当前位置： SCI文献检索 > Molecular Metabolism期刊下所有文献 > Mitochondrial dysfunction has divergent, cell type-dependent effects on insulin action.

Mitochondrial dysfunction has divergent, cell type-dependent effects on insulin action.

Abstract：

:The contribution of mitochondrial dysfunction to insulin resistance is a contentious issue in metabolic research. Recent evidence implicates mitochondrial dysfunction as contributing to multiple forms of insulin resistance. However, some models of mitochondrial dysfunction fail to induce insulin resistance, suggesting greater complexity describes mitochondrial regulation of insulin action. We report that mitochondrial dysfunction is not necessary for cellular models of insulin resistance. However, impairment of mitochondrial function is sufficient for insulin resistance in a cell type-dependent manner, with impaired mitochondrial function inducing insulin resistance in adipocytes, but having no effect, or insulin sensitising effects in hepatocytes. The mechanism of mitochondrial impairment was important in determining the impact on insulin action, but was independent of mitochondrial ROS production. These data can account for opposing findings on this issue and highlight the complexity of mitochondrial regulation of cell type-specific insulin action, which is not described by current reductionist paradigms.

journal_name

Mol Metab

journal_title

Molecular metabolism

authors

Martin SD,Morrison S,Konstantopoulos N,McGee SL

doi

10.1016/j.molmet.2014.02.001

subject

Has Abstract

pub_date

2014-03-12 00:00:00

pages

408-18

issue

4

issn

2212-8778

pii

S2212-8778(14)00042-8

journal_volume

3

pub_type

杂志文章

相关文献

Molecular Metabolism文献大全
  • α/β-Hydrolase domain-6 and saturated long chain monoacylglycerol regulate insulin secretion promoted by both fuel and non-fuel stimuli.

    abstract：OBJECTIVE:α/β-Hydrolase domain-6 (ABHD6) is a newly identified monoacylglycerol (MAG) lipase. We recently reported that it negatively regulates glucose stimulated insulin secretion (GSIS) in the β cells by hydrolyzing lipolysis-derived MAG that acts as a metabolic coupling factor and signaling molecule via exocytotic r...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2015.09.012

    authors： Zhao S,Poursharifi P,Mugabo Y,Levens EJ,Vivot K,Attane C,Iglesias J,Peyot ML,Joly E,Madiraju SR,Prentki M

    更新日期：2015-10-08 00:00:00

  • IL-13 improves beta-cell survival and protects against IL-1beta-induced beta-cell death.

    abstract：OBJECTIVES:IL-13 is a cytokine classically produced by anti-inflammatory T-helper-2 lymphocytes; it is decreased in the circulation of type 2 diabetic patients and impacts positively on liver and skeletal muscle. Although IL-13 can exert positive effects on beta-cell lines, its impact and mode of action on primary beta...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2015.11.003

    authors： Rütti S,Howald C,Arous C,Dermitzakis E,Halban PA,Bouzakri K

    更新日期：2015-11-17 00:00:00

  • GPR142 prompts glucagon-like Peptide-1 release from islets to improve β cell function.

    abstract：OBJECTIVE:GPR142 agonists are being pursued as novel diabetes therapies by virtue of their insulin secretagogue effects. But it is undetermined whether GPR142's functions in pancreatic islets are limited to regulating insulin secretion. The current study expands research on its action. METHODS AND RESULTS:We demonstra...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2018.02.008

    authors： Lin HV,Wang J,Wang J,Li W,Wang X,Alston JT,Thomas MK,Briere DA,Syed SK,Efanov AM

    更新日期：2018-05-01 00:00:00

  • An unbiased silencing screen in muscle cells identifies miR-320a, miR-150, miR-196b, and miR-34c as regulators of skeletal muscle mitochondrial metabolism.

    abstract：OBJECTIVE:Strategies improving skeletal muscle mitochondrial capacity are commonly paralleled by improvements in (metabolic) health. We and others previously identified microRNAs regulating mitochondrial oxidative capacity, but data in skeletal muscle are limited. Therefore, the present study aimed to identify novel mi...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2017.08.007

    authors： Dahlmans D,Houzelle A,Andreux P,Jörgensen JA,Wang X,de Windt LJ,Schrauwen P,Auwerx J,Hoeks J

