当前位置： SCI文献检索 > Molecular Metabolism期刊下所有文献 > Granulocyte colony-stimulating factor (G-CSF): A saturated fatty acid-induced myokine with insulin-desensitizing properties in humans.

Granulocyte colony-stimulating factor (G-CSF): A saturated fatty acid-induced myokine with insulin-desensitizing properties in humans.

Abstract：

OBJECTIVE:Circulating long-chain free fatty acids (FFAs) are important metabolic signals that acutely enhance fatty acid oxidation, thermogenesis, energy expenditure, and insulin secretion. However, if chronically elevated, they provoke inflammation, insulin resistance, and β-cell failure. Moreover, FFAs act via multiple signaling pathways as very potent regulators of gene expression. In human skeletal muscle cells differentiated in vitro (myotubes), we have shown in previous studies that the expression of CSF3, the gene encoding granulocyte colony-stimulating factor (G-CSF), is markedly induced upon FFA treatment and exercise. METHODS AND RESULTS:We now report that CSF3 is induced in human myotubes by saturated, but not unsaturated, FFAs via Toll-like receptor 4-dependent and -independent pathways including activation of Rel-A, AP-1, C/EBPα, Src, and stress kinases. Furthermore, we show that human adipocytes and myotubes treated with G-CSF become insulin-resistant. In line with this, a functional polymorphism in the CSF3 gene affects adipose tissue- and whole-body insulin sensitivity and glucose tolerance in human subjects with elevated plasma FFA concentrations. CONCLUSION:G-CSF emerges as a new player in FFA-induced insulin resistance and thus may be of interest as a target for prevention and treatment of type 2 diabetes.

journal_name

Mol Metab

journal_title

Molecular metabolism

authors

Ordelheide AM,Gommer N,Böhm A,Hermann C,Thielker I,Machicao F,Fritsche A,Stefan N,Häring HU,Staiger H

doi

10.1016/j.molmet.2016.02.001

subject

Has Abstract

pub_date

2016-02-13 00:00:00

pages

305-316

issue

4

issn

2212-8778

pii

S2212-8778(16)00023-5

journal_volume

5

pub_type

杂志文章

相关文献

Molecular Metabolism文献大全
  • A spontaneous leptin receptor point mutation causes obesity and differentially affects leptin signaling in hypothalamic nuclei resulting in metabolic dysfunctions distinct from db/db mice.

    abstract：OBJECTIVE:Leptin (Lep) plays a crucial role in controlling food intake and energy expenditure. Defective Lep/LepRb-signaling leads to fat accumulation, massive obesity, and the development of diabetes. We serendipitously noticed spontaneous development of obesity similar to LepR-deficient (db/db) mice in offspring from...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2019.04.010

    authors： Piattini F,Le Foll C,Kisielow J,Rosenwald E,Nielsen P,Lutz T,Schneider C,Kopf M

    更新日期：2019-07-01 00:00:00

  • The taming of PARP1 and its impact on NAD+ metabolism.

    abstract：BACKGROUND:Poly-ADP-ribose polymerases (PARPs) are key mediators of cellular stress response. They are intimately linked to cellular metabolism through the consumption of NAD+. PARP1/ARTD1 in the nucleus is the major NAD+ consuming activity and plays a key role in maintaining genomic integrity. SCOPE OF REVIEW:In this...

    journal_title：Molecular metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/j.molmet.2020.01.014

    authors： Hurtado-Bagès S,Knobloch G,Ladurner AG,Buschbeck M

    更新日期：2020-08-01 00:00:00

  • Maternal obesity persistently alters cardiac progenitor gene expression and programs adult-onset heart disease susceptibility.

    abstract：OBJECTIVE:Heart disease risk can be programmed by intrauterine exposure to obesity. Dysregulating key transcription factors in cardiac progenitors can cause subsequent adult-onset heart disease. In this study, we investigated the transcriptional pathways that are altered in the embryonic heart and linked to heart disea...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2020.101116

    authors： Ahmed A,Liang M,Chi L,Zhou YQ,Sled JG,Wilson MD,Delgado-Olguín P

    更新日期：2021-01-01 00:00:00

  • Melanocortin-3 receptors in the limbic system mediate feeding-related motivational responses during weight loss.

