当前位置： SCI文献检索 > Molecular Metabolism期刊下所有文献 > Parental obesity leads to metabolic changes in the F2 generation in Drosophila.

Parental obesity leads to metabolic changes in the F2 generation in Drosophila.

Abstract：

OBJECTIVE:A significant portion of the heritable risk for complex metabolic disorders cannot be attributed to classic Mendelian genetic factors. At least some of this missing heritability is thought to be due to the epigenetic influence of parental and grandparental metabolic state on offspring health. Previous work suggests that this transgenerational phenomenon is evolutionarily conserved in Drosophila. These studies, however, have all depended on dietary paradigms to alter parental metabolic state, which can have inconsistent heritable effects on the metabolism of offspring. METHODS:Here we use AKHR null alleles to induce obesity in the parental generation and then score both metabolic parameters and genome-wide transcriptional responses in AKHR heterozygote F1 progeny and genetically wild-type F2 progeny. RESULTS:Unexpectedly, we observe elevated glycogen levels and changes in gene expression in AKHR heterozygotes due to haploinsufficiency at this locus. We also show that genetic manipulation of parental metabolism using AKHR mutations results in significant physiological changes in F2 wild-type offspring of the grandpaternal/maternal lineage. CONCLUSIONS:Our results demonstrate that genetic manipulation of parental metabolism in Drosophila can have an effect on the health of F2 progeny, providing a non-dietary paradigm to better understand the mechanisms behind the transgenerational inheritance of metabolic state.

journal_name

Mol Metab

journal_title

Molecular metabolism

authors

Palu RAS,Praggastis SA,Thummel CS

doi

10.1016/j.molmet.2017.03.012

subject

Has Abstract

pub_date

2017-04-26 00:00:00

pages

631-639

issue

7

issn

2212-8778

pii

S2212-8778(17)30114-X

journal_volume

6

pub_type

杂志文章

相关文献

Molecular Metabolism文献大全
  • The Hepatokine TSK does not affect brown fat thermogenic capacity, body weight gain, and glucose homeostasis.

    abstract：OBJECTIVES:Hepatokines are proteins secreted by the liver that impact the functions of the liver and various tissues through autocrine, paracrine, and endocrine signaling. Recently, Tsukushi (TSK) was identified as a new hepatokine that is induced by obesity and cold exposure. It was proposed that TSK controls sympathe...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2019.09.014

    authors： Mouchiroud M,Camiré É,Aldow M,Caron A,Jubinville É,Turcotte L,Kaci I,Beaulieu MJ,Roy C,Labbé SM,Varin TV,Gélinas Y,Lamothe J,Trottier J,Mitchell PL,Guénard F,Festuccia WT,Joubert P,Rose CF,Karvellas CJ,Barbier O,

    更新日期：2019-12-01 00:00:00

  • Altered ghrelin secretion in mice in response to diet-induced obesity and Roux-en-Y gastric bypass.

    abstract：:The current study examined potential mechanisms for altered circulating ghrelin levels observed in diet-induced obesity (DIO) and following weight loss resulting from Roux-en-Y gastric bypass (RYGB). We hypothesized that circulating ghrelin levels were altered in obesity and after weight loss through changes in ghreli...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2014.07.009

    authors： Uchida A,Zechner JF,Mani BK,Park WM,Aguirre V,Zigman JM

    更新日期：2014-08-01 00:00:00

  • Functional analysis reveals differential effects of glutamate and MCH neuropeptide in MCH neurons.

    abstract：OBJECTIVES:Melanin-concentrating hormone (MCH) neurons in the lateral hypothalamus (LH) regulate food intake and body weight, glucose metabolism and convey the reward value of sucrose. In this report, we set out to establish the respective roles of MCH and conventional neurotransmitters in these neurons. METHODS:MCH n...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2018.05.001

    authors： Schneeberger M,Tan K,Nectow AR,Parolari L,Caglar C,Azevedo E,Li Z,Domingos A,Friedman JM

    更新日期：2018-07-01 00:00:00

  • GPRC6A: Jack of all metabolism (or master of none).

    abstract：BACKGROUND:GPRC6A, a widely expressed G-protein coupled receptor, is proposed to be a master regulator of complex endocrine networks and metabolic processes. GPRC6A is activated by multiple ligands, including osteocalcin (Ocn), testosterone (T), basic amino acids, and various cations. SCOPE OF REVIEW:We review the con...