    更新日期：2017-11-01 00:00:00

  • Interdependence of nutrient metabolism and the circadian clock system: Importance for metabolic health.

    abstract：BACKGROUND:While additional research is needed, a number of large epidemiological studies show an association between circadian disruption and metabolic disorders. Specifically, obesity, insulin resistance, cardiovascular disease, and other signs of metabolic syndrome all have been linked to circadian disruption in hum...

    journal_title：Molecular metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/j.molmet.2015.12.006

    authors： Ribas-Latre A,Eckel-Mahan K

    更新日期：2016-01-14 00:00:00

  • Regulation of muscle and metabolic physiology by hypothalamic erythropoietin independently of its peripheral action.

    abstract：OBJECTIVE:The glycoprotein hormone erythropoietin (EPO) is required for erythropoiesis, and the kidney is the primary site of adult EPO synthesis. Limited evidence has suggested that EPO could be detectable in the brain under certain conditions, but it remains unknown if the brain might have its own EPO system for biol...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2019.12.001

    authors： Wang Z,Khor S,Cai D

    更新日期：2020-02-01 00:00:00

  • Melanocortin-3 receptors in the limbic system mediate feeding-related motivational responses during weight loss.

    abstract：OBJECTIVE:Appetitive responses to weight loss are mediated by a nutrient-sensing neural network comprised of melanocortin neurons. The role of neural melanocortin-3 receptors (MC3R) in mediating these responses is enigmatic. Mc3r knockout mice exhibit a paradoxical phenotype of obesity and reduced feeding-related behav...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2016.05.002

    authors： Mavrikaki M,Girardet C,Kern A,Faruzzi Brantley A,Miller CA,Macarthur H,Marks DL,Butler AA

    更新日期：2016-05-12 00:00:00

  • Deletion of the glucagon receptor gene before and after experimental diabetes reveals differential protection from hyperglycemia.

    abstract：OBJECTIVE:Mice with congenital loss of the glucagon receptor gene (Gcgr-/- mice) remain normoglycemic in insulinopenic conditions, suggesting that unopposed glucagon action is the driving force for hyperglycemia in Type-1 Diabetes Mellitus (T1DM). However, chronic loss of GCGR results in a neomorphic phenotype that inc...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2018.07.012

    authors： Rivero-Gutierrez B,Haller A,Holland J,Yates E,Khrisna R,Habegger K,Dimarchi R,D'Alessio D,Perez-Tilve D

    更新日期：2018-11-01 00:00:00

  • Beige fat is dispensable for the metabolic benefits associated with myostatin deletion.

    abstract：OBJECTIVE:Increasing muscle mass and activating beige fat both have great potential for ameliorating obesity and its comorbidities. Myostatin null mice have increased skeletal muscle mass and are protected from obesity and its sequelae. Deletion of myostatin has also been suggested to result in the activation of beige ...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2020.101120

    authors： Marchildon F,Chi J,O'Connor S,Bediako H,Cohen P

    更新日期：2021-01-01 00:00:00

  • The disassembly of the neuromuscular synapse in high-fat diet-induced obese male mice.

    abstract：OBJECTIVE:A sustained high fat diet in mice mimics many features of human obesity. We used male and female Non-Swiss albino mice to investigate the impact of short and long-term high-fat diet-(HFD)-induced obesity on the peripheral neuromuscular junction (NMJ) and whether obesity-related synaptic structural alterations...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2020.100979

    authors： Martinez-Pena Y Valenzuela I,Akaaboune M

    更新日期：2020-06-01 00:00:00

  • Evidence for a novel functional role of astrocytes in the acute homeostatic response to high-fat diet intake in mice.