    abstract：OBJECTIVE:Appetitive responses to weight loss are mediated by a nutrient-sensing neural network comprised of melanocortin neurons. The role of neural melanocortin-3 receptors (MC3R) in mediating these responses is enigmatic. Mc3r knockout mice exhibit a paradoxical phenotype of obesity and reduced feeding-related behav...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2016.05.002

    authors： Mavrikaki M,Girardet C,Kern A,Faruzzi Brantley A,Miller CA,Macarthur H,Marks DL,Butler AA

    更新日期：2016-05-12 00:00:00

  • Regulation of inflammation in diabetes: From genetics to epigenomics evidence.

    abstract：BACKGROUND:Diabetes is one of the greatest public health challenges worldwide, and we still lack complementary approaches to significantly enhance the efficacy of preventive and therapeutic approaches. Genetic and environmental factors are the culprits involved in diabetes risk. Evidence from the last decade has highli...

    journal_title：Molecular metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/j.molmet.2020.101041

    authors： Diedisheim M,Carcarino E,Vandiedonck C,Roussel R,Gautier JF,Venteclef N

    更新日期：2020-11-01 00:00:00

  • High-fidelity Glucagon-CreER mouse line generated by CRISPR-Cas9 assisted gene targeting.

    abstract：OBJECTIVE:α-cells are the second most prominent cell type in pancreatic islets and are responsible for producing glucagon to increase plasma glucose levels in times of fasting. α-cell dysfunction and inappropriate glucagon secretion occur in both type 1 and type 2 diabetes. Thus, there is growing interest in studying b...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2017.01.003

    authors： Ackermann AM,Zhang J,Heller A,Briker A,Kaestner KH

    更新日期：2017-01-12 00:00:00

  • "Omics" and "epi-omics" underlying the β-cell adaptation to insulin resistance.

    abstract：BACKGROUND:Pancreatic β-cells adapt to high metabolic demand by expanding their β-cell mass and/or enhancing insulin secretion to maintain glucose homeostasis. Type 2 diabetes (T2D) is typically characterized by β-cell decompensation. SCOPE OF THE REVIEW:The current review focuses on summarizing the "omics" and "epi-o...

    journal_title：Molecular metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/j.molmet.2019.06.003

    authors： De Jesus DF,Kulkarni RN

    更新日期：2019-09-01 00:00:00

  • The Hepatokine TSK does not affect brown fat thermogenic capacity, body weight gain, and glucose homeostasis.

    abstract：OBJECTIVES:Hepatokines are proteins secreted by the liver that impact the functions of the liver and various tissues through autocrine, paracrine, and endocrine signaling. Recently, Tsukushi (TSK) was identified as a new hepatokine that is induced by obesity and cold exposure. It was proposed that TSK controls sympathe...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2019.09.014

    authors： Mouchiroud M,Camiré É,Aldow M,Caron A,Jubinville É,Turcotte L,Kaci I,Beaulieu MJ,Roy C,Labbé SM,Varin TV,Gélinas Y,Lamothe J,Trottier J,Mitchell PL,Guénard F,Festuccia WT,Joubert P,Rose CF,Karvellas CJ,Barbier O,

    更新日期：2019-12-01 00:00:00

  • Peroxisome proliferator-activated receptor alpha plays a crucial role in behavioral repetition and cognitive flexibility in mice.

    abstract：BACKGROUND/OBJECTIVES:Nuclear peroxisome proliferator activated receptor-α (PPAR-α) plays a fundamental role in the regulation of lipid homeostasis and is the target of medications used to treat dyslipidemia. However, little is known about the role of PPAR-α in mouse behavior. METHODS:To investigate the function of Pp...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2015.04.005

    authors： D'Agostino G,Cristiano C,Lyons DJ,Citraro R,Russo E,Avagliano C,Russo R,Raso GM,Meli R,De Sarro G,Heisler LK,Calignano A

    更新日期：2015-05-02 00:00:00

  • The insulin like growth factor and binding protein family: Novel therapeutic targets in obesity & diabetes.

    abstract：BACKGROUND:Recent changes in nutrition and lifestyle have provoked an unprecedented increase in the prevalence of obesity and metabolic disorders. Recognition of the adverse effects on health has prompted intense efforts to understand the molecular determinants of insulin sensitivity and dysglycemia. In many respects, ...