    journal_title：Molecular metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/j.molmet.2016.12.006

    authors： Pi M,Nishimoto SK,Quarles LD

    更新日期：2016-12-21 00:00:00

  • Neonatal GLP1R activation limits adult adiposity by durably altering hypothalamic architecture.

    abstract：OBJECTIVE:Adult obesity risk is influenced by alterations to fetal and neonatal environments. Modifying neonatal gut or neurohormone signaling pathways can have negative metabolic consequences in adulthood. Here we characterize the effect of neonatal activation of glucagon like peptide-1 (GLP-1) receptor (GLP1R) signal...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2017.05.006

    authors： Rozo AV,Babu DA,Suen PA,Groff DN,Seeley RJ,Simmons RA,Seale P,Ahima RS,Stoffers DA

    更新日期：2017-05-15 00:00:00

  • Maternal obesity persistently alters cardiac progenitor gene expression and programs adult-onset heart disease susceptibility.

    abstract：OBJECTIVE:Heart disease risk can be programmed by intrauterine exposure to obesity. Dysregulating key transcription factors in cardiac progenitors can cause subsequent adult-onset heart disease. In this study, we investigated the transcriptional pathways that are altered in the embryonic heart and linked to heart disea...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2020.101116

    authors： Ahmed A,Liang M,Chi L,Zhou YQ,Sled JG,Wilson MD,Delgado-Olguín P

    更新日期：2021-01-01 00:00:00

  • Preadipocytes of obese humans display gender-specific bioenergetic responses to glucose and insulin.

    abstract：BACKGROUND/OBJECTIVES:Although the prevalence of obesity and its associated metabolic disorders is increasing in both sexes, the clinical phenotype differs between men and women, highlighting the need for individual treatment options. Mitochondrial dysfunction in various tissues, including white adipose tissue (WAT), h...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2018.11.006

    authors： Keuper M,Berti L,Raedle B,Sachs S,Böhm A,Fritsche L,Fritsche A,Häring HU,Hrabě de Angelis M,Jastroch M,Hofmann SM,Staiger H

    更新日期：2019-02-01 00:00:00

  • Interdependence of nutrient metabolism and the circadian clock system: Importance for metabolic health.

    abstract：BACKGROUND:While additional research is needed, a number of large epidemiological studies show an association between circadian disruption and metabolic disorders. Specifically, obesity, insulin resistance, cardiovascular disease, and other signs of metabolic syndrome all have been linked to circadian disruption in hum...

    journal_title：Molecular metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/j.molmet.2015.12.006

    authors： Ribas-Latre A,Eckel-Mahan K

    更新日期：2016-01-14 00:00:00

  • Skeletal muscle autophagy and mitophagy in endurance-trained runners before and after a high-fat meal.

    abstract：OBJECTIVE:We tested the hypothesis that skeletal muscle of endurance-trained male runners would exhibit elevated autophagy and mitophagy markers, which would be associated with greater metabolic flexibility following a high-fat meal (HFM). METHODS:Muscle biopsies were collected to determine differences in autophagy an...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2017.10.006

    authors： Tarpey MD,Davy KP,McMillan RP,Bowser SM,Halliday TM,Boutagy NE,Davy BM,Frisard MI,Hulver MW

    更新日期：2017-12-01 00:00:00

  • Control of hepatic gluconeogenesis by Argonaute2.

    abstract：OBJECTIVE:The liver performs a central role in regulating energy homeostasis by increasing glucose output during fasting. Recent studies on Argonaute2 (Ago2), a key RNA-binding protein mediating the microRNA pathway, have illustrated its role in adaptive mechanisms according to changes in metabolic demand. Here we soug...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2018.10.003

    authors： Yan X,Wang Z,Bishop CA,Weitkunat K,Feng X,Tarbier M,Luo J,Friedländer MR,Burkhardt R,Klaus S,Willnow TE,Poy MN

    更新日期：2018-12-01 00:00:00

  • Reprogramming the body weight set point by a reciprocal interaction of hypothalamic leptin sensitivity and Pomc gene expression reverts extreme obesity.

