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(11)C-meta-hydroxyephedrine PET/CT imaging allows in vivo study of adaptive thermogenesis and white-to-brown fat conversion.

Abstract：

:Several lines of evidence suggest that novel pharmacological approaches aimed at converting white adipose tissue (WAT) into brown adipose tissue (BAT) may represent an effective therapeutic strategy for obesity and related disorders. ((18))F-fluorodeoxyglucose ((18)F-FDG) is the only positron emission tomography (PET) tracer commonly used to study BAT function, and so far no functional tools have been described to investigate in vivo white-to-brown fat conversion. In this report, we show that the PET tracer (11)C-meta-hydroxyephedrine ((11)C-MHED, a norepinephrine analogue) is a useful tool to investigate the sympathetic nervous system (SNS) activity in BAT of lean and dietary obese mice. Moreover, we demonstrate that (11)C-MHED is a specific marker of the SNS-mediated thermogenesis in typical BAT depots, and that this tracer can detect in vivo WAT to BAT conversion.

journal_name

Mol Metab

journal_title

Molecular metabolism

authors

Quarta C,Lodi F,Mazza R,Giannone F,Boschi L,Nanni C,Nisoli E,Boschi S,Pasquali R,Fanti S,Iozzo P,Pagotto U

doi

10.1016/j.molmet.2013.04.002

subject

Has Abstract

pub_date

2013-04-21 00:00:00

pages

153-60

issue

3

issn

2212-8778

pii

S2212-8778(13)00029-X

journal_volume

2

pub_type

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