    journal_title：Molecular metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/j.molmet.2018.10.008

    authors： Haywood NJ,Slater TA,Matthews CJ,Wheatcroft SB

    更新日期：2019-01-01 00:00:00

  • Neonatal GLP1R activation limits adult adiposity by durably altering hypothalamic architecture.

    abstract：OBJECTIVE:Adult obesity risk is influenced by alterations to fetal and neonatal environments. Modifying neonatal gut or neurohormone signaling pathways can have negative metabolic consequences in adulthood. Here we characterize the effect of neonatal activation of glucagon like peptide-1 (GLP-1) receptor (GLP1R) signal...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2017.05.006

    authors： Rozo AV,Babu DA,Suen PA,Groff DN,Seeley RJ,Simmons RA,Seale P,Ahima RS,Stoffers DA

    更新日期：2017-05-15 00:00:00

  • Nav1.8 neurons are involved in limiting acute phase responses to dietary fat.

    abstract：OBJECTIVE AND METHODS:Metabolic viscera and their vasculature are richly innervated by peripheral sensory neurons. Here, we examined the metabolic and inflammatory profiles of mice with selective ablation of all Nav1.8-expressing primary afferent neurons. RESULTS:While mice lacking sensory neurons displayed no differe...

    journal_title：Molecular metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/j.molmet.2017.07.012

    authors： Udit S,Burton M,Rutkowski JM,Lee S,Bookout AL,Scherer PE,Elmquist JK,Gautron L

    更新日期：2017-10-01 00:00:00

  • Integration of body temperature into the analysis of energy expenditure in the mouse.

    abstract：OBJECTIVES:We quantified the effect of environmental temperature on mouse energy homeostasis and body temperature. METHODS:The effect of environmental temperature (4-33 °C) on body temperature, energy expenditure, physical activity, and food intake in various mice (chow diet, high-fat diet, Brs3 (-/y) , lipodystrophic...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2015.03.001

    authors： Abreu-Vieira G,Xiao C,Gavrilova O,Reitman ML

    更新日期：2015-03-10 00:00:00

  • Metabolic dysfunction in polycystic ovary syndrome: Pathogenic role of androgen excess and potential therapeutic strategies.

    abstract：BACKGROUND:Polycystic ovary syndrome (PCOS) is the most common endocrinopathy among reproductive age women. Although its cardinal manifestations include hyperandrogenism, oligo/anovulation, and/or polycystic ovarian morphology, PCOS women often display also notable metabolic comorbidities. An array of pathogenic mechan...

    journal_title：Molecular metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/j.molmet.2020.01.001

    authors： Sanchez-Garrido MA,Tena-Sempere M

    更新日期：2020-05-01 00:00:00

  • Autonomous interconversion between adult pancreatic α-cells and β-cells after differential metabolic challenges.

    abstract：BACKGROUND:Evidence hints at the ability of β-cells to emerge from non-β-cells upon genetic or pharmacological interventions. However, their quantitative contributions to the process of autonomous β-cell regeneration without genetic or pharmacological manipulations remain to be determined. METHODS & RESULTS:Using PANI...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2016.05.001

    authors： Ye R,Wang M,Wang QA,Spurgin SB,Wang ZV,Sun K,Scherer PE

    更新日期：2016-05-10 00:00:00

  • Surplus fat rapidly increases fat oxidation and insulin resistance in lipodystrophic mice.

    abstract：OBJECTIVE:Surplus dietary fat cannot be converted into other macronutrient forms or excreted, so has to be stored or oxidized. Healthy mammals store excess energy in the form of triacylgycerol (TAG) in lipid droplets within adipocytes rather than oxidizing it, and thus ultimately gain weight. The 'overflow hypothesis' ...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2018.05.006

    authors： Girousse A,Virtue S,Hart D,Vidal-Puig A,Murgatroyd PR,Mouisel E,Sengenès C,Savage DB

    更新日期：2018-07-01 00:00:00

  • Glycerol not lactate is the major net carbon source for gluconeogenesis in mice during both short and prolonged fasting.

    abstract：OBJECTIVE:Fasting results in major metabolic changes including a switch from glycogenolysis to gluconeogenesis to maintain glucose homeostasis. However, the relationship between the length of fasting and the relative contribution of gluconeogenic substrates remains unclear. We investigated the relative contribution of ...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2019.11.005

    authors： Wang Y,Kwon H,Su X,Wondisford FE

    更新日期：2020-01-01 00:00:00

  • Ablation of intact hypothalamic and/or hindbrain TrkB signaling leads to perturbations in energy balance.

