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Lipin-1 and lipin-3 together determine adiposity in vivo.

Abstract：

:The lipin protein family of phosphatidate phosphatases has an established role in triacylglycerol synthesis and storage. Physiological roles for lipin-1 and lipin-2 have been identified, but the role of lipin-3 has remained mysterious. Using lipin single- and double-knockout models we identified a cooperative relationship between lipin-3 and lipin-1 that influences adipogenesis in vitro and adiposity in vivo. Furthermore, natural genetic variations in Lpin1 and Lpin3 expression levels across 100 mouse strains correlate with adiposity. Analysis of PAP activity in additional metabolic tissues from lipin single- and double-knockout mice also revealed roles for lipin-1 and lipin-3 in spleen, kidney, and liver, for lipin-1 alone in heart and skeletal muscle, and for lipin-1 and lipin-2 in lung and brain. Our findings establish that lipin-1 and lipin-3 cooperate in vivo to determine adipose tissue PAP activity and adiposity, and may have implications in understanding the protection of lipin-1-deficient humans from overt lipodystrophy.

journal_name

Mol Metab

journal_title

Molecular metabolism

authors

Csaki LS,Dwyer JR,Li X,Nguyen MH,Dewald J,Brindley DN,Lusis AJ,Yoshinaga Y,de Jong P,Fong L,Young SG,Reue K

doi

10.1016/j.molmet.2013.11.008

subject

Has Abstract

pub_date

2013-11-28 00:00:00

pages

145-54

issue

2

issn

2212-8778

pii

S2212-8778(13)00126-9

journal_volume

3

pub_type

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