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SIRT1 metabolic actions: Integrating recent advances from mouse models.

Abstract：

:SIRT1 has attracted a lot of interest since it was discovered as a mammalian homolog of Sir2, a protein that influences longevity in yeast. Intensive early research suggested a key role of SIRT1 in mammalian development, metabolic flexibility and oxidative metabolism. However, it is the growing body of transgenic models that are allowing us to clearly define the true range of SIRT1 actions. In this review we aim to summarize the most recent lessons that transgenic animal models have taught us about the role of SIRT1 in mammalian metabolic homeostasis and lifespan.

journal_name

Mol Metab

journal_title

Molecular metabolism

authors

Boutant M,Cantó C

doi

10.1016/j.molmet.2013.10.006

subject

Has Abstract

pub_date

2013-10-23 00:00:00

pages

5-18

issue

1

issn

2212-8778

pii

S2212-8778(13)00104-X

journal_volume

3

pub_type

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