    abstract：OBJECTIVE:Brain-derived neurotrophic factor (BDNF) and its receptor, tropomyosin receptor kinase B (TrkB), play a paramount role in the central regulation of energy balance. Despite the substantial body of genetic evidence implicating BDNF- or TrkB-deficiency in human obesity, the critical brain region(s) contributing ...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2015.08.002

    authors： Ozek C,Zimmer DJ,De Jonghe BC,Kalb RG,Bence KK

    更新日期：2015-08-18 00:00:00

  • Cadm2 regulates body weight and energy homeostasis in mice.

    abstract：OBJECTIVE:Obesity is strongly linked to genes regulating neuronal signaling and function, implicating the central nervous system in the maintenance of body weight and energy metabolism. Genome-wide association studies identified significant associations between body mass index (BMI) and multiple loci near Cell adhesion...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2017.11.010

    authors： Yan X,Wang Z,Schmidt V,Gauert A,Willnow TE,Heinig M,Poy MN

    更新日期：2018-02-01 00:00:00

  • Skeletal muscle autophagy and mitophagy in endurance-trained runners before and after a high-fat meal.

    abstract：OBJECTIVE:We tested the hypothesis that skeletal muscle of endurance-trained male runners would exhibit elevated autophagy and mitophagy markers, which would be associated with greater metabolic flexibility following a high-fat meal (HFM). METHODS:Muscle biopsies were collected to determine differences in autophagy an...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2017.10.006

    authors： Tarpey MD,Davy KP,McMillan RP,Bowser SM,Halliday TM,Boutagy NE,Davy BM,Frisard MI,Hulver MW

    更新日期：2017-12-01 00:00:00

  • Intestinal stem cell-derived enteroids from morbidly obese patients preserve obesity-related phenotypes: Elevated glucose absorption and gluconeogenesis.

    abstract：OBJECTIVE:The mechanisms behind the efficacy of bariatric surgery (BS) for treating obesity and type 2 diabetes, particularly with respect to the influence of the small bowel, remain poorly understood. In vitro and animal models are suboptimal with respect to their ability to replicate the human intestinal epithelium u...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2020.101129

    authors： Hasan NM,Johnson KF,Yin J,Baetz NW,Fayad L,Sherman V,Blutt SE,Estes MK,Kumbhari V,Zachos NC,Kovbasnjuk O

    更新日期：2020-11-25 00:00:00

  • Control of hepatic gluconeogenesis by Argonaute2.

    abstract：OBJECTIVE:The liver performs a central role in regulating energy homeostasis by increasing glucose output during fasting. Recent studies on Argonaute2 (Ago2), a key RNA-binding protein mediating the microRNA pathway, have illustrated its role in adaptive mechanisms according to changes in metabolic demand. Here we soug...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2018.10.003

    authors： Yan X,Wang Z,Bishop CA,Weitkunat K,Feng X,Tarbier M,Luo J,Friedländer MR,Burkhardt R,Klaus S,Willnow TE,Poy MN

    更新日期：2018-12-01 00:00:00

  • Cannabinoid control of brain bioenergetics: Exploring the subcellular localization of the CB1 receptor.

    abstract：:Brain mitochondrial activity is centrally involved in the central control of energy balance. When studying mitochondrial functions in the brain, however, discrepant results might be obtained, depending on the experimental approaches. For instance, immunostaining experiments and biochemical isolation of organelles expo...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2014.03.007

    authors： Hebert-Chatelain E,Reguero L,Puente N,Lutz B,Chaouloff F,Rossignol R,Piazza PV,Benard G,Grandes P,Marsicano G

    更新日期：2014-04-02 00:00:00

  • Adipocyte Gs but not Gi signaling regulates whole-body glucose homeostasis.

    abstract：OBJECTIVE:The sympathetic nervous system (SNS) is a key regulator of the metabolic and endocrine functions of adipose tissue. Increased SNS outflow promotes fat mobilization, stimulates non-shivering thermogenesis, promotes browning, and inhibits leptin production. Most of these effects are attributed to norepinephrine...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2019.06.019

    authors： Caron A,Reynolds RP,Castorena CM,Michael NJ,Lee CE,Lee S,Berdeaux R,Scherer PE,Elmquist JK

