde MR,Vistisen J,Møller PM,Petersen R,Brewer JR,Ma T,Colleluori G,Severi I,Cinti S,Gerhart-Hines Z,Mandrup S,Færgeman NJ

    更新日期：2020-12-18 00:00:00

  • Mitochondrial Dynamin-Related Protein 1 (DRP1) translocation in response to cerebral glucose is impaired in a rat model of early alteration in hypothalamic glucose sensing.

    abstract：OBJECTIVE:Hypothalamic glucose sensing (HGS) initiates insulin secretion (IS) via a vagal control, participating in energy homeostasis. This requires mitochondrial reactive oxygen species (mROS) signaling, dependent on mitochondrial fission, as shown by invalidation of the hypothalamic DRP1 protein. Here, our objective...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2018.11.007

    authors： Desmoulins L,Chrétien C,Paccoud R,Collins S,Cruciani-Guglielmacci C,Galinier A,Liénard F,Quinault A,Grall S,Allard C,Fenech C,Carneiro L,Mouillot T,Fournel A,Knauf C,Magnan C,Fioramonti X,Pénicaud L,Leloup C

    更新日期：2019-02-01 00:00:00