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Genome-wide DNA promoter methylation and transcriptome analysis in human adipose tissue unravels novel candidate genes for obesity.

Abstract：

OBJECTIVE/METHODS:DNA methylation plays an important role in obesity and related metabolic complications. We examined genome-wide DNA promoter methylation along with mRNA profiles in paired samples of human subcutaneous adipose tissue (SAT) and omental visceral adipose tissue (OVAT) from non-obese vs. obese individuals. RESULTS:We identified negatively correlated methylation and expression of several obesity-associated genes in our discovery dataset and in silico replicated ETV6 in two independent cohorts. Further, we identified six adipose tissue depot-specific genes (HAND2, HOXC6, PPARG, SORBS2, CD36, and CLDN1). The effects were further supported in additional independent cohorts. Our top hits might play a role in adipogenesis and differentiation, obesity, lipid metabolism, and adipose tissue expandability. Finally, we show that in vitro methylation of SORBS2 directly represses gene expression. CONCLUSIONS:Taken together, our data show distinct tissue specific epigenetic alterations which associate with obesity.

journal_name

Mol Metab

journal_title

Molecular metabolism

authors

Keller M,Hopp L,Liu X,Wohland T,Rohde K,Cancello R,Klös M,Bacos K,Kern M,Eichelmann F,Dietrich A,Schön MR,Gärtner D,Lohmann T,Dreßler M,Stumvoll M,Kovacs P,DiBlasio AM,Ling C,Binder H,Blüher M,Böttcher Y

doi

10.1016/j.molmet.2016.11.003

subject

Has Abstract

pub_date

2016-11-16 00:00:00

pages

86-100

issue

1

issn

2212-8778

pii

S2212-8778(16)30275-7

journal_volume

6

pub_type

杂志文章

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