    abstract：OBJECTIVE:A major challenge for obesity treatment is the maintenance of reduced body weight. Diet-induced obese mice are resistant to achieving normoweight once the obesogenic conditions are reversed, in part because lowered circulating leptin leads to a reduction in metabolic rate and a rebound of hyperphagia that def...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2016.07.012

    authors： Chhabra KH,Adams JM,Jones GL,Yamashita M,Schlapschy M,Skerra A,Rubinstein M,Low MJ

    更新日期：2016-08-05 00:00:00

  • PPARγ is dispensable for clear cell renal cell carcinoma progression.

    abstract：OBJECTIVE:Clear cell renal cell carcinoma (ccRCC) is a subtype of kidney cancer defined by robust lipid accumulation, which prior studies have indicated plays an important role in tumor progression. We hypothesized that the peroxisome proliferator-activated receptor gamma (PPARγ), detected in both ccRCC tumors and cell...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2018.05.013

    authors： Sanchez DJ,Steger DJ,Skuli N,Bansal A,Simon MC

    更新日期：2018-08-01 00:00:00

  • Gut microbiota and glucometabolic alterations in response to recurrent partial sleep deprivation in normal-weight young individuals.

    abstract：OBJECTIVE:Changes to the microbial community in the human gut have been proposed to promote metabolic disturbances that also occur after short periods of sleep loss (including insulin resistance). However, whether sleep loss affects the gut microbiota remains unknown. METHODS:In a randomized within-subject crossover s...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2016.10.003

    authors： Benedict C,Vogel H,Jonas W,Woting A,Blaut M,Schürmann A,Cedernaes J

    更新日期：2016-10-24 00:00:00

  • Metabolic functions of the tumor suppressor p53: Implications in normal physiology, metabolic disorders, and cancer.

    abstract：BACKGROUND:The TP53 gene is one of the most commonly inactivated tumor suppressors in human cancers. p53 functions during cancer progression have been linked to a variety of transcriptional and non-transcriptional activities that lead to the tight control of cell proliferation, senescence, DNA repair, and cell death. H...

    journal_title：Molecular metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/j.molmet.2019.10.002

    authors： Lacroix M,Riscal R,Arena G,Linares LK,Le Cam L

    更新日期：2020-03-01 00:00:00

  • Knockdown of ATP citrate lyase in pancreatic beta cells does not inhibit insulin secretion or glucose flux and implicates the acetoacetate pathway in insulin secretion.

    abstract：OBJECTIVE:Glucose-stimulated insulin secretion in pancreatic beta cells requires metabolic signals including the generation of glucose-derived short chain acyl-CoAs in the cytosol from mitochondrially-derived metabolites. One concept of insulin secretion is that ATP citrate lyase generates short chain acyl-CoAs in the ...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2016.07.011

    authors： El Azzouny M,Longacre MJ,Ansari IH,Kennedy RT,Burant CF,MacDonald MJ

    更新日期：2016-08-08 00:00:00

  • Peroxisome proliferator-activated receptor alpha plays a crucial role in behavioral repetition and cognitive flexibility in mice.

    abstract：BACKGROUND/OBJECTIVES:Nuclear peroxisome proliferator activated receptor-α (PPAR-α) plays a fundamental role in the regulation of lipid homeostasis and is the target of medications used to treat dyslipidemia. However, little is known about the role of PPAR-α in mouse behavior. METHODS:To investigate the function of Pp...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2015.04.005

    authors： D'Agostino G,Cristiano C,Lyons DJ,Citraro R,Russo E,Avagliano C,Russo R,Raso GM,Meli R,De Sarro G,Heisler LK,Calignano A

    更新日期：2015-05-02 00:00:00

  • Metabolic dysfunction in polycystic ovary syndrome: Pathogenic role of androgen excess and potential therapeutic strategies.

    abstract：BACKGROUND:Polycystic ovary syndrome (PCOS) is the most common endocrinopathy among reproductive age women. Although its cardinal manifestations include hyperandrogenism, oligo/anovulation, and/or polycystic ovarian morphology, PCOS women often display also notable metabolic comorbidities. An array of pathogenic mechan...

    journal_title：Molecular metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/j.molmet.2020.01.001

    authors： Sanchez-Garrido MA,Tena-Sempere M

    更新日期：2020-05-01 00:00:00

  • TOSO promotes β-cell proliferation and protects from apoptosis.