    abstract：OBJECTIVE:Introduction of a high-fat diet to mice results in a period of voracious feeding, known as hyperphagia, before homeostatic mechanisms prevail to restore energy intake to an isocaloric level. Acute high-fat diet hyperphagia induces astrocyte activation in the rodent hypothalamus, suggesting a potential role of...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2014.10.001

    authors： Buckman LB,Thompson MM,Lippert RN,Blackwell TS,Yull FE,Ellacott KL

    更新日期：2014-10-16 00:00:00

  • N-terminal transactivation function, AF-1, of estrogen receptor alpha controls obesity through enhancement of energy expenditure.

    abstract：OBJECTIVE:Studies using the estrogen receptor alpha (ERα) knock-out (αERKO) mice have demonstrated that ERα plays a crucial role in various estrogen-mediated metabolic regulations. ERα is a ligand dependent transcription regulator and its activity is regulated by estrogenic compounds. ERα consists of two transcriptiona...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2018.09.006

    authors： Arao Y,Hamilton KJ,Lierz SL,Korach KS

    更新日期：2018-12-01 00:00:00

  • Cadm2 regulates body weight and energy homeostasis in mice.

    abstract：OBJECTIVE:Obesity is strongly linked to genes regulating neuronal signaling and function, implicating the central nervous system in the maintenance of body weight and energy metabolism. Genome-wide association studies identified significant associations between body mass index (BMI) and multiple loci near Cell adhesion...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2017.11.010

    authors： Yan X,Wang Z,Schmidt V,Gauert A,Willnow TE,Heinig M,Poy MN

    更新日期：2018-02-01 00:00:00

  • Mitochondrial Dynamin-Related Protein 1 (DRP1) translocation in response to cerebral glucose is impaired in a rat model of early alteration in hypothalamic glucose sensing.

    abstract：OBJECTIVE:Hypothalamic glucose sensing (HGS) initiates insulin secretion (IS) via a vagal control, participating in energy homeostasis. This requires mitochondrial reactive oxygen species (mROS) signaling, dependent on mitochondrial fission, as shown by invalidation of the hypothalamic DRP1 protein. Here, our objective...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2018.11.007

    authors： Desmoulins L,Chrétien C,Paccoud R,Collins S,Cruciani-Guglielmacci C,Galinier A,Liénard F,Quinault A,Grall S,Allard C,Fenech C,Carneiro L,Mouillot T,Fournel A,Knauf C,Magnan C,Fioramonti X,Pénicaud L,Leloup C

    更新日期：2019-02-01 00:00:00

  • AVP neurons in the paraventricular nucleus of the hypothalamus regulate feeding.

    abstract：:Melanocortins and their receptors are critical components of energy homeostasis and the paraventricular nucleus of the hypothalamus (PVH) is an important site of melanocortin action. Although best known for its role in osmoregulation, arginine vasopressin (AVP) has been implicated in feeding and is robustly expressed ...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2013.12.006

    authors： Pei H,Sutton AK,Burnett KH,Fuller PM,Olson DP

    更新日期：2014-01-08 00:00:00

  • 11β-Hydroxysteroid dehydrogenase-1 is involved in bile acid homeostasis by modulating fatty acid transport protein-5 in the liver of mice.

    abstract：:11β-Hydroxysteroid dehydrogenase-1 (11β-HSD1) plays a key role in glucocorticoid receptor (GR) activation. Besides, it metabolizes some oxysterols and bile acids (BAs). The GR regulates BA homeostasis; however, the impact of impaired 11β-HSD1 activity remained unknown. We profiled plasma and liver BAs in liver-specifi...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2014.04.008

    authors： Penno CA,Morgan SA,Rose AJ,Herzig S,Lavery GG,Odermatt A

    更新日期：2014-05-02 00:00:00

  • Bidirectional manipulation of gene expression in adipocytes using CRISPRa and siRNA.

    abstract：OBJECTIVE:Functional investigation of novel gene/protein targets associated with adipocyte differentiation or function heavily relies on efficient and accessible tools to manipulate gene expression in adipocytes in vitro. Recent advances in gene-editing technologies such as CRISPR-Cas9 have not only eased gene editing ...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2017.07.001

    authors： Lundh M,Pluciñska K,Isidor MS,Petersen PSS,Emanuelli B

    更新日期：2017-10-01 00:00:00

  • Action and therapeutic potential of oxyntomodulin.

