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Altered ghrelin secretion in mice in response to diet-induced obesity and Roux-en-Y gastric bypass.

Abstract：

:The current study examined potential mechanisms for altered circulating ghrelin levels observed in diet-induced obesity (DIO) and following weight loss resulting from Roux-en-Y gastric bypass (RYGB). We hypothesized that circulating ghrelin levels were altered in obesity and after weight loss through changes in ghrelin cell responsiveness to physiological cues. We confirmed lower ghrelin levels in DIO mice and demonstrated elevated ghrelin levels in mice 6 weeks post-RYGB. In both DIO and RYGB settings, these changes in ghrelin levels were associated with altered ghrelin cell responsiveness to two key physiological modulators of ghrelin secretion - glucose and norepinephrine. In DIO mice, increases in ghrelin cell density within both the stomach and duodenum and in somatostatin-immunoreactive D cell density in the duodenum were observed. Our findings provide new insights into the regulation of ghrelin secretion and its relation to circulating ghrelin within the contexts of obesity and weight loss.

journal_name

Mol Metab

journal_title

Molecular metabolism

authors

Uchida A,Zechner JF,Mani BK,Park WM,Aguirre V,Zigman JM

doi

10.1016/j.molmet.2014.07.009

subject

Has Abstract

pub_date

2014-08-01 00:00:00

pages

717-30

issue

7

issn

2212-8778

pii

S2212-8778(14)00135-5

journal_volume

3

pub_type

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