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The taming of PARP1 and its impact on NAD+ metabolism.

Abstract：

BACKGROUND:Poly-ADP-ribose polymerases (PARPs) are key mediators of cellular stress response. They are intimately linked to cellular metabolism through the consumption of NAD+. PARP1/ARTD1 in the nucleus is the major NAD+ consuming activity and plays a key role in maintaining genomic integrity. SCOPE OF REVIEW:In this review, we discuss how different organelles are linked through NAD+ metabolism and how PARP1 activation in the nucleus can impact the function of distant organelles. We discuss how differentiated cells tame PARP1 function by upregulating an endogenous inhibitor, the histone variant macroH2A1.1. MAJOR CONCLUSIONS:The presence of macroH2A1.1, particularly in differentiated cells, raises the threshold for the activation of PARP1 with consequences for DNA repair, gene transcription, and NAD+ homeostasis.

journal_name

Mol Metab

journal_title

Molecular metabolism

authors

Hurtado-Bagès S,Knobloch G,Ladurner AG,Buschbeck M

doi

10.1016/j.molmet.2020.01.014

subject

Has Abstract

pub_date

2020-08-01 00:00:00

pages

100950

issn

2212-8778

pii

S2212-8778(20)30022-3

journal_volume

38

pub_type

杂志文章,评审

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