    abstract：:Oxyntomodulin (OXM) is a peptide hormone released from the gut in post-prandial state that activates both the glucagon-like peptide-1 receptor (GLP1R) and the glucagon receptor (GCGR) resulting in superior body weight lowering to selective GLP1R agonists. OXM reduces food intake and increases energy expenditure in hum...

    journal_title：Molecular metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/j.molmet.2013.12.001

    authors： Pocai A

    更新日期：2013-12-14 00:00:00

  • Lipin-1 and lipin-3 together determine adiposity in vivo.

    abstract：:The lipin protein family of phosphatidate phosphatases has an established role in triacylglycerol synthesis and storage. Physiological roles for lipin-1 and lipin-2 have been identified, but the role of lipin-3 has remained mysterious. Using lipin single- and double-knockout models we identified a cooperative relation...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2013.11.008

    authors： Csaki LS,Dwyer JR,Li X,Nguyen MH,Dewald J,Brindley DN,Lusis AJ,Yoshinaga Y,de Jong P,Fong L,Young SG,Reue K

    更新日期：2013-11-28 00:00:00

  • A novel crosstalk between Alk7 and cGMP signaling differentially regulates brown adipocyte function.

    abstract：OBJECTIVE:Obesity is an enormous burden for patients and health systems world-wide. Brown adipose tissue dissipates energy in response to cold and has been shown to be metabolically active in human adults. The type I transforming growth factor β (TGFβ) receptor Activin receptor-like kinase 7 (Alk7) is highly expressed ...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2015.06.003

    authors： Balkow A,Jagow J,Haas B,Siegel F,Kilić A,Pfeifer A

    更新日期：2015-06-14 00:00:00

  • Metabolic functions of the tumor suppressor p53: Implications in normal physiology, metabolic disorders, and cancer.

    abstract：BACKGROUND:The TP53 gene is one of the most commonly inactivated tumor suppressors in human cancers. p53 functions during cancer progression have been linked to a variety of transcriptional and non-transcriptional activities that lead to the tight control of cell proliferation, senescence, DNA repair, and cell death. H...

    journal_title：Molecular metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/j.molmet.2019.10.002

    authors： Lacroix M,Riscal R,Arena G,Linares LK,Le Cam L

    更新日期：2020-03-01 00:00:00

  • The insulin like growth factor and binding protein family: Novel therapeutic targets in obesity & diabetes.

    abstract：BACKGROUND:Recent changes in nutrition and lifestyle have provoked an unprecedented increase in the prevalence of obesity and metabolic disorders. Recognition of the adverse effects on health has prompted intense efforts to understand the molecular determinants of insulin sensitivity and dysglycemia. In many respects, ...

    journal_title：Molecular metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/j.molmet.2018.10.008

    authors： Haywood NJ,Slater TA,Matthews CJ,Wheatcroft SB

    更新日期：2019-01-01 00:00:00

  • Nicotinamide N-methyltransferase: At the crossroads between cellular metabolism and epigenetic regulation.

    abstract：BACKGROUND:The abundance of energy metabolites is intimately interconnected with the activity of chromatin-modifying enzymes in order to guarantee the finely tuned modulation of gene expression in response to cellular energetic status. Metabolism-induced epigenetic gene regulation is a key molecular axis for the mainte...

    journal_title：Molecular metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/j.molmet.2021.101165

    authors： Roberti A,Fernández AF,Fraga MF

    更新日期：2021-01-14 00:00:00

  • Rasal2 deficiency reduces adipogenesis and occurrence of obesity-related disorders.

    abstract：OBJECTIVE:Identification of additional regulatory factors involved in the onset of obesity is important to understand the mechanisms underlying this prevailing disease and its associated metabolic disorders and to develop therapeutic strategies. Through isolation and analysis of a mutant, we aimed to uncover the functi...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2017.03.003

    authors： Zhu X,Xie S,Xu T,Wu X,Han M

    更新日期：2017-03-18 00:00:00

  • Surplus fat rapidly increases fat oxidation and insulin resistance in lipodystrophic mice.

