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IL-13 improves beta-cell survival and protects against IL-1beta-induced beta-cell death.

Abstract：

OBJECTIVES:IL-13 is a cytokine classically produced by anti-inflammatory T-helper-2 lymphocytes; it is decreased in the circulation of type 2 diabetic patients and impacts positively on liver and skeletal muscle. Although IL-13 can exert positive effects on beta-cell lines, its impact and mode of action on primary beta-cell function and survival remain largely unexplored. METHODS:Beta-cells were cultured for 48 h in the presence of IL-13 alone or in combination with IL-1β or cytokine cocktail (IL-1β, IFNγ, TNFα). RESULTS:IL-13 protected human and rat beta-cells against cytokine induced death. However, IL-13 was unable to protect from IL-1β impaired glucose stimulated insulin secretion and did not influence NFκB nuclear relocalization induced by IL-1β. IL-13 induced phosphorylation of Akt, increased IRS2 protein expression and counteracted the IL-1β induced regulation of several beta-cell stress response genes. CONCLUSIONS:The prosurvival effects of IL-13 thus appear to be mediated through IRS2/Akt signaling with NFκB independent regulation of gene expression. In addition to previously documented beneficial effects on insulin target tissues, these data suggest that IL-13 may be useful for treatment of type 2 diabetes by preserving beta-cell mass or slowing its rate of decline.

journal_name

Mol Metab

journal_title

Molecular metabolism

authors

Rütti S,Howald C,Arous C,Dermitzakis E,Halban PA,Bouzakri K

doi

10.1016/j.molmet.2015.11.003

subject

Has Abstract

pub_date

2015-11-17 00:00:00

pages

122-131

issue

2

issn

2212-8778

pii

S2212-8778(15)00215-X

journal_volume

5

pub_type

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