    更新日期：2019-09-01 00:00:00

  • N-terminal transactivation function, AF-1, of estrogen receptor alpha controls obesity through enhancement of energy expenditure.

    abstract：OBJECTIVE:Studies using the estrogen receptor alpha (ERα) knock-out (αERKO) mice have demonstrated that ERα plays a crucial role in various estrogen-mediated metabolic regulations. ERα is a ligand dependent transcription regulator and its activity is regulated by estrogenic compounds. ERα consists of two transcriptiona...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2018.09.006

    authors： Arao Y,Hamilton KJ,Lierz SL,Korach KS

    更新日期：2018-12-01 00:00:00

  • Profiling plasma N-Acylethanolamine levels and their ratios as a biomarker of obesity and dysmetabolism.

    abstract：OBJECTIVE:N-acylethanolamines play different roles in energy balance; anandamide (AEA) stimulates energy intake and storage, N-palmitoylethanolamide (PEA) counters inflammation, and N-oleoylethanolamide (OEA) mediates anorectic signals and lipid oxidation. Inconsistencies in the association of plasma N-acylethanolamine...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2018.06.002

    authors： Fanelli F,Mezzullo M,Repaci A,Belluomo I,Ibarra Gasparini D,Di Dalmazi G,Mastroroberto M,Vicennati V,Gambineri A,Morselli-Labate AM,Pasquali R,Pagotto U

    更新日期：2018-08-01 00:00:00

  • Human beta cell mass and function in diabetes: Recent advances in knowledge and technologies to understand disease pathogenesis.

    abstract：BACKGROUND:Plasma insulin levels are predominantly the product of the morphological mass of insulin producing beta cells in the pancreatic islets of Langerhans and the functional status of each of these beta cells. Thus, deficiency in either beta cell mass or function, or both, can lead to insufficient levels of insuli...

    journal_title：Molecular metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/j.molmet.2017.06.019

    authors： Chen C,Cohrs CM,Stertmann J,Bozsak R,Speier S

    更新日期：2017-07-08 00:00:00

  • FGF21 resistance is not mediated by downregulation of beta-klotho expression in white adipose tissue.

    abstract：OBJECTIVE:Fibroblast growth factor 21 (FGF21) is an endocrine hormone that regulates metabolic homeostasis. Previous work has suggested that impairment of FGF21 signaling in adipose tissue may occur through downregulation of the obligate FGF21 co-receptor, β-klotho, which leads to "FGF21 resistance" during the onset of...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2017.03.009

    authors： Markan KR,Naber MC,Small SM,Peltekian L,Kessler RL,Potthoff MJ

    更新日期：2017-03-27 00:00:00

  • Metabolic remodeling of dystrophic skeletal muscle reveals biological roles for dystrophin and utrophin in adaptation and plasticity.

    abstract：OBJECTIVES:Preferential damage to fast, glycolytic myofibers is common in many muscle-wasting diseases, including Duchenne muscular dystrophy (DMD). Promoting an oxidative phenotype could protect muscles from damage and ameliorate the dystrophic pathology with therapeutic relevance, but developing efficacious strategie...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2020.101157

    authors： Hardee JP,Martins KJB,Miotto PM,Ryall JG,Gehrig SM,Reljic B,Naim T,Chung JD,Trieu J,Swiderski K,Philp AM,Philp A,Watt MJ,Stroud DA,Koopman R,Steinberg GR,Lynch GS

    更新日期：2020-12-24 00:00:00

  • An unbiased silencing screen in muscle cells identifies miR-320a, miR-150, miR-196b, and miR-34c as regulators of skeletal muscle mitochondrial metabolism.

    abstract：OBJECTIVE:Strategies improving skeletal muscle mitochondrial capacity are commonly paralleled by improvements in (metabolic) health. We and others previously identified microRNAs regulating mitochondrial oxidative capacity, but data in skeletal muscle are limited. Therefore, the present study aimed to identify novel mi...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2017.08.007

    authors： Dahlmans D,Houzelle A,Andreux P,Jörgensen JA,Wang X,de Windt LJ,Schrauwen P,Auwerx J,Hoeks J

    更新日期：2017-11-01 00:00:00