    abstract：OBJECTIVE:Surplus dietary fat cannot be converted into other macronutrient forms or excreted, so has to be stored or oxidized. Healthy mammals store excess energy in the form of triacylgycerol (TAG) in lipid droplets within adipocytes rather than oxidizing it, and thus ultimately gain weight. The 'overflow hypothesis' ...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2018.05.006

    authors： Girousse A,Virtue S,Hart D,Vidal-Puig A,Murgatroyd PR,Mouisel E,Sengenès C,Savage DB

    更新日期：2018-07-01 00:00:00

  • Single-cell transcriptomics of human islet ontogeny defines the molecular basis of β-cell dedifferentiation in T2D.

    abstract：OBJECTIVE:Dedifferentiation of pancreatic β-cells may reduce islet function in type 2 diabetes (T2D). However, the prevalence, plasticity and functional consequences of this cellular state remain unknown. METHODS:We employed single-cell RNAseq to detail the maturation program of α- and β-cells during human ontogeny. W...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2020.101057

    authors： Avrahami D,Wang YJ,Schug J,Feleke E,Gao L,Liu C,HPAP Consortium.,Naji A,Glaser B,Kaestner KH

    更新日期：2020-12-01 00:00:00

  • Physiological roles of the GIP receptor in murine brown adipose tissue.

    abstract：OBJECTIVE:Glucose-dependent insulinotropic polypeptide (GIP) is secreted from the gut in response to nutrient ingestion and promotes meal-dependent insulin secretion and lipid metabolism. Loss or attenuation of GIP receptor (GIPR) action leads to resistance to diet-induced obesity through incompletely understood mechan...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2019.08.006

    authors： Beaudry JL,Kaur KD,Varin EM,Baggio LL,Cao X,Mulvihill EE,Bates HE,Campbell JE,Drucker DJ

    更新日期：2019-10-01 00:00:00

  • Metabolically phenotyped pancreatectomized patients as living donors for the study of islets in health and diabetes.

    abstract：BACKGROUND:The availability of human pancreatic islets with characteristics closely resembling those present in vivo is instrumental for ex vivo studies in diabetes research. SCOPE OF REVIEW:In this review we propose metabolically phenotyped surgical patients as a novel source of pancreatic tissue for islet research. ...

    journal_title：Molecular metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/j.molmet.2019.06.006

    authors： Barovic M,Distler M,Schöniger E,Radisch N,Aust D,Weitz J,Ibberson M,Schulte AM,Solimena M

    更新日期：2019-09-01 00:00:00

  • The role of GluN2A and GluN2B NMDA receptor subunits in AgRP and POMC neurons on body weight and glucose homeostasis.

    abstract：OBJECTIVE:Hypothalamic agouti-related peptide (AgRP) and pro-opiomelanocortin (POMC) expressing neurons play critical roles in control of energy balance. Glutamatergic input via n-methyl-d-aspartate receptors (NMDARs) is pivotal for regulation of neuronal activity and is required in AgRP neurons for normal body weight ...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2015.06.010

    authors： Üner A,Gonçalves GH,Li W,Porceban M,Caron N,Schönke M,Delpire E,Sakimura K,Bjørbæk C

    更新日期：2015-07-06 00:00:00

  • Neonatal GLP1R activation limits adult adiposity by durably altering hypothalamic architecture.

    abstract：OBJECTIVE:Adult obesity risk is influenced by alterations to fetal and neonatal environments. Modifying neonatal gut or neurohormone signaling pathways can have negative metabolic consequences in adulthood. Here we characterize the effect of neonatal activation of glucagon like peptide-1 (GLP-1) receptor (GLP1R) signal...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2017.05.006

    authors： Rozo AV,Babu DA,Suen PA,Groff DN,Seeley RJ,Simmons RA,Seale P,Ahima RS,Stoffers DA

    更新日期：2017-05-15 00:00:00