Abstract:
OBJECTIVE AND METHODS:Metabolic viscera and their vasculature are richly innervated by peripheral sensory neurons. Here, we examined the metabolic and inflammatory profiles of mice with selective ablation of all Nav1.8-expressing primary afferent neurons. RESULTS:While mice lacking sensory neurons displayed no differences in body weight, food intake, energy expenditure, or body composition compared to controls on chow diet, ablated mice developed an exaggerated inflammatory response to high-fat feeding characterized by bouts of weight loss, splenomegaly, elevated circulating interleukin-6 and hepatic serum amyloid A expression. This phenotype appeared to be directly mediated by the ingestion of saturated lipids. CONCLUSIONS:These data demonstrate that the Nav1.8-expressing afferent neurons are not essential for energy balance but are required for limiting the acute phase response caused by an obesogenic diet.
journal_name
Mol Metabjournal_title
Molecular metabolismauthors
Udit S,Burton M,Rutkowski JM,Lee S,Bookout AL,Scherer PE,Elmquist JK,Gautron Ldoi
10.1016/j.molmet.2017.07.012subject
Has Abstractpub_date
2017-10-01 00:00:00pages
1081-1091issue
10issn
2212-8778pii
S2212-8778(17)30496-9journal_volume
6pub_type
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journal_title:Molecular metabolism
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journal_title:Molecular metabolism
pub_type: 杂志文章
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doi:10.1016/j.molmet.2016.10.003
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1016/j.molmet.2019.04.010
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journal_title:Molecular metabolism
pub_type: 杂志文章
doi:10.1016/j.molmet.2018.05.006
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doi:10.1016/j.molmet.2018.03.014
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journal_title:Molecular metabolism
pub_type: 杂志文章
doi:10.1016/j.molmet.2017.08.003
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2018-04-01 00:00:00
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更新日期:2019-08-01 00:00:00
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journal_title:Molecular metabolism
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更新日期:2018-12-01 00:00:00
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journal_title:Molecular metabolism
pub_type: 杂志文章
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更新日期:2019-09-01 00:00:00
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更新日期:2014-03-12 00:00:00
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journal_title:Molecular metabolism
pub_type: 杂志文章
doi:10.1016/j.molmet.2018.07.012
更新日期:2018-11-01 00:00:00