    abstract：:Decreased β-cell mass reflects a shift from quiescence/proliferation into apoptosis, it plays a crucial role in the pathophysiology of diabetes. A major attempt to restore β-cell mass and normoglycemia is to improve β-cell survival. Here we show that switching off the Fas pathway using Fas apoptotic inhibitory protein...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2012.08.006

    authors： Dharmadhikari G,Mühle M,Schulthess FT,Laue S,Oberholzer J,Pattou F,Kerr-Conte J,Maedler K

    更新日期：2012-08-17 00:00:00

  • Adult neural stem cell fate is determined by thyroid hormone activation of mitochondrial metabolism.

    abstract：OBJECTIVE:In the adult brain, neural stem cells (NSCs) located in the subventricular zone (SVZ) produce both neuronal and glial cells. Thyroid hormones (THs) regulate adult NSC differentiation towards a neuronal phenotype, but also have major roles in mitochondrial metabolism. As NSC metabolism relies mainly on glycoly...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2017.08.003

    authors： Gothié JD,Sébillot A,Luongo C,Legendre M,Nguyen Van C,Le Blay K,Perret-Jeanneret M,Remaud S,Demeneix BA

    更新日期：2017-11-01 00:00:00

  • Bile acid-induced inflammatory signaling in mice lacking Foxa2 in the liver leads to activation of mTOR and age-onset obesity.

    abstract：:Cytokine signaling has been connected to regulation of metabolism and energy balance. Numerous cytokine gene expression changes are stimulated by accumulation of bile acids in livers of young Foxa2 liver-conditional null mice. We hypothesized that bile acid-induced inflammation in young Foxa2 mutants, once chronic, af...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2013.08.005

    authors： Bochkis IM,Shin S,Kaestner KH

    更新日期：2013-08-24 00:00:00

  • White adipose remodeling during browning in mice involves YBX1 to drive thermogenic commitment.

    abstract：OBJECTIVE:Increasing adaptive thermogenesis by stimulating browning in white adipose tissue is a promising method of improving metabolic health. However, the molecular mechanisms underlying this transition remain elusive. Our study examined the molecular determinants driving the differentiation of precursor cells into ...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2020.101137

    authors： Rabiee A,Plucińska K,Isidor MS,Brown EL,Tozzi M,Sidoli S,Petersen PSS,Agueda-Oyarzabal M,Torsetnes SB,Chehabi GN,Lundh M,Altıntaş A,Barrès R,Jensen ON,Gerhart-Hines Z,Emanuelli B

    更新日期：2020-12-05 00:00:00

  • Profiling plasma N-Acylethanolamine levels and their ratios as a biomarker of obesity and dysmetabolism.

    abstract：OBJECTIVE:N-acylethanolamines play different roles in energy balance; anandamide (AEA) stimulates energy intake and storage, N-palmitoylethanolamide (PEA) counters inflammation, and N-oleoylethanolamide (OEA) mediates anorectic signals and lipid oxidation. Inconsistencies in the association of plasma N-acylethanolamine...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2018.06.002

    authors： Fanelli F,Mezzullo M,Repaci A,Belluomo I,Ibarra Gasparini D,Di Dalmazi G,Mastroroberto M,Vicennati V,Gambineri A,Morselli-Labate AM,Pasquali R,Pagotto U

    更新日期：2018-08-01 00:00:00

  • Rfx6 promotes the differentiation of peptide-secreting enteroendocrine cells while repressing genetic programs controlling serotonin production.

    abstract：OBJECTIVE:Enteroendocrine cells (EECs) of the gastro-intestinal tract sense gut luminal factors and release peptide hormones or serotonin (5-HT) to coordinate energy uptake and storage. Our goal is to decipher the gene regulatory networks controlling EECs specification from enteroendocrine progenitors. In this context,...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2019.08.007

    authors： Piccand J,Vagne C,Blot F,Meunier A,Beucher A,Strasser P,Lund ML,Ghimire S,Nivlet L,Lapp C,Petersen N,Engelstoft MS,Thibault-Carpentier C,Keime C,Correa SJ,Schreiber V,Molina N,Schwartz TW,De Arcangelis A,Gradwohl G

    更新日期：2019-11-01 00:00:00

  • 14-3-3ζ mediates an alternative, non-thermogenic mechanism in male mice to reduce heat loss and improve cold tolerance.

    abstract：OBJECTIVE:Adaptive thermogenesis, which is partly mediated by sympathetic input on brown adipose tissue (BAT), is a mechanism of heat production that confers protection against prolonged cold exposure. Various endogenous stimuli, for example, norepinephrine and FGF-21, can also promote the conversion of inguinal white ...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2020.101052

    authors： Diallo K,Dussault S,Noll C,Lopez AF,Rivard A,Carpentier AC,Lim GE

    更新日期：2020-11-01 00:00:00

  • High-fidelity Glucagon-CreER mouse line generated by CRISPR-Cas9 assisted gene targeting.

    abstract：OBJECTIVE:α-cells are the second most prominent cell type in pancreatic islets and are responsible for producing glucagon to increase plasma glucose levels in times of fasting. α-cell dysfunction and inappropriate glucagon secretion occur in both type 1 and type 2 diabetes. Thus, there is growing interest in studying b...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2017.01.003

    authors： Ackermann AM,Zhang J,Heller A,Briker A,Kaestner KH

    更新日期：2017-01-12 00:00:00

  • Metabolic endotoxemia directly increases the proliferation of adipocyte precursors at the onset of metabolic diseases through a CD14-dependent mechanism.

    abstract：:Metabolic endotoxemia triggers inflammation, targets cells from the stroma-vascular fraction of adipose depots, and metabolic disease. To identify these cells we here infused mice with lipopolysaccharides and showed by FACS analyses and BrdU staining that the number of small subcutaneous adipocytes, preadipocytes and ...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2013.06.005

    authors： Luche E,Cousin B,Garidou L,Serino M,Waget A,Barreau C,André M,Valet P,Courtney M,Casteilla L,Burcelin R

    更新日期：2013-07-04 00:00:00

  • Beige fat is dispensable for the metabolic benefits associated with myostatin deletion.

    abstract：OBJECTIVE:Increasing muscle mass and activating beige fat both have great potential for ameliorating obesity and its comorbidities. Myostatin null mice have increased skeletal muscle mass and are protected from obesity and its sequelae. Deletion of myostatin has also been suggested to result in the activation of beige ...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2020.101120

    authors： Marchildon F,Chi J,O'Connor S,Bediako H,Cohen P

    更新日期：2021-01-01 00:00:00

  • Surplus fat rapidly increases fat oxidation and insulin resistance in lipodystrophic mice.

    abstract：OBJECTIVE:Surplus dietary fat cannot be converted into other macronutrient forms or excreted, so has to be stored or oxidized. Healthy mammals store excess energy in the form of triacylgycerol (TAG) in lipid droplets within adipocytes rather than oxidizing it, and thus ultimately gain weight. The 'overflow hypothesis' ...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2018.05.006

    authors： Girousse A,Virtue S,Hart D,Vidal-Puig A,Murgatroyd PR,Mouisel E,Sengenès C,Savage DB

    更新日期：2018-07-01 00:00:00

  • The role of GluN2A and GluN2B NMDA receptor subunits in AgRP and POMC neurons on body weight and glucose homeostasis.

    abstract：OBJECTIVE:Hypothalamic agouti-related peptide (AgRP) and pro-opiomelanocortin (POMC) expressing neurons play critical roles in control of energy balance. Glutamatergic input via n-methyl-d-aspartate receptors (NMDARs) is pivotal for regulation of neuronal activity and is required in AgRP neurons for normal body weight ...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2015.06.010

    authors： Üner A,Gonçalves GH,Li W,Porceban M,Caron N,Schönke M,Delpire E,Sakimura K,Bjørbæk C

    更新日期：2015-07-06 00:00:00

  • Receptor structure-based discovery of non-metabolite agonists for the succinate receptor GPR91.

    abstract：OBJECTIVE:Besides functioning as an intracellular metabolite, succinate acts as a stress-induced extracellular signal through activation of GPR91 (SUCNR1) for which we lack suitable pharmacological tools. METHODS AND RESULTS:Here we first determined that the cis conformation of the succinate backbone is preferred and ...

    journal_title：Molecular metabolism

    pub_type： 杂志文章

    doi：10.1016/j.molmet.2017.09.005

    authors： Trauelsen M,Rexen Ulven E,Hjorth SA,Brvar M,Monaco C,Frimurer TM,Schwartz TW

    更新日期：2017-12-